Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2

Journal of Experimental Medicine

Volumn 211, Issue 3, 2014, Pages 395-404

  Wang, Chen ^a   Qin, Lingfeng ^a   Manes, Thomas D ^a   Kirkiles smith, Nancy C ^a   Tellides, George ^a   Pober, Jordan S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; INTERFERON REGULATORY FACTOR 1; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; PROTEIN KINASE B; RAPAMYCIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG INHIBITION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; GLOMERULUS; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VASCULAR ENDOTHELIUM;

ANALYSIS OF VARIANCE; BLOTTING, WESTERN; CELL ADHESION; CHROMATIN IMMUNOPRECIPITATION; DNA PRIMERS; ENDOTHELIAL CELLS; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; MICROSCOPY, FLUORESCENCE; MULTIPROTEIN COMPLEXES; ONCOGENE PROTEIN V-AKT; REAL-TIME POLYMERASE CHAIN REACTION; SIROLIMUS; T-LYMPHOCYTES; TOR SERINE-THREONINE KINASES; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84896813589     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20131125     Document Type: Article

References (20)

1. Ahmad, M., N. Marui, R.W. Alexander, and R.M. Medford. 1995. Cell type-specific transactivation of the VCAM-1 promoter through an NF-kB enhancer motif. J. Biol. Chem. 270:8976-8983. http://dx.doi.org/10.1074/jbc.270.15.8976
2. Al-Lamki, R.S., J.R. Bradley, and J.S. Pober. 2008. Endothelial cells in allograft rejection. Transplantation. 86:1340-1348. http://dx.doi.org/10.1097/TP.0b013e3181891d8b
3. Cook-Mills, J.M., M.E. Marchese, and H. Abdala-Valencia. 2011. Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants. Antioxid. Redox Signal. 15:1607-1638. http://dx.doi.org/10.1089/ars.2010.3522
4. Fritsche-Guenther, R., F. Witzel, A. Sieber, R. Herr, N. Schmidt, S. Braun, T. Brummer, C. Sers, and N. Blüthgen. 2011. Strong negative feedback from Erk to Raf confers robustness to MAPK signalling. Mol. Syst. Biol. 7:489. http://dx.doi.org/10.1038/msb.2011.27
5. Jacinto, E., V. Facchinetti, D. Liu, N. Soto, S. Wei, S.Y. Jung, Q. Huang, J. Qin, and B. Su. 2006. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell. 127:125-137. http://dx.doi.org/10.1016/j.cell.2006.08.033
6. Koch, A.E., J.C. Burrows, G.K. Haines, T.M. Carlos, J.M. Harlan, and S.J. Leibovich. 1991. Immunolocalization of endothelial and leukocyte adhesion molecules in human rheumatoid and osteoarthritic synovial tissues. Lab. Invest. 64:313-320.
7. Laplante, M., and D.M. Sabatini. 2012. mTOR signaling in growth control and disease. Cell. 149:274-293. http://dx.doi.org/10.1016/j.cell.2012.03.017
8. Lechleitner, S., J. Gille, D.R. Johnson, and P. Petzelbauer. 1998. Interferon enhances tumor necrosis factor-induced vascular cell adhesion molecule 1 (CD106) expression in human endothelial cells by an interferon-related factor 1-dependent pathway. J. Exp. Med. 187:2023-2030. http://dx.doi.org/10.1084/jem.187.12.2023
9. Madge, L.A., and J.S. Pober. 2001. TNF signaling in vascular endothelial cells. Exp. Mol. Pathol. 70:317-325. http://dx.doi.org/10.1006/exmp.2001.2368
10. Manes, T.D., J.S. Pober, and M.S. Kluger. 2006. Endothelial cell-T lymphocyte interactions: IP[corrected]-10 stimulates rapid transendothelial migration of human effort but not central memory CD4+ T cells. Requirements for shear stress and adhesion molecules. Transplantation. 82:S9-S14. http://dx.doi.org/10.1097/01.tp.0000231356.57576.82
11. O'Brien, K.D., M.D. Allen, T.O. McDonald, A. Chait, J.M. Harlan, D. Fishbein, J. McCarty, M. Ferguson, K. Hudkins, C.D. Benjamin, et al. 1993. Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis. J. Clin. Invest. 92:945-951. http://dx.doi.org/10.1172/JCI116670
12. Pober, J.S., and W.C. Sessa. 2007. Evolving functions of endothelial cells in inflammation. Nat. Rev. Immunol. 7:803-815. http://dx.doi.org/10.1038/nri2171
13. Ren, B., Y. Deng, A. Mukhopadhyay, A.A. Lanahan, Z.W. Zhuang, K.L. Moodie, M.J. Mulligan-Kehoe, T.V. Byzova, R.T. Peterson, and M. Simons. 2010. ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish. J. Clin. Invest. 120:1217-1228. http://dx.doi.org/10.1172/JCI39837
14. Roberts, P.J., and C.J. Der. 2007. Targeting the Raf-MEK-ERK mitogenactivated protein kinase cascade for the treatment of cancer. Oncogene. 26:3291-3310. http://dx.doi.org/10.1038/sj.onc.1210422 Sarbassov, D.D., S.M. Ali, S. Sengupta, J.H. Sheen, P.P. Hsu, A.F. Bagley, A.L.
15. Sarbassov, D.D., S.M. Ali, S. Sengupta, J.H. Sheen, P.P. Hsu, A.F. Bagley, A.L. Markhard, and D.M. Sabatini. 2006. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol. Cell. 22:159-168. http://dx.doi.org/10.1016/j.molcel.2006.03.029
16. Sun, C., K. Alkhoury, Y.I. Wang, G.A. Foster, C.E. Radecke, K. Tam, C.M. Edwards, M.T. Facciotti, E.J. Armstrong, A.A. Knowlton, et al. 2012. IRF-1 and miRNA126 modulate VCAM-1 expression in response to a high-fat meal. Circ. Res. 111:1054-1064. http://dx.doi.org/10.1161/CIRCRESAHA.112.270314
17. Tellides, G., and J.S. Pober. 2007. Interferon-gamma axis in graft arteriosclerosis. Circ. Res. 100:622-632. http://dx.doi.org/10.1161/01.RES.0000258861.72279.29
18. Tsoyi, K., H.J. Jang, I.T. Nizamutdinova, K. Park, Y.M. Kim, H.J. Kim, H.G. Seo, J.H. Lee, and K.C. Chang. 2010. PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells. Atherosclerosis. 213:115-121. http://dx.doi.org/10.1016/j.atherosclerosis.2010.07.061
19. Wang, C., T. Yi, L. Qin, R.A. Maldonado, U.H. von Andrian, S. Kulkarni, G. Tellides, and J.S. Pober. 2013. Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells. J. Clin. Invest. 123:1677-1693. http://dx.doi.org/10.1172/JCI66204
20. Xu, X.S., C. Vanderziel, C.F. Bennett, and B.P. Monia. 1998. A role for c-Raf kinase and Ha-Ras in cytokine-mediated induction of cell adhesion molecules. J. Biol. Chem. 273:33230-33238. http://dx.doi.org/10.1074/jbc.273.50.33230