Small-molecule induction of neural crest-like cells derived from human neural progenitors

Stem Cells

Volumn 27, Issue 12, 2009, Pages 2896-2905

  Hotta, Ryo ^a   Pepdjonovic, Lana ^a   Anderson, Richard B ^a   Zhang, Dongcheng ^b   Bergner, Annette J ^a   Leung, Jessie ^a   Pébay, Alice ^a   Young, Heather M ^a   Newgreen, Donald F ^b   Dottori, Mirella ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

Hirschsprung's disease; Human embryonic stem cells; Neural crest; Neural progenitors; ROCK1 2 inhibitor; Small molecule

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE ROCK 1; PROTEIN SERINE THREONINE KINASE ROCK 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MIGRATION; COCULTURE; EMBRYO; EMBRYONIC STEM CELL; FIBROBLAST; FOWL; HIRSCHSPRUNG DISEASE; HUMAN; HUMAN CELL; MOUSE; NEURAL CREST CELL; NONHUMAN;

AMIDES; ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; COCULTURE TECHNIQUES; EMBRYO, MAMMALIAN; EMBRYO, NONMAMMALIAN; EMBRYONIC STEM CELLS; HUMANS; MICE; NEURAL CREST; PYRIDINES; QUAIL; SIGNAL TRANSDUCTION;

AVES; MURINAE; SPONDIAS PURPUREA;

EID: 73349120563     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.208     Document Type: Article

References (54)

