Formulation development, in vitro and in vivo evaluation of microemulsion-based gel loaded with ketoprofen

Drug Delivery

Volumn 22, Issue 4, 2015, Pages 509-515

  Nikumbh, Kishor V ^a   Sevankar, Shailesh G ^a   Patil, Moreshwar P ^a  

^a MET's Institute of Pharmacy   (India)

Author keywords

Anti inflammatory activity; emulgel; ex vivo release; globule size; zeta potential

Indexed keywords

CARBOPOL 934; CARBOPOL 940; CARRAGEENAN; CLOVE OIL; DICLOFENAC; GELLING AGENT; HYDROXYPROPYLMETHYLCELLULOSE; KETOPROFEN; POLYSORBATE 20; PROPYLENE GLYCOL; SURFACTANT; EMULSION; EXCIPIENT; GEL; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARRAGEENAN-INDUCED PAW EDEMA; CONTROLLED STUDY; DIFFUSION; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; EX VIVO STUDY; FLOW KINETICS; GEL; GLOBULE SIZE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MEASUREMENT; MICROEMULSION; MOUSE; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; SKIN IRRITATION; SPECTROPHOTOMETER; VISCOSITY; ZETA POTENTIAL; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; DRUG DELIVERY SYSTEM; DRUG STABILITY; EMULSION; MEDICINAL CHEMISTRY; SKIN ABSORPTION; SOLUBILITY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; EXCIPIENTS; GELS; HYDROGEN-ION CONCENTRATION; INFLAMMATION; KETOPROFEN; MICE; PARTICLE SIZE; SKIN ABSORPTION; SOLUBILITY; SURFACE-ACTIVE AGENTS; VISCOSITY;

EID: 84933510117     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2013.859186     Document Type: Article

References (25)

1. Bhanu VP, Shanmugam V, Lakshmi PK. (2011). Development and optimization of novel diclofenac sodium emulgel for topical drug delivery. Int J Comprehen Pharm 9:1-4.
2. Bugay DE, Findlay WP. (1999). Pharmaceutical excipients. Vol 94. New York: Marcel Dekker, 116-7.
3. Chen H, Chang X, Weng T, et al. (2004). A study of microemulsion system for transdermal delivery of triptiolide. J Control Rel 98: 427-36.
4. Gordon LA, Jennifer JS, Nehal AK, et al. (2006). Solubalization and dissolution of insoluble weak acid, ketoprofen: effects of pH combined with surfactants. Eur J Pharm Sci 29:306-14.
5. Graf A, Rades T, Hook SM. (2009). Oral insulin delivery using nanoparticles based on microemulsions with different structure-types: optimization and in-vivo evaluation. Eur J Pharm Sci 37:53-61.
6. Hyun JC, Wan SK, Ubovan T, et al. (2012). Development of udenefil loaded microemulsions for intranasal delivery: in vitro and in vivo evaluations. Int J Pharm 423:153-60.
7. Indian pharmacopoeia Vol II. (2007). Government of India, Controller of Publications, Ghaziabad: Ministry of health and family welfare, 1259.
8. Jain A, Gautam S, Gupta Y, et al. (2010). Development and characterization of ketoconazole emulgel for topical drug delivery. Pelagia Res Lib 1:221-31.
9. Joshi B, Singh G, Rana AC, et al. (2011). Emulgel: a comprehensive review on the recent advances in topical drug delivery. Int Res J Pharm 2:66-70.
10. Joshi B, Singh G, Rana AC, Saini S. (2012). Development and characterization of clarithromycin emulgel for topical delivery. Int J Drug Dev Res 4:310-23.
11. Khatib NA, Pawase K, Patil PA. (2010). Evaluation of anti-inflammatory activity of Garcinica Indica fruit rind extracts in wistar rats. Int J Res Ayu Pharm 1:66-70.
12. Khullar R, Kumar D, Seth N, Saini S. (2012). Formulation and evaluation of mefenamic acid emulgel for topical drug delivery. Saudi Pharm J 20:63-7.
13. Khullar R, Rana AC, Seth N, Saini S. (2011). Emulgels: a surrogate approach for topically used hydrophobic drugs. Int J Pharm Bio Sci 1: 117-28.
14. Khunt MD, Mishra AD, Shah DR. (2012). Formulation design and development of piroxicam emulgel. Int J Pharm Tech Res 4:1332-44.
15. Magdy IM. (2004). Optimization of chlorphenesin emulgel formulation. The AAPS J 6:1-7.
16. Mostafa S, Hady S, Hammad M, Mortada N. (2011). Optimized formulation for topical administration of clotrimazole using pemulen polymeric emulsifier. Drug Dev Ind Pharm 27:1083-97.
17. Patravale VB, Bachhav YG. (2009). Microemulsion based vaginal gel of flucanazole: formulation, in-vitro and in-vivo evaluation. Int J Pharm 365:175-9.
18. Renceber S, Karavana S, Ozyazici M. (2009). Bioavailability file: ketoprofen. J Pharm Sci 34:203-16.
19. th ed. New York: Pharmaceutical Press, 108-9.
20. Sahle FF, Metz H, Wohlrab J, Neubert R. (2012). Polyglycerol fatty acid ester surfactant-based microemulsions for targeted delivery of ceramide AP into the stratum corneum: formulation, characterization, in vitro release and penetration investigation. Eur J Pharm Biopharm 3:139-50.
21. Singla V, Saini S, Joshi B, Rana AC. (2012). Emulgel: a new platform for topical drug delivery. Int J Pharm Bio Sci 3:485-95.
22. Thakur V, Prashar B, Arora S. (2012). Formulation and in-vitro evaluation of gel for topical delivery of antifungal agent flucanazole using different penetration enhancers. Drug Invent Today 4:414-19.
23. th ed. New Delhi: Jaypee Brothers Medical Publishers Pvt. Ltd, 168.
24. th ed. New York: McGraw-Hill, pp. 756-9.
25. Yang X, Chen H, Chang X, et al. (2006). Microemulsion-based hydrogel formulation of ibuprofen for topical delivery. Int J Pharm 315:52-8.