Formulation and evaluation of mefenamic acid emulgel for topical delivery

Saudi Pharmaceutical Journal

Volumn 20, Issue 1, 2012, Pages 63-67

  Khullar, Rachit ^a   Kumar, Deepinder ^a   Seth, Nimrata ^a   Saini, Seema ^a  

^a Rayat Institute of Pharmacy   (India)

Author keywords

Emulgel; Mefenamic acid; NSAIDs; Topical drug delivery

Indexed keywords

CARBOPOL 940; CLOVE OIL; DICLOFENAC; MEFENAMIC ACID; MENTHA OIL; UNCLASSIFIED DRUG; VEGETABLE OIL;

ADHESION; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; DRUG SAFETY; DRUG STABILITY; EMULGEL; EMULSION; EX VIVO STUDY; FLOW KINETICS; GEL; HISTOPATHOLOGY; IN VITRO STUDY; MALE; NONHUMAN; PAIN; PAW EDEMA; RAT; SKIN IRRITATION; VISCOSITY;

EID: 83355169588     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsps.2011.08.001     Document Type: Article

References (19)

1. Ansel H.C., Allen L.V., Popovich N.G. Pharmaceutical Dosage Forms and Drug Delivery Systems 1999, Lippincott Williams and Wilkins, New York. 7th ed.
2. Bonacucina G., Cespi M., Palmieri G.F. Characterization and stability of emulsion gels based on acrylamide/sodium acryloyldimethyl taurate copolymer. AAPS PharmSciTech. 2009, 2:10.
3. Choi H.G., Yong C.S., Sah H., Jahng Y., Chang H.W., Son J.K., Lee S.H., Jeong T.C., Rhee J.D., Baek S.H., et al. Physiochemical characterization of diclofenac sodium loaded poloxamer gels as a rectal delivery system with fast absorption. Drug Dev. Ind. Pharm. 2003, 29:545-553.
4. Crunkhorn P., Mencock S.C. Mediators of inflammation induced in rat paw carregeenan. Br. J. Pharmacol. 1971, 42:371-402.
5. Remington: the Science and Practice of Pharmacy 1995, Mack Publishing Company, Easton. 19th ed. A.R. Gennaro (Ed.).
6. Gupta G.D., Gaud R.S. Release rate of tenoxicam from acrypol gels. Ind. Pharm. 2005, 69-76.
7. Gupta A., Mishra A.K., Singh A.K., Gupta V., Bansal P. Formulation and evaluation of topical gel of diclofenac sodium using different polymers. Drug Invention Today 2010, 2:250-253.
8. ICH Harmonized Tripartite Guidelines, Stability Testing of New Drug Substances and Products. ICH Committee 2003; 8.
9. Jain A., Deveda P., Vyas N., Chauhan J., et al. Development of antifungal emulsion based gel for topical fungal infection(s). IJPRD 2011, 2(03).
10. Junping K., Yun N., Wang N., Liang L., Zhi-Hong H. Analgesic and anti-inflammatory activities of total extract and individual fractions of Chinese medicinal plants Polyrhachis lamellidens. Bio. Pharm. Bull. 2005, 23:176-180.
11. Kakkar A.P., Gupta A. Gelatin based transdermal therapeutic system. Ind. Drugs 1992, 29:308-312.
12. Kasliwal N., Derle D., Negi J., Gohil J. Effect of permeation enhancers on the release and permeationkinetics of meloxicam gel formulations through rat skin. Asian J. Pharm. Sci. 2008, 3(5):193-199.
13. Kumar L., Verma R. In vitro evaluation of topical gel prepared using natural polymer. International Journal of Drug Delivery 2010, 2:58-63.
14. Lionberger D.R., Brennan M.J. Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch. J Pain Research 2010, 3:223-233.
15. Mohamed M.I. Optimization of chlorphenesin emulgel formulation. AAPS J. 2004, 6(3).
16. Murty S.N., Hiremath S.R.R. Physical and chemical enhancers in transdermal delivery of terbutaline sulphate. AAPS Pharm. Sci. Tech. 2001, 2:1-5.
17. Schreier H., Bouwstra J.A. Liposomes and Niosomes as topical drug carriers: Dermal and Transdermal delivery. J. Contr. Rel. 1985, 30:863-868.
18. Stanos S.P. Topical agents for the management of musculoskeletal pain. J. Pain Sympt. Manage. 2007, 33.
19. Topical Emulsion, Gel Composition Comprising Diclofenac Sodium. Patent no. WO/2004/017998).