-
1
-
-
0031881032
-
The genetic basis of tuberous sclerosis
-
DOI 10.1016/S1357-4310(98)01245-3, PII S1357431098012453
-
Young J, Povey S: The genetic basis of tuberous sclerosis. Mol Med Today 1998, 4:313-319 (Pubitemid 28364109)
-
(1998)
Molecular Medicine Today
, vol.4
, Issue.7
, pp. 313-319
-
-
Young, J.1
Povey, S.2
-
2
-
-
0032422687
-
Renal angiomyolipomas, cysts, and cancer in tuberous sclerosis complex
-
DOI 10.1016/S1071-9091(98)80005-3
-
Neumann HP, Schwarzkopf G, Henske EP: Renal angiomyolipomas, cysts, and cancer in tuberous sclerosis complex. Semin Pediatr Neurol 1998, 5:269-275 (Pubitemid 29011302)
-
(1998)
Seminars in Pediatric Neurology
, vol.5
, Issue.4
, pp. 269-275
-
-
Neumann, H.P.H.1
Schwarzkopf, G.2
Henske, E.P.3
-
3
-
-
0027770784
-
Identification and characterization of the tuberous sclerosis gene on chromosome 16
-
European Chromosome 16 Tuberous Sclerosis Consortium
-
European Chromosome 16 Tuberous Sclerosis Consortium: Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 1993, 75:1305-1315
-
(1993)
Cell
, vol.75
, pp. 1305-1315
-
-
-
4
-
-
0030879277
-
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
-
DOI 10.1126/science.277.5327.805
-
van Slegtenhorst M, de Hoogt R, Hermans C, Nellist M, Jansen B, Verhoef S, Lindhout D, van den Ouweland A, Halley D, Young J, Burley M, Jeremiah S, Woodward K, Nahmias J, Fox M, Ekong R, Osborne J, Wolfe J, Povey S, Snell RG, Cheadle JP, Jones AC, Tachataki M, Ravine D, Sampson JR, Reeve MP, Richardson P, Wilmer F, Munro C, Hawkins TL, Sepp T, Ali JB, Ward S, Green AJ, Yates JR, Kwiatkowska J, Henske EP, Short MP, Haines JH, Jozwiak S, Kwiatkowski DJ: Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 1997, 277:805-808 (Pubitemid 27366729)
-
(1997)
Science
, vol.277
, Issue.5327
, pp. 805-808
-
-
Van Slegtenhorst, M.1
De Hoogt, R.2
Hermans, C.3
Nellist, M.4
Janssen, B.5
Verhoef, S.6
Lindhout, D.7
Van Den Ouweland, A.8
Halley, D.9
Young, J.10
Burley, M.11
Jeremiah, S.12
Woodward, K.13
Nahmias, J.14
Fox, M.15
Ekong, R.16
Osborne, J.17
Wolfe, J.18
Povey, S.19
Snell, R.G.20
Cheadle, J.P.21
Jones, A.C.22
Tachataki, M.23
Ravine, D.24
Sampson, J.R.25
Reeve, M.P.26
Richardson, P.27
Wilmer, F.28
Munro, C.29
Hawkins, T.L.30
Sepp, T.31
Ali, J.B.M.32
Ward, S.33
Green, A.J.34
Yates, J.R.W.35
Kwiatkowska, J.36
Henske, E.P.37
Short, M.P.38
Haines, J.H.39
Jozwiak, S.40
Kwiatkowski, D.J.41
more..
