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Volumn 218, Issue 4, 2013, Pages 1051-1060

Differential distribution and activation of microglia in the brain of male C57BL/6J mice

Author keywords

LPS; Microglia; Mouse; Substantia nigra; Systemic inflammation; TNF receptor 1

Indexed keywords

LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR 1; UNCLASSIFIED DRUG;

EID: 84879794919     PISSN: 18632653     EISSN: 18632661     Source Type: Journal    
DOI: 10.1007/s00429-012-0446-x     Document Type: Article
Times cited : (72)

References (44)
  • 1
    • 0035478029 scopus 로고    scopus 로고
    • Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia
    • 11567062 1:STN:280:DC%2BD3MritFGluw%3D%3D
    • Asahi M, Wang X, Mori T, Sumii T, Jung JC, Moskowitz MA, Fini ME, Lo EH (2001) Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci 21:7724-7732
    • (2001) J Neurosci , vol.21 , pp. 7724-7732
    • Asahi, M.1    Wang, X.2    Mori, T.3    Sumii, T.4    Jung, J.C.5    Moskowitz, M.A.6    Fini, M.E.7    Lo, E.H.8
  • 2
    • 0033104019 scopus 로고    scopus 로고
    • Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor
    • 10024357 1:CAS:528:DyaK1MXhtlCrtL8%3D
    • Batchelor PE, Liberatore GT, Wong JY, Porritt MJ, Frerichs F, Donnan GA, Howells DW (1999) Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. J Neurosci 19:1708-1716
    • (1999) J Neurosci , vol.19 , pp. 1708-1716
    • Batchelor, P.E.1    Liberatore, G.T.2    Wong, J.Y.3    Porritt, M.J.4    Frerichs, F.5    Donnan, G.A.6    Howells, D.W.7
  • 3
    • 16344393716 scopus 로고    scopus 로고
    • Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia
    • 15671154 1:CAS:528:DC%2BD2MXjtFaksLs%3D
    • Bechmann I, Goldmann J, Kovac AD, Kwidzinski E, Simburger E, Naftolin F, Dirnagl U, Nitsch R, Priller J (2005) Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia. FASEB J 19:647-649
    • (2005) FASEB J , vol.19 , pp. 647-649
    • Bechmann, I.1    Goldmann, J.2    Kovac, A.D.3    Kwidzinski, E.4    Simburger, E.5    Naftolin, F.6    Dirnagl, U.7    Nitsch, R.8    Priller, J.9
  • 4
    • 33846887598 scopus 로고    scopus 로고
    • Microglial control of neuronal death and synaptic properties
    • 17106878 10.1002/glia.20459
    • Bessis A, Bechade C, Bernard D, Roumier A (2007) Microglial control of neuronal death and synaptic properties. Glia 55:233-238
    • (2007) Glia , vol.55 , pp. 233-238
    • Bessis, A.1    Bechade, C.2    Bernard, D.3    Roumier, A.4
  • 5
    • 24144453087 scopus 로고    scopus 로고
    • Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
    • 16081203 10.1016/j.pneurobio.2005.06.004 1:CAS:528:DC%2BD2MXpvFemu7o%3D
    • Block ML, Hong JS (2005) Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 76:77-98
    • (2005) Prog Neurobiol , vol.76 , pp. 77-98
    • Block, M.L.1    Hong, J.S.2
  • 6
    • 34147162708 scopus 로고    scopus 로고
    • Immune cells may fend off Alzheimer disease
    • 17415372 10.1038/nm0407-408 1:CAS:528:DC%2BD2sXjvVaqtLg%3D
    • Britschgi M, Wyss-Coray T (2007) Immune cells may fend off Alzheimer disease. Nat Med 13:408-409
    • (2007) Nat Med , vol.13 , pp. 408-409
    • Britschgi, M.1    Wyss-Coray, T.2
  • 7
    • 14044279966 scopus 로고    scopus 로고
    • Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines
    • 15716415 10.1523/JNEUROSCI.4268-04.2005 1:CAS:528:DC%2BD2MXhvFGqu7g%3D
    • Chakravarty S (2005) Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines. J Neurosci 25:1788-1796
    • (2005) J Neurosci , vol.25 , pp. 1788-1796
    • Chakravarty, S.1
  • 8
    • 60849135712 scopus 로고    scopus 로고
    • Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factor α signaling during peripheral organ inflammation
