Multi-cancer computational analysis reveals invasion-associated variant of desmoplastic reaction involving INHBA, THBS2 and COL11A1

BMC Medical Genomics

Volumn 3, Issue , 2010, Pages

  Kim, Hoon ^a   Watkinson, John ^a   Varadan, Vinay ^b   Anastassiou, Dimitris ^a  

^a Columbia University ^*  (United States)

^b PHILIPS RESEARCH LABORATORIES   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; BIOLOGICAL MARKER; COLLAGEN TYPE 11; HOMODIMER; INHIBIN; THROMBOSPONDIN 2; TRANSFORMING GROWTH FACTOR BETA; INHIBIN BETA A SUBUNIT; MICRORNA; THROMBOSPONDIN;

ARTICLE; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER INVASION; CANCER STAGING; COLORECTAL CANCER; COMPUTER ANALYSIS; DISEASE ASSOCIATION; DRUG TARGETING; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENETIC VARIABILITY; METASTASIS INHIBITION; NUCLEOTIDE SEQUENCE; OVARY CANCER; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; BIOLOGY; FIBROBLAST; GENETICS; HUMAN; METABOLISM; METASTASIS; METHODOLOGY; METHYLATION; NEOPLASM; PATHOLOGY; TREATMENT OUTCOME;

COLLAGEN TYPE XI; COMPUTATIONAL BIOLOGY; FIBROBLASTS; HUMANS; INHIBIN-BETA SUBUNITS; METHYLATION; MICRORNAS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM STAGING; NEOPLASMS; THROMBOSPONDINS; TREATMENT OUTCOME;

EID: 78049348480     PISSN: None     EISSN: 17558794     Source Type: Journal    
DOI: 10.1186/1755-8794-3-51     Document Type: Article

References (27)

