A naturally occurring variant of the human prion protein completely prevents prion disease

Nature

Volumn 522, Issue 7557, 2015, Pages 478-481

  Asante, Emmanuel A ^a   Smidak, Michelle ^a   Grimshaw, Andrew ^a   Houghton, Richard ^a,c   Tomlinson, Andrew ^a   Jeelani, Asif ^a   Jakubcova, Tatiana ^a   Hamdan, Shyma ^a   Richard Londt, Angela ^a   Linehan, Jacqueline M ^a   Brandner, Sebastian ^a   Alpers, Michael ^a,b   Whitfield, Jerome ^a,b   Mead, Simon ^a   Wadsworth, Jonathan D F ^a   Collinge, John ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b PAPUA NEW GUINEA INSTITUTE OF MEDICAL RESEARCH   (Papua New Guinea)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; PRION PROTEIN; PRION PROTEIN G127; PRION PROTEIN V127; PROTEIN VARIANT; UNCLASSIFIED DRUG; PRION;

ALLELE; CYTOLOGY; DISEASE TRANSMISSION; GENE EXPRESSION; GENETICALLY MODIFIED ORGANISM; MOLECULAR ANALYSIS; PRION DISEASE; PROTEIN; RODENT;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASYMPTOMATIC INFECTION; CODON; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; CREUTZFELDT JAKOB DISEASE AGENT; DISEASE RESISTANCE; DISEASE TRANSMISSION; DURA MATER; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HOMOZYGOTE; HUMAN; HUMAN TISSUE; IATROGENIC CREUTZFELDT JAKOB DISEASE; IMMUNOHISTOCHEMISTRY; KURU; MOUSE; NONHUMAN; PAPUA NEW GUINEA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN POLYMORPHISM; PROTEIN PROTEIN INTERACTION; SPORADIC CREUTZFELDT JAKOB DISEASE; VARIANT CREUTZFELDT JAKOB DISEASE; ALLELE; ANIMAL; BOVINE; BOVINE SPONGIFORM ENCEPHALOPATHY; CHEMISTRY; CREUTZFELDT-JAKOB SYNDROME; FEMALE; GENETIC POLYMORPHISM; GENETICS; HETEROZYGOTE; METABOLISM; PHARMACOLOGY; PRION; PRION DISEASES; TRANSGENIC MOUSE; TRANSMISSION;

PAPUA NEW GUINEA;

BOVINAE; MAMMALIAN PRION; MUS; MUS MUSCULUS; VERTEBRATA;

ALLELES; AMINO ACID SUBSTITUTION; ANIMALS; CATTLE; CREUTZFELDT-JAKOB SYNDROME; ENCEPHALOPATHY, BOVINE SPONGIFORM; FEMALE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; KURU; MICE; MICE, TRANSGENIC; PAPUA NEW GUINEA; POLYMORPHISM, GENETIC; PRION DISEASES; PRIONS; PRPSC PROTEINS;

EID: 84933041955     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14510     Document Type: Article

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