    • 19228962 10.1523/JNEUROSCI.3567-08.2009
    • D'Mello C, Le T, Swain MG (2009) Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factor α signaling during peripheral organ inflammation. J Neurosci 29:2089-2102
    • (2009) J Neurosci , vol.29 , pp. 2089-2102
    • D'Mello, C.1    Le, T.2    Swain, M.G.3
  • 9
    • 0014481730 scopus 로고
    • Equilibrium and kinetic properties of the Evans Blue-ablumin system
    • 5765622 1:CAS:528:DyaF1MXosVehsw%3D%3D
    • Freedman FB, Johnson JA (1969) Equilibrium and kinetic properties of the Evans Blue-ablumin system. Am J Physiol 216:675-681
    • (1969) Am J Physiol , vol.216 , pp. 675-681
    • Freedman, F.B.1    Johnson, J.A.2
  • 10
    • 50549085408 scopus 로고    scopus 로고
    • Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration
    • 18650345 10.1523/JNEUROSCI.0143-07.2008 1:CAS:528:DC%2BD1cXpt12muro%3D
    • Gao HM, Kotzbauer PT, Uryu K, Leight S, Trojanowski JQ, Lee VM (2008) Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration. J Neurosci 28:7687-7698
    • (2008) J Neurosci , vol.28 , pp. 7687-7698
    • Gao, H.M.1    Kotzbauer, P.T.2    Uryu, K.3    Leight, S.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 12
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
    • 17965659 10.1038/nn1997 1:CAS:528:DC%2BD2sXht1ajsbbE
    • Hanisch UK, Kettenmann H (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10:1387-1394
    • (2007) Nat Neurosci , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 13
    • 51349127386 scopus 로고    scopus 로고
    • Differential neutrophil infiltration contributes to regional differences in brain inflammation in the substantia nigra pars compacta and cortex
    • 18381656 10.1002/glia.20677
    • Ji K-A, Eu MY, Kang S-H, Gwag BJ, Jou I, Joe E-H (2008) Differential neutrophil infiltration contributes to regional differences in brain inflammation in the substantia nigra pars compacta and cortex. Glia 56:1039-1047
    • (2008) Glia , vol.56 , pp. 1039-1047
    • Ji, K.-A.1    Eu, M.Y.2    Kang, S.-H.3    Gwag, B.J.4    Jou, I.5    Joe, E.-H.6
  • 15
    • 25444495866 scopus 로고    scopus 로고
    • Microglia in health and disease
    • 15954124 10.1002/jnr.20562 1:CAS:528:DC%2BD2MXnsVelt7g%3D
    • Kim SU, de Vellis J (2005) Microglia in health and disease. J Neurosci Res 81:302-313
    • (2005) J Neurosci Res , vol.81 , pp. 302-313
    • Kim, S.U.1    De Vellis, J.2
  • 16
    • 0034663061 scopus 로고    scopus 로고
    • Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: Role of microglia
    • 10934283 1:CAS:528:DC%2BD3cXlvVGjtbs%3D
    • Kim WG, Mohney RP, Wilson B, Jeohn GH, Liu B, Hong JS (2000) Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J Neurosci 20:6309-6316
    • (2000) J Neurosci , vol.20 , pp. 6309-6316
    • Kim, W.G.1    Mohney, R.P.2    Wilson, B.3    Jeohn, G.H.4    Liu, B.5    Hong, J.S.6
  • 17
    • 1542396688 scopus 로고    scopus 로고
    • Differential expression of chemokines and chemokine receptors during microglial activation and inhibition
    • 15020059 10.1016/j.jneuroim.2003.11.012 1:CAS:528:DC%2BD2cXitFCht7o%3D
    • Kremlev SG, Roberts RL, Palmer C (2004) Differential expression of chemokines and chemokine receptors during microglial activation and inhibition. J Neuroimmunol 149:1-9
    • (2004) J Neuroimmunol , vol.149 , pp. 1-9
    • Kremlev, S.G.1    Roberts, R.L.2    Palmer, C.3
  • 18
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • 8843599 10.1016/0166-2236(96)10049-7 1:STN:280:DyaK2s%2FgtVGitg%3D%3D
    • Kreutzberg GW (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19:312-318
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 19
