메뉴 건너뛰기




Volumn 22, Issue 7, 2015, Pages 512-518

Recent advancement of molecular mechanisms of liver fibrosis

Author keywords

Alcoholic liver disease; Angiogenesis; Autophagy; Hepatic stellate cells; IL 17; IL 22; IL 33; Liver cirrhosis; Reversal; Senescence

Indexed keywords

ANTIFIBROTIC AGENT; CYTOKINE; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA;

EID: 84932100243     PISSN: 18686974     EISSN: 18686982     Source Type: Journal    
DOI: 10.1002/jhbp.245     Document Type: Article
Times cited : (274)

References (62)
  • 4
    • 84923482955 scopus 로고    scopus 로고
    • Hepatic Inflammation and Fibrosis: Functional Links and Key Pathways
    • Seki E, Schwabe RF,. Hepatic Inflammation and Fibrosis: Functional Links and Key Pathways. Hepatology. 2015; 61: 1066-79.
    • (2015) Hepatology , vol.61 , pp. 1066-1079
    • Seki, E.1    Schwabe, R.F.2
  • 6
    • 84873461095 scopus 로고    scopus 로고
    • Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury
    • Li Y, Wang J, Asahina K,. Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury. Proc Natl Acad Sci U S A. 2013; 110: 2324-9.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 2324-2329
    • Li, Y.1    Wang, J.2    Asahina, K.3
  • 7
    • 84888339170 scopus 로고    scopus 로고
    • Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology
    • Mederacke I, Hsu CC, Troeger JS, Huebener P, Mu X, Dapito DH, et al., Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology. Nat Commun. 2013; 4: 2823.
    • (2013) Nat Commun , vol.4 , pp. 2823
    • Mederacke, I.1    Hsu, C.C.2    Troeger, J.S.3    Huebener, P.4    Mu, X.5    Dapito, D.H.6
  • 9
    • 79952205821 scopus 로고    scopus 로고
    • Questioning the challenging role of epithelial-to-mesenchymal transition in liver injury
    • Scholten D, Weiskirchen R,. Questioning the challenging role of epithelial-to-mesenchymal transition in liver injury. Hepatology. 2011; 53: 1048-51.
    • (2011) Hepatology , vol.53 , pp. 1048-1051
    • Scholten, D.1    Weiskirchen, R.2
  • 10
    • 79955123951 scopus 로고    scopus 로고
    • Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis
    • Chu AS, Diaz R, Hui JJ, Yanger K, Zong Y, Alpini G, et al., Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis. Hepatology. 2011; 53: 1685-95.
    • (2011) Hepatology , vol.53 , pp. 1685-1695
    • Chu, A.S.1    Diaz, R.2    Hui, J.J.3    Yanger, K.4    Zong, Y.5    Alpini, G.6
  • 11
    • 84898824175 scopus 로고    scopus 로고
    • Interactions between the intestinal microbiome and liver diseases
    • Schnabl B, Brenner DA,. Interactions between the intestinal microbiome and liver diseases. Gastroenterology. 2014; 146: 1513-24.
    • (2014) Gastroenterology , vol.146 , pp. 1513-1524
    • Schnabl, B.1    Brenner, D.A.2
  • 12
    • 84856350648 scopus 로고    scopus 로고
    • Role of innate immunity and the microbiota in liver fibrosis: Crosstalk between the liver and gut
    • Seki E, Schnabl B,. Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut. J Physiol. 2012; 590: 447-58.
    • (2012) J Physiol , vol.590 , pp. 447-458
    • Seki, E.1    Schnabl, B.2
  • 14
    • 84896754721 scopus 로고    scopus 로고
    • Transcriptional repression of the transforming growth factor beta (TGF-beta) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor kappaB (NF-kappaB) p50 enhances TGF-beta signaling in hepatic stellate cells
    • Liu C, Chen X, Yang L, Kisseleva T, Brenner DA, Seki E,. Transcriptional repression of the transforming growth factor beta (TGF-beta) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor kappaB (NF-kappaB) p50 enhances TGF-beta signaling in hepatic stellate cells. J Biol Chem. 2014; 289: 7082-91.
