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Volumn 21, Issue 2, 2015, Pages 118-125

Advancing parental age and autism: Multifactorial pathways

Author keywords

Animal models; Autism; De novo mutations; Epidemiology; Parental age

Indexed keywords

AGING; ANIMAL MODEL; AUTISM; GENETIC ASSOCIATION; HUMAN; INFERTILITY THERAPY; MATERNAL AGE; NONHUMAN; PARENTAL AGE; PATERNAL AGE; PREVALENCE; PROGENY; REPRODUCTION; REVIEW; AGE; ANIMAL; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; FEMALE; GENETICS; MALE; PARENT;

EID: 84931201751     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2014.11.005     Document Type: Review
Times cited : (40)

References (94)
  • 1
    • 34249735268 scopus 로고    scopus 로고
    • The epidemiology of autism spectrum disorders
    • Newschaffer C.J., et al. The epidemiology of autism spectrum disorders. Annu. Rev. Public Health 2007, 28:235-258.
    • (2007) Annu. Rev. Public Health , vol.28 , pp. 235-258
    • Newschaffer, C.J.1
  • 2
    • 84859394070 scopus 로고    scopus 로고
    • Prevalence of Autism Spectrum Disorders - Autism and Developmental Disabilities Monitoring Network, 14 Sites, United States, 2008
    • Baio J. Prevalence of Autism Spectrum Disorders - Autism and Developmental Disabilities Monitoring Network, 14 Sites, United States, 2008. MMWR Surveill. Summ. 2012, 61:1-19.
    • (2012) MMWR Surveill. Summ. , vol.61 , pp. 1-19
    • Baio, J.1
  • 3
    • 84902441615 scopus 로고    scopus 로고
    • Should we believe the Centers for Disease Control and Prevention's autism spectrum disorder prevalence estimates?
    • Mandell D., Lecavalier L. Should we believe the Centers for Disease Control and Prevention's autism spectrum disorder prevalence estimates?. Autism 2014, 18:482-484.
    • (2014) Autism , vol.18 , pp. 482-484
    • Mandell, D.1    Lecavalier, L.2
  • 4
    • 84925028001 scopus 로고    scopus 로고
    • Explaining the increase in the prevalence of autism spectrum disorders: the proportion attributable to changes in reporting practices
    • Published online November 3, 2014
    • Hansen S.N., et al. Explaining the increase in the prevalence of autism spectrum disorders: the proportion attributable to changes in reporting practices. JAMA Pediatr. 2014, Published online November 3, 2014. 10.1001/jamapediatrics.2014.1893.
    • (2014) JAMA Pediatr.
    • Hansen, S.N.1
  • 5
    • 67349152455 scopus 로고    scopus 로고
    • The rise in autism and the role of age at diagnosis
    • Hertz-Picciotto I., Delwiche L. The rise in autism and the role of age at diagnosis. Epidemiology 2009, 20:84-90.
    • (2009) Epidemiology , vol.20 , pp. 84-90
    • Hertz-Picciotto, I.1    Delwiche, L.2
  • 6
    • 84859629408 scopus 로고    scopus 로고
    • Cohort effects explain the increase in autism diagnosis among children born from 1992 to 2003 in California
    • Keyes K.M., et al. Cohort effects explain the increase in autism diagnosis among children born from 1992 to 2003 in California. Int. J. Epidemiol. 2012, 41:495-503.
    • (2012) Int. J. Epidemiol. , vol.41 , pp. 495-503
    • Keyes, K.M.1
  • 7
    • 83355171073 scopus 로고    scopus 로고
    • Demographic and medical consequences of the postponement of parenthood
    • Schmidt L., et al. Demographic and medical consequences of the postponement of parenthood. Hum. Reprod. Update 2012, 18:29-43.
    • (2012) Hum. Reprod. Update , vol.18 , pp. 29-43
    • Schmidt, L.1
  • 8
    • 84855426425 scopus 로고    scopus 로고
    • Advanced paternal age, reproductive outcome
    • Wiener-Megnazi Z., et al. Advanced paternal age, reproductive outcome. Asian J. Androl. 2012, 14:69-76.
    • (2012) Asian J. Androl. , vol.14 , pp. 69-76
    • Wiener-Megnazi, Z.1
  • 9
    • 84896808343 scopus 로고    scopus 로고
    • Parental age and the risk of autism spectrum disorders: findings from a Swedish population-based cohort
