Early intervention following trauma may mitigate genetic risk for PTSD in civilians: A pilot prospective emergency department study

Journal of Clinical Psychiatry

Volumn 75, Issue 12, 2014, Pages 1380-1387

  Rothbaum, Barbara O ^a   Kearns, Megan C ^a   Reiser, Emily ^a   Davis, Jennifer S ^a   Kerley, Kimberly A ^a   Rothbaum, Alex O ^a   Mercer, Kristina B ^a   Price, Matthew ^b   Houry, Debra ^a   Ressler, Kerry J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VERMONT   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADCYAP1R1 GENE; ADULT; AGE DISTRIBUTION; ARTICLE; COMT GENE; CRHR1 GENE; DBH GENE; DNA POLYMORPHISM; DRD2 GENE; EDUCATIONAL STATUS; EMERGENCY WARD; ETHNICITY; FAAH GENE; FEMALE; FKBP5 GENE; GENE; GENE FREQUENCY; GENETIC RISK; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NTRK2 GENE; NYP GENE; PCLO GENE; PILOT STUDY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; PSYCHOLOGICAL RATING SCALE; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; CONTROLLED STUDY; EARLY INTERVENTION; EMERGENCY HEALTH SERVICE; GENETIC PREDISPOSITION; GENETICS; IMPLOSIVE THERAPY; PREVENTION AND CONTROL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; STRESS DISORDERS, POST-TRAUMATIC; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; EARLY MEDICAL INTERVENTION; EMERGENCY SERVICE, HOSPITAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMPLOSIVE THERAPY; MALE; PILOT PROJECTS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; STRESS DISORDERS, POST-TRAUMATIC; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84932133921     PISSN: 01606689     EISSN: 15552101     Source Type: Journal    
DOI: 10.4088/JCP.13m08715     Document Type: Article

References (60)

