Blood vessels in allotransplantation

American Journal of Transplantation

Volumn 15, Issue 7, 2015, Pages 1748-1754

  Abrahimi, P ^a   Liu, R ^a   Pober, J S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Editorial; immunobiology; organ transplantation in general; personal viewpoint; rejection: antibody mediated (ABMR); rejection: chronic; rejection: T cell mediated (TCMR); rejection: vascular; vascular biology

Indexed keywords

ADAPTIVE IMMUNITY; ALLOGRAFT; ALLOTRANSPLANTATION; ANTIBODY MEDIATED REJECTION; ARTERITIS; ARTICLE; BLOOD VESSEL; BLOOD VESSEL GRAFT; CELL DAMAGE; ENDOTHELIUM CELL; GRAFT REJECTION; HOMEOSTASIS; HOST; HUMAN; HYPERACUTE GRAFT REJECTION; IMMUNOSURVEILLANCE; INFLAMMATION; INNATE IMMUNITY; NECROSIS; PERFUSION; PERICYTE; PRIORITY JOURNAL; REPERFUSION INJURY; SMOOTH MUSCLE FIBER; THROMBOSIS; GRAFT SURVIVAL; IMMUNOLOGY; ORGAN TRANSPLANTATION; PHYSIOLOGY; PROGNOSIS;

BLOOD VESSELS; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; ORGAN TRANSPLANTATION; PROGNOSIS; TRANSPLANTATION, HOMOLOGOUS;

EID: 84931359489     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.13242     Document Type: Article

References (40)