-
5
-
-
17844369428
-
The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination
-
DOI 10.1038/sj.onc.1204009
-
Benvenuto G, Li S, Brown SJ, Braverman R, Vass WC, Cheadle JP, Halley DJ, Sampson JR, Wienecke R, DeClue JE: The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene 2000, 19:6306-6316 (Pubitemid 32641844)
-
(2000)
Oncogene
, vol.19
, Issue.54
, pp. 6306-6316
-
-
Benvenuto, G.1
Li, S.2
Brown, S.J.3
Braverman, R.4
Vass, W.C.5
Cheadle, J.P.6
Halley, D.J.J.7
Sampson, J.R.8
Wienecke, R.9
Declue, J.E.10
-
6
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
DOI 10.1016/S1097-2765(03)00220-X
-
Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G: Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell 2003, 11:1457-1466 (Pubitemid 36776533)
-
(2003)
Molecular Cell
, vol.11
, Issue.6
, pp. 1457-1466
-
-
Garami, A.1
Zwartkruis, F.J.T.2
Nobukuni, T.3
Joaquin, M.4
Roccio, M.5
Stocker, H.6
Kozma, S.C.7
Hafen, E.8
Bos, J.L.9
Thomas, G.10
-
7
-
-
0043127125
-
Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
DOI 10.1101/gad.1110003
-
Inoki K, Li Y, Xu T, Guan KL: Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 2003, 17:1829-1834 (Pubitemid 36944560)
-
(2003)
Genes and Development
, vol.17
, Issue.15
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.-L.4
-
8
-
-
11244297916
-
Dysregulation of the TSC-mTOR pathway in human disease
-
DOI 10.1038/ng1494
-
Inoki K, Corradetti MN, Guan KL: Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 2005, 37:19-24 (Pubitemid 40070934)
-
(2005)
Nature Genetics
, vol.37
, Issue.1
, pp. 19-24
-
-
Inoki, K.1
Corradetti, M.N.2
Guan, K.-L.3
-
9
-
-
10044259616
-
Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: Biallelic inactivation of TSC1 or TSC2 leads to mTOR activation
-
Chan JA, Zhang H, Roberts PS, Jozwiak S, Wieslawa G, Lewin-Kowalik J, Kotulska K, Kwiatkowski DJ: Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. J Neuropathol Exp Neurol 2004, 63:1236-1242 (Pubitemid 39603395)
-
(2004)
Journal of Neuropathology and Experimental Neurology
, vol.63
, Issue.12
, pp. 1236-1242
-
-
Chan, J.A.1
Zhang, H.2
Roberts, P.S.3
Jozwiak, S.4
Wieslawa, G.5
Lewin-Kowalik, J.6
Kotulska, K.7
Kwiatkowski, D.J.8
-
10
-
-
0029831886
-
Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions
-
Henske EP, Scheithauer BW, Short MP, Wollmann R, Nahmias J, Hornigold N, van Slegtenhorst M, Welsh CT, Kwiatkowski DJ: Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions. Am J Hum Genet 1996, 59:400-406 (Pubitemid 26266356)
-
(1996)
American Journal of Human Genetics
, vol.59
, Issue.2
, pp. 400-406
-
-
Henske, E.P.1
Scheithauer, B.W.2
Short, M.P.3
Wollmann, R.4
Nahmias, J.5
Hornigold, N.6
Van Slegtenhorst, M.7
Welsh, C.T.8
Kwiatkowski, D.J.9
-
11
-
-
0034887907
-
Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions
-
DOI 10.1086/321972
-
Niida Y, Stemer-Rachamimow AO, Logrip M, Tapon D, Perez R, Kwiatkowski DJ, Sims K, MacCollin M, Louis DN, Ramesh V: Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions. Am J Hum Genet 2001, 69:493-503 (Pubitemid 32777689)
-
(2001)
American Journal of Human Genetics
, vol.69
, Issue.3
, pp. 493-503
-
-
Niida, Y.1
Stemmer-Rachamimov, A.O.2
Logrip, M.3
Tapon, D.4
Perez, R.5
Kwiatkowski, D.J.6
Sims, K.7
MacCollin, M.8
Louis, D.N.9
Ramesh, V.10
-
12
-
-
0033358523
-
Complete inactivation of the TSC2 gene leads to formation of hamartomas [6]
-
DOI 10.1086/302648
-
Au KS, Hebert AA, Roach ES, Northrup H: Complete inactivation of the TSC2 gene leads to formation of hamartomas. Am J Hum Genet 1999, 65:1790-1795 (Pubitemid 30468695)
-
(1999)
American Journal of Human Genetics
, vol.65
, Issue.6
, pp. 1790-1795
-
-
Au, K.-S.1
Hebert, A.A.2
Roach, E.S.3
Northrup, H.4
-
13
-
-
0033817428
-
Molecular genetic advances in tuberous sclerosis
-