    • 0038744340 scopus 로고    scopus 로고
    • Cooperation between toll-like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram-negative and gram-positive bacteria
    • 12672079 10.1002/eji.200323821 1:CAS:528:DC%2BD3sXjtVaksrs%3D
    • Laflamme N, Echchannaoui H, Landmann R, Rivest S (2003) Cooperation between toll-like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram-negative and gram-positive bacteria. Eur J Immunol 33:1127-1138
    • (2003) Eur J Immunol , vol.33 , pp. 1127-1138
    • Laflamme, N.1    Echchannaoui, H.2    Landmann, R.3    Rivest, S.4
  • 20
    • 0025220976 scopus 로고
    • Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
    • 2089275 10.1016/0306-4522(90)90229-W 1:STN:280:DyaK3M3htFyiuw%3D%3D
    • Lawson LJ, Perry VH, Dri P, Gordon S (1990) Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 39:151-170
    • (1990) Neuroscience , vol.39 , pp. 151-170
    • Lawson, L.J.1    Perry, V.H.2    Dri, P.3    Gordon, S.4
  • 21
    • 0015795772 scopus 로고
    • Investigation of glial cells in semithin sections. II. Variation with age in the numbers of the various glial cell types in rat cortex and corpus callosum
    • 4121706 10.1002/cne.901490105 1:STN:280:DyaE3s7ms1KksQ%3D%3D
    • Ling E-A, Leblond CP (1973) Investigation of glial cells in semithin sections. II. Variation with age in the numbers of the various glial cell types in rat cortex and corpus callosum. J Comp Neurol 149:73-81
    • (1973) J Comp Neurol , vol.149 , pp. 73-81
    • Ling, E.-A.1    Leblond, C.P.2
  • 22
    • 0037381043 scopus 로고    scopus 로고
    • Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation
    • 12649371 10.1124/jpet.102.043166 1:CAS:528:DC%2BD3sXis1anurk%3D
    • Liu Y, Qin L, Li G, Zhang W, An L, Liu B, Hong JS (2003) Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. J Pharmacol Exp Ther 305:212-218
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 212-218
    • Liu, Y.1    Qin, L.2    Li, G.3    Zhang, W.4    An, L.5    Liu, B.6    Hong, J.S.7
  • 23
    • 77955091162 scopus 로고    scopus 로고
    • Microglia activation and anti-inflammatory regulation in Alzheimer's disease
    • 20195797 10.1007/s12035-010-8106-8 1:CAS:528:DC%2BC3cXmsFSru78%3D
    • Lue LF, Kuo YM, Beach T, Walker DG (2010) Microglia activation and anti-inflammatory regulation in Alzheimer's disease. Mol Neurobiol 41:115-128
    • (2010) Mol Neurobiol , vol.41 , pp. 115-128
    • Lue, L.F.1    Kuo, Y.M.2    Beach, T.3    Walker, D.G.4
  • 24
    • 0028935631 scopus 로고
    • Cell counts in the substantia nigra: A comparison of single section counts and disector counts in patients with Parkinson's disease and in controls
    • 7770115 10.1111/j.1365-2990.1995.tb01023.x 1:STN:280:DyaK2M3osl2gsQ%3D%3D
    • Ma SY, Collan Y, Roytta M, Rinne JO, Rinne UK (1995) Cell counts in the substantia nigra: a comparison of single section counts and disector counts in patients with Parkinson's disease and in controls. Neuropathol Appl Neurobiol 21:10-17
    • (1995) Neuropathol Appl Neurobiol , vol.21 , pp. 10-17
    • Ma, S.Y.1    Collan, Y.2    Roytta, M.3    Rinne, J.O.4    Rinne, U.K.5
  • 25
    • 3042729682 scopus 로고    scopus 로고
    • Microglia release activators of neuronal proliferation mediated by activation of mitogen-activated protein kinase, phosphatidylinositol-3-kinase/ Akt and delta-Notch signalling cascades
    • 15198670 10.1111/j.1471-4159.2004.02461.x 1:CAS:528:DC%2BD2cXlvFKls7s%3D
    • Morgan SC, Taylor DL, Pocock JM (2004) Microglia release activators of neuronal proliferation mediated by activation of mitogen-activated protein kinase, phosphatidylinositol-3-kinase/Akt and delta-Notch signalling cascades. J Neurochem 90:89-101