1. Minami E, Laflamme MA, Saffitz JE, Murry CE., Extracardiac progenitor cells repopulate most major cell types in the transplanted human heart. Circulation 2005; 112: 2951-2958.
2. Pober JS, Sessa WC., Inflammation and the blood microvascular system. Cold Spring Harb Perspect Biol 2014; 7/1/a016345.
3. Pober JS, Tellides G., Participation of blood vessel cells in human adaptive immune responses. Trends Immunol 2012; 33: 49-57.
4. Tse D, Stan RV., Morphological heterogeneity of endothelium. Semin Thromb Hemost 2010; 36: 236-245.
5. van Hinsbergh VW., Endothelium-role in regulation of coagulation and inflammation. Semin Immunopathol 2012; 34: 93-106.
6. + T cells. J Immunol 2008; 180: 8386-8392.
7. Manes TD, Pober JS., Polarized granzyme release is required for antigen-driven transendothelial migration of human effector memory CD4 T cells. J Immunol 2014; 193: 5809-5815.
8. Ghani S, Feuerer M, Doebis C, et al., T cells as pioneers: Antigen-specific T cells condition inflamed sites for high-rate antigen-non-specific effector cell recruitment. Immunology 2009; 128: e870-e880.
9. + T cell migration to vascularized transplants. J Clin Invest 2013; 123: 2663-2671.
10. Takeuchi O, Akira S., Pattern recognition receptors and inflammation. Cell 2010; 140: 805-820.
11. Fitzner N, Clauberg S, Essmann F, Liebmann J, Kolb-Bachofen V., Human skin endothelial cells can express all 10 TLR genes and respond to respective ligands. Clin Vaccine Immunol 2008; 15: 138-146.
12. Schroder K, Tschopp J., The inflammasomes. Cell 2010; 140: 821-832.
13. Pober JS, Sessa WC., Evolving functions of endothelial cells in inflammation. Nat Rev Immunol 2007; 7: 803-815.
14. Proebstl D, Voisin MB, Woodfin A, et al., Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med 2012; 209: 1219-1234.
15. Hancock WW, Lu B, Gao W, et al., Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J Exp Med 2000; 192: 1515-1520.
16. Cuvelier SL, Patel KD., Shear-dependent eosinophil transmigration on interleukin 4-stimulated endothelial cells: A role for endothelium-associated eotaxin-3. J Exp Med 2001; 194: 1699-1709.
17. Maier CL, Pober JS., Human placental pericytes poorly stimulate and actively regulate allogeneic CD4 T cell responses. Arterioscler Thromb Vasc Biol 2011; 31: 183-189.
18. Domev H, Milkov I, Itskovitz-Eldor J, Dar A., Immunoevasive pericytes from human pluripotent stem cells preferentially modulate induction of allogeneic regulatory T cells. Stem Cells Transl Med 2014; 3: 1169-1181.
19. Zhang P, Manes TD, Pober JS, Tellides G., Human vascular smooth muscle cells lack essential costimulatory molecules to activate allogeneic memory T cells. Arterioscler Thromb Vasc Biol 2010; 30: 1795-1801.
20. Cuffy MC, Silverio AM, Qin L, et al., Induction of indoleamine 2,3-dioxygenase in vascular smooth muscle cells by interferon-gamma contributes to medial immunoprivilege. J Immunol 2007; 179: 5246-5254.
21. Tullius SG, Tilney NL., Both alloantigen-dependent and -independent factors influence chronic allograft rejection. Transplantation 1995; 59: 313-318.
22. + regulatory T cells. J Immunol 2011; 187: 6268-6280.
23. Colvin RB., Antibody-mediated renal allograft rejection: Diagnosis and pathogenesis. J Am Soc Nephrol 2007; 18: 1046-1056.
24. Strehlau J, Pavlakis M, Lipman M, et al., Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation. Proc Natl Acad Sci USA 1997; 94: 695-700.
25. Biedermann BC, Pober JS., Human endothelial cells induce and regulate cytolytic T cell differentiation. J Immunol 1998; 161: 4679-4687.
26. Colvin RB, Cohen AH, Saiontz C, et al., Evaluation of pathologic criteria for acute renal allograft rejection: Reproducibility, sensitivity, and clinical correlation. J Am Soc Nephrol 1997; 8: 1930-1941.
27. Kato M, Morozumi K, Takeuchi O, et al., Complement fragment C4d deposition in peritubular capillaries in acute humoral rejection after ABO blood group-incompatible human kidney transplantation. Transplantation 2003; 75: 663-665.
28. Yamakuchi M, Kirkiles-Smith NC, Ferlito M, et al., Antibody to human leukocyte antigen triggers endothelial exocytosis. Proc Natl Acad Sci USA 2007; 104: 1301-1306.
29. Pober JS, Jane-wit D, Qin L, Tellides G., Interacting mechanisms in the pathogenesis of cardiac allograft vasculopathy. Arterioscler Thromb Vasc Biol 2014; 34: 1609-1614.
30. Ticehurst EH, Molina MR, Frank R, et al., Antibody-mediated rejection in heart transplant patients: Long-term follow up of patients with high levels of donor-directed anti-DQ antibodies. Clin Transpl 2011; 409-414.
31. Wang C, Yi T, Qin L, et al., Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells. J Clin Invest 2013; 123: 1677-1693.
32. Wang C, Qin L, Manes TD, Kirkiles-Smith NC, Tellides G, Pober JS., Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2. J Exp Med 2014; 211: 395-404.
33. Jindra PT, Jin YP, Rozengurt E, Reed EF., HLA class I antibody-mediated endothelial cell proliferation via the mTOR pathway. J Immunol 2008; 180: 2357-2366.
34. Andreassen AK, Andersson B, Gustafsson F, et al., Everolimus initiation and early calcineurin inhibitor withdrawal in heart transplant recipients: A randomized trial. Am J Transplant 2014; 14: 1828-1838.
35. Cronstein BN, Kimmel SC, Levin RI, Martiniuk F, Weissmann G., A mechanism for the antiinflammatory effects of corticosteroids: The glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci USA 1992; 89: 9991-9995.
36. Zapolska-Downar D, Siennicka A, Kaczmarczyk M, Kolodziej B, Naruszewicz M., Simvastatin modulates TNFalpha-induced adhesion molecules expression in human endothelial cells. Life Sci 2004; 75: 1287-1302.
37. Mella A, Messina M, Lavacca A, Biancone L., Complement cascade and kidney transplantation: The rediscovery of an ancient enemy. World J Transplant 2014; 4: 168-175.
38. Dahlman JE, Barnes C, Khan OF, et al., In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nat Nanotechnol 2014; 9: 648-655.
39. Cypel M, Keshavjee S., The clinical potential of ex vivo lung perfusion. Expert Rev Respir Med 2012; 6: 27-35.
40. Hosgood SA, van Heurn E, Nicholson ML., Normothermic machine perfusion of the kidney: Better conditioning and repair ? Transpl Int 2014; doi: 10.1111/tri.12319.