Urinary metabolite profiling combined with computational analysis predicts interstitial cystitis-associated candidate biomarkers

Journal of Proteome Research

Volumn 14, Issue 1, 2015, Pages 541-548

  Wen, He ^a   Lee, Tack ^b   You, Sungyong ^c   Park, Soo Hwan ^b   Song, Hosook ^b   Eilber, Karyn S ^c   Anger, Jennifer T ^c   Freeman, Michael R ^c,d,e   Park, Sunghyouk ^a   Kim, Jayoung ^c,d,e  

^a Seoul National University   (South Korea)

^b Inha University School of Medicine   (South Korea)

^c CEDARS SINAI MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

biomarker; bladder; interstitial cystitis; metabolites; Metabolomics; NMR

Indexed keywords

2 OXOGLUTARIC ACID; BIOLOGICAL MARKER; TRIGONELLINE; TYRAMINE;

ADULT; AMINO ACID SYNTHESIS; ANALYSIS; ARTICLE; BLADDER CANCER; CELL PROLIFERATION; CITRIC ACID CYCLE; CLINICAL ARTICLE; COMPUTATIONAL ANALYSIS; CONTROLLED STUDY; CRYOPROBE; FEMALE; HUMAN; INTERSTITIAL CYSTITIS; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; MIDDLE AGED; OXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE; URINALYSIS; URINE; BIOLOGY; COHORT ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRINCIPAL COMPONENT ANALYSIS; PROCEDURES; SOUTH KOREA;

BIOMARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COHORT STUDIES; COMPUTATIONAL BIOLOGY; CYSTITIS, INTERSTITIAL; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; PRINCIPAL COMPONENT ANALYSIS; REPUBLIC OF KOREA;

EID: 84920279443     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr5007729     Document Type: Article

References (30)