    • (2004) J Neurochem , vol.90 , pp. 89-101
    • Morgan, S.C.1    Taylor, D.L.2    Pocock, J.M.3
  • 26
    • 0014447594 scopus 로고
    • Identification of microglia in light and electron microscopy
    • 4181000 10.1002/cne.901350104 1:STN:280:DyaF1M7ms1yjtg%3D%3D
    • Mori S, Leblond CP (1969) Identification of microglia in light and electron microscopy. J Comp Neurol 135:57-79
    • (1969) J Comp Neurol , vol.135 , pp. 57-79
    • Mori, S.1    Leblond, C.P.2
  • 27
    • 0036690599 scopus 로고    scopus 로고
    • Regulating factors for microglial activation
    • 12186424 10.1248/bpb.25.945 1:CAS:528:DC%2BD38Xmt1Sjtro%3D
    • Nakamura Y (2002) Regulating factors for microglial activation. Biol Pharm Bull 25:945-953
    • (2002) Biol Pharm Bull , vol.25 , pp. 945-953
    • Nakamura, Y.1
  • 28
    • 60149098421 scopus 로고    scopus 로고
    • Debris clearance by microglia: An essential link between degeneration and regeneration
    • 18567623 10.1093/brain/awn109 1:STN:280:DC%2BD1M7jtVeltA%3D%3D
    • Neumann H, Kotter MR, Franklin RJ (2009) Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132:288-295
    • (2009) Brain , vol.132 , pp. 288-295
    • Neumann, H.1    Kotter, M.R.2    Franklin, R.J.3
  • 29
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • 15831717 10.1126/science.1110647 1:CAS:528:DC%2BD2MXks1Ciuro%3D
    • Nimmerjahn A, Kirchhoff F, Helmchen F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308:1314-1318
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 30
    • 0036935553 scopus 로고    scopus 로고
    • An inflammatory review of Parkinson's disease
    • 12531233 10.1016/S0301-0082(02)00127-2 1:CAS:528:DC%2BD3sXislynsQ%3D%3D
    • Orr CF, Rowe DB, Halliday GM (2002) An inflammatory review of Parkinson's disease. Prog Neurobiol 68:325-340
    • (2002) Prog Neurobiol , vol.68 , pp. 325-340
    • Orr, C.F.1    Rowe, D.B.2    Halliday, G.M.3
  • 31
    • 13144258735 scopus 로고    scopus 로고
    • Microglial activation and dopamine terminal loss in early Parkinson's disease
    • 15668962 10.1002/ana.20338 1:CAS:528:DC%2BD2MXhs1Cisb8%3D
    • Ouchi Y, Yoshikawa E, Sekine Y, Futatsubashi M, Kanno T, Ogusu T, Torizuka T (2005) Microglial activation and dopamine terminal loss in early Parkinson's disease. Ann Neurol 57:168-175
    • (2005) Ann Neurol , vol.57 , pp. 168-175
    • Ouchi, Y.1    Yoshikawa, E.2    Sekine, Y.3    Futatsubashi, M.4    Kanno, T.5    Ogusu, T.6    Torizuka, T.7
  • 33
    • 0346463000 scopus 로고    scopus 로고
    • NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia
    • 14578353 10.1074/jbc.M307657200 1:CAS:528:DC%2BD2cXhtV2jtw%3D%3D
    • Qin L, Liu Y, Wang T, Wei SJ, Block ML, Wilson B, Liu B, Hong JS (2004) NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J Biol Chem 279:1415-1421
    • (2004) J Biol Chem , vol.279 , pp. 1415-1421
    • Qin, L.1    Liu, Y.2    Wang, T.3    Wei, S.J.4    Block, M.L.5    Wilson, B.6    Liu, B.7    Hong, J.S.8
  • 34
    • 33847759064 scopus 로고    scopus 로고
    • Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
    • 17203472 10.1002/glia.20467
    • Qin L, Wu X, Block ML, Liu Y, Breese GR, Hong JS, Knapp DJ, Crews FT (2007) Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 55:453-462
    • (2007) Glia , vol.55 , pp. 453-462
    • Qin, L.1    Wu, X.2    Block, M.L.3    Liu, Y.4    Breese, G.R.5    Hong, J.S.6    Knapp, D.J.7    Crews, F.T.8
  • 35
    • 0031022698 scopus 로고    scopus 로고
    • Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowth
    • 8981236 10.1002/(SICI)1097-4547(19970101)47:1<34: AID-JNR4>3.0. CO;2-G 1:CAS:528:DyaK2sXms1ei
