Glutamate mediates hyperoxia-induced newborn rat lung injury Through N-methyl-D-aspartate receptors

American Journal of Respiratory Cell and Molecular Biology

Volumn 40, Issue 3, 2009, Pages 260-267

  Wang, Mingjie ^a   Luo, Ziqiang ^b   Liu, Shuang ^a,c   Li, An ^b   Deng, Xiaodan ^a   Huang, Furong ^a   Shang, Lihong ^a   Jian, Change ^a   Yue, Shaojie ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b Central South University   (China)

^c CAPITAL INSTITUTE OF PEDIATRICS   (China)

Author keywords

Glutamate; Hyperoxia; Lung injury; N methyl D aspartate receptor; Newborn

Indexed keywords

DIZOCILPINE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2D; OXYGEN; AMINO ACID RECEPTOR BLOCKING AGENT; DIZOCILPINE MALEATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DRUG EFFECT; HISTOPATHOLOGY; HYPEROXIA; INFLAMMATION; LUNG INJURY; LUNG LAVAGE; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; CHEMISTRY; CYTOLOGY; FEMALE; LUNG; METABOLISM; ORGAN SIZE; PATHOLOGY; PREGNANCY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; BRONCHOALVEOLAR LAVAGE FLUID; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GLUTAMIC ACID; HYPEROXIA; LUNG; LUNG INJURY; ORGAN SIZE; PREGNANCY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

RATTUS;

EID: 61549089329     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2008-0135OC     Document Type: Article

References (24)

1. Mayer ML, Westbrook GL. The physiology of excitatory amino acids in the vertebrate central nervous system. Prog Neurobiol 1987;28:197-276.
2. Zorumski CF, Olney JW. Excitotoxic neuronal damage and neuropsychiatric disorders. Pharmacol Ther 1993;59:145-162.
3. Choi DW. Excitotoxic cell death. J Neurobiol 1992;23:1261-1276.
4. 2+ influx underlies potent induction of injury. J Neurosci 1996;16:5457-5465.
5. Hinoi E, Takarada T, Ueshima T. Glutamate signaling in peripheral tissues. Eur J Biochem 2004;271:1-13.
6. Said SI, Berisha HI, Pakbaz H. Excitoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly (ADP-ribose) polymerase. Proc Natl Acad Sci USA 1996;93:4688-4692.
7. Shen L, Luo ZQ, Han JZ, Yue SJ, Qin XQ, Li C, Liu HJ. Experimental study of acute lung injury induced by glutamate in vivo. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2007;32:78-81.
8. Shen L, Han JZ, Li C, Yue SJ, Liu Y, Qin XQ, Liu HJ, Luo ZQ. Protective effect of ginsenoside Rg1 on glutamate-induced lung injury. Acta Pharmacol Sin 2007;28:392-397.
9. Said SI, Pakbaz H, Berisha HI, Raza S, Foda HD. NMDA receptor activation: critical role in oxidant tissue injury. Free Radic Biol Med 2000;28:1300-1302.
10. Dickman KG, Youssef JG, Mathew SM, Said SI. Ionotropic glutamate receptors in lungs and airways molecular basis for glutamate toxicity. Am J Respir Cell Mol Biol 2004;30:139-144.
11. Tang FG, Yue SJ, Luo ZQ, Feng DY, Wang M, Qian C, Zhen XR, Duan YD. Role of N-methyl-D-aspartate receptor in hyperoxia-induced lung injury. Pediatr Pulmonol 2005;40:437-444.
12. Kobayashi H, Hataishi R, Mitsufuji H, Tanaka M, Jacobson M, Tomita T, Zapol WM, Jones RC. Antiinflammatory properties of inducible nitric oxide synthase in acute hyperoxic lung injury. Am J Respir Cell Mol Biol 2001;24:390-397.
13. Lowry OH, Rosebrough NJ, Farr AL. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:265-275.
14. Roberts JD, Roberts CT, Jones RC, Zapol WM, Bloch KD. Continuous nitric oxide inhalation reduces pulmonary arterial structural changes, right ventricular hypertrophy, and growth retardation in the hypoxic newborn rat. Circ Res 1995;76:215-222.
15. Piani D, Frei K, Do KQ, Cuénod M, Fontana A. Murine brain macrophages induced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate. Neurosci Lett 1991;133:159-162.
16. Collard CD, Park KA, Montalto MC, Alapati S, Buras JA, Stahl GL, Colgan SP. Neutrophil-derived glutamate regulates vascular endothelial barrier function. J Biol Chem 2002;277:14801-14811.
17. Lynch DR, Guttmann RP. Excitotoxicity: perspectives based on N-methyl-D-aspartate receptor subtypes. J Pharmacol Exp Ther 2002;300:717-723.
18. Said SI. Glutamate receptors and asthmatic airway disease. Trends Pharmacol Sci 1999;20:132-135.
19. McBain CJ, Mayer ML. N-methyl-D-aspartic acid receptor structure and function. Physiol Rev 1994;74:723-760.
20. Dingledine R, Borges K, Bowie D, Traynelis SF. The glutamate receptorion channels. Pharmacol Rev 1999;51:7-61.
21. Zukin RS, Bennett MV. Alternatively spliced isoforms of the NMDR1 receptor subunit. Trends Neurosci 1995;18:306-313.
22. Robertson B, Dey RD, Huffman LJ, Polak MJ, Said SI. Autoradiographic localization of NMDA receptors to the rat lung, and implications in lung injury. Abstr Soc Neurosci 1997;23:931.
23. Robertson BS, Satterfield BE, Said SI, Dey RD. N-methyl-D-aspartate receptors are expressed by intrinsic neurons of rat larynx and esophagus. Neurosci Lett 1998;244:77-80.
24. Van Genechten J, Brouns I, Scheuermann DW, Timmermans JP, Adriaensen D. Reduced number of intrinsic pulmonary nitrergic neurons in Fawn-Hooded rats as compared to control rat strains. Anat Rec A Discov Mol Cell Evol Biol 2003;272:446-453.