Relation of depot-specific adipose inflammation to insulin resistance in human obesity

Nutrition and Diabetes

Volumn 2, Issue MARCH, 2012, Pages

  Bigornia, S J ^a   Farb, M G ^a   Mott, M M ^a   Hess, D T ^a   Carmine, B ^a   Fiscale, A ^a   Joseph, L ^a   Apovian, C M ^a   Gokce, N ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Inflammation; Insulin resistance; Obesity

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; INSULIN;

ADULT; ARTICLE; BARIATRIC SURGERY; BODY MASS; CHRONIC INFLAMMATION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HOMEOSTASIS; HUMAN; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; LIPID STORAGE; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MESENTERY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OMENTUM; PRIORITY JOURNAL; SUBCUTANEOUS FAT; WAIST CIRCUMFERENCE;

EID: 84879556071     PISSN: None     EISSN: 20444052     Source Type: Journal    
DOI: 10.1038/nutd.2012.3     Document Type: Article

References (41)

1. Samuel VT, Petersen KF, Shulman GI. Lipid-induced insulin resistance: Unravelling the mechanism. Lancet 2010; 375: 2267-2277.
2. Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis. BMC Public Health 2009; 9: 88.
3. Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA 2010; 303: 235-241.
4. Ogden CL, Carroll MD, Curtin LR, Lamb MM, Flegal KM. Prevalence of high body mass index in US children and adolescents, 2007-2008. JAMA 2010; 303: 242-249.
5. Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet 2011; 378: 815-825.
6. Mathieu P, Poirier P, Pibarot P, Lemieux I, Despres JP. Visceral obesity: The link among inflammation, hypertension, and cardiovascular disease. Hypertension 2009; 53: 577-584.
7. Compher C, Badellino KO. Obesity and inflammation: Lessons from bariatric surgery. JPEN J Parenter Enteral Nutr 2008; 32: 645-647.
8. Fuentes L, Roszer T, Ricote M. Inflammatory mediators and insulin resistance in obesity: Role of nuclear receptor signaling in macrophages. Mediators Inflamm 2010; 2010: 219583.
9. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest 2006; 116: 1793-1801.
10. Bremer AA, Devaraj S, Afify A, Jialal I. Adipose tissue dysregulation in patients with metabolic syndrome. J Clin Endocrinol Metab 2011; 96: E1782-E1788.
11. Apovian CM, Bigornia S, Mott M, Meyers MR, Ulloor J, Gagua M et al. Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects. Arterioscler Thromb Vasc Biol 2008; 28: 1654-1659.
12. Wentworth JM, Naselli G, Brown WA, Doyle L, Phipson B, Smyth GK et al. Proinflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity. Diabetes 2010; 59: 1648-1656.
13. Anderson WA, Greene GW, Forse RA, Apovian CM, Istfan NW. Weight loss and health outcomes in African Americans and whites after gastric bypass surgery. Obesity (Silver Spring) 2007; 15: 1455-1463.
14. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
15. Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 2005; 46: 2347-2355.
16. Harman-Boehm I, Bluher M, Redel H, Sion-Vardy N, Ovadia S, Avinoach E et al. Macrophage infiltration into omental versus subcutaneous fat across different populations: Effect of regional adiposity and the comorbidities of obesity. J Clin Endocrinol Metab 2007; 92: 2240-2247.
17. Alkhouri N, Gornicka A, Berk MP, Thapaliya S, Dixon LJ, Kashyap S et al. Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis. J Biol Chem 2009; 285: 3428-3438.
18. Murano I, Barbatelli G, Parisani V, Latini C, Muzzonigro G, Castellucci M et al. Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice. J Lipid Res 2008; 49: 1562-1568.
19. Hocking SL, Chisholm DJ, James DE. Studies of regional adipose transplantation reveal a unique and beneficial interaction between subcutaneous adipose tissue and the intra-abdominal compartment. Diabetologia 2008; 51: 900-902.
