메뉴 건너뛰기




Volumn 2015, Issue , 2015, Pages

Anti-EGFR antibody reduces lung nodules by inhibition of EGFR-pathway in a model of lymphangioleiomyomatosis

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; ALPHA SMOOTH MUSCLE ACTIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; ESTROGEN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PROGESTERONE RECEPTOR; PROTEIN S6; RAPAMYCIN; RAS PROTEIN; TRANSCRIPTION FACTOR SNAIL; TUBERIN; ANTIIDIOTYPIC ANTIBODY; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR; TUMOR SUPPRESSOR PROTEIN;

EID: 84933060264     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/315240     Document Type: Article
Times cited : (16)

References (45)
  • 2
    • 76349113563 scopus 로고    scopus 로고
    • Epidermal growth factor signalling and bone metastasis
    • X. Lu and Y. Kang, "Epidermal growth factor signalling and bone metastasis, " British Journal of Cancer, vol. 102, no. 3, pp. 457-461, 2010.
    • (2010) British Journal of Cancer , vol.102 , Issue.3 , pp. 457-461
    • Lu, X.1    Kang, Y.2
  • 4
    • 0034121340 scopus 로고    scopus 로고
    • Downregulation of estrogen and progesterone receptors in the abnormal smooth muscle cells in pulmonary lymphangioleiomyomatosis following therapy: An immunohistochemical study
    • K. Matsui, K. Takeda, Z. X. Yu et al., "Downregulation of estrogen and progesterone receptors in the abnormal smooth muscle cells in pulmonary lymphangioleiomyomatosis following therapy: an immunohistochemical study, " The American Journal of Respiratory and Critical Care Medicine, vol. 161, no. 3 I, pp. 1002-1009, 2000.
    • (2000) The American Journal of Respiratory and Critical Care Medicine , vol.161 , Issue.31 , pp. 1002-1009
    • Matsui, K.1    Takeda, K.2    Yu, Z.X.3
  • 8
    • 77949846455 scopus 로고    scopus 로고
    • MTOR activation, lymphangiogenesis, and estrogen-mediated cell survival: The "perfect storm" of prometastatic factors in LAM pathogenesis
    • J. Yu and E. P. Henske, "MTOR activation, lymphangiogenesis, and estrogen-mediated cell survival: the "perfect storm" of prometastatic factors in LAM pathogenesis, " Lymphatic Research and Biology, vol. 8, no. 1, pp. 43-49, 2010.
    • (2010) Lymphatic Research and Biology , vol.8 , Issue.1 , pp. 43-49
    • Yu, J.1    Henske, E.P.2
  • 12
    • 79955510505 scopus 로고    scopus 로고
    • Efficacy and safety of sirolimus in lymphangioleiomyomatosis
    • F. X. McCormack, Y. Inoue, J. Moss et al., "Efficacy and safety of sirolimus in lymphangioleiomyomatosis, " The New England Journal of Medicine, vol. 364, no. 17, pp. 1595-1606, 2011.
    • (2011) The New England Journal of Medicine , vol.364 , Issue.17 , pp. 1595-1606
    • McCormack, F.X.1    Inoue, Y.2    Moss, J.3
  • 13
    • 84874746597 scopus 로고    scopus 로고
    • Everolimus for angiomyolipoma associatedwith tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): A multicentre, randomised, double-blind, placebo-controlled trial
    • J. J. Bissler, J. C. Kingswood, E. Radzikowska et al., "Everolimus for angiomyolipoma associatedwith tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial, " The Lancet, vol. 381, no. 9869, pp. 817-824, 2013.
    • (2013) The Lancet , vol.381 , Issue.9869 , pp. 817-824
    • Bissler, J.J.1    Kingswood, J.C.2    Radzikowska, E.3
  • 14
    • 67049164007 scopus 로고    scopus 로고
    • The methylation of the TSC2 promoter underlies the abnormal growth of TSC2 angiomyolipoma-derived smooth muscle cells
    • E. Lesma, S. M. Sirchia, S. Ancona et al., "The methylation of the TSC2 promoter underlies the abnormal growth of TSC2 angiomyolipoma-derived smooth muscle cells, " The American Journal of Pathology, vol. 174, no. 6, pp. 2150-2159, 2009.