    • Rabchevsky AG, Streit WJ (1997) Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowth. J Neurosci Res 47:34-48
    • (1997) J Neurosci Res , vol.47 , pp. 34-48
    • Rabchevsky, A.G.1    Streit, W.J.2
  • 36
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: Unique stimuli, specialized responses
    • 19302036 10.1146/annurev.immunol.021908.132528 1:CAS:528: DC%2BD1MXlsFSlsbs%3D
    • Ransohoff RM, Perry VH (2009) Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol 27:119-145
    • (2009) Annu Rev Immunol , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 37
    • 0035101188 scopus 로고    scopus 로고
    • Dynamics of microglial activation: A confocal time-lapse analysis in hippocampal slices
    • 11241743 10.1002/1098-1136(200103)33:3<256: AID-GLIA1024>3.0.CO;2-J 1:STN:280:DC%2BD3M3lvFOgsQ%3D%3D
    • Stence N, Waite M, Dailey ME (2001) Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 33:256-266
    • (2001) Glia , vol.33 , pp. 256-266
    • Stence, N.1    Waite, M.2    Dailey, M.E.3
  • 38
    • 0032937860 scopus 로고    scopus 로고
    • The role of microglia and macrophages in the pathophysiology of the CNS
    • 10.1016/S0301-0082(98)00083-5
    • Stollg G, Jander S (1999) The role of microglia and macrophages in the pathophysiology of the CNS. Prog Neurobiol 58:233-247
    • (1999) Prog Neurobiol , vol.58 , pp. 233-247
    • Stollg, G.1    Jander, S.2
  • 39
    • 7744224673 scopus 로고    scopus 로고
    • Microglia and neuroinflammation: A pathological perspective
    • 15285801 10.1186/1742-2094-1-14
    • Streit WJ, Mrak RE, Griffin WS (2004) Microglia and neuroinflammation: a pathological perspective. J Neuroinflammation 1:14
    • (2004) J Neuroinflammation , vol.1 , pp. 14
    • Streit, W.J.1    Mrak, R.E.2    Griffin, W.S.3
  • 40
    • 77952095680 scopus 로고    scopus 로고
    • Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microglia
    • 19728078 10.1007/s10571-009-9446-7 1:CAS:528:DC%2BC3cXjtlahtL0%3D
    • Sumi N, Nishioku T, Takata F, Matsumoto J, Watanabe T, Shuto H, Yamauchi A, Dohgu S, Kataoka Y (2010) Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microglia. Cell Mol Neurobiol 30:247-253
    • (2010) Cell Mol Neurobiol , vol.30 , pp. 247-253
    • Sumi, N.1    Nishioku, T.2    Takata, F.3    Matsumoto, J.4    Watanabe, T.5    Shuto, H.6    Yamauchi, A.7    Dohgu, S.8    Kataoka, Y.9
  • 42
    • 0016261856 scopus 로고
    • Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: An electron microscope study
    • 4373545 10.1007/BF01098730 1:STN:280:DyaE2M%2FmtFCqsQ%3D%3D
    • Vaughan DW, Peters A (1974) Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: an electron microscope study. J Neurocytol 3:405-429
    • (1974) J Neurocytol , vol.3 , pp. 405-429
    • Vaughan, D.W.1    Peters, A.2
  • 43
    • 0026339976 scopus 로고
    • Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
    • 1793176 10.1002/ar.1092310411 1:STN:280:DyaK387ntFWrtw%3D%3D
    • West MJ, Slomianka L, Gundersen HJ (1991) Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 231:482-497
    • (1991) Anat Rec , vol.231 , pp. 482-497
    • West, M.J.1    Slomianka, L.2    Gundersen, H.J.3
  • 44
    • 78649318267 scopus 로고    scopus 로고
    • Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway
    • 20851176 10.1016/j.bbi.2010.09.006 1:CAS:528:DC%2BC3cXhsVGrsLbP
    • Wu SY, Wang TF, Yu L, Jen CJ, Chuang JI, Wu FS, Wu CW, Kuo YM (2011) Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway. Brain Behav Immun 25:135-146
    • (2011) Brain Behav Immun , vol.25 , pp. 135-146
    • Wu, S.Y.1    Wang, T.F.2    Yu, L.3    Jen, C.J.4    Chuang, J.I.5    Wu, F.S.6    Wu, C.W.7    Kuo, Y.M.8


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