-
1
-
-
76149093586
-
A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
-
Kappos L, Radue EW, O'Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med. 2010; 362: 387-401.
-
(2010)
N Engl J Med
, vol.362
, pp. 387-401
-
-
Kappos, L.1
Radue, E.W.2
O'Connor, P.3
-
2
-
-
33745927144
-
FTY720: placebo-controlled study of the effect on cardiac rate and rhythm in healthy subjects
-
Schmouder R, Serra D, Wang Y, et al. FTY720: placebo-controlled study of the effect on cardiac rate and rhythm in healthy subjects. J Clin Pharmacol. 2006; 46: 895-904.
-
(2006)
J Clin Pharmacol
, vol.46
, pp. 895-904
-
-
Schmouder, R.1
Serra, D.2
Wang, Y.3
-
3
-
-
84938838488
-
First-dose effects of fingolimod: pooled safety data from three phase 3 studies
-
DiMarco JP, O'Connor P, Cohen JA, et al. First-dose effects of fingolimod: pooled safety data from three phase 3 studies. Mult Scler. 2014; 3: 629-38.
-
(2014)
Mult Scler
, vol.3
, pp. 629-638
-
-
DiMarco, J.P.1
O'Connor, P.2
Cohen, J.A.3
-
4
-
-
84957088865
-
Intermittent atrioventricular block following fingolimod initiation
-
Gialafos E, Gerakoulis S, Grigoriou A, et al. Intermittent atrioventricular block following fingolimod initiation. Case Rep Neurol Med. 2014; 2014: 191305.
-
(2014)
Case Rep Neurol Med
, vol.2014
, pp. 191305
-
-
Gialafos, E.1
Gerakoulis, S.2
Grigoriou, A.3
-
5
-
-
33845650073
-
Differential expression of ion channel transcripts in atrial muscle and sinoatrial node in rabbit
-
Tellez JO, Dobrzynski H, Greener ID, et al. Differential expression of ion channel transcripts in atrial muscle and sinoatrial node in rabbit. Circ Res. 2006; 99: 1384-93.
-
(2006)
Circ Res
, vol.99
, pp. 1384-1393
-
-
Tellez, J.O.1
Dobrzynski, H.2
Greener, I.D.3
-
6
-
-
33846866051
-
Organisation of the mouse sinoatrial node: structure and expression of HCN channels
-
Liu J, Dobrzynski H, Yanni J, et al. Organisation of the mouse sinoatrial node: structure and expression of HCN channels. Cardiovasc Res. 2007; 73: 729-38.
-
(2007)
Cardiovasc Res
, vol.73
, pp. 729-738
-
-
Liu, J.1
Dobrzynski, H.2
Yanni, J.3
-
7
-
-
76149140914
-
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
-
Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med. 2010; 362: 402-15.
-
(2010)
N Engl J Med
, vol.362
, pp. 402-415
-
-
Cohen, J.A.1
Barkhof, F.2
Comi, G.3
-
8
-
-
67449128428
-
Sphingosine kinase regulation and cardioprotection
-
Karliner JS. Sphingosine kinase regulation and cardioprotection. Cardiovasc Res. 2009; 82: 184-92.
-
(2009)
Cardiovasc Res
, vol.82
, pp. 184-192
-
-
Karliner, J.S.1
-
9
-
-
33947147730
-
Sphingosine-1-phosphate signaling in the cardiovascular system
-
Peters SLM, Alewijnse AE. Sphingosine-1-phosphate signaling in the cardiovascular system. Curr Opin Pharmacol. 2007; 7: 186-92.
-
(2007)
Curr Opin Pharmacol
, vol.7
, pp. 186-192
-
-
Peters, S.L.M.1
Alewijnse, A.E.2
-
10
-
-
77954341984
-
Cardioprotection in ischemia/reperfusion injury: spotlight on sphingosine-1-phosphate and bradykinin signalling
-
Egom EE, Ke Y, Solaro RJ, et al. Cardioprotection in ischemia/reperfusion injury: spotlight on sphingosine-1-phosphate and bradykinin signalling. Prog Biophys Mol Biol. 2010; 103: 142-7.
-
(2010)
Prog Biophys Mol Biol
, vol.103
, pp. 142-147
-
-
Egom, E.E.1
Ke, Y.2
Solaro, R.J.3
-
11
-
-
74149086892
-
FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling
-
Egom EE, Ke Y, Musa H, et al. FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. J Mol Cell Cardiol. 2010; 48: 406-14.
-
(2010)
J Mol Cell Cardiol
, vol.48
, pp. 406-414
-
-
Egom, E.E.1
Ke, Y.2
Musa, H.3
-
12
-
-
80053266443
-
Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury
-
Egom EE, Mohamed TM, Mamas MA, et al. Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury. Am J Physiol Heart Circ Physiol. 2011; 301: H1487-95.
