Resistance to the most common optic neuropathy is associated with systemic mitochondrial efficiency

Neurobiology of Disease

Volumn 82, Issue , 2015, Pages 78-85

  Lascaratos, Gerassimos ^a   Chau, Kai Yin ^b   Zhu, Haogang ^c   Gkotsi, Despoina ^a   King, Rosalind ^b   Gout, Ivan ^d   Kamal, Deborah ^a   Luthert, Philip J ^a,e   Schapira, Anthony H V ^b   Garway Heath, David F ^a  

^a MOORFIELDS EYE HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c CITY UNIVERSITY   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Glaucoma; Intraocular pressure; Mitochondria; Neurodegeneration; Normal tension glaucoma; Ocular hypertension

Indexed keywords

ADENOSINE DIPHOSPHATE; CALCIUM; CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE);

AGED; ARTICLE; CONTROLLED STUDY; CYTOSOL; DISEASE PREDISPOSITION; DISEASE RESISTANCE; ENZYME PHOSPHORYLATION; FEMALE; GLAUCOMA; GLAUCOMATOUS OPTIC NEUROPATHY; HUMAN; HUMAN CELL; INTRAOCULAR PRESSURE; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; COMPLICATION; METABOLISM; MIDDLE AGED; OPTIC NERVE DISEASES; PHOSPHORYLATION; PHYSIOLOGY; PROSPECTIVE STUDY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; DNA, MITOCHONDRIAL; FEMALE; GLAUCOMA; HUMANS; INTRAOCULAR PRESSURE; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MIDDLE AGED; MITOCHONDRIA; OPTIC NERVE DISEASES; OXIDATIVE STRESS; PHOSPHORYLATION; PROSPECTIVE STUDIES;

EID: 84931275579     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2015.05.012     Document Type: Article

References (41)

