Structure-Activity Relationships of Neplanocin A Analogues as S -Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities

Journal of Medicinal Chemistry

Volumn 58, Issue 12, 2015, Pages 5108-5120

  Chandra, Girish ^a,b   Moon, Yang Won ^c   Lee, Yoonji ^c   Jang, Ji Yong ^c   Song, Jayoung ^a   Nayak, Akshata ^a   Oh, Kawon ^a,c   Mulamoottil, Varughese A ^c   Sahu, Pramod K ^a   Kim, Gyudong ^a   Chang, Tong Shin ^c   Noh, Minsoo ^a   Lee, Sang Kook ^a   Choi, Sun ^c   Jeong, Lak Shin ^a  

^a Seoul National University   (South Korea)

^b CENTRAL UNIVERSITY OF SOUTH BIHAR   (India)

^c Ewha Womans University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

1 (6 AMINOPURINE 9 YL) 2 FLUORO 4,5 (O ISOPROPYLIDENEDIOXY) 3 (TRITYLOXYMETHYL) 2 CYCLOPENTENE; 1 (6 CHLORO 7 DEAZAPURINE 9 YL) 2 FLUORO 4,5 (O ISOPROPYLIDENEDIOXY) 3 (TRITYLOXYMETHYL) 2 CYCLOPENTENE; 1 [2,3 (O ISOPROPYLIDENEDIOXY) 4 [2 (TERT BUTYLDIPHENYLSILYOXY)ETHYL]CYCLOPENT 4(5)EN] (6 CHLOROPURINE 9 YL); 2 2 DIMETHYLPROPIONIC ACID 2 [4 (6 CHLOROPURINE 9 YL) 5 FLUORO 2,3 DIHYDROXYCYCLOPENT 1(5) EN]ETHYL ESTER; 2 FLUORO 3 HYDROXY 4,5 (O ISOPROPYLIDENEDIOXY) 3 (TRITYLOXYMETHYL)CYCLOPENTANONE; 2 FLUORO 4,5 (O ISOPROPYLIDENEDIOXY) 1 (TRITYLOXYMETHYL)CYCLOPENT 1,3 DIOL; 2 FLUORO 4,5 (O ISOPROPYLIDENEDIOXY) 3 (TRITYLOXYMETHYL) CYCLOPENT 2 ENE 1 ONE; 2 FLUORO 4,5 (O ISOPROPYLIDENEDIOXY) 3 (TRITYLOXYMETHYL)CYCLOPENT 2 ENE 1 OL; 2 FLUORO 4,5 (O ISOPROPYLIDENEDIOXY) 3 (TRITYLOXYMETHYL)CYCLOPENT 2 ENE 1 ONE; 4 FLUORO 3 (HYDROXYLMETHYL) 5 [SPIRO([1,3]OXATHIOLANE 2,4' PYRROLO[2,3 D]PYRIMIDINE) 7' YL]CYCLOPENT 3 ENE 1,2 DIOL; 4,5 (O ISOPROPYLIDENEDIOXY) 2(3)OXIRANE 3 (TRITYLOXYMETHYL) CYCLOPENT 1 OL; 4,5 (O ISOPROPYLIDENEDIOXY) 2(3)OXIRANE 3 (TRITYLOXYMETHYL)CYCLOPENT 1 OL; 4,5 (O ISOPROPYLIDENEDIOXY) 3 (TRITYLOXYMETHYL) CYCLOPENT 2 ENE 1 OL; 5 (3 DEAZA 6 AMINOPURINE 9 YL) 3 HYDROXYETHYLCYCLOPENT 3 EN 1,2 DIOL; 5 (6 AMINOPURIN 9 YL) 4 FLURO 3 HYDROXYMETHYL CYCLOPENT 3 ENE 1,2 DIOL; 5 (6 AMINOPURINE 9 YL) 3 HYDROXYETHYLCYCLOPENT 3 EN 1,2 DIOL; 5 (6 AMINOPURINE 9 YL) 3 HYDROXYMETHYL CYCLOPENT 3(4) ENE 1,2 DIOL; 5 (6 CHLOROPURINE 9 YL) 3 HYDROXYETHYLCYCLOPENT 3 EN 1,2 DIOL; 5 (6 N METHYLAMINE 7 DEAZAPURINE 9 YL) 3 HYDROXYMETHYLCYCLOPENT 3(4) ENE 1,2 DIOL; 5 (7 DEAZA 6 AMINOPURINE 9 YL) 3 HYDROXYMETHYLCYCLOPENT 3(4) ENE 1,2 DIOL; 5 (7 DEAZA 6 AMINOPURINE 9 YL) 4 FLUORO 3 HYDROXYMETHYLCYCLOPENT 3(4) ENE 1,2 DIOL; 5 (7 DEAZA 6 N METHYLAMINOPURINE 9 YL) 4 FLUORO 3 HYDROXYMETHYLCYCLOPENT 3(4) ENE 1,2 DIOL; 5 (7 DEAZA AMINOPURINE 9 YL) 3 HYDROXYETHYLCYCLOPENT 3 EN 1,2 DIOL; 5 (7 DEAZAHYPOXANTHINE 9 YL) 3 HYDROXYMETHYLCYCLOPENT 3(4) ENE 1,2 DIOL; 5 (DEAZAHYPOXANTHINE 9 YL) 4 FLUORO 3 HYDROXYMETHYLCYCLOPENT 3(4) ENE 1,2 DIOL; ADENOSYLHOMOCYSTEINASE INHIBITOR; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; NEPLANOCIN A; UNCLASSIFIED DRUG; UNINDEXED DRUG; 3-DEAZAADENINE; 7-DEAZAADENINE; ADENINE; ADENOSINE; ADENOSYLHOMOCYSTEINASE; ENZYME INHIBITOR;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; PICORNAVIRIDAE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; VESICULOVIRUS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CHLOROCEBUS AETHIOPS; DRUG EFFECTS; METABOLISM; NEOPLASMS; TUMOR CELL LINE; VERO CELL LINE; VIRUS; VIRUS DISEASES;

ADENINE; ADENOSINE; ADENOSYLHOMOCYSTEINASE; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; ENZYME INHIBITORS; HUMANS; MOLECULAR DOCKING SIMULATION; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS; VIRUS DISEASES; VIRUSES;

EID: 84933038083     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00553     Document Type: Article

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