    • (2014) J Biol Chem , vol.289 , pp. 7082-7091
    • Liu, C.1    Chen, X.2    Yang, L.3    Kisseleva, T.4    Brenner, D.A.5    Seki, E.6
  • 15
    • 84858702708 scopus 로고    scopus 로고
    • Intestinal decontamination inhibits TLR4 dependent fibronectin-mediated cross-talk between stellate cells and endothelial cells in liver fibrosis in mice
    • Zhu Q, Zou L, Jagavelu K, Simonetto DA, Huebert RC, Jiang ZD, et al., Intestinal decontamination inhibits TLR4 dependent fibronectin-mediated cross-talk between stellate cells and endothelial cells in liver fibrosis in mice. J Hepatol. 2012; 56: 893-9.
    • (2012) J Hepatol , vol.56 , pp. 893-899
    • Zhu, Q.1    Zou, L.2    Jagavelu, K.3    Simonetto, D.A.4    Huebert, R.C.5    Jiang, Z.D.6
  • 17
    • 34548301514 scopus 로고    scopus 로고
    • A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C
    • Huang H, Shiffman ML, Friedman S, Venkatesh R, Bzowej N, Abar OT, et al., A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C. Hepatology. 2007; 46: 297-306.
    • (2007) Hepatology , vol.46 , pp. 297-306
    • Huang, H.1    Shiffman, M.L.2    Friedman, S.3    Venkatesh, R.4    Bzowej, N.5    Abar, O.T.6
  • 18
    • 84868136560 scopus 로고    scopus 로고
    • Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor i contribute to liver fibrosis in mice
    • e1331.
    • Hartmann P, Haimerl M, Mazagova M, Brenner DA, Schnabl B,. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. Gastroenterology. 2012; 143: 1330-40 e1331.
    • (2012) Gastroenterology , vol.143 , pp. 1330-1340
    • Hartmann, P.1    Haimerl, M.2    Mazagova, M.3    Brenner, D.A.4    Schnabl, B.5
  • 19
    • 84861192672 scopus 로고    scopus 로고
    • Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease
    • Fouts DE, Torralba M, Nelson KE, Brenner DA, Schnabl B,. Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease. J Hepatol. 2012; 56: 1283-92.
    • (2012) J Hepatol , vol.56 , pp. 1283-1292
    • Fouts, D.E.1    Torralba, M.2    Nelson, K.E.3    Brenner, D.A.4    Schnabl, B.5
  • 21
    • 84879888338 scopus 로고    scopus 로고
    • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    • Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, et al., Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature. 2013; 499: 97-101.
    • (2013) Nature , vol.499 , pp. 97-101
    • Yoshimoto, S.1    Loo, T.M.2    Atarashi, K.3    Kanda, H.4    Sato, S.5    Oyadomari, S.6
  • 23
  • 24
    • 79251575277 scopus 로고    scopus 로고
    • Role of IL-17 and Th17 cells in liver diseases
    • Hammerich L, Heymann F, Tacke F,. Role of IL-17 and Th17 cells in liver diseases. Clin Dev Immunol. 2011; 2011: 345803.
    • (2011) Clin Dev Immunol , vol.2011 , pp. 345803
    • Hammerich, L.1    Heymann, F.2    Tacke, F.3
  • 25
    • 84865461464 scopus 로고    scopus 로고
    • Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice
    • e761-3.
    • Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, et al., Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology. 2012; 143: 765-776 e761-3.
