Influence of glutathione-S-transferase (GST) inhibition on lung epithelial cell injury: Role of oxidative stress and metabolism

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 308, Issue 12, 2015, Pages 1274-1285

  Fletcher, Marianne E ^a   Boshier, Piers R ^a   Wakabayashi, Kenji ^a   Keun, Hector C ^a   Smolenski, Ryszard T ^b,g   Kirkham, Paul A ^c,d   Adcock, Ian M ^c   Barton, Paul J ^c   Takata, Masao ^a   Marczin, Nandor ^a,e,f  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^d UNIVERSITY OF WOLVERHAMPTON   (United Kingdom)

^e HAREFIELD HOSPITAL   (United Kingdom)

^f SEMMELWEIS UNIVERSITY   (Hungary)

^g UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Caffeic acid; Ethacrynic acid; N acetylcysteine; Reactive oxygen species; Viability

Indexed keywords

ACETYLCYSTEINE; CAFFEIC ACID; CARBONYL DERIVATIVE; DICHLOROFLUORESCEIN; DIHYDRORHODAMINE 123; ETACRYNIC ACID; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE MU; HYDROGEN PEROXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SMALL INTERFERING RNA; TERT BUTYL HYDROPEROXIDE; TRANSFERASE; UNCLASSIFIED DRUG; ANTIOXIDANT; CAFFEIC ACID DERIVATIVE; ENZYME INHIBITOR; GLUTATHIONE; MESSENGER RNA;

ACUTE LUNG INJURY; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL DEATH; CELL ENERGY; CELL METABOLISM; CELL STRESS; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIUM CELL; EX VIVO STUDY; FLUORESCENCE; HYPOXIA; LUNG ALVEOLUS EPITHELIUM; LUNG MECHANICS; LUNG MODEL; LUNG PERMEABILITY; METABOLIC STRESS; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REOXYGENATION; RESPIRATORY TRACT PARAMETERS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; ENZYME IMMUNOASSAY; ENZYMOLOGY; GENETICS; LUNG INJURY; METABOLISM; METABOLOMICS; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; CAFFEIC ACIDS; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CELLS, CULTURED; ENZYME INHIBITORS; EPITHELIAL CELLS; ETHACRYNIC ACID; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HYDROGEN PEROXIDE; IMMUNOENZYME TECHNIQUES; LUNG INJURY; METABOLOMICS; MICE; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 84932091348     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00220.2014     Document Type: Article

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