A protein tyrosine kinase receptor, c-RET signaling pathway contributes to the enteric neurogenesis induced by a 5-HT4 receptor agonist at an anastomosis after transection of the gut in rodents

Journal of Physiological Sciences

Volumn 65, Issue 4, 2015, Pages 377-383

  Goto, Kei ^a   Kawahara, Isao ^a   Kuniyasu, Hiroki ^a   Takaki, Miyako ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

5 HT4 receptor; Enteric neuron; Granulation tissue; PKA; RET

Indexed keywords

BENZAMIDE DERIVATIVE; INDOLE DERIVATIVE; MORPHOLINE DERIVATIVE; MOSAPRIDE; PGP9.5 PROTEIN, MOUSE; PROTEIN RET; PROTEIN TYROSINE KINASE; RPI-1 COMPOUND; SEROTONIN 4 AGONIST; UBIQUITIN THIOLESTERASE; WITHAFERIN A; WITHANOLIDE;

ANASTOMOSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BIOLOGICAL MODEL; DRUG EFFECTS; FEMALE; GROWTH, DEVELOPMENT AND AGING; ILEUM; INTESTINE INNERVATION; MALE; METABOLISM; MOUSE; NERVOUS SYSTEM DEVELOPMENT; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; SURGERY; WISTAR RAT;

ANASTOMOSIS, SURGICAL; ANIMALS; BENZAMIDES; ENTERIC NERVOUS SYSTEM; FEMALE; ILEUM; INDOLES; MALE; MICE; MICE, INBRED BALB C; MODELS, NEUROLOGICAL; MORPHOLINES; NEUROGENESIS; PROTO-ONCOGENE PROTEINS C-RET; RATS; RATS, WISTAR; RECEPTOR PROTEIN-TYROSINE KINASES; SEROTONIN 5-HT4 RECEPTOR AGONISTS; SIGNAL TRANSDUCTION; UBIQUITIN THIOLESTERASE; WITHANOLIDES;

EID: 84931562436     PISSN: 18806546     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12576-015-0377-4     Document Type: Article

References (21)

1. Gershon MD (2010) Developmental determinants of the independence and complexity of the enteric nervous system. Trends Neurosci 33:446–456
2. Lake JI, Heuckeroth RO (2013) Enteric nervous system development: migration, differentiation, and disease. Am J Physiol Gastrointest Liver Physiol 305:G1–G24
3. Obermayr F, Hotta R, Enomoto H, Young HM (2013) Development and developmental disorders of the enteric nervous system. Nat Rev Gastroenterol Hepatol 10:43–57
4. Hotta R, Pepdjonovic L, Anderson RB, D Zhang, Bergner AJ, Leun J, PéBay A, Young HM, Newgreen DF, Dottori M (2009) Small-molecule induction of neural crest-like cells derived from human neural progenitors. Stem Cells 27:2896–2905
5. 4-receptor activation-induced neural plasticity enhances in vivo reconstructs of enteric nerve circuit insult. Neurogastroenterol Motil 22:806
6. 4 receptor agonist on in vivo neurogenesis at the rectal anastomosis in rats. Am J Physiol Gastrointest Liver Physiol 302:G588–G597
7. Goto K, Kato G, Kawahara I, Luo Y, Obata K, Misawa H, Ishikawa T, Kuniyasu H, Nabekura J, Takaki M (2013) In vivo imaging of enteric neurogenesis in the deep tissue of mouse small intestine. PLoS one 8:e54814–e54822
8. Takaki M, Nakayama S, Misawa H, Nakagawa T, Kuniyasu H (2006) In vitro formation of enteric neural network structure in a gut-like organ differentiated from mouse embryonic stem cells. Stem Cells 24:1414–1422
9. 4-receptor activation. Biochem Biophys Res Commun 406:529–533
10. Nagoshi N, Shibata S, Kubota Y, Nakamura M, Nagai Y, Satoh E, Morikawa S, Okada Y, Mabuchi Y, Katoh H, Okada S, Fukuda K, Suda T, Matsuzaki Y, Toyama Y, Okano H (2008) Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad. Cell Stem Cell 2:392–403
11. Goto K, Kato G, Kawahara I, Kuniyasu H, Nabekura J, Takaki M (2013) Endogenously and exogenously newborn enteric neurons in the deep tissue of mouse small intestine underwent transection and anastomosis. J Physiol Sci 64(Supplement 1):S195
12. Samadi AK, Mukerji R, Shah A, Timmermann BN, Cohen MS (2010) A novel RET inhibitor with potent efficacy against medullary thyroid cancer in vivo. Surgery 148:1228–1236
13. Cuccuru G, Lanzi C, Cassinelli G, Pratesi G, Tortoreto M, Petrangolini G, Seregni E, Martinetti A, Laccabue D, Zanchi C, Zunino F (2004) Cellular effects and antitumor activity of RET inhibitor RPI-1 on MEN2A-associated medullary thyroid carcinoima. J Natl Cancer Inst 96:1006–1014
14. 4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. J Neurosci 29:9683–9699
15. Enomoto H, Hughes I, Golden J, Baloh RH, Yonemura S, Heuckeroth RO, Johnson EM Jr, Milbrandt J (2004) GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration. Neuron 44:623–636
16. Uesaka T, Jain S, Yonemura S, Uchiyama Y, Milbrandt J, Enomoto H (2007) Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung’s disease phenotype. Development 134:2171–2181
17. Uesaka T, Nagashimada M, Yonemura S, Enomoto H (2008) Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice. J Clin Invest 118:1890–1898
18. Kobayashi K, Ikeda Y, Haneda E, Suzuki H (2008) Chronic fluoxetine bidirectionally modulates potentiating effects of serotonin on the hippocampal mossy fiber synaptic transmission. J Neurosci 28:6272–6280
19. Shah BH, Catt KJ (2004) GPCR-mediated transactivation of RTKs in the CNS: mechanisms and consequences. Trends Neurosci 27:48–53
20. Takaki M, Goto K, Kawahara I (2014) The 5-hydroxytryptamine 4 receptor agonist-induced actions and enteric neurogenesis in the gut. J Neurogastroenterol Motil 20:17–30
21. Asai N, Fukuda T, Wu Z, Enomoto A, Pachnis V, Takahashi M, Costantini F (2006) Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells. Development 133:4507–4516