1. Rothbaum BO, Kearns MC, Price M, et al. Early intervention may prevent the development of posttraumatic stress disorder: a randomized pilot civilian study with modified prolonged exposure. Biol Psychiatry. 2012;72(11):957-963.
2. Rothbaum BO, Foa EB, Riggs D, et al. A prospective examination of post-traumatic stress disorder in rape victims. J Trauma Stress. 1992;5(3):455-475.
3. Kearns MC, Ressler KJ, Zatzick D, et al. Early interventions for PTSD: a review. Depress Anxiety. 2012;29(10):833-842.
4. Ozer EJ, Best SR, Lipsey TL, et al. Predictors of posttraumatic stress disorder and symptoms in adults: a meta-analysis. Psychol Bull. 2003;129(1):52-73.
5. Brewin CR, Andrews B, Valentine JD. Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. J Consult Clin Psychol. 2000;68(5):748-766.
6. Richmond TS, Ruzek J, Ackerson T, et al. Predicting the future development of depression or PTSD after injury. Gen Hosp Psychiatry. 2011;33(4):327-335.
7. Shih RA, Schell TL, Hambarsoomian K, et al. Prevalence of posttraumatic stress disorder and major depression after trauma center hospitalization. J Trauma. 2010;69(6):1560-1566.
8. O'Donnell ML, Creamer MC, Parslow R, et al. A predictive screening index for posttraumatic stress disorder and depression following traumatic injury. J Consult Clin Psychol. 2008;76(6):923-932.
9. Koenen KC, Amstadter AB, Nugent NR. Gene-environment interaction in posttraumatic stress disorder: an update. J Trauma Stress. 2009;22(5):416-426.
10. Stein MB, Jang KL, Taylor S, et al. Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: a twin study. Am J Psychiatry. 2002;159(10):1675-1681.
11. True WR, Rice J, Eisen SA, et al. A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms. Arch Gen Psychiatry. 1993;50(4):257-264.
12. Binder EB, Bradley RG, Liu W, et al. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA. 2008;299(11):1291-1305.
13. Xie P, Kranzler HR, Poling J, et al. Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder. Neuropsychopharmacology. 2010;35(8):1684-1692.
14. Boscarino JA, Erlich PM, Hoffman SN, et al. Association of FKBP5, COMT and CHRNA5 polymorphisms with PTSD among outpatients at risk for PTSD. Psychiatry Res. 2011;188(1):173-174.
15. Sarapas C, Cai G, Bierer LM, et al. Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks. Dis Markers. 2011;30(2-3):101-110.
16. Mehta D, Gonik M, Klengel T, et al. Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies. Arch Gen Psychiatry. 2011;68(9):901-910.
17. Bremner JD, Licinio J, Darnell A, et al. Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. Am J Psychiatry. 1997;154(5):624-629.
18. Bradley RG, Binder EB, Epstein MP, et al. Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry. 2008;65(2):190-200.
19. Amstadter AB, Nugent NR, Yang BZ, et al. Corticotrophin-releasing hormone type 1 receptor gene (CRHR1) variants predict posttraumatic stress disorder onset and course in pediatric injury patients. Dis Markers. 2011;30(2-3):89-99.
20. Ressler KJ, Mercer KB, Bradley B, et al. Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. Nature. 2011;470(7335):492-497.
21. Foa EB, Hembree E, Rothbaum BO. Prolonged Exposure Therapy for PTSD: Emotional Processing of Traumatic Experiences, Therapist Guide. New York, NY: Oxford University Press; 2007.
22. Foa EB, Tolin DF. Comparison of the PTSD Symptom Scale-Interview Version and the Clinician-Administered PTSD scale. J Trauma Stress. 2000;13(2):181-191.
23. Foa EB, Cashman L, Jaycox L, et al. The validation of a self-report measure of posttraumatic stress disorder: the Posttraumatic Diagnostic Scale. Psychol Assess. 1997;9(4):445-451.
24. Bernstein DP, Fink L, Handelsman L, et al. Initial reliability and validity of a new retrospective measure of child abuse and neglect. Am J Psychiatry. 1994;151(8):1132-1136.
25. Bernstein DP, Ahluvalia T, Pogge D, et al. Validity of the Childhood Trauma Questionnaire in an adolescent psychiatric population. J Am Acad Child Adolesc Psychiatry. 1997;36(3):340-348.
26. Bernstein D, Fink L. Childhood Trauma Questionnaire: A Retrospective Self-Report. San Antonio, TX: The Psychological Corporation; 1998.
27. Fink LA, Bernstein DP, Handelsman L, et al. Initial reliability and validity of the childhood trauma interview: a new multidimensional measure of childhood interpersonal trauma. Am J Psychiatry. 1995;152(9):1329-1335.
28. Foa EB, Riggs DS, Dancu CV, et al. Reliability and validity of a brief instrument for assessing post-traumatic stress disorder. J Trauma Stress. 1993;6(4):459-473.
29. Jovanovic T, Norrholm SD, Davis J, et al. PAC1 receptor (ADCYAP1R1) genotype is associated with dark-enhanced startle in children [published online ahead of print July 10, 2012]. Mol Psychiatry. 2013;18(7):742-743.
30. Boscarino JA, Erlich PM, Hoffman SN, et al. Higher FKBP5, COMT, CHRNA5, and CRHR1 allele burdens are associated with PTSD and interact with trauma exposure: implications for neuropsychiatric research and treatment. Neuropsychiatr Dis Treat. 2012;8:131-139.
