SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 16, 2015, Pages 3382-3389

Development of small molecules targeting the pseudokinase Her3

(11) Lim, Sang Min a,b,c Xie, Ting a,b,c Westover, Kenneth D d Ficarro, Scott B a,b Tae, Hyun Seop e Gurbani, Deepak d Sim, Taebo f Marto, Jarrod A a,b Jänne, Pasi A a Crews, Craig M e Gray, Nathanael S a,b

a DANA FARBER CANCER INSTITUTE (United States)

b HARVARD MEDICAL SCHOOL (United States)

c HARVARD UNIVERSITY (United States)

d UNIVERSITY OF TEXAS AT DALLAS (United States)

e YALE UNIVERSITY (United States)

f Korea Institute of Science and Technology (South Korea)

Author keywords

Cancer; Her3; Hydrophobic tagging; Pseudokinase; Pyrazolopyrimidine

Indexed keywords

ADAMANTANE; BOSUTINIB; CYSTEINE; DASATINIB; HER3 PROTEIN; KIN 001 111; KIN 001 51; LIGAND; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN; SML 4 82 1; TX 1 85 1; TX 2 120 1; TX 2 121 1; UNCLASSIFIED DRUG; ACRYLAMIDE DERIVATIVE; ADENINE; EPIDERMAL GROWTH FACTOR RECEPTOR 3; ERBB3 PROTEIN, HUMAN; MOLECULAR LIBRARY; N-(2-(4-(3-(3-ACRYLAMIDO-4-PHENOXYPHENYL)-4-AMINO-1H-PYRAZOLO(3,4-D)PYRIMIDIN-1-YL)PIPERIDIN-1-YL)ETHYL)-4-(1-ADAMANTANYL)-2-METHYLBUTANAMIDE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; TX1-85-1;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; COVALENT BOND; DIMERIZATION; DRUG DEVELOPMENT; DRUG STRUCTURE; HYDROPHOBICITY; IC50; MEDICINAL CHEMISTRY; MOLECULAR DOCKING; PROTEOMICS; SIGNAL TRANSDUCTION; SUZUKI REACTION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG SCREENING; HUMAN; MOLECULAR LIBRARY; PHARMACOLOGY; SYNTHESIS; TUMOR CELL LINE;

ACRYLAMIDES; ADENINE; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PYRAZOLES; PYRIMIDINES; RECEPTOR, ERBB-3; SMALL MOLECULE LIBRARIES;

EID: 84933556335 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.04.103 Document Type: Article

Times cited : (52)

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