    • (2009) The American Journal of Pathology , vol.174 , Issue.6 , pp. 2150-2159
    • Lesma, E.1    Sirchia, S.M.2    Ancona, S.3
  • 15
    • 84900546727 scopus 로고    scopus 로고
    • TSC2 epigenetic defect in primary LAM cells. Evidence of an anchorage-independent survival
    • E. Lesma, S.Ancona, S. M. Sirchia et al., "TSC2 epigenetic defect in primary LAM cells. Evidence of an anchorage-independent survival, " Journal of Cellular and MolecularMedicine, vol. 18, no. 5, pp. 766-779, 2014.
    • (2014) Journal of Cellular and MolecularMedicine , vol.18 , Issue.5 , pp. 766-779
    • Lesma, E.1    Ancona, S.2    Sirchia, S.M.3
  • 16
    • 55849129236 scopus 로고    scopus 로고
    • -/- smooth muscle cell proliferation. Possible treatment options for TSCand LAM
    • E. Lesma, V. Grande, S. Ancona, S. Carelli, A. M. Di Giulio, and A. Gorio, "Anti-EGFR antibody efficiently and specifically inhibits human TSC2-/- smooth muscle cell proliferation. Possible treatment options for TSCand LAM, " PLoSONE, vol. 3, no. 10, Article ID e3558, 2008.
    • (2008) PLoSONE , vol.3 , Issue.10
    • Lesma, E.1    Grande, V.2    Ancona, S.3    Carelli, S.4    Di Giulio, A.M.5    Gorio, A.6
  • 17
    • 34250658843 scopus 로고    scopus 로고
    • Survivin expression in tuberous sclerosis complex cells
    • S. Carelli, E. Lesma, S. Paratore et al., "Survivin expression in tuberous sclerosis complex cells, " Molecular Medicine, vol. 13, no. 3-4, pp. 166-177, 2007.
    • (2007) Molecular Medicine , vol.13 , Issue.3-4 , pp. 166-177
    • Carelli, S.1    Lesma, E.2    Paratore, S.3
  • 18
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • D. C. Fingar and J. Blenis, "Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression, " Oncogene, vol. 23, no. 18, pp. 3151-3171, 2004.
    • (2004) Oncogene , vol.23 , Issue.18 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 19
    • 79251475582 scopus 로고    scopus 로고
    • Enhanced epidermal growth factor, hepatocyte growth factor, and vascular endothelial growth factor expression in tuberous sclerosis complex
    • W. E. Parker, K. A. Orlova, G. G. Heuer et al., "Enhanced epidermal growth factor, hepatocyte growth factor, and vascular endothelial growth factor expression in tuberous sclerosis complex, " The American Journal of Pathology, vol. 178, no. 1, pp. 296-305, 2011.
    • (2011) The American Journal of Pathology , vol.178 , Issue.1 , pp. 296-305
    • Parker, W.E.1    Orlova, K.A.2    Heuer, G.G.3
  • 20
    • 84865213374 scopus 로고    scopus 로고
    • -/- smooth muscle cells in mice
    • E. Lesma, E.Chiaramonte, E. Isaia et al., "Development of a lymphangioleiomyomatosis model by endonasal administration of human TSC2-/- smooth muscle cells in mice, " The American Journal of Pathology, vol. 181, no. 3, pp. 947-960, 2012.
    • (2012) The American Journal of Pathology , vol.181 , Issue.3 , pp. 947-960
    • Lesma, E.1    Chiaramonte, E.2    Isaia, E.3
  • 21
    • 26244465902 scopus 로고    scopus 로고
    • Isolation and growth of smooth muscle-like cells derived from tuberous sclerosis complex-2 human renal angiomyolipoma: Epidermal growth factor is the required growth factor
    • E. Lesma, V. Grande, S. Carelli et al., "Isolation and growth of smooth muscle-like cells derived from tuberous sclerosis complex-2 human renal angiomyolipoma: epidermal growth factor is the required growth factor, " The American Journal of Pathology, vol. 167, no. 4, pp. 1093-1103, 2005.
