Formulation and in vitro evaluation of gel for topical delivery of antifungal agent fluconazole using different penetration enhancers

Drug Invention Today

Volumn 4, Issue 8, 2012, Pages 414-419

  Thakur, Varun ^a   Prashar, Bharat ^a   Arora, Sonia ^a  

^a Manav Bharti University   (India)

Author keywords

Antifungal activity; Carbopol; Drug content; Fluconazole

Indexed keywords

CARBOPOL 940; FLUCONAZOLE; HYDROXYPROPYLMETHYLCELLULOSE; OLEIC ACID; POLYSORBATE 80; PROPYLENE GLYCOL; XANTHAN;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG PENETRATION; DRUG SENSITIVITY; GEL; HUMAN; IN VITRO STUDY; INFRARED SPECTROSCOPY; PH; SKIN IRRITATION; VISCOSITY;

EID: 84869022014     PISSN: 09757619     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Surver, C. and Davis, F.A., Bioaviability and Bioequivalence, In Walter, K.A. (Ed.), Dermatological and Transdermal Formulation, Marcal Dekker, INC. NewYork, 119, 2002, pp. 403,323,326,327,403.
2. Prorost C. Transparent oil-water gels. A review. Int J Cosmet Sci. 1986; 8(3): 233-247.
3. Sakurai. K., Maegawa. T., Takahashi. T.; Glass transition temperature of chitosan and miscibility of chitosan/poly (Nvinyl pyrrolidone) blends. Polymer, 41(2000) 7051-7056.
4. V Lognathan; S Manimaran; A Jaswanth; A Sulaiman; BS Kumar ; A Rajaseskaran. Ind. J. Pharm. Sci., 2001, 63, 200-204.
5. Grove. J., Durr. M., Quint. M.P., Plazonnet. B.; The effect of vehicle viscosity on the ocular bioavailability of L- 653328. Int J Pharm 66, (1990) 23-28.
6. Panigrahi, John T, Sharif A, Shobha Rani and Hiremath R. Formulation and evaluation of lincomycin HCl gels. Indian Journal of Pharmaceutical Sciences. 1992 Nov-Dec. P.330-332.
7. Sanjay, Bidkar Devendra Jain, Amol Padsaly, Krishna Patel and Vinod Mokale. Formulation, development and evaluation of Fluconazole gel in various polymers bases. Asian Journal of Pharmaceutics. 2007 Apr-Jun; 1(1): P.63-68.
8. Bhalaria M, Naik S, Misra A. A novel delivery system for antifungal drugs in the treatment of topical fungal disease. Indian J Exp Biol 2009; 47(5):368-75.
9. Genta. I., Perugini. P., Pavanetto. F.; Different molecular weight chitosan microspheres: influence on drug loading and drug release. Drug Dev Ind Pharm, 24(1994) 779-784.
10. Miyazaki. S.; Chitin and chitosan as vehicle for drug delivery, Zairyo Gijutsu 16 (1998) 276.