Cheadle J, Reeve M, Sampson J, Kwiatkowski D: Molecular genetic advances in tuberous sclerosis complex. Hum Genet 2000, 107:97-104 (Pubitemid 30686962)
-
(2000)
Human Genetics
, vol.107
, Issue.2
, pp. 97-114
-
-
Cheadle, J.P.1
Reeve, M.P.2
Sampson, J.R.3
Kwiatkowski, D.J.4
-
15
-
-
0032168678
-
CpG methylation, chromatin structure and gene silencing - A three-way connection
-
DOI 10.1093/emboj/17.17.4905
-
Razin A: CpG methylation, chromatin structure and gene silencing-a three-way connection. EMBO J 1998, 17:4905-4908 (Pubitemid 28408457)
-
(1998)
EMBO Journal
, vol.17
, Issue.17
, pp. 4905-4908
-
-
Razin, A.1
-
16
-
-
16844384332
-
Estrogen enhances whereas tamoxifen retards development of Tsc mouse liver hemangioma: A tumor related to renal angiomyolipoma and pulmonary lymphangioleiomyomatosis
-
DOI 10.1158/0008-5472.CAN-04-3840
-
El-Hashemite N, Walker V, Kwiatkowski DJ: Estrogen enhances whereas tamoxifen retards development of Tsc mouse liver hemangioma: a tumor related to renal angiomyolipoma and pulmonary lymphangioleiomyomatosis. Cancer Res 2005, 65:2474-2481 (Pubitemid 40490160)
-
(2005)
Cancer Research
, vol.65
, Issue.6
, pp. 2474-2481
-
-
El-Hashemite, N.1
Walter, V.2
Kwiatkowski, D.J.3
-
17
-
-
35948944905
-
TSC2 loss in lymphangioleiomyomatosis cells correlated with expression of CD44v6, a molecular determinant of metastasis
-
DOI 10.1158/0008-5472.CAN-07-1356
-
Pacheco-Rodriguez G, Steagall WK, Crooks DM, Stevens LA, Hashimoto H, Li S, Wang JA, Darling TN, Moss J: TSC2 loss in lymphangioleiomyomatosis cells correlated with expression of CD44v6, a molecular determinant of metastasis. Cancer Res 2007, 67:10573-10581 (Pubitemid 350070834)
-
(2007)
Cancer Research
, vol.67
, Issue.21
, pp. 10573-10581
-
-
Pacheco-Rodriguez, G.1
Steagall, W.K.2
Crooks, D.M.3
Stevens, L.A.4
Hashimoto, H.5
Li, S.6
Wang, J.-A.7
Darling, T.N.8
Moss, J.9
-
18
-
-
26244465902
-
Isolation and growth of smooth muscle-like cells derived from tuberous sclerosis complex-2 human renal angiomyolipoma: Epidermal growth factor is the required growth factor
-
Lesma E, Grande V, Lesma E, Carelli S, Brancaccio D, Canevini MP, Alfano RM, Coggi G, Di Giulio AM, Gorio A: Isolation and growth of smooth muscle-like cells derived from tuberous sclerosis complex-2 human renal angiomyolipoma: EGF is the required growth factor. Am J Pathol 2005, 167:1093-1103 (Pubitemid 41416260)
-
(2005)
American Journal of Pathology
, vol.167
, Issue.4
, pp. 1093-1103
-
-
Lesma, E.1
Grande, V.2
Carelli, S.3
Brancaccio, D.4
Canevini, M.P.5
Alfano, R.M.6
Coggi, G.7
Di Giulio, A.M.8
Gorio, A.9
-
19
-
-
34250658843
-
Survivin expression in tuberous sclerosis complex cells
-
DOI 10.2119/2006-00091.Carelli
-
Carelli S, Lesma E, Paratore S, Grande V, Zadra G, Di Giulio AM, Gorio A: Survivin expression in tuberous sclerosis complex cells. Mol Med 2007, 13:166-177 (Pubitemid 46944959)
-
(2007)
Molecular Medicine
, vol.13
, Issue.3-4
, pp. 166-177
-
-
Carelli, S.1
Lesma, E.2
Paratore, S.3
Grande, V.4
Zadra, G.5
Bosari, S.6
Di Giulio, A.M.7
Gorio, A.8
-
20
-
-
0034880110
-
The generation and characterization of a cell line derived from a sporadic renal angiomyolipoma
-
Arbiser JL, Yeung R, Weiss SH, Arbiser ZK, Amin MB, Cohen C, Frank D, Mahajan S, Herron GS, Yang J, Onda H, Zhang HB, Bai X, Uhlmann E, Loehr A, Northrup H, Au P, Davis I, Fisher DE, Gutmann DH: The generation and characterization of a cell line derived from a sporadic renal angiomyolipoma. Am J Pathol 2001, 159:483-491
-
(2001)
Am J Pathol
, vol.159
, pp. 483-491
-
-
Arbiser, J.L.1
Yeung, R.2
Weiss, S.H.3
Arbiser, Z.K.4
Amin, M.B.5
Cohen, C.6
Frank, D.7
Mahajan, S.8
Herron, G.S.9
Yang, J.10
Onda, H.11
Zhang, H.B.12
Bai, X.13
Uhlmann, E.14
Loehr, A.15
Northrup, H.16
Au, P.17
Davis, I.18
Fisher, D.E.19
Gutmann, D.H.20
more..