    • (2012) Gastroenterology , vol.143 , pp. 765-776
    • Meng, F.1    Wang, K.2    Aoyama, T.3    Grivennikov, S.I.4    Paik, Y.5    Scholten, D.6
  • 26
    • 84894728578 scopus 로고    scopus 로고
    • Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver
    • Guillot A, Hamdaoui N, Bizy A, Zoltani K, Souktani R, Zafrani ES, et al., Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver. Hepatology. 2014; 59: 296-306.
    • (2014) Hepatology , vol.59 , pp. 296-306
    • Guillot, A.1    Hamdaoui, N.2    Bizy, A.3    Zoltani, K.4    Souktani, R.5    Zafrani, E.S.6
  • 27
    • 84871313216 scopus 로고    scopus 로고
    • Protective and pathological properties of IL-22 in liver disease: Implications for viral hepatitis
    • Cobleigh MA, Robek MD,. Protective and pathological properties of IL-22 in liver disease: implications for viral hepatitis. Am J Pathol. 2013; 182: 21-8.
    • (2013) Am J Pathol , vol.182 , pp. 21-28
    • Cobleigh, M.A.1    Robek, M.D.2
  • 28
    • 84865962962 scopus 로고    scopus 로고
    • Interleukin-22 predicts severity and death in advanced liver cirrhosis: A prospective cohort study
    • Kronenberger B, Rudloff I, Bachmann M, Brunner F, Kapper L, Filmann N, et al., Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study. BMC Med. 2012; 10: 102.
    • (2012) BMC Med , vol.10 , pp. 102
    • Kronenberger, B.1    Rudloff, I.2    Bachmann, M.3    Brunner, F.4    Kapper, L.5    Filmann, N.6
  • 29
    • 80052023399 scopus 로고    scopus 로고
    • Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3
    • Jiang R, Tan Z, Deng L, Chen Y, Xia Y, Gao Y, et al., Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3. Hepatology. 2011; 54: 900-9.
    • (2011) Hepatology , vol.54 , pp. 900-909
    • Jiang, R.1    Tan, Z.2    Deng, L.3    Chen, Y.4    Xia, Y.5    Gao, Y.6
  • 30
    • 2342462460 scopus 로고    scopus 로고
    • Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
    • Radaeva S, Sun R, Pan HN, Hong F, Gao B,. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology. 2004; 39: 1332-42.
    • (2004) Hepatology , vol.39 , pp. 1332-1342
    • Radaeva, S.1    Sun, R.2    Pan, H.N.3    Hong, F.4    Gao, B.5
  • 31
    • 77957946415 scopus 로고    scopus 로고
    • Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of signal transducer and activator of transcription 3
    • Ki SH, Park O, Zheng M, Morales-Ibanez O, Kolls JK, Bataller R, et al., Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology. 2010; 52: 1291-1300.
    • (2010) Hepatology , vol.52 , pp. 1291-1300
    • Ki, S.H.1    Park, O.2    Zheng, M.3    Morales-Ibanez, O.4    Kolls, J.K.5    Bataller, R.6
  • 32
    • 84907030420 scopus 로고    scopus 로고
    • Acute and chronic effects of IL-22 on acetaminophen-induced liver injury
    • Feng D, Wang Y, Wang H, Weng H, Kong X, Martin-Murphy BV, et al., Acute and chronic effects of IL-22 on acetaminophen-induced liver injury. J Immunol. 2014; 193: 2512-18.
    • (2014) J Immunol , vol.193 , pp. 2512-2518
    • Feng, D.1    Wang, Y.2    Wang, H.3    Weng, H.4    Kong, X.5    Martin-Murphy, B.V.6
  • 33
    • 84865564349 scopus 로고    scopus 로고
    • Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice
    • Kong X, Feng D, Wang H, Hong F, Bertola A, Wang FS, et al., Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice. Hepatology. 2012; 56: 1150-9.
    • (2012) Hepatology , vol.56 , pp. 1150-1159
    • Kong, X.1    Feng, D.2    Wang, H.3    Hong, F.4    Bertola, A.5    Wang, F.S.6
  • 34
    • 84896489484 scopus 로고    scopus 로고
    • Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment
    • Zhao J, Zhang Z, Luan Y, Zou Z, Sun Y, Li Y, et al., Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment. Hepatology. 2014; 59: 1331-42.
