Cofilin Activation during Podosome Belt Formation in Osteoclasts

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Blangy, Anne ^a   Touaitahuata, Heiani ^a   Cres, Gaelle ^a   Pawlak, Geraldine ^a,b  

^a Centre National de la Recherche Scientifique   (France)

^b UNIV GRENOBLE ALPES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; COFILIN; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATASE; SLINGSHOT 1 PHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL MATURATION; CELL STRUCTURE; CELL TRANSFORMATION; CONTROLLED STUDY; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; PODOSOME BELT; PRIMARY CELL CULTURE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; ANTIBODIES, MONOCLONAL; BONE MARROW CELLS; CELL DIFFERENTIATION; COFILIN 1; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; MACROPHAGES; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; OSTEOCLASTS; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; RANK LIGAND; RETROVIRIDAE;

EID: 84866707093     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045909     Document Type: Article

References (46)

1. Novack DV, Faccio R, (2011) Osteoclast motility: putting the brakes on bone resorption. Ageing Res Rev 10: 54-61.
2. Linder S, Aepfelbacher M, (2003) Podosomes: adhesion hot-spots of invasive cells. Trends Cell Biol 13: 376-385.
3. Chabadel A, Bañon-Rodríguez I, Cluet D, Rudkin BB, Wehrle-Haller B, et al. (2007) CD44 and beta3 integrin organize two functionally distinct actin-based domains in osteoclasts. Mol Biol Cell 18: 4899-4910.
4. Destaing O, Saltel F, Géminard JC, Jurdic P, Bard F, (2003) Podosomes display actin turnover and dynamic self-organization in osteoclasts expressing actin-green fluorescent protein. Mol Biol Cell 14: 407-416.
5. Luxenburg C, Winograd-Katz S, Addadi L, Geiger B, (2012) Involvement of actin polymerization in podosome dynamics. J Cell Sci 125: 1666-1672.
6. Luxenburg C, Geblinger D, Klein E, Anderson K, Hanein D, et al. (2007) The architecture of the adhesive apparatus of cultured osteoclasts: from podosome formation to sealing zone assembly. PLoS One 2: e179.
7. Saltel F, Destaing O, Bard F, Eichert D, Jurdic P, (2004) Apatite-mediated actin dynamics in resorbing osteoclasts. Mol Biol Cell 15: 5231-5241.
8. Ory S, Brazier H, Pawlak G, Blangy A, (2008) Rho GTPases in osteoclasts: orchestrators of podosome arrangement. Eur J Cell Biol 87: 469-477.
9. Saltel F, Daubon T, Juin A, Ganuza IE, Veillat V, et al. (2011) Invadosomes: intriguing structures with promise. Eur J Cell Biol 90: 100-107.
10. Bernstein BW, Bamburg JR, (2010) ADF/cofilin: a functional node in cell biology. Trends Cell Biol 20: 187-195.
11. Van Troys M, Huyck L, Leyman S, Dhaese S, Vandekerkhove J, et al. (2008) Ins and outs of ADF/cofilin activity and regulation. Eur J Cell Biol 87: 649-667.
12. Oser M, Condeelis J, (2009) The cofilin activity cycle in lamellipodia and invadopodia. J Cell Biochem 108: 1252-1262.
13. Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, et al. (1998) Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393: 805-809.
14. Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T, (2002) Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. Cell 108: 233-246.
15. Gohla A, Birkenfeld J, Bokoch GM, (2005) Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nat Cell Biol 7: 21-29.
16. Huang TY, DerMardirossian C, Bokoch GM, (2006) Cofilin phosphatases and regulation of actin dynamics. Curr Opin Cell Biol 18: 26-31.
17. Serezani CH, Kane S, Medeiros AI, Cornett AM, Kim SH, et al. (2012) PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi. Sci Signal 5: ra12.
18. Yamaguchi H, Lorenz M, Kempiak S, Sarmiento C, Coniglio S, et al. (2005) Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. J Cell Biol 168: 441-452.
19. Bravo-Cordero JJ, Oser M, Chen X, Eddy R, Hodgson L, et al. (2011) A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Curr Biol 21: 635-644.
20. Murphy DA, Courtneidge SA, (2011) The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nat Rev Mol Cell Biol 12: 413-426.
21. Oser M, Yamaguchi H, Mader CC, Bravo-Cordero JJ, Arias M, et al. (2009) Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. J Cell Biol 186: 571-587.