    • Idring S., et al. Parental age and the risk of autism spectrum disorders: findings from a Swedish population-based cohort. Int. J. Epidemiol. 2014, 43:107-115.
    • (2014) Int. J. Epidemiol. , vol.43 , pp. 107-115
    • Idring, S.1
  • 10
    • 33748297511 scopus 로고    scopus 로고
    • Advancing paternal age and autism
    • Reichenberg A., et al. Advancing paternal age and autism. Arch. Gen. Psychiatry 2006, 63:1026-1032.
    • (2006) Arch. Gen. Psychiatry , vol.63 , pp. 1026-1032
    • Reichenberg, A.1
  • 11
    • 2942529375 scopus 로고    scopus 로고
    • Perinatal factors and the development of autism: a population study
    • Glasson E.J., et al. Perinatal factors and the development of autism: a population study. Arch. Gen. Psychiatry 2004, 61:618.
    • (2004) Arch. Gen. Psychiatry , vol.61 , pp. 618
    • Glasson, E.J.1
  • 12
    • 18544369453 scopus 로고    scopus 로고
    • Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status
    • discussion 926-918
    • Larsson H.J., et al. Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. Am. J. Epidemiol. 2005, 161:916-925. discussion 926-918.
    • (2005) Am. J. Epidemiol. , vol.161 , pp. 916-925
    • Larsson, H.J.1
  • 13
    • 84860223780 scopus 로고    scopus 로고
    • Advancing maternal age is associated with increasing risk for autism: a review and meta-analysis
    • e1
    • Sandin S., et al. Advancing maternal age is associated with increasing risk for autism: a review and meta-analysis. J. Am. Acad. Child Adolesc. Psychiatry 2012, 51:477-486. e1.
    • (2012) J. Am. Acad. Child Adolesc. Psychiatry , vol.51 , pp. 477-486
    • Sandin, S.1
  • 14
    • 81755176467 scopus 로고    scopus 로고
    • Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studies
    • Hultman C., et al. Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studies. Mol. Psychiatry 2010, 16:1203-1212.
    • (2010) Mol. Psychiatry , vol.16 , pp. 1203-1212
    • Hultman, C.1
  • 15
    • 67650869592 scopus 로고    scopus 로고
    • Prenatal risk factors for autism: comprehensive meta-analysis
    • Gardener H., et al. Prenatal risk factors for autism: comprehensive meta-analysis. Br. J. Psychiatry 2009, 195:7-14.
    • (2009) Br. J. Psychiatry , vol.195 , pp. 7-14
    • Gardener, H.1
  • 16
    • 84896786321 scopus 로고    scopus 로고
    • A comprehensive assessment of parental age and psychiatric disorders
    • McGrath J.J., et al. A comprehensive assessment of parental age and psychiatric disorders. JAMA Psychiatry 2014, 71:301-309.
    • (2014) JAMA Psychiatry , vol.71 , pp. 301-309
    • McGrath, J.J.1
  • 17
    • 84855243382 scopus 로고    scopus 로고
    • New perspectives on rodent models of advanced paternal age: relevance to autism
    • Foldi C.J., et al. New perspectives on rodent models of advanced paternal age: relevance to autism. Front. Behav. Neurosci. 2011, 5:32.
    • (2011) Front. Behav. Neurosci. , vol.5 , pp. 32
    • Foldi, C.J.1
  • 18
    • 65349165871 scopus 로고    scopus 로고
    • Why schizophrenia epidemiology needs neurobiology--and vice versa
    • McGrath J.J., Richards L.J. Why schizophrenia epidemiology needs neurobiology--and vice versa. Schizophr. Bull. 2009, 35:577-581.
    • (2009) Schizophr. Bull. , vol.35 , pp. 577-581
    • McGrath, J.J.1    Richards, L.J.2
  • 19
    • 0020580436 scopus 로고
    • Decrease of learning capacity in offspring with increasing paternal age in the rat
    • Auroux M. Decrease of learning capacity in offspring with increasing paternal age in the rat. Teratology 1983, 27:141-148.
    • (1983) Teratology , vol.27 , pp. 141-148
    • Auroux, M.1
  • 20
    • 59949093273 scopus 로고    scopus 로고
    • Long-term effects of delayed fatherhood in mice on postnatal development and behavioral traits of offspring
    • Garcia-Palomares S., et al. Long-term effects of delayed fatherhood in mice on postnatal development and behavioral traits of offspring. Biol. Reprod. 2009, 80:337-342.