-
(2011)
Am J Physiol Heart Circ Physiol
, vol.301
, pp. H1487-H1495
-
-
Egom, E.E.1
Mohamed, T.M.2
Mamas, M.A.3
-
13
-
-
65949105042
-
Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors
-
Mullershausen F, Zecri F, Cetin C, et al. Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. Nat Chem Biol. 2009; 5: 428-34.
-
(2009)
Nat Chem Biol
, vol.5
, pp. 428-434
-
-
Mullershausen, F.1
Zecri, F.2
Cetin, C.3
-
14
-
-
53749090260
-
Parasympathetic nervous system and heart failure: pathophysiology and potential implications for therapy
-
Olshansky B, Sabbah HN, Hauptman PJ, et al. Parasympathetic nervous system and heart failure: pathophysiology and potential implications for therapy. Circulation. 2008; 118: 863-71.
-
(2008)
Circulation
, vol.118
, pp. 863-871
-
-
Olshansky, B.1
Sabbah, H.N.2
Hauptman, P.J.3
-
15
-
-
84895445228
-
Assessment of cardiac safety during fingolimod treatment initiation in a real-world relapsing multiple sclerosis population: a phase 3b, open-label study
-
Gold R, Comi G, Palace J, et al.; FIRST Study Investigators. Assessment of cardiac safety during fingolimod treatment initiation in a real-world relapsing multiple sclerosis population: a phase 3b, open-label study. J Neurol. 2014; 261: 267-76.
-
(2014)
J Neurol
, vol.261
, pp. 267-276
-
-
Gold, R.1
Comi, G.2
Palace, J.3
-
16
-
-
14644408845
-
The heart rate decrease caused by the sphingosine 1-phosphate receptor agonist FTY720 results from activation of the G protein-gated potassium channel IKACh
-
Koyrakh L, Roman MI, Brinkmann V, et al. The heart rate decrease caused by the sphingosine 1-phosphate receptor agonist FTY720 results from activation of the G protein-gated potassium channel IKACh. Am J Transplant. 2005; 5: 529-36.
-
(2005)
Am J Transplant
, vol.5
, pp. 529-536
-
-
Koyrakh, L.1
Roman, M.I.2
Brinkmann, V.3
-
17
-
-
11144353922
-
Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate
-
Sanna MG, Liao J, Jo E, et al. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem. 2004; 279: 13839-48.
-
(2004)
J Biol Chem
, vol.279
, pp. 13839-13848
-
-
Sanna, M.G.1
Liao, J.2
Jo, E.3
-
18
-
-
34250832664
-
Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology
-
Brinkmann V. Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol Ther. 2007; 115: 84-105.
-
(2007)
Pharmacol Ther
, vol.115
, pp. 84-105
-
-
Brinkmann, V.1
-
19
-
-
0028785438
-
G protein regulation of cardiac muscarinic potassium channel
-
Kurachi Y. G protein regulation of cardiac muscarinic potassium channel. Am J Physiol. 1995; 269: C821-30.
-
(1995)
Am J Physiol
, vol.269
, pp. C821-C830
-
-
Kurachi, Y.1
-
20
-
-
84908345883
-
Analysis of onset mechanisms of a sphingosine 1-phosphate receptor modulator fingolimod-induced atrioventricular conduction block and QT-interval prolongation
-
Yagi Y, Nakamura Y, Kitahara K, et al. Analysis of onset mechanisms of a sphingosine 1-phosphate receptor modulator fingolimod-induced atrioventricular conduction block and QT-interval prolongation. Toxicol Appl Pharmacol. 2014; 281: 39-47.
-
(2014)
Toxicol Appl Pharmacol
, vol.281
, pp. 39-47
-
-
Yagi, Y.1
Nakamura, Y.2
Kitahara, K.3
-
21
-
-
48149111313
-
Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts
-
Sugiyama A. Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts. Br J Pharmacol. 2008; 154: 1528-37.
-
(2008)
Br J Pharmacol
, vol.154
, pp. 1528-1537
-
-
Sugiyama, A.1
-
22
-
-
0033780037
-
The bee venom peptide tertiapin underlines the role of I(KACh) in acetylcholine-induced atrioventricular blocks
-
Drici MD, Diochot S, Terrenoire C, et al. The bee venom peptide tertiapin underlines the role of I(KACh) in acetylcholine-induced atrioventricular blocks. Br J Pharmacol. 2000; 131: 569-77.
-
(2000)
Br J Pharmacol
, vol.131
, pp. 569-577
-
-
Drici, M.D.1
Diochot, S.2
Terrenoire, C.3
|