1. Hanno, P.; Keay, S.; Moldwin, R.; Van Ophoven, A. International Consultation on IC-Rome, September 2004/Forging an International Consensus: progress in painful bladder syndrome/interstitial cystitis. Report and abstracts Int. Urogynecol. J. Pelvic Floor Dysfunct. 2005, 16, S2-S34
2. Ness, T. J.; Powell-Boone, T.; Cannon, R.; Lloyd, L. K.; Fillingim, R. B. Psychophysical evidence of hypersensitivity in subjects with interstitial cystitis J. Urol. 2005, 173, 1983-7
3. Nordling, J.; Anjum, F. H.; Bade, J. J.; Bouchelouche, K.; Bouchelouche, P.; Cervigni, M.; Elneil, S.; Fall, M.; Hald, T.; Hanus, T.; Hedlund, H.; Hohlbrugger, G.; Horn, T.; Larsen, S.; Leppilahti, M.; Mortensen, S.; Nagendra, M.; Oliveira, P. D.; Osborne, J.; Riedl, C.; Sairanen, J.; Tinzl, M.; Wyndaele, J. J. Primary evaluation of patients suspected of having interstitial cystitis (IC) Eur. Urol. 2004, 45, 662-9
4. Warren, J. W.; Keay, S. K. Interstitial cystitis Curr. Opin. Urol. 2002, 12, 69-74
5. Johansson, S. L.; Fall, M. Clinical features and spectrum of light microscopic changes in interstitial cystitis J. Urol. 1990, 143, 1118-24
6. Hanno, P. M.; Burks, D. A.; Clemens, J. Q.; Dmochowski, R. R.; Erickson, D.; Fitzgerald, M. P.; Forrest, J. B.; Gordon, B.; Gray, M.; Mayer, R. D.; Newman, D.; Nyberg, L., Jr.; Payne, C. K.; Wesselmann, U.; Faraday, M. M. AUA guideline for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome J. Urol. 2011, 185, 2162-70
7. Ottem, D. P.; Teichman, J. M. What is the value of cystoscopy with hydrodistension for interstitial cystitis? Urology 2005, 66, 494-9
8. Parsons, C. L.; Greenberger, M.; Gabal, L.; Bidair, M.; Barme, G. The role of urinary potassium in the pathogenesis and diagnosis of interstitial cystitis J. Urol. 1998, 159, 1862-6
9. Ryan, D.; Robards, K.; Prenzler, P. D.; Kendall, M. Recent and potential developments in the analysis of urine: a review Anal. Chim. Acta 2011, 684, 8-20
10. Duarte, I. F.; Diaz, S. O.; Gil, A. M. NMR metabolomics of human blood and urine in disease research J. Pharm. Biomed. Anal. 2014, 93, 17-26
11. Medina, S.; Dominguez-Perles, R.; Gil, J. I.; Ferreres, F.; Gil-Izquierdo, A. Metabolomics and the diagnosis of human diseases-a guide to the markers and pathophysiological pathways affected Curr. Med. Chem. 2014, 21, 823-48
12. Bezabeh, T.; Somorjai, R. L.; Smith, I. C. MR metabolomics of fecal extracts: applications in the study of bowel diseases Magn. Reson. Chem. 2009, 47, S54-61
13. Yang, H. J.; Choi, M. J.; Wen, H.; Kwon, H. N.; Jung, K. H.; Hong, S. W.; Kim, J. M.; Hong, S. S.; Park, S. An effective assessment of simvastatin-induced toxicity with NMR-based metabonomics approach PLoS One 2011, 6, e16641
14. Xia, J.; Mandal, R.; Sinelnikov, I. V.; Broadhurst, D.; Wishart, D. S. MetaboAnalyst 2.0-a comprehensive server for metabolomic data analysis Nucleic Acids Res. 2012, 40, W127-33
15. Xia, J.; Sinelnikov, I. V.; Wishart, D. S. MetATT: a web-based metabolomics tool for analyzing time-series and two-factor datasets Bioinformatics 2011, 27, 2455-6
16. Kim, J.; Ji, M.; DiDonato, J. A.; Rackley, R. R.; Kuang, M.; Sadhukhan, P. C.; Mauney, J. R.; Keay, S. K.; Freeman, M. R.; Liou, L. S.; Adam, R. M. An hTERT-immortalized human urothelial cell line that responds to anti-proliferative factor In Vitro Cell. Dev. Biol.: Anim. 2011, 47, 2-9
17. Jin, X.; Yun, S. J.; Jeong, P.; Kim, I. Y.; Kim, W. J.; Park, S. Diagnosis of bladder cancer and prediction of survival by urinary metabolomics Oncotarget 2014, 5, 1635-45
18. D'Andrea, G.; D'Arrigo, A.; Dalle Carbonare, M.; Leon, A. Pathogenesis of migraine: role of neuromodulators Headache 2012, 52, 1155-63
19. Rzeski, W.; Walczak, K.; Juszczak, M.; Langner, E.; Pozarowski, P.; Kandefer-Szerszen, M.; Pierzynowski, S. G. Alpha-ketoglutarate (AKG) inhibits proliferation of colon adenocarcinoma cells in normoxic conditions Scand. J. Gastroenterol. 2012, 47, 565-71
20. Matsumoto, K.; Obara, N.; Ema, M.; Horie, M.; Naka, A.; Takahashi, S.; Imagawa, S. Antitumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model Cancer Sci. 2009, 100, 1639-47
21. Gosetti, F.; Mazzucco, E.; Gennaro, M. C.; Marengo, E. Simultaneous determination of sixteen underivatized biogenic amines in human urine by HPLC-MS/MS Anal. Bioanal. Chem. 2013, 405, 907-16
22. VanDenBerg, C. M. The transdermal delivery system of monoamine oxidase inhibitors J. Clin. Psychiatry 2012, 73, 25-30
23. D'Andrea, G.; Perini, F.; Terrazzino, S.; Nordera, G. P. Contributions of biochemistry to the pathogenesis of primary headaches Neurol. Sci. 2004, 25, S89-92
24. Aghabeigi, B.; Feinmann, C.; Glover, V.; Goodwin, B.; Hannah, P.; Harris, M.; Sandler, M.; Wasil, M. Tyramine conjugation deficit in patients with chronic idiopathic temporomandibular joint and orofacial pain Pain 1993, 54, 159-63
25. Babusyte, A.; Kotthoff, M.; Fiedler, J.; Krautwurst, D. Biogenic amines activate blood leukocytes via trace amine-associated receptors TAAR1 and TAAR2 J. Leukocte Biol. 2013, 93, 387-94
26. Han, S. K.; Simon, M. I. Intracellular signaling and the origins of the sensations of itch and pain Sci. Signaling 2011, 4, pe38
27. Juszczak, K.; Thor, P. J. The basic neurophysiologic concept of lower urinary tract function-the role of vanilloid TRPV1 receptors of urinary bladder afferent nerve endings Adv. Clin. Exp. Med. 2012, 21, 417-21
28. Birder, L.; de Groat, W.; Mills, I.; Morrison, J.; Thor, K.; Drake, M. Neural control of the lower urinary tract: peripheral and spinal mechanisms Neurourol. Urodyn. 2010, 29, 128-39
29. Moran, M. M.; McAlexander, M. A.; Biro, T.; Szallasi, A. Transient receptor potential channels as therapeutic targets Nat. Rev. Drug Discovery 2011, 10, 601-20
30. Chapple, C. R. Muscarinic receptor antagonists in the treatment of overactive bladder Urology 2000, 55, 33-46