31. Amstadter AB, Nugent NR, Koenen KC, et al. Association between COMT, PTSD, and increased smoking following hurricane exposure in an epidemiologic sample. Psychiatry. 2009;72(4):360-369.
32. Polanczyk G, Caspi A, Williams B, et al. Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. Arch Gen Psychiatry. 2009;66(9):978-985.
33. Laucht M, Treutlein J, Blomeyer D, et al. Interactive effects of corticotropinreleasing hormone receptor 1 gene and childhood adversity on depressive symptoms in young adults: Findings from a longitudinal study. Eur Neuropsychopharmacol.2013;23(5):358-367.
34. Cubells JF, Kranzler HR, McCance-Katz E, et al. A haplotype at the DBH locus, associated with low plasma dopamine beta-hydroxylase activity, also associates with cocaine-induced paranoia. Mol Psychiatry. 2000;5(1):56-63.
35. Tang YL, Li W, Mercer K, et al. Genotype-controlled analysis of serum dopamine β-hydroxylase activity in civilian post-traumatic stress disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(8):1396-1401.
36. Mustapić M, Pivac N, Kozarić-Kovacić D, et al. Dopamine beta-hydroxylase (DBH) activity and -1021C/T polymorphism of DBH gene in combat-related post-traumatic stress disorder. Am J Med Genet B Neuropsychiatr Genet. 2007;144B(8):1087-1089.
37. Huuhka K, Anttila S, Huuhka M, et al. Dopamine 2 receptor C957T and catechol-o-methyltransferase Val158Met polymorphisms are associated with treatment response in electroconvulsive therapy. Neurosci Lett. 2008;448(1):79-83.
38. Jutras-Aswad D, Jacobs MM, Yiannoulos G, et al. Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study. PLoS One. 2012;7(6):e39243.
39. Huertas E, Ponce G, Koeneke MA, et al. The D2 dopamine receptor gene variant C957T affects human fear conditioning and aversive priming. Genes Brain Behav. 2010;9(1):103-109.
40. Sipe JC, Chiang K, Gerber AL, et al. A missense mutation in human fatty acid amide hydrolase associated with problem drug use. Proc Natl Acad Sci U S A. 2002;99(12):8394-8399.
41. Monteleone P, Bifulco M, Maina G, et al. Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression. Pharmacol Res. 2010;61(5):400-404.
42. Gunduz-Cinar O, MacPherson KP, Cinar R, et al. Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity [published online ahead of print June 12, 2012]. Mol Psychiatry. 2013;18(7):813-823.
43. Zhou Z, Zhu G, Hariri AR, et al. Genetic variation in human NPY expression affects stress response and emotion. Nature. 2008;452(7190):997-1001.
44. Amstadter AB, Koenen KC, Ruggiero KJ, et al. NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults. Depress Anxiety. 2010;27(3):270-275.
45. Kohli MA, Salyakina D, Pfennig A, et al. Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients. Arch Gen Psychiatry. 2010;67(4):348-359.
46. Sullivan PF, de Geus EJ, Willemsen G, et al. Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry. 2009;14(4):359-375.
47. Hek K, Mulder CL, Luijendijk HJ, et al. The PCLO gene and depressive disorders: replication in a population-based study. Hum Mol Genet. 2010;19(4):731-734.
48. Kuehner C, Huffziger S, Witt SH, et al. PCLO rs2522833 impacts HPA system activity in healthy young adults. Transcult Psychiatry. 2011;1(5):e10.
49. Almli LM, Mercer KB, Kerley K, et al. ADCYAP1R1 genotype associates with post-traumatic stress symptoms in highly traumatized African-American females. Am J Med Genet B Neuropsychiatr Genet. 2013;162B(3):262-272.
50. Wang L, Cao C, Wang R, et al. PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors. J Affect Disord. 2013;150(1):156-159.
51. Uddin M, Chang SC, Zhang C, et al. ADCYAP1R1 genotype, posttraumatic stress disorder, and depression among women exposed to childhood maltreatment. Depress Anxiety. 2013;30(3):251-258.
52. Chang SC, Xie P, Anton RF, et al. No association between ADCYAP1R1 and post-traumatic stress disorder in two independent samples. Mol Psychiatry. 2012;17(3):239-241.
53. Kessler RC, Sonnega A, Bromet E, et al. Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry. 1995;52(12):1048-1060.
54. Johansen JP, Cain CK, Ostroff LE, et al. Molecular mechanisms of fear learning and memory. Cell. 2011;147(3):509-524.
55. Cain CK, Maynard GD, Kehne JH. Targeting memory processes with drugs to prevent or cure PTSD. Expert Opin Investig Drugs. 2012;21(9):1323-1350.
56. Malcoun E, Houry D, Arndt-Jordan C, et al. Feasibility of identifying eligible trauma patients for posttraumatic stress disorder intervention. West J Emerg Med. 2010;11(3):274-278.
57. Zatzick DF, Galea S. An epidemiologic approach to the development of early trauma focused intervention. J Trauma Stress. 2007;20(4):401-412.
58. Cunningham RM, Resko SM, Harrison SR, et al. Screening adolescents in the emergency department for weapon carriage. Acad Emerg Med. 2010;17(2):168-176.
59. Cunningham RM, Chermack ST, Zimmerman MA, et al. Brief motivational interviewing intervention for peer violence and alcohol use in teens: one-year follow-up. Pediatrics. 2012;129(6):1083-1090.
60. Koenen KC, Duncan LE, Liberzon I, et al. From candidate genes to genomewide association: the challenges and promise of posttraumatic stress disorder genetic studies. Biol Psychiatry. 2013;74(9):634-636.