-
21
-
-
0033917014
-
Application and evaluation of denaturing HPLC for molecular genetic analysis in tuberous sclerosis
-
DOI 10.1007/s004390050040
-
Jones AC, Sampson JR, Hoogendoorn B, Cohen D, Cheadle JP: Application and evaluation of denaturing HPLC for molecular genetic analysis in tuberous sclerosis. Hum Genet 2000, 106:663-668 (Pubitemid 30427022)
-
(2000)
Human Genetics
, vol.106
, Issue.6
, pp. 663-668
-
-
Jones, A.C.1
Sampson, J.R.2
Hoogendoorn, B.3
Cohen, D.4
Cheadle, J.P.5
-
22
-
-
0033598745
-
Promoter-specific hypoacetylation of X-inactivated genes
-
Gilbert SL, Sharp PA: Promoter-specific hypoacetylation of X-inactivated genes. Proc Natl Acad Sci USA 1999, 96:13825-13830
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 13825-13830
-
-
Gilbert, S.L.1
Sharp, P.A.2
-
23
-
-
0034673671
-
Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor β2 promoter in breast cancer cells
-
Sirchia SM, Ferguson AT, Sironi E, Subramanyan S, Orlandi R, Sukumar S, Sacchi N: Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor β2 promoter in breast cancer cells. Oncogene 2000, 19:1556-1563 (Pubitemid 30175677)
-
(2000)
Oncogene
, vol.19
, Issue.12
, pp. 1556-1563
-
-
Sirchia, S.M.1
Ferguson, A.T.2
Sironi, E.3
Subramanyan, S.4
Orlandi, R.5
Sukumar, S.6
Sacchi, N.7
-
24
-
-
0036558155
-
Endogenous reactivation of the RAR beta2 tumor suppressor gene epigenetically silenced in breast cancer
-
Sirchia SM, Ren M, Pili R, Sironi E, Somenzi G, Ghidoni R, Toma S, Nicolò G, Sacchi N: Endogenous reactivation of the RAR beta2 tumor suppressor gene epigenetically silenced in breast cancer. Cancer Res 2002, 62:2455-2461
-
(2002)
Cancer Res
, vol.62
, pp. 2455-2461
-
-
Sirchia, S.M.1
Ren, M.2
Pili, R.3
Sironi, E.4
Somenzi, G.5
Ghidoni, R.6
Toma, S.7
Nicolò, G.8
Sacchi, N.9
-
25
-
-
20144389742
-
Loss of the inactive X chromosome and replication of the active X in BRCA1-defective and wild-type breast cancer cells
-
DOI 10.1158/0008-5472.CAN-04-3465
-
Sirchia SM, Ramoscelli L, Grati FR, Barbera F, Cordini D, Rossella F, Porta G, Lesma E, Ruggeri A, Radice P, Simoni G, Miozzo M: Loss of the inactive X chromosome and replication of the active X in BRCA1 effective and wild-type breast cancer cells. Cancer Res 2005, 65:2139-2146 (Pubitemid 40490120)
-
(2005)
Cancer Research
, vol.65
, Issue.6
, pp. 2139-2146
-
-
Sirchia, S.M.1
Ramoscelli, L.2
Grati, F.R.3
Barbera, F.4
Coradini, D.5
Rossella, F.6
Porta, G.7
Lesma, E.8
Ruggeri, A.9
Radice, P.10
Simoni, G.11
Miozzo, M.12
-
27
-
-
0030725540
-
Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors
-
Henske EP, Wessner LL, Golden J, Scheithauer BW, Vortmeyer AO, Zhuang Z, Klein-Szanto AJ, Kwiatkowski DJ, Yeung RS: Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of the tuberous sclerosis tumors. Am J Pathol 1997, 151:1639-1647 (Pubitemid 27527926)
-
(1997)
American Journal of Pathology
, vol.151
, Issue.6
, pp. 1639-1647
-
-
Henske, E.P.1
Wessner, L.L.2
Golden, J.3
Scheithauer, B.W.4
Vortmeyer, A.O.5
Zhuang, Z.6
Klein-Szanto, A.J.P.7
Kwiatkowski, D.J.8
Yeung, R.S.9
-
28
-
-
0035805180
-
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
-
DOI 10.1016/S0092-8674(01)00332-4
-
Tapon N, Ito N, Dickson BJ, Treisman JE, Hariharan IK: The drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 2001, 105:345-355 (Pubitemid 32455341)
