Synthesis and evaluation of thymidine kinase 1-targeting carboranyl pyrimidine nucleoside analogs for boron neutron capture therapy of cancer

European Journal of Medicinal Chemistry

Volumn 100, Issue , 2015, Pages 197-209

  Agarwal, Hitesh K ^a   Khalil, Ahmed ^a   Ishita, Keisuke ^a   Yang, Weilian ^a   Nakkula, Robin J ^a   Wu, Lai Chu ^a   Ali, Tehane ^a   Tiwari, Rohit ^a   Byun, Youngjoo ^b   Barth, Rolf F ^b   Tjarks, Werner ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b Korea University   (South Korea)

Author keywords

Boron neutron capture therapy (BNCT); Carborane; Carboranyl pyrimidine nucleoside analog; Thymidine kinase 1 (TK1)

Indexed keywords

3 (2 AMINOETHYL)THYMIDINE; 3 (2 CYANOETHYL)THYMIDINE; 3 (3 AMINOPROPYL)THYMIDINE; 3 (3 CYANOPROPYL)THYMIDINE; 3 (4 AMINOBUTYL)THYMIDINE; 3 AMINO 3',5' BIS O (TERT BUTYLDIMETHYLSILYL)THYMIDINE; 3 AMINOTHYMIDINE; 3 [[2 [2 (CLOSO 1,7 CARBORANYL)ETHYL]AMINO] 2 OXOETHYL]THYMIDINE; 3 [[2 [2 (CLOSO 1,7 CARBORANYL)ETHYL]AMINO]ETHYL]THYMIDINE; 3 [[2 [3 (CLOSO 1,7 CARBORANYL)PROPYL]AMINO] 2 OXOETHYL]THYMIDINE; 3 [[2 [3 (CLOSO 1,7 CARBORANYL)PROPYL]AMINO]ETHYL]THYMIDINE; 3 [[2 [4 (CLOSO 1,7 CARBORANYL)BUTYL]AMINO] 2 OXOETHYL]THYMIDINE; 3 [[2 [4 (CLOSO 1,7 CARBORANYL)BUTYL]AMINO]ETHYL]THYMIDINE; 3 [[3 (CLOSO 1,7 CARBORANYL)PROPYL]AMINO]THYMIDINE; 3 [[3 [3 (CLOSO 1,7 CARBORANYL)PROPYL]AMINO]PROPYL]THYMIDINE; 3 [[3 [4 (CLOSO 1,7 CARBORANYL)BUTYL]AMINO]PROPYL]THYMIDINE; 3 [[4 [3 (CLOSO 1,7 CARBORANYL)PROPYL]AMINO]BUTYL]THYMIDINE; 3 [[4 [4 (CLOSO 1,7 CARBORANYL)BUTYL]AMINO]BUTYL]THYMIDINE; 3',5' BIS O (TERT BUTYLDIMETHYLSILYL) 3 (METHOXYCARBONYLMETHYL)THYMIDINE; 3',5' BIS O (TERT BUTYLDIMETHYLSILYL) 3 [[2 [2 (CLOSO 1,7 CARBORANYL)ETHYL]AMINO]OXOETHYL]THYMIDINE; 3',5' BIS O (TERT BUTYLDIMETHYLSILYL) 3 [[3 (CLOSO 1,7 CARBORANYL)PROPYL]AMINO]THYMIDINE; 3',5' BIS O (TERT BUTYLDIMETHYLSILYL) N4 [2 (CLOSO 1,7 CARBORANYL)ETHYL] 5 METHYL 2' DEOXYCYTIDINE; 3',5' BIS O (TERT BUTYLDIMETHYLSILYL) N4 [3 (CLOSO 1,7 CARBORANYL)PROPYL] 5 METHYL 2' DEOXYCYTIDINE; 3,5' BIS O (TERT BUTYLDIMETHYLSILYL) N4 [4 (CLOSO 1,7 CARBORANYL)BUTYL] 5 METHYL 2' DEOXYCYTIDINE; ANTINEOPLASTIC AGENT; N4 [2 (CLOSO 1,7 CARBORANYL)ETHYL] 5 METHYL 2' DEOXYCYTIDINE; N4 [3 (CLOSO 1,7 CARBORANYL)PROPYL] 5 METHYL 2' DEOXYCYTIDINE; N4 [4 (CLOSO 1,7 CARBORANYL)BUTYL] 5 METHYL 2' DEOXYCYTIDINE; PYRIMIDINE NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; BORON DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIMIDINE NUCLEOSIDE; THYMIDINE KINASE; THYMIDINE KINASE 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER THERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME SUBSTRATE; GLIOMA CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; NEUTRON CAPTURE THERAPY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BORON NEUTRON CAPTURE THERAPY; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; GLIOMA; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; BORON COMPOUNDS; BORON NEUTRON CAPTURE THERAPY; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; GLIOMA; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRIMIDINE NUCLEOSIDES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE KINASE;

EID: 84931262600     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.05.042     Document Type: Article

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