1. Abu-Amero K.K., Morales J., Bosley T.M. Mitochondrial abnormalities in patients with primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 2006, 47:2533-2541.
2. Baltan S., Inman D.M., Danilov C.A., Morrison R.S., Calkins D.J., Horner P.J. Metabolic vulnerability disposes retinal ganglion cell axons to dysfunction in a model of glaucomatous degeneration. J. Neurosci. 2010, 30:5644-5652.
3. Bosley T.M., Abu-Amero K.K., Ozand P.T. Mitochondrial DNA nucleotide changes in non-arteritic ischemic optic neuropathy. Neurology 2004, 63:1305-1308.
4. Chen L.B. Mitochondrial membrane potential in living cells. Annu. Rev. Cell Biol. 1988, 4:155-181.
5. Chrysostomou V., Trounce I.A., Crowston J.G. Mechanisms of retinal ganglion cell injury in aging and glaucoma. Ophthalmic Res. 2010, 44:173-178.
6. Chrysostomou V., Kezic J.M., Trounce I.A., et al. Forced exercise protects the aged optic nerve against intraocular pressure injury. Neurobiol. Aging 2014, 35(7):1722-1725.
7. Coleman A.L. Glaucoma. Lancet 1999, 354:1803-1810.
8. Collaborative Normal-Tension Glaucoma Study Group Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures. Am J. Ophthalmol. 1998, 126:487-497.
9. Gasser P., Flammer J., Guthauser U., et al. Do vasospasms provoke ocular diseases?. Angiology 1990, 41:213-220.
10. Giordano C., Iommarini L., Giordano L., et al. Efficient mitochondrial biogenesis drives incomplete penetrance in Leber's hereditary optic neuropathy. Brain 2014, 137. (335-5).
11. Hayreh S.S. The blood supply of the optic nerve head and the evaluation of it - myth and reality. Prog. Retin. Eye Res. 2001, 20:563-593.
12. Heijl A., Leske M.C., Bengtsson B., et al. Early Manifest Glaucoma Trial Group. Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch. Ophthalmol. 2002, 120:1268-1279.
13. Kong G.Y., Van Bergen N.J., Trounce I.A., et al. Mitochondrial dysfunction and glaucoma. J. Glaucoma 2009, 18:93-100.
14. Kong Y.X.G., Van Bergen N., Trounce I.A., et al. Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injury. Aging Cell 2011, 10:572-583.
15. Kong Y.X., van Bergen N., Bui B.V., et al. Impact of aging and diet restriction on retinal function during and after acute intraocular pressure injury. Neurobiol. Aging 2012, 33(1126):e15-e25.
16. Lascaratos G., Garway-Heath D.F., Willoughby C., et al. Mitochondrial dysfunction in glaucoma: understanding genetic influences. Mitochondrion 2012, 12:202-212.
17. Lee S., Sheck L., Crowston J.G., et al. Impaired complex-I-linked respiration and ATP synthesis in primary open-angle glaucoma patient lymphoblasts. Invest. Ophthalmol. Vis. Sci. 2012, 53:2431-2437.
18. Leske M.C., Heijl A., Hyman L., et al. Predictors of long-term progression in the early manifest glaucoma trial. Ophthalmology 2007, 114:1965-1972.
19. Lin M.T., Beal M.F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006, 443:787-795.
20. Linden M., Andersson G., Gellerfors P., et al. Subcellular distribution of rat liver porin. Biochim. Biophys. Acta 1984, 770:93-96.
21. Maxwell S.R., Thomason H., Sandler D., et al. Antioxidant status in patients with uncomplicated insulin-dependent and non-insulin-dependent diabetes mellitus. Eur. J. Clin. Investig. 1997, 27:484-490.
22. McElnea E.M., Quill B., Docherty N.G., et al. Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors. Mol. Vis. 2011, 17:1182-1191.
23. Memarzadeh F., Ying-Lai M., Chung J., et al. Blood pressure, perfusion pressure, and open-angle glaucoma: The Los Angeles Latino Eye Study. Invest. Ophthalmol. Vis. Sci. 2010, 51:2872-2877.
24. Mitchell P., Smith W., Attebo K., et al. Prevalence of open-angle glaucoma in Australia. The Blue Mountains Eye Study. Ophthalmology 1996, 103:1661-1669.
25. Nouri-Mahdavi K., Hoffman D., Coleman A.L., et al. Predictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study. Ophthalmology 2004, 111:1627-1635.
26. Osborne N.N. Pathogenesis of ganglion "cell death" in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria. Prog. Brain Res. 2008, 173:339-352.
27. Patel P.R., Bevan R.J., Mistry N., et al. Evidence of oligonucleotides containing 8-hydroxy-2'-deoxyguanosine in human urine. Free Radic. Biol. Med. 2007, 42:552-558.
28. Quigley H.A. Glaucoma. Lancet 2011, 377:1367-1377.
29. Raichle M.E., Gusnard D.A. Appraising the brain's energy budget. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:10237-10239.
30. Schapira A.H. Mitochondrial diseases. Lancet 2012, 379:1825-1834.
31. Schapira A.H., Tolosa E. Molecular and clinical prodrome of Parkinson disease: implications for treatment. Nat. Rev. Neurol. 2010, 6:309-317.
32. Schapira A.H., Cooper J.M., Dexter D., Jenner P., Clark J.B., Marsden C.D. Mitochondrial complex I deficiency in Parkinson's disease. Lancet 1989, 1:1269.
33. Sundaresan P., Simpson D.A., Sambare C., et al. Whole-mitochondrial genome sequencing in primary open-angle glaucoma using massively parallel sequencing identifies novel and known pathogenic variants. Genet. Med. 2015, 17:279-284.
34. Tezel G. The role of glia, mitochondria, and the immune system in glaucoma. Invest. Ophthalmol. Vis. Sci. 2009, 50:1001-1012.
35. Van Bergen N.J., Crowston J.G., Kearns L.S., et al. Mitochondrial oxidative phosphorylation compensation may preserve vision in patients with OPA1-linked autosomal dominant optic atrophy. PLoS One 2011, 6(6):e21347.
36. Wallace D.C., Singh G., Lott M.T., et al. Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. Science 1988, 242(4884):1427-1430.
37. Wallace D.C., Fan W., Procaccio V. Mitochondrial energetics and therapeutics. Annu. Rev. Pathol. 2010, 5:297-348.
38. Wayner D.D., Burton G.W., Ingold K.U., et al. The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma. Biochim. Biophys. Acta 1987, 22:408-419.
39. Weinreb R.N., Khaw P.T. Primary open-angle glaucoma. Lancet 2004, 363:1711-1720.
40. Wurm C.A., Neumann D., Lauterbach M.A., et al. Nanoscale distribution of mitochondrial import receptor Tom20 is adjusted to cellular conditions and exhibits an inner-cellular gradient. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:13546-13551.
41. Yu-Wai-Man P., Griffiths P.G., Chinnery P.F. Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies. Prog. Retin. Eye Res. 2011, 30:81-114.