    • (2014) Hepatology , vol.59 , pp. 1331-1342
    • Zhao, J.1    Zhang, Z.2    Luan, Y.3    Zou, Z.4    Sun, Y.5    Li, Y.6
  • 35
    • 80054847781 scopus 로고    scopus 로고
    • A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus
    • Zhang Y, Cobleigh MA, Lian JQ, Huang CX, Booth CJ, Bai XF, et al., A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus. Gastroenterology. 2011; 141: 1897-906.
    • (2011) Gastroenterology , vol.141 , pp. 1897-1906
    • Zhang, Y.1    Cobleigh, M.A.2    Lian, J.Q.3    Huang, C.X.4    Booth, C.J.5    Bai, X.F.6
  • 36
    • 84862769727 scopus 로고    scopus 로고
    • Interleukin-22 promotes proliferation of liver stem/progenitor cells in mice and patients with chronic hepatitis B virus infection
    • e187.
    • Feng D, Kong X, Weng H, Park O, Wang H, Dooley S, et al., Interleukin-22 promotes proliferation of liver stem/progenitor cells in mice and patients with chronic hepatitis B virus infection. Gastroenterology. 2012; 143: 188-98 e187.
    • (2012) Gastroenterology , vol.143 , pp. 188-198
    • Feng, D.1    Kong, X.2    Weng, H.3    Park, O.4    Wang, H.5    Dooley, S.6
  • 38
    • 84964314988 scopus 로고    scopus 로고
    • Interleukin-33 promotes disease progression in patients with primary biliary cirrhosis
    • Sun Y, Zhang JY, Lv S, Wang H, Gong M, Du N, et al., Interleukin-33 promotes disease progression in patients with primary biliary cirrhosis. Tohoku J Exp Med. 2014; 234: 255-61.
    • (2014) Tohoku J Exp Med , vol.234 , pp. 255-261
    • Sun, Y.1    Zhang, J.Y.2    Lv, S.3    Wang, H.4    Gong, M.5    Du, N.6
  • 39
    • 84903783722 scopus 로고    scopus 로고
    • Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation
    • Li J, Razumilava N, Gores GJ, Walters S, Mizuochi T, Mourya R, et al., Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation. J Clin Invest. 2014; 124: 3241-51.
    • (2014) J Clin Invest , vol.124 , pp. 3241-3251
    • Li, J.1    Razumilava, N.2    Gores, G.J.3    Walters, S.4    Mizuochi, T.5    Mourya, R.6
  • 40
    • 84859445823 scopus 로고    scopus 로고
    • TGF-beta in progression of liver disease
    • Dooley S, ten Dijke P,. TGF-beta in progression of liver disease. Cell Tissue Res. 2012; 347: 245-56.
    • (2012) Cell Tissue Res , vol.347 , pp. 245-256
    • Dooley, S.1    Ten Dijke, P.2
  • 41
    • 84889886646 scopus 로고    scopus 로고
    • Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs
    • Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, et al., Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013; 19: 1617-24.
    • (2013) Nat Med , vol.19 , pp. 1617-1624
    • Henderson, N.C.1    Arnold, T.D.2    Katamura, Y.3    Giacomini, M.M.4    Rodriguez, J.D.5    McCarty, J.H.6
  • 42
    • 71049139747 scopus 로고    scopus 로고
    • Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling
    • Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, et al., Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. J Biol Chem. 2009; 284: 30097-104.
    • (2009) J Biol Chem , vol.284 , pp. 30097-30104
    • Yan, X.1    Lin, Z.2    Chen, F.3    Zhao, X.4    Chen, H.5    Ning, Y.6
  • 43
    • 84876928036 scopus 로고    scopus 로고
    • A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response
    • Ding N, Yu RT, Subramaniam N, Sherman MH, Wilson C, Rao R, et al., A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. Cell. 2013; 153: 601-13.