-
(2001)
Cell
, vol.105
, Issue.3
, pp. 345-355
-
-
Tapon, N.1
Ito, N.2
Dickson, B.J.3
Treisman, J.E.4
Hariharan, I.K.5
-
29
-
-
0035009866
-
Tuberous sclerosis gene products in proliferation control
-
DOI 10.1016/S1383-5742(01)00058-8, PII S1383574201000588
-
Hengstschläger M, Rodman DM, Miloloza A, Hengstschlager-Ottnad E, Rosner M, Kubista M: Tuberous sclerosis gene products in proliferation control. Mutat Res 2001, 488:233-239 (Pubitemid 32521034)
-
(2001)
Mutation Research - Reviews in Mutation Research
, vol.488
, Issue.3
, pp. 233-239
-
-
Hengstschlager, M.1
Rodman, D.M.2
Miloloza, A.3
Hengstschlager-Ottnad, E.4
Rosner, M.5
Kubista, M.6
-
31
-
-
0034639655
-
Genetic evidence for a trans-heterozygous model for cystogenesis in autosomal dominant polycystic kidney disease
-
Koptides M, Mean R, Demetriou K, Pierides A, Deltas CC: Genetic evidence for a trans-heterozygous model for cytogenesis in autosomal dominant polycystic kidney disease. Hum Mol Genet 2000, 9:447-452 (Pubitemid 30098739)
-
(2000)
Human Molecular Genetics
, vol.9
, Issue.3
, pp. 447-452
-
-
Koptides, M.1
Mean, R.2
Demetriou, K.3
Pierides, A.4
Deltas, C.C.5
-
32
-
-
0029011539
-
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
-
Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D: 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1995, 1:686-692
-
(1995)
Nat Med
, vol.1
, pp. 686-692
-
-
Merlo, A.1
Herman, J.G.2
Mao, L.3
Lee, D.J.4
Gabrielson, E.5
Burger, P.C.6
Baylin, S.B.7
Sidransky, D.8
-
33
-
-
12444282686
-
Epigenetic down-regulation of death-associated protein kinase in lung cancers
-
Toyooka S, Toyooka KO, Miyajima K, Reddy JL, Toyota M, Sathyanarayana UG, Padar A, Tockman MS, Lam S, Shivapurkar N, Gazdar AF: Epigenetic down-regulation of death-associated protein kinase in lung cancers. Clin Cancer Res 2003, 9:3034-3041 (Pubitemid 36993264)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.8
, pp. 3034-3041
-
-
Toyooka, S.1
Toyooka, K.O.2
Miyajima, K.3
Reddy, J.L.4
Toyota, M.5
Sathyanarayana, U.G.6
Padar, A.7
Tockman, M.S.8
Lam, S.9
Shivapurkar, N.10
Gazdar, A.F.11
-
34
-
-
0016439429
-
DNA modification mechanism and gene activity during development
-
Holliday R, Pugh JE: DNA modification mechanism and gene activity during development. Science 1975, 187:226-232
-
(1975)
Science
, vol.187
, pp. 226-232
-
-
Holliday, R.1
Pugh, J.E.2
-
35
-
-
0030846212
-
Alterations in DNA methylation: A fundamental aspect of neoplasia
-
Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP: Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 1998, 72:141-196
-
(1998)
Adv Cancer Res
, vol.72
, pp. 141-196
-
-
Baylin, S.B.1
Herman, J.G.2
Graff, J.R.3
Vertino, P.M.4
Issa, J.P.5
-
36
-
-
0032960181
-
Cancer epigenetics come to age
-
Jones PA, Laird PW: Cancer epigenetics come to age. Nat Genet 1999, 21:163-167
-
(1999)
Nat Genet
, vol.21
, pp. 163-167
-
-
Jones, P.A.1
Laird, P.W.2
-
37
-
-
22144438660
-
Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: The role of promoter methylation of TSC genes
-
DOI 10.1016/j.ejca.2005.03.023, PII S0959804905003266
-
Jiang WG, Sampson J, Martin TA, Lee-Jones L, Watkins G, Douglas- Jones A, Mokbel K, Mansel RE: Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: the role of promoter methylation of TSC genes. Eur J Cancer 2005, 41:1628-1636 (Pubitemid 40981846)