    • (2005) The American Journal of Pathology , vol.167 , Issue.4 , pp. 1093-1103
    • Lesma, E.1    Grande, V.2    Carelli, S.3
  • 22
    • 84897574523 scopus 로고    scopus 로고
    • Targeting estrogen-related receptor alpha inhibits epithelial-to-mesenchymal transition and stem cell properties of ovarian cancer cells
    • S. S.N. Lam, A. S. C.Mak, J.W. P. Yam, A. N. Y. Cheung, H. Y. S. Ngan, and A. S. T. Wong, "Targeting estrogen-related receptor alpha inhibits epithelial-to-mesenchymal transition and stem cell properties of ovarian cancer cells, " Molecular Therapy, vol. 22, no. 4, pp. 743-751, 2014.
    • (2014) Molecular Therapy , vol.22 , Issue.4 , pp. 743-751
    • Lam, S.S.N.1    Mak, A.S.C.2    Yam, J.W.P.3    Cheung, A.N.Y.4    Ngan, H.Y.S.5    Wong, A.S.T.6
  • 23
    • 3242755680 scopus 로고    scopus 로고
    • Lymphangiogenesis in lymphangioleiomyomatosis: Its implication in the progression of lymphangioleiomyomatosis
    • T. Kumasaka, K. Seyama, K. Mitani et al., "Lymphangiogenesis in lymphangioleiomyomatosis: its implication in the progression of lymphangioleiomyomatosis, " American Journal of Surgical Pathology, vol. 28, no. 8, pp. 1007-1016, 2004.
    • (2004) American Journal of Surgical Pathology , vol.28 , Issue.8 , pp. 1007-1016
    • Kumasaka, T.1    Seyama, K.2    Mitani, K.3
  • 24
    • 0032939325 scopus 로고    scopus 로고
    • Multiple positive and negative regulators of signaling by the EGF-receptor
    • N.Moghal and P.W. Sternberg, "Multiple positive and negative regulators of signaling by the EGF-receptor, " CurrentOpinion in Cell Biology, vol. 11, no. 2, pp. 190-196, 1999.
    • (1999) CurrentOpinion in Cell Biology , vol.11 , Issue.2 , pp. 190-196
    • Moghal, N.1    Sternberg, P.W.2
  • 25
    • 84867950688 scopus 로고    scopus 로고
    • Current role of EGF receptor monoclonal antibodies and tyrosine kinase inhibitors in the management of head and neck squamous cell carcinoma
    • A. Markovic and C. H. Chung, "Current role of EGF receptor monoclonal antibodies and tyrosine kinase inhibitors in the management of head and neck squamous cell carcinoma, " Expert ReviewofAnticancerTherapy, vol. 12, no. 9, pp. 1149-1159, 2012.
    • (2012) Expert ReviewofAnticancerTherapy , vol.12 , Issue.9 , pp. 1149-1159
    • Markovic, A.1    Chung, C.H.2
  • 26
    • 84874115779 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition in lung cancer: Status 2012
    • F. R. Hirsch, P. A. Jänne, W. E. Eberhardt et al., "Epidermal growth factor receptor inhibition in lung cancer: status 2012, " Journal of Thoracic Oncology, vol. 8, no. 3, pp. 373-384, 2013.
    • (2013) Journal of Thoracic Oncology , vol.8 , Issue.3 , pp. 373-384
    • Hirsch, F.R.1    Jänne, P.A.2    Eberhardt, W.E.3
  • 27
    • 84883196385 scopus 로고    scopus 로고
    • Faslodex inhibits estradiolinduced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis
    • C. Li, X. Zhou, Y. Sun et al., "Faslodex inhibits estradiolinduced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis, " The American Journal of Respiratory Cell and Molecular Biology, vol. 49, no. 1, pp. 135-142, 2013.
    • (2013) The American Journal of Respiratory Cell and Molecular Biology , vol.49 , Issue.1 , pp. 135-142
    • Li, C.1    Zhou, X.2    Sun, Y.3
  • 28
    • 85042737720 scopus 로고    scopus 로고
    • LAM/TSC cell migration to uterus in an experimental model of lymphangioleiomyomatosis. Regulation by antiepidermal growth factor receptor antibody and rapamycin
    • E. Lesma, E. Chiaramonte, S. Ancona, A. M. di Giulio, and A. Gorio, "LAM/TSC cell migration to uterus in an experimental model of lymphangioleiomyomatosis. Regulation by antiepidermal growth factor receptor antibody and rapamycin, " Journal of Cytology & Histology, vol. S4, article 007, 2014.