1. The basics of epithelial-mesenchymal transition. R Kalluri RA Weinberg, J Clin Invest 2009 119 1420 1428 10.1172/JCI39104 19487818
2. Epithelial-mesenchymal transitions in tumour progression. JP Thiery, Nat Rev Cancer 2002 2 442 454 10.1038/nrc822 12189386
3. The tumour microenvironment as a target for chemoprevention. A Albini MB Sporn, Nat Rev Cancer 2007 7 139 147 10.1038/nrc2067 17218951
4. A delicate balance: TGF-beta and the tumor microenvironment. DG Stover B Bierie HL Moses, J Cell Biochem 2007 101 851 861 10.1002/jcb.21149 17486574
5. Fibroblasts in cancer. R Kalluri M Zeisberg, Nat Rev Cancer 2006 6 392 401 10.1038/nrc1877 16572188
6. RA Weinberg, The biology of cancer New York: Garland Science 2007
7. Gene expression profile of ovarian serous papillary carcinomas: identification of metastasis-associated genes. E Bignotti RA Tassi S Calza A Ravaggi E Bandiera E Rossi C Donzelli B Pasinetti S Pecorelli AD Santin, Am J Obstet Gynecol 2007 196 245 e241-211 10.1016/j.ajog.2006.10.874 17346539
8. Estimating the number of clusters in a dataset via the Gap statistic. R Tibshirani G Walther T Hastie, J R Statist Soc B 2001 63 411 423 10.1111/1467-9868.00293
9. Computational analysis of the synergy among multiple interacting genes. D Anastassiou, Mol Syst Biol 2007 3 83 10.1038/msb4100124 17299419
10. Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. RW Tothill AV Tinker J George R Brown SB Fox S Lade DS Johnson MK Trivett D Etemadmoghadam B Locandro,, et al. Clin Cancer Res 2008 14 5198 5208 10.1158/1078-0432.CCR-08-0196 18698038
11. Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer. RN Jorissen P Gibbs M Christie S Prakash L Lipton J Desai D Kerr LA Aaltonen D Arango M Kruhoffer,, et al. Clin Cancer Res 2009 15 7642 7651 10.1158/1078-0432.CCR-09-1431 19996206
12. Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. JJ Smith NG Deane F Wu NB Merchant B Zhang A Jiang P Lu JC Johnson C Schmidt CE Bailey,, et al. Gastroenterology 2010 138 958 968 10.1053/j.gastro.2009.11.005 19914252
13. Progression-specific genes identified by expression profiling of matched ductal carcinomas in situ and invasive breast tumors, combining laser capture microdissection and oligonucleotide microarray analysis. CS Schuetz M Bonin SE Clare K Nieselt K Sotlar M Walter T Fehm E Solomayer O Riess D Wallwiener,, et al. Cancer Res 2006 66 5278 5286 10.1158/0008-5472.CAN-05-4610 16707453
14. Gene expression analysis of early and advanced gastric cancers. M Vecchi P Nuciforo S Romagnoli S Confalonieri C Pellegrini G Serio M Quarto M Capra GC Roviaro E Contessini Avesani,, et al. Oncogene 2007 26 4284 4294 10.1038/sj.onc.1210208 17297478
15. Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia. L Badea V Herlea SO Dima T Dumitrascu I Popescu, Hepatogastroenterology 2008 55 2016 2027 19260470
16. The Desmoplastic Reaction in Pancreatic Cancer: An Increasingly Recognised Foe. MV Apte JS Wilson, Pancreatology 2007 7 378 379 10.1159/000107399 17703086
17. Great potential of a panel of multiple hMTH1, SPD, ITGA11 and COL11A1 markers for diagnosis of patients with non-small cell lung cancer. IW Chong MY Chang HC Chang YP Yu CC Sheu JR Tsai JY Hung SH Chou MS Tsai JJ Hwang SR Lin, Oncol Rep 2006 16 981 988 17016581
18. Molecular profiling and the identification of genes associated with metastatic oral cavity/pharynx squamous cell carcinoma. CE Schmalbach DB Chepeha TJ Giordano MA Rubin TN Teknos CR Bradford GT Wolf R Kuick DE Misek DK Trask S Hanash, Arch Otolaryngol Head Neck Surg 2004 130 295 302 10.1001/archotol.130.3. 295 15023835
19. Inference of regulatory gene interactions from expression data using three-way mutual information. J Watkinson KC Liang X Wang T Zheng D Anastassiou, Ann N Y Acad Sci 2009 1158 302 313 10.1111/j.1749-6632.2008.03757.x 19348651
20. A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer. P Farmer H Bonnefoi P Anderle D Cameron P Wirapati V Becette S Andre M Piccart M Campone E Brain,, et al. Nat Med 2009 15 68 74 10.1038/nm.1908 19122658
21. Matrix metalloproteinases: Regulators of the tumor microenvironment. K Kessenbrock V Plaks Z Werb, Cell 2010 141 52 67 10.1016/j.cell.2010.03.015 20371345
22. Activin receptors are expressed on human lung fibroblast and activin A facilitates fibroblast-mediated collagen gel contraction. E Ohga T Matsuse S Teramoto Y Ouchi, Life Sci 2000 66 1603 1613 10.1016/S0024-3205(00)00480-X 11261590
23. Lib, transcriptionally induced in senile plaque-associated astrocytes, promotes glial migration through extracellular matrix. K Satoh M Hata T Shimizu H Yokota H Akatsu T Yamamoto K Kosaka T Yamada, Biochem Biophys Res Commun 2005 335 631 636 10.1016/j.bbrc.2005.07.117 16098915
24. Follistatin as an inhibitor of experimental metastasis. JE Talmadge, Clin Cancer Res 2008 14 624 626 10.1158/1078-0432.CCR-07-2216 18245519
25. Follistatin suppresses the production of experimental multiple-organ metastasis by small cell lung cancer cells in natural killer cell-depleted SCID mice. H Ogino S Yano S Kakiuchi H Muguruma K Ikuta M Hanibuchi H Uehara K Tsuchida H Sugino S Sone, Clin Cancer Res 2008 14 660 667 10.1158/1078-0432.CCR- 07-1221 18245525
26. Cancer as an overhealing wound: an old hypothesis revisited. M Schafer S Werner, Nat Rev Mol Cell Biol 2008 9 628 638 10.1038/nrm2455 18628784
27. Ovarian cancer development and metastasis. E Lengyel, Am J Pathol 2010 177 1053 1064 10.2353/ajpath.2010.100105 20651229