    • (2013) Cell , vol.153 , pp. 601-613
    • Ding, N.1    Yu, R.T.2    Subramaniam, N.3    Sherman, M.H.4    Wilson, C.5    Rao, R.6
  • 44
    • 84898987733 scopus 로고    scopus 로고
    • Vascular endothelial growth factor promotes fibrosis resolution and repair in mice
    • e1331.
    • Yang L, Kwon J, Popov Y, Gajdos GB, Ordog T, Brekken RA, et al., Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology. 2014; 146: 1339-50 e1331.
    • (2014) Gastroenterology , vol.146 , pp. 1339-1350
    • Yang, L.1    Kwon, J.2    Popov, Y.3    Gajdos, G.B.4    Ordog, T.5    Brekken, R.A.6
  • 45
    • 36348932917 scopus 로고    scopus 로고
    • Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes
    • Weng HL, Ciuclan L, Liu Y, Hamzavi J, Godoy P, Gaitantzi H, et al., Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes. Hepatology. 2007; 46: 1257-70.
    • (2007) Hepatology , vol.46 , pp. 1257-1270
    • Weng, H.L.1    Ciuclan, L.2    Liu, Y.3    Hamzavi, J.4    Godoy, P.5    Gaitantzi, H.6
  • 46
    • 0037370003 scopus 로고    scopus 로고
    • Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype
    • Schnabl B, Purbeck CA, Choi YH, Hagedorn CH, Brenner D,. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Hepatology. 2003; 37: 653-64.
    • (2003) Hepatology , vol.37 , pp. 653-664
    • Schnabl, B.1    Purbeck, C.A.2    Choi, Y.H.3    Hagedorn, C.H.4    Brenner, D.5
  • 49
    • 84859444880 scopus 로고    scopus 로고
    • Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues
    • Hernandez-Gea V, Ghiassi-Nejad Z, Rozenfeld R, Gordon R, Fiel MI, Yue Z, et al., Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology. 2012; 142: 938-46.
    • (2012) Gastroenterology , vol.142 , pp. 938-946
    • Hernandez-Gea, V.1    Ghiassi-Nejad, Z.2    Rozenfeld, R.3    Gordon, R.4    Fiel, M.I.5    Yue, Z.6
  • 50
    • 77953187568 scopus 로고    scopus 로고
    • Rapamycin reduces intrahepatic alpha-1-antitrypsin mutant Z protein polymers and liver injury in a mouse model
    • Kaushal S, Annamali M, Blomenkamp K, Rudnick D, Halloran D, Brunt EM, et al., Rapamycin reduces intrahepatic alpha-1-antitrypsin mutant Z protein polymers and liver injury in a mouse model. Exp Biol Med. 2010; 235: 700-9.
    • (2010) Exp Biol Med , vol.235 , pp. 700-709
    • Kaushal, S.1    Annamali, M.2    Blomenkamp, K.3    Rudnick, D.4    Halloran, D.5    Brunt, E.M.6
  • 51
    • 77954597127 scopus 로고    scopus 로고
    • An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis
    • Hidvegi T, Ewing M, Hale P, Dippold C, Beckett C, Kemp C, et al., An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis. Science. 2010; 329: 229-32.
    • (2010) Science , vol.329 , pp. 229-232
    • Hidvegi, T.1    Ewing, M.2    Hale, P.3    Dippold, C.4    Beckett, C.5    Kemp, C.6
  • 52
    • 0034804406 scopus 로고    scopus 로고
    • Hepatic blood flow regulation by stellate cells in normal and injured liver
    • Rockey DC,. Hepatic blood flow regulation by stellate cells in normal and injured liver. Semin Liver Dis. 2001; 21: 337-49.