    • (2014) Journal of Cytology & Histology , vol.S4
    • Lesma, E.1    Chiaramonte, E.2    Ancona, S.3    Di Giulio, A.M.4    Gorio, A.5
  • 29
    • 38049169559 scopus 로고    scopus 로고
    • Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
    • J. J. Bissler, F. X. McCormack, L. R. Young et al., "Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis, " The New England Journal of Medicine, vol. 358, no. 2, pp. 140-151, 2008.
    • (2008) The New England Journal of Medicine , vol.358 , Issue.2 , pp. 140-151
    • Bissler, J.J.1    McCormack, F.X.2    Young, L.R.3
  • 31
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelialmesenchymal transition
    • R. Kalluri and R. A. Weinberg, "The basics of epithelialmesenchymal transition, " Journal of Clinical Investigation, vol. 119, no. 6, pp. 1420-1428, 2009.
    • (2009) Journal of Clinical Investigation , vol.119 , Issue.6 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 33
    • 77950353276 scopus 로고    scopus 로고
    • ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events
    • S. Shin, C. A. Dimitri, S.-O. Yoon, W. Dowdle, and J. Blenis, "ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events, " Molecular Cell, vol. 38, no. 1, pp. 114-127, 2010.
    • (2010) Molecular Cell , vol.38 , Issue.1 , pp. 114-127
    • Shin, S.1    Dimitri, C.A.2    Yoon, S.-O.3    Dowdle, W.4    Blenis, J.5
  • 34
    • 84904741452 scopus 로고    scopus 로고
    • EGF/EGFR axis contributes to the progression of cholangiocarcinoma through the induction of an epithelial-mesenchymal transition
    • A. Clapéron, M. Mergey, T. H. Nguyen Ho-Bouldoires et al., "EGF/EGFR axis contributes to the progression of cholangiocarcinoma through the induction of an epithelial-mesenchymal transition, " Journal of Hepatology, vol. 61, no. 2, pp. 325-332, 2014.
    • (2014) Journal of Hepatology , vol.61 , Issue.2 , pp. 325-332
    • Clapéron, A.1    Mergey, M.2    Nguyen Ho-Bouldoires, T.H.3
  • 35
    • 84869752511 scopus 로고    scopus 로고
    • Hypoxia activated EGFR signaling induces epithelial to mesenchymal transition (EMT)
    • A. Misra, C. Pandey, S. K. Sze, and T.Thanabalu, "Hypoxia activated EGFR signaling induces epithelial to mesenchymal transition (EMT), " PLoS ONE, vol. 7, no. 11, Article ID e49766, 2012.
    • (2012) PLoS ONE , vol.7 , Issue.11
    • Misra, A.1    Pandey, C.2    Sze, S.K.3    Thanabalu, T.4
  • 36
    • 79955486858 scopus 로고    scopus 로고
    • MTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways
    • P. Gulhati, K. A. Bowen, J. Liu et al., "mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways, " Cancer Research, vol. 71, no. 9, pp. 3246-3256, 2011.
    • (2011) Cancer Research , vol.71 , Issue.9 , pp. 3246-3256
    • Gulhati, P.1    Bowen, K.A.2    Liu, J.3
  • 37
    • 34547587877 scopus 로고    scopus 로고
    • Cell size and invasion in TGF-β-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
    • S. Lamouille and R. Derynck, "Cell size and invasion in TGF-β-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway, " The Journal of Cell Biology, vol. 178, no. 3, pp. 437-451, 2007.
    • (2007) The Journal of Cell Biology , vol.178 , Issue.3 , pp. 437-451
    • Lamouille, S.1    Derynck, R.2
  • 38
    • 84860538871 scopus 로고    scopus 로고
    • Active PI3K pathway causes an invasive phenotype which can be reversed or promoted by blocking the pathway at divergent nodes
    • J. J. Wallin, J. Guan, K. A. Edgar et al., "Active PI3K pathway causes an invasive phenotype which can be reversed or promoted by blocking the pathway at divergent nodes, " PLoS ONE, vol. 7, no. 5, Article ID e36402, 2012.