22. Brazier H, Pawlak G, Vives V, Blangy A, (2009) The Rho GTPase Wrch1 regulates osteoclast precursor adhesion and migration. Int J Biochem Cell Biol 41: 1391-1401.
23. Brazier H, Stephens S, Ory S, Fort P, Morrison N, et al. (2006) Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: identification of essential genes in osteoclasts. J Bone Miner Res 21: 1387-1398.
24. Sumi T, Matsumoto K, Takai Y, Nakamura T, (1999) Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2. J Cell Biol 147: 1519-1532.
25. Destaing O, Saltel F, Gilquin B, Chabadel A, Khochbin S, et al. (2005) A novel Rho-mDia2-HDAC6 pathway controls podosome patterning through microtubule acetylation in osteoclasts. J Cell Sci 118: 2901-2911.
26. McMichael BK, Cheney RE, Lee BS, (2010) Myosin X regulates sealing zone patterning in osteoclasts through linkage of podosomes and microtubules. J Biol Chem 285: 9506-9515.
27. Linder S, (2007) The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. Trends Cell Biol 17: 107-117.
28. Kim JS, Huang TY, Bokoch GM, (2009) Reactive oxygen species regulate a slingshot-cofilin activation pathway. Mol Biol Cell 20: 2650-2660.
29. Ambach A, Saunus J, Konstandin M, Wesselborg S, Meuer SC, et al. (2000) The serine phosphatases PP1 and PP2A associate with and activate the actin-binding protein cofilin in human T lymphocytes. Eur J Immunol 30: 3422-3431.
30. Kurita S, Watanabe Y, Gunji E, Ohashi K, Mizuno K, (2008) Molecular dissection of the mechanisms of substrate recognition and F-actin-mediated activation of cofilin-phosphatase Slingshot-1. J Biol Chem 283: 32542-32552.
31. Chellaiah M, Kizer N, Silva M, Alvarez U, Kwiatkowski D, et al. (2000) Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength. J Cell Biol 148: 665-678.
32. Hammarfjord O, Falet H, Gurniak C, Hartwig JH, Wallin RP, (2011) Gelsolin-independent podosome formation in dendritic cells. PLoS One 6: e21615.
33. Burgstaller G, Gimona M, (2004) Actin cytoskeleton remodelling via local inhibition of contractility at discrete microdomains. J Cell Sci 117: 223-231.
34. Crimaldi L, Courtneidge SA, Gimona M, (2009) Tks5 recruits AFAP-110, p190RhoGAP, and cortactin for podosome formation. Exp Cell Res 315: 2581-2592.
35. Nagata-Ohashi K, Ohta Y, Goto K, Chiba S, Mori R, et al. (2004) A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. J Cell Biol 165: 465-471.
36. Tang W, Zhang Y, Xu W, Harden TK, Sondek J, et al. (2011) A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis. Dev Cell 21: 1038-1050.
37. Nishita M, Wang Y, Tomizawa C, Suzuki A, Niwa R, et al. (2004) Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. J Biol Chem 279: 7193-7198.
38. Vitolo MI, Boggs AE, Whipple RA, Yoon JR, Thompson K, et al. (2012) Loss of PTEN induces microtentacles through PI3K-independent activation of cofilin. Oncogene doi: 10.1038/onc.2012.234.
39. Wang LH, Xiang J, Yan M, Zhang Y, Zhao Y, et al. (2010) The mitotic kinase Aurora-A induces mammary cell migration and breast cancer metastasis by activating the Cofilin-F-actin pathway. Cancer Res 70: 9118-9128.
40. Destaing O, Sanjay A, Itzstein C, Horne WC, Toomre D, et al. (2008) The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts. Mol Biol Cell 19: 394-404.
41. Luxenburg C, Addadi L, Geiger B, (2006) The molecular dynamics of osteoclast adhesions. Eur J Cell Biol 85: 203-211.
42. Luxenburg C, Parsons JT, Addadi L, Geiger B, (2006) Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts. J Cell Sci 119: 4878-4888.
43. Granot-Attas S, Luxenburg C, Finkelshtein E, Elson A, (2009) Protein tyrosine phosphatase epsilon regulates integrin-mediated podosome stability in osteoclasts by activating Src. Mol Biol Cell 20: 4324-4334.
44. Ochoa GC, Slepnev VI, Neff L, Ringstad N, Takei K, et al. (2000) A functional link between dynamin and the actin cytoskeleton at podosomes. J Cell Biol 150: 377-389.
45. Gil-Henn H, Destaing O, Sims NA, Aoki K, Alles N, et al. (2007) Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice. J Cell Biol 178: 1053-1064.
46. Mooren OL, Kotova TI, Moore AJ, Schafer DA, (2009) Dynamin2 GTPase and cortactin remodel actin filaments. J Biol Chem 284: 23995-24005.