20. Palou M, Priego T, Sanchez J, Rodriguez AM, Palou A, Pico C. Gene expression patterns in visceral and subcutaneous adipose depots in rats are linked to their morphologic features. Cell Physiol Biochem 2009; 24: 547-556.
21. Rytka JM, Wueest S, Schoenle EJ, Konrad D. The portal theory supported by venous drainage-selective fat transplantation. Diabetes 2010; 60: 56-63.
22. Yu R, Kim CS, Kwon BS, Kawada T. Mesenteric adipose tissue-derived monocyte chemoattractant protein-1 plays a crucial role in adipose tissue macrophage migration and activation in obese mice. Obesity (Silver Spring) 2006; 14: 1353-1362.
23. Klimcakova E, Roussel B, Marquez-Quinones A, Kovacova Z, Kovacikova M, Combes M et al. Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: Decreased metabolism and increased immune response. J Clin Endocrinol Metab 2011; 96: E73-E82.
24. Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY et al. Abdominal visceral and subcutaneous adipose tissue compartments: Association with metabolic risk factors in the Framingham Heart Study. Circulation 2007; 116: 39-48.
25. Pou KM, Massaro JM, Hoffmann U, Vasan RS, Maurovich-Horvat P, Larson MG et al. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: The Framingham Heart Study. Circulation 2007; 116: 1234-1241.
26. Evans J, Goedecke JH, Soderstrom I, Buren J, Alvehus M, Blomquist C et al. Depot- and ethnic-specific differences in the relationship between adipose tissue inflammation and insulin sensitivity. Clin Endocrinol (Oxf) 2011; 74: 51-59.
27. Klimcakova E, Roussel B, Kovacova Z, Kovacikova M, Siklova-Vitkova M, Combes M et al. Macrophage gene expression is related to obesity and the metabolic syndrome in human subcutaneous fat as well as in visceral fat. Diabetologia 2011; 54: 876-887.
28. Aron-Wisnewsky J, Tordjman J, Poitou C, Darakhshan F, Hugol D, Basdevant A et al. Human adipose tissue macrophages: M1 and m2 cell surface markers in subcutaneous and omental depots and after weight loss. J Clin Endocrinol Metab 2009; 94: 4619-4623.
29. McLaughlin TM, Liu T, Yee G, Abbasi F, Lamendola C, Reaven GM et al. Pioglitazone increases the proportion of small cells in human abdominal subcutaneous adipose tissue. Obesity (Silver Spring) 2010; 18: 926-931.
30. Mutch DM, Pers TH, Temanni MR, Pelloux V, Marquez-Quinones A, Holst C et al. A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects. Am J Clin Nutr 2011; 94: 1399-1409.
31. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 2005; 11: 191-198.
32. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112: 1821-1830.
33. Cancello R, Tordjman J, Poitou C, Guilhem G, Bouillot JL, Hugol D et al. Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes 2006; 55: 1554-1561.
34. Di Gregorio GB, Yao-Borengasser A, Rasouli N, Varma V, Lu T, Miles LM et al. Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: Association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes 2005; 54: 2305-2313.
35. Cancello R, Henegar C, Viguerie N, Taleb S, Poitou C, Rouault C et al. Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 2005; 54: 2277-2286.
36. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol 2011; 29: 415-445.
37. Farb MG, Bigornia S, Mott M, Tanriverdi K, Morin KM, Freedman JE et al. Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity. J Am Coll Cardiol 2011; 58: 232-237.
38. Ouchi N, Higuchi A, Ohashi K, Oshima Y, Gokce N, Shibata R et al. Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science 2010; 329: 454-457.
39. Kim JY, van de Wall E, Laplante M, Azzara A, Trujillo ME, Hofmann SM et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 2007; 117: 2621-2637.
40. Kloting N, Fasshauer M, Dietrich A, Kovacs P, Schon MR, Kern M et al. Insulinsensitive obesity. Am J Physiol Endocrinol Metab 2010; 299: E506-E515.
41. Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K et al. Bariatric surgery: A systematic review and meta-analysis. JAMA 2004; 292: 1724-1737.