    • (2001) Semin Liver Dis , vol.21 , pp. 337-349
    • Rockey, D.C.1
  • 53
    • 32944478021 scopus 로고    scopus 로고
    • Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells
    • Aleffi S, Petrai I, Bertolani C, Parola M, Colombatto S, Novo E, et al., Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells. Hepatology. 2005; 42: 1339-48.
    • (2005) Hepatology , vol.42 , pp. 1339-1348
    • Aleffi, S.1    Petrai, I.2    Bertolani, C.3    Parola, M.4    Colombatto, S.5    Novo, E.6
  • 54
  • 55
    • 0042887507 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis
    • Yoshiji H, Kuriyama S, Yoshii J, Ikenaka Y, Noguchi R, Hicklin DJ, et al., Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis. Gut. 2003; 52: 1347-54.
    • (2003) Gut , vol.52 , pp. 1347-1354
    • Yoshiji, H.1    Kuriyama, S.2    Yoshii, J.3    Ikenaka, Y.4    Noguchi, R.5    Hicklin, D.J.6
  • 56
    • 84892370936 scopus 로고    scopus 로고
    • Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis
    • Ding BS, Cao Z, Lis R, Nolan DJ, Guo P, Simons M, et al., Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature. 2014; 505: 97-102.
    • (2014) Nature , vol.505 , pp. 97-102
    • Ding, B.S.1    Cao, Z.2    Lis, R.3    Nolan, D.J.4    Guo, P.5    Simons, M.6
  • 57
    • 0032146551 scopus 로고    scopus 로고
    • Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
    • Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, et al., Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest. 1998; 102: 538-49.
    • (1998) J Clin Invest , vol.102 , pp. 538-549
    • Iredale, J.P.1    Benyon, R.C.2    Pickering, J.3    McCullen, M.4    Northrop, M.5    Pawley, S.6
  • 58
    • 14244257340 scopus 로고    scopus 로고
    • Adipogenic transcriptional regulation of hepatic stellate cells
    • She H, Xiong S, Hazra S, Tsukamoto H,. Adipogenic transcriptional regulation of hepatic stellate cells. J Biol Chem. 2005; 280: 4959-67.
    • (2005) J Biol Chem , vol.280 , pp. 4959-4967
    • She, H.1    Xiong, S.2    Hazra, S.3    Tsukamoto, H.4
  • 59
    • 84866692545 scopus 로고    scopus 로고
    • Deactivation of hepatic stellate cells during liver fibrosis resolution in mice
    • e1022.
    • Troeger JS, Mederacke I, Gwak GY, Dapito DH, Mu X, Hsu CC, et al., Deactivation of hepatic stellate cells during liver fibrosis resolution in mice. Gastroenterology. 2012; 143: 1073-1083 e1022.
    • (2012) Gastroenterology , vol.143 , pp. 1073-1083
    • Troeger, J.S.1    Mederacke, I.2    Gwak, G.Y.3    Dapito, D.H.4    Mu, X.5    Hsu, C.C.6
  • 61
    • 84869208905 scopus 로고    scopus 로고
    • Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
    • Ramachandran P, Pellicoro A, Vernon MA, Boulter L, Aucott RL, Ali A, et al., Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc Natl Acad Sci U S A. 2012; 109: E3186-95.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E3186-E3195
    • Ramachandran, P.1    Pellicoro, A.2    Vernon, M.A.3    Boulter, L.4    Aucott, R.L.5    Ali, A.6
  • 62
    • 84929266699 scopus 로고    scopus 로고
    • Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial
    • Neuschwander-Tetri BA, Loomba R, Sanyal AJ, Lavine JE, Van Natta ML, Abdelmalek MF, et al., Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet. 2015; 385: 956-65.
    • (2015) Lancet , vol.385 , pp. 956-965
    • Neuschwander-Tetri, B.A.1    Loomba, R.2    Sanyal, A.J.3    Lavine, J.E.4    Van Natta, M.L.5    Abdelmalek, M.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.