The N-terminal acidic residue of the cytosolic helix 8 of an odorant receptor is responsible for different response dynamics via G-protein

FEBS Letters

Volumn 589, Issue 10, 2015, Pages 1136-1142

  Kawasaki, Takashi ^a   Saka, Takahiro ^b   Mine, Shouhei ^a   Mizohata, Eiichi ^b   Inoue, Tsuyoshi ^b   Matsumura, Hiroyoshi ^b   Sato, Takaaki ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Ca2+ imaging; G protein coupled receptor; Homology model; Interaction; Mouse; Odorant receptor

Indexed keywords

G PROTEIN ALPHA 16; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; OLFACTORY RECEPTOR;

ANIMAL; CHEMISTRY; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MOUSE; OLFACTORY RECEPTOR; POINT MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

ANIMALS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEK293 CELLS; HUMANS; MICE; POINT MUTATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ODORANT;

EID: 84933516134     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2015.03.025     Document Type: Article

References (29)

1. L. Buck, and R. Axel A novel multigene family may encode odorant receptors: a molecular basis for odor recognition Cell 65 1991 175 187
2. 2 adrenergic G-protein-coupled receptor Nature 450 2007 383 387
3. 2-adrenergic G protein-coupled receptor Science 318 2007 1258 1265
4. H.W. Choe Crystal structure of metarhodopsin II Nature 471 2011 651 655
5. s protein complex Nature 477 2011 549 555
6. R.C. Kling, H. Lanig, T. Clark, and P. Gmeiner Active-state models of ternary GPCR complexes: determinants of selective receptor-G-protein coupling PLoS One 8 2013 e67244
7. A. Bruno, G. Costantino, G. de Fabritiis, M. Pastor, and J. Selent Membrane-sensitive conformational states of helix 8 in the metabotropic Glu2 receptor, a class C GPCR PLoS One 7 2012 e42023
8. A.G. Krishna, S.T. Menon, T.J. Terry, and T.P. Sakmar Evidence that helix 8 of rhodopsin acts as a membrane-dependent conformational switch Biochemistry 41 2002 8298 8309
9. K. Kuwasako, K. Kitamura, S. Nagata, T. Hikosaka, and J. Kato Structure-function analysis of helix 8 of human calcitonin receptor-like receptor within the adrenomedullin 1 receptor Peptides 32 2011 144 149
10. A.M. Knepp, X. Periole, S.J. Marrink, T.P. Sakmar, and T. Huber Rhodopsin forms a dimer with cytoplasmic helix 8 contacts in native membranes Biochemistry 51 2012 1819 1821
11. R. Herrmann Sequence of interactions in receptor-G protein coupling J. Biol. Chem. 279 2004 24283 24290
12. 1-adrenergic receptor that are involved in coupling the receptor to G proteins J. Biol. Chem. 281 2006 12896 12907
13. K. Palczewski Crystal structure of rhodopsin: a G protein-coupled receptor Science 289 2000 739 745
14. O. Fritze Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation Proc. Natl. Acad. Sci. U.S.A. 100 2003 2290 2295
15. A. Hamamoto, M. Horikawa, T. Saho, and Y. Saito Mutation of Phe318 within the NPxxY(x)(5,6)F motif in melanin-concentrating hormone receptor 1 results in an efficient signaling activity Front. Endocrinol. 3 2012 147
16. M. Tetsuka, Y. Saito, K. Imai, H. Doi, and K. Maruyama The basic residues in the membrane-proximal C-terminal tail of the rat melanin-concentrating hormone receptor 1 are required for receptor function Endocrinology 145 2004 3712 3723
17. S. Katada, M. Tanaka, and K. Touhara Structural determinants for membrane trafficking and G protein selectivity of a mouse olfactory receptor J. Neurochem. 90 2004 1453 1463
18. H. Hamana, L. Shou-xin, L. Breuils, J. Hirono, and T. Sato Heterologous functional expression system for odorant receptors J. Neurosci. Methods 185 2010 213 220
19. R. Nygaard The dynamic process of β(2)-adrenergic receptor activation Cell 152 2013 532 542
20. D.W. Laird, and R.S. Molday Evidence against the role of rhodopsin in rod outer segment binding to RPE cells Invest. Ophthalmol. Vis. Sci. 29 1988 419 428
21. K. Katoh, K. Kuma, H. Toh, and T. Miyata MAFFT version 5: improvement in accuracy of multiple sequence alignment Nucleic Acids Res. 33 2005 511 518
22. A. Sali, and T.L. Blundell Comparative protein modelling by satisfaction of spatial restraints J. Mol. Biol. 234 1993 779 815
23. R. Laskowski, M. MacArthur, D. Moss, and J. Thornton PROCHECK: a program to check the stereochemical quality of protein structures J. Appl. Cryst. 26 1993 283 291
24. J. Hu Structural basis of G protein-coupled receptor-G protein interactions Nat. Chem. Biol. 6 2010 541 548
25. A. Kato, S. Katada, and K. Touhara Amino acids involved in conformational dynamics and G protein coupling of an odorant receptor: targeting gain-of-function mutation J. Neurochem. 107 2008 1261 1270
26. J.Y. Shim, K.H. Ahn, and D.A. Kendall Molecular basis of cannabinoid CB1 receptor coupling to the G protein heterotrimer Gαibg: identification of key CB1 contacts with the C-terminal helix α5 of Galphai J. Biol. Chem. 288 2013 32449 32465
27. i by the CB1 cannabinoid receptor C-terminal juxtamembrane region: structural requirements determined by peptide analysis Biochemistry 38 1999 3447 3455
28. 2-adrenergic receptors Mol. Endocrinol. 25 2011 1416 1430
29. A. Chakrabartty, T. Kortemme, and R.L. Baldwin Helix propensities of the amino acids measured in alanine-based peptides without helix-stabilizing side-chain interactions Protein Sci. 3 1994 843 852