    • (2012) PLoS ONE , vol.7 , Issue.5
    • Wallin, J.J.1    Guan, J.2    Edgar, K.A.3
  • 39
    • 84888345142 scopus 로고    scopus 로고
    • Genetic and pharmacologic inhibition of mTORC1 promotes EMT by a TGF-β-independent mechanism
    • I. Mikaelian, M. Malek, R. Gadet et al., "Genetic and pharmacologic inhibition of mTORC1 promotes EMT by a TGF-β-independent mechanism, " Cancer Research, vol. 73, no. 22, pp. 6621-6631, 2013.
    • (2013) Cancer Research , vol.73 , Issue.22 , pp. 6621-6631
    • Mikaelian, I.1    Malek, M.2    Gadet, R.3
  • 40
    • 77957329131 scopus 로고    scopus 로고
    • Tuberin regulates E-cadherin localization: Implications in epithelialmesenchymal transition
    • E.A.Barnes, H. L. Kenerson, X. Jiang, and R. S. Yeung, "Tuberin regulates E-cadherin localization: implications in epithelialmesenchymal transition, " American Journal of Pathology, vol. 177, no. 4, pp. 1765-1778, 2010.
    • (2010) American Journal of Pathology , vol.177 , Issue.4 , pp. 1765-1778
    • Barnes, E.A.1    Kenerson, H.L.2    Jiang, X.3    Yeung, R.S.4
  • 41
    • 84881555986 scopus 로고    scopus 로고
    • Activation of the epidermal growth factor receptor promotes lymphangiogenesis in the skin
    • D. Marino, Y. Angehrn, S. Klein et al., "Activation of the epidermal growth factor receptor promotes lymphangiogenesis in the skin, " Journal of Dermatological Science, vol. 71, no. 3, pp. 184-194, 2013.
    • (2013) Journal of Dermatological Science , vol.71 , Issue.3 , pp. 184-194
    • Marino, D.1    Angehrn, Y.2    Klein, S.3
  • 42
    • 84867748641 scopus 로고    scopus 로고
    • Interaction of tumor cells and lymphatic vessels in cancer progression
    • A. Alitalo and M. Detmar, "Interaction of tumor cells and lymphatic vessels in cancer progression, " Oncogene, vol. 31, no. 42, pp. 4499-4508, 2012.
    • (2012) Oncogene , vol.31 , Issue.42 , pp. 4499-4508
    • Alitalo, A.1    Detmar, M.2
  • 43
    • 0033063774 scopus 로고    scopus 로고
    • The epidermal growth factor receptor and its inhibition in cancer therapy
    • J. R.Woodburn, "The epidermal growth factor receptor and its inhibition in cancer therapy, " Pharmacology and Therapeutics, vol. 82, no. 2-3, pp. 241-250, 1999.
    • (1999) Pharmacology and Therapeutics , vol.82 , Issue.2-3 , pp. 241-250
    • Woodburn, J.R.1
  • 44
    • 25444532780 scopus 로고    scopus 로고
    • Lymphangiogenesis-mediated sheddinq of LAM cell clusters as a mechanism for dissemination in lymphangioleiomyomatosis
    • T. Kumasaka, K. Seyama, K.Mitani et al., "Lymphangiogenesis-mediated sheddinq of LAM cell clusters as a mechanism for dissemination in lymphangioleiomyomatosis, " The American Journal of Surgical Pathology, vol. 29, no. 10, pp. 1356-1366, 2005.
    • (2005) The American Journal of Surgical Pathology , vol.29 , Issue.10 , pp. 1356-1366
    • Kumasaka, T.1    Seyama, K.2    Mitani, K.3
  • 45
    • 84867229035 scopus 로고    scopus 로고
    • Prevention of alveolar destruction and airspace enlargement in a mouse model of pulmonary lymphnagioleiomyomatosis (LAM)
    • E. A. Gonchorova, D. A. Gonchorov, and M. Fehrenbach, "Prevention of alveolar destruction and airspace enlargement in a mouse model of pulmonary lymphnagioleiomyomatosis (LAM), " Science Translational Medicine, vol. 4, no. 154, 2012.
    • (2012) Science Translational Medicine , vol.4 , Issue.154
    • Gonchorova, E.A.1    Gonchorov, D.A.2    Fehrenbach, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.