1. Steventon B, Araya C, Linker C et al. Differential requirements of BMP and Wnt signalling during gastrulation and neurulation define two steps in neural crest induction. Development 2009;136:771-779.
2. Basch ML, Bronner-Fraser M. Neural crest inducing signals. Adv Exp Med Biol 2006;589:24-31.
3. Sauka-Spengler T, Bronner-Fraser M. A gene regulatory network orchestrates neural crest formation. Nat Rev Mol Cell Biol 2008;9:557-568.
4. Raible DW. Development of the neural crest: Achieving specificity in regulatory pathways. Curr Opin Cell Biol 2006;18:698-703.
5. Jessen KR, Mirsky R. Signals that determine Schwann cell identity. J Anat 2002;200:367-376.
6. Huber K. The sympathoadrenal cell lineage: Specification, diversification, and new perspectives. Dev Biol 2006;298:335-343.
7. Newgreen D, Young HM. Enteric nervous system: Development and developmental disturbances-part 1. Pediatr Dev Pathol 2002;5:224-247.
8. Heanue TA, Pachnis V. Enteric nervous system development and Hirschsprung's disease: Advances in genetic and stem cell studies. Nat Rev Neurosci 2007;8:466-479.
9. Landman KA, Simpson MJ, Newgreen DF. Mathematical and experimental insights into the development of the enteric nervous system and Hirschsprung's disease. Dev Growth Differ 2007;49:277-286.
10. Simpson MJ, Zhang DC, Mariani M et al. Cell proliferation drives neural crest cell invasion of the intestine. Dev Biol 2007;302:553-568.
11. Barlow AJ, Wallace AS, Thapar N et al. Critical numbers of neural crest cells are required in the pathways from the neural tube to the foregut to ensure complete enteric nervous system formation. Development 2008;135:1681-1691.
12. Amiel J, Sproat-Emison E, Garcia-Barcelo M et al. Hirschsprung disease, associated syndromes and genetics: A review. J Med Genet 2008;45:1-14.
13. Catto-Smith AG, Trajanovska M, Taylor RG. Long-term continence after surgery for Hirschsprung's disease. J Gastroenterol Hepatol 2007;22:2273-2282.
14. Metzger M, Caldwell C, Barlow AJ et al. Enteric nervous system stem cells derived from human gut mucosa for the treatment of aganglionic gut disorders. Gastroenterology 2009;136:2214-2225. e1-3.
15. Micci MA, Pasricha PJ. Neural stem cells for the treatment of disorders of the enteric nervous system: Strategies and challenges. Dev Dyn 2007;236:33-43.
16. Schäfer KH, Micci MA, Pasricha PJ. Neural stem cell transplantation in the enteric nervous system: Roadmaps and roadblocks. Neurogastroenterol Motil 2009;21:103-112.
17. Young HM. Neural stem cell therapy and gastrointestinal biology. Gastroenterology 2005;129:2092-2095.
18. Bondurand N, Natarajan D, Thapar N et al. Neuron and glia generating progenitors of the mammalian enteric nervous system isolated from foetal and postnatal gut cultures. Development 2003;130:6387-6400.
19. Bixby S, Kruger GM, Mosher JT et al. Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity. Neuron 2002;35:643-656.
20. Mosher JT, Yeager KJ, Kruger GM et al. Intrinsic differences among spatially distinct neural crest stem cells in terms of migratory properties, fate determination, and ability to colonize the enteric nervous system. Dev Biol 2007;303:1-15.
21. Martucciello G, Brizzolara A, Favre A et al. Neural crest neuroblasts can colonise aganglionic and ganglionic gut in vivo. Eur J Pediatr Surg 2007;17:34-40.
22. Kruger GM, Mosher JT, Bixby S et al. Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness. Neuron 2002;35:657-669.
23. Almond S, Lindley RM, Kenny SE et al. Characterisation and transplantation of enteric nervous system progenitor cells. Gut 2007;56:489-496.
24. Micci MA, Kahrig KM, Simmons RS et al. Neural stem cell transplantation in the stomach rescues gastric function in neuronal nitric oxide synthase-deficient mice. Gastroenterology 2005;129:1817-1824.
25. Natarajan D, Grigoriou M, Marcos-Gutierrez CV et al. Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture. Development 1999;126:157-168.
26. Lindley RM, Hawcutt DB, Connell MG et al. Human and mouse enteric nervous system neurosphere transplants regulate the function of aganglionic embryonic distal colon. Gastroenterology 2008;135:205-216.e6.
27. Liu W, Wu RD, Dong YL et al. Neuroepithelial stem cells differentiate into neuronal phenotypes and improve intestinal motility recovery after transplantation in the aganglionic colon of the rat. Neurogastroenterol Motil 2007;19:1001-1009.
28. Yamada T, Yoshikawa M, Takaki M et al. In vitro functional gut-like organ formation from mouse embryonic stem cells. Stem Cells 2002;20:41-49.
29. Takaki M, Nakayama S, Misawa H et al. In vitro formation of enteric neural network structure in a gut-like organ differentiated from mouse embryonic stem cells. Stem Cells 2006;24:1414-1422.
30. Torihashi S, Kuwahara M, Ogaeri T et al. Gut-like structures from mouse embryonic stem cells as an in vitro model for gut organogenesis preserving developmental potential after transplantation. Stem Cells 2006;24:2618-2626.
31. Chalazonitis A. Neurotrophin-3 in the development of the enteric nervous system. Prog Brain Res 2004;146:243-263.
32. Dottori M, Pera MF. Neural differentiation of human embryonic stem cells. Methods Mol Biol 2008;438:19-30.
33. McKeown SJ, Lee VM, Bronner-Fraser M et al. Sox10 overexpression induces neural crest-like cells from all dorsoventral levels of the neural tube but inhibits differentiation. Dev Dyn 2005;233:430-444.
34. Young HM, Ciampoli D. Transient expression of neuronal nitric oxide synthase by neurons of the submucous plexus of the mouse small intestine. Cell Tissue Res 1998;291:395-401.
35. Fairman CL, Clagett-Dame M, Lennon VA et al. Appearance of neurons in the developing chick gut. Dev Dyn 1995;204:192-201.
36. Le Douarin NM, Dieterlen-Lievre F, Teillet MA et al. Interspecific chimeras in avian embryos. Methods Mol Biol 2000;135:373-386.
37. Hearn CJ, Young HM, Ciampoli D et al. Catenary cultures of embryonic gastrointestinal tract support organ morphogenesis, motility, neural crest cell migration, and cell differentiation. Dev Dyn 1999;214:239-247.
38. Anderson RB, Bergner AJ, Taniguchi M et al. Effects of different regions of the developing gut on the migration of enteric neural crest-derived cells: A role for Sema3A, but not Sema3F. Dev Biol 2007;305:287-299.
39. Pera MF, Andrade J, Houssami S et al. Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin. J Cell Sci 2004;117:1269-1280.
40. Ben-Hur T, Idelson M, Khaner H et al. Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats. Stem Cells 2004;22:1246-1255.
41. Davidson KC, Jamshidi P, Daly R et al. Wnt3a regulates survival, expansion, and maintenance of neural progenitors derived from human embryonic stem cells. Mol Cell Neurosci 2007;36:408-415.
42. Wang G, Zhang H, Zhao Y et al. Noggin and bFGF cooperate to maintain the pluripotency of human embryonic stem cells in the absence of feeder layers. Biochem Biophys Res Commun 2005;330:934-942.
43. Sato N, Meijer L, Skaltsounis L et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 2004;10:55-63.
44. Newgreen DF, Minichiello J. Control of epitheliomesenchymal transformation. II. Cross-modulation of cell adhesion and cytoskeletal systems in embryonic neural cells. Dev Biol 1996;176:300-312.
45. Rathjen J, Haines BP, Hudson KM et al. Directed differentiation of pluripotent cells to neural lineages: Homogeneous formation and differentiation of a neurectoderm population. Development 2002;129:2649-2661.
46. Groysman M, Shoval I, Kalcheim C. A negative modulatory role for rho and rho-associated kinase signaling in delamination of neural crest cells. Neural Dev 2008;3:27.
47. Pomp O, Brokhman I, Ben-Dor I et al. Generation of peripheral sensory and sympathetic neurons and neural crest cells from human embryonic stem cells. Stem Cells 2005;23:923-930.
48. Lee G, Kim H, Elkabetz Y et al. Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells. Nat Biotechnol 2007;25:1468-1475.
49. Furness JB. Types of neurons in the enteric nervous system. J Auton Nerv Syst 2000;81:87-96.
50. Pomp O, Brokhman I, Ziegler L et al. PA6-induced human embryonic stem cell-derived neurospheres: A new source of human peripheral sensory neurons and neural crest cells. Brain Res 2008;1230:50-60.
51. Jiang X, Gwye Y, McKeown SJ et al. Isolation and characterization of neural crest stem cells derived from in vitro differentiated human embryonic stem cells. Stem Cells Dev 2008 Dec 19. [Epub ahead of print].
52. Fernandes KJ, Kobayashi NR, Gallagher CJ et al. Analysis of the neurogenic potential of multipotent skin-derived precursors. Exp Neurol 2006;201:32-48.
53. Arthur A, Rychkov G, Shi S et al. Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues. Stem Cells 2008;26:1787-1795.
54. Nishikawa S, Goldstein RA, Nierras CR. The promise of human induced pluripotent stem cells for research and therapy. Nat Rev Mol Cell Biol 2008;9:725-729.