-
(2005)
European Journal of Cancer
, vol.41
, Issue.11
, pp. 1628-1636
-
-
Jiang, W.G.1
Sampson, J.2
Martin, T.A.3
Lee-Jones, L.4
Watkins, G.5
Douglas-Jones, A.6
Mokbel, K.7
Mansel, R.E.8
-
38
-
-
45949107072
-
Involvement of TSC genes and differential expression of other members of the mTOR signaling pathway in oral squamous cell carcinoma
-
DOI 10.1186/1471-2407-8-163
-
Chakraborty S, Mohiyuddin SMA, Gopinath KS, Kumar A: Involvement of TSC genes and differential expression of other members of the mTOR signalling pathway in oral squamous cell carcinoma. BMC Cancer 2008, 8:163-175 (Pubitemid 351891408)
-
(2008)
BMC Cancer
, vol.8
, pp. 163
-
-
Chakraborty, S.1
Azeem, S.M.A.2
Gopinath, K.S.3
Kumar, A.4
-
39
-
-
34248649731
-
The molecular mechanism of HDAC inhibitors in anticancer effects
-
Bi G, Jiang G: The molecular mechanism of HDAC inhibitors in anticancer effects. Cell Mol Immunol 2006, 3:285-290
-
(2006)
Cell Mol Immunol
, vol.3
, pp. 285-290
-
-
Bi, G.1
Jiang, G.2
-
40
-
-
33846122993
-
Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug
-
DOI 10.1038/nbt1272, PII NBT1272
-
Marks PA, Breslow R: Dimethyl sulfoxide to varinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat Biotechnol 2007, 25:84-90 (Pubitemid 46087907)
-
(2007)
Nature Biotechnology
, vol.25
, Issue.1
, pp. 84-90
-
-
Marks, P.A.1
Breslow, R.2
-
41
-
-
38049169559
-
Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
-
Bissler J, McCormack FX, Young LR, Elwing JM, Chuck G: Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med 2008, 358:140-151
-
(2008)
N Engl J Med
, vol.358
, pp. 140-151
-
-
Bissler, J.1
McCormack, F.X.2
Young, L.R.3
Elwing, J.M.4
Chuck, G.5
-
42
-
-
33750103211
-
Anti-EGFR therapies: Clinical experience in colorectal, lung, and head and neck cancers
-
Vokes EE, Chu E: Anti-EGFR therapies: clinical experience in colorectal, lung, and head and neck cancers. Oncology 2006, 20(5 Suppl 2):15-25
-
(2006)
Oncology
, vol.20
, Issue.5 SUPPL. 2
, pp. 15-25
-
-
Vokes, E.E.1
Chu, E.2
-
43
-
-
19944431403
-
Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models
-
DOI 10.1002/gcc.20118
-
Lee L, Sudentas P, Donohue B, Asrican K, Worku A, Walker V, Sun Y, Schmidt K, Albert MS, El-Hashemite N, Lader AS, Onda AS, Zhang H, Kwiatkowski DJ, Dabora SL: Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse model. Genes Chromosom Cancer 2005, 42:213-227 (Pubitemid 40171186)
-
(2005)
Genes Chromosomes and Cancer
, vol.42
, Issue.3
, pp. 213-227
-
-
Lee, L.1
Sudentas, P.2
Donohue, B.3
Asrican, K.4
Worku, A.5
Walker, V.6
Sun, Y.7
Schmidt, K.8
Albert, M.S.9
El-Hashemite, N.10
Lader, A.S.11
Onda, H.12
Zhang, H.13
Kwiatkowski, D.J.14
Dabora, S.L.15
-
44
-
-
45849110311
-
Response of a neural model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: Effects on mTORC1 and Akt signaling lead to improved survival and function
-
Meikle L, Pollizzi K, Egnor A, Kramvis I, Lane H, Sahin M, Kwiatkowski DJ: Response of a neural model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function. J Neurosci 2008, 28:5422-5432
-
(2008)
J Neurosci
, vol.28
, pp. 5422-5432
-
-
Meikle, L.1
Pollizzi, K.2
Egnor, A.3
Kramvis, I.4
Lane, H.5
Sahin, M.6
Kwiatkowski, D.J.7
|