Conditional ablation of GFRα1 in postmigratory eneric neurons triggers unconventional neuronal death in the colon and causes Hirschsprungs's disease phenotype

Development

Volumn 134, Issue 11, 2007, Pages 2171-2181

  Uesaka, Toshihiro ^a   Jain, Sanjay ^b   Yonemura, Shigenobu ^a   Uchiyama, Yasuo ^c   Milbrandt, Jeffrey ^b   Enomoto, Hideki ^a  

^a RIKEN Center for Biosystems Dynamics Research   (Japan)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Enteric neuron; GDNF; GFR 1; Mouse

Indexed keywords

CASPASE 3; CASPASE 7; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR ALPHA 1; PROTEIN BAX; UNCLASSIFIED DRUG; CASPASE; GFRA1 PROTEIN, MOUSE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR; OLIGONUCLEOTIDE;

AGANGLIONOSIS; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CHROMATIN ASSEMBLY AND DISASSEMBLY; COLON; GENE EXPRESSION; GENOTYPE; HIRSCHSPRUNG DISEASE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTESTINE INNERVATION; MITOCHONDRION; MORPHOLOGICAL ADAPTATION; MOUSE; NERVE CELL DEGENERATION; NERVE CELL DIFFERENTIATION; NONHUMAN; ORGANOGENESIS; PHENOTYPE; PRIORITY JOURNAL; ANIMAL; COMPARATIVE STUDY; GENE SILENCING; GENETICS; INNERVATION; METABOLISM; NERVE CELL; NONPARAMETRIC TEST; PATHOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT; TRANSGENIC MOUSE; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

MUS;

ANIMALS; CASPASES; CELL DEATH; COLON; ENTERIC NERVOUS SYSTEM; GENE SILENCING; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; HIRSCHSPRUNG DISEASE; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; NEURONS; OLIGONUCLEOTIDES; PHENOTYPE; STATISTICS, NONPARAMETRIC;

EID: 34250885111     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.001388     Document Type: Article

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