    • (2009) Biol. Reprod. , vol.80 , pp. 337-342
    • Garcia-Palomares, S.1
  • 21
    • 77949537571 scopus 로고    scopus 로고
    • Advancing paternal age is associated with deficits in social and exploratory behaviors in the offspring: a mouse model
    • Smith R.G., et al. Advancing paternal age is associated with deficits in social and exploratory behaviors in the offspring: a mouse model. PLoS ONE 2009, 4:e8456.
    • (2009) PLoS ONE , vol.4 , pp. e8456
    • Smith, R.G.1
  • 22
    • 75749145826 scopus 로고    scopus 로고
    • Advanced paternal age is associated with alterations in discrete behavioural domains and cortical neuroanatomy of C57BL/6J mice
    • Foldi C.J., et al. Advanced paternal age is associated with alterations in discrete behavioural domains and cortical neuroanatomy of C57BL/6J mice. Eur. J. Neurosci. 2010, 31:556-564.
    • (2010) Eur. J. Neurosci. , vol.31 , pp. 556-564
    • Foldi, C.J.1
  • 23
    • 0038601952 scopus 로고    scopus 로고
    • Evidence of brain overgrowth in the first year of life in autism
    • Courchesne E., et al. Evidence of brain overgrowth in the first year of life in autism. JAMA 2003, 290:337-344.
    • (2003) JAMA , vol.290 , pp. 337-344
    • Courchesne, E.1
  • 24
    • 4944227121 scopus 로고    scopus 로고
    • Brain development in autism: early overgrowth followed by premature arrest of growth
    • Courchesne E. Brain development in autism: early overgrowth followed by premature arrest of growth. Ment. Retard. Dev. Disabil. Res. Rev. 2004, 10:106-111.
    • (2004) Ment. Retard. Dev. Disabil. Res. Rev. , vol.10 , pp. 106-111
    • Courchesne, E.1
  • 25
    • 80052325133 scopus 로고    scopus 로고
    • Increased de novo copy number variants in the offspring of older males
    • Flatscher-Bader T., et al. Increased de novo copy number variants in the offspring of older males. Transl. Psychiatry 2011, 1:e34.
    • (2011) Transl. Psychiatry , vol.1 , pp. e34
    • Flatscher-Bader, T.1
  • 26
    • 0036993811 scopus 로고    scopus 로고
    • Identification of a novel gene on chromosome 7q11. 2 interrupted by a translocation breakpoint in a pair of autistic twins
    • Sultana R., et al. Identification of a novel gene on chromosome 7q11. 2 interrupted by a translocation breakpoint in a pair of autistic twins. Genomics 2002, 80:129-134.
    • (2002) Genomics , vol.80 , pp. 129-134
    • Sultana, R.1
  • 27
    • 34250005849 scopus 로고    scopus 로고
    • Transcriptomic changes in the frontal cortex associated with paternal age
    • Smith R.G., et al. Transcriptomic changes in the frontal cortex associated with paternal age. Mol. Autism 2014, 5:24.
    • (2014) Mol. Autism , vol.5 , pp. 24
    • Smith, R.G.1
  • 28
    • 84878253884 scopus 로고    scopus 로고
    • Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease
    • Smith R.G., et al. Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease. Mol. Psychiatry 2013, 18:635-636.
    • (2013) Mol. Psychiatry , vol.18 , pp. 635-636
    • Smith, R.G.1
  • 29
    • 0031916242 scopus 로고    scopus 로고
    • Rates of spontaneous mutation
    • Drake J.W., et al. Rates of spontaneous mutation. Genetics 1998, 148:1667-1686.
    • (1998) Genetics , vol.148 , pp. 1667-1686
    • Drake, J.W.1
  • 30
    • 84881664021 scopus 로고    scopus 로고
    • Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing
    • Jiang Y.H., et al. Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing. Am. J. Hum. Genet. 2013, 93:249-263.
    • (2013) Am. J. Hum. Genet. , vol.93 , pp. 249-263
    • Jiang, Y.H.1
  • 31
    • 84865208871 scopus 로고    scopus 로고
    • Rate of de novo mutations and the importance of father/'s age to disease risk
    • Kong A., et al. Rate of de novo mutations and the importance of father/'s age to disease risk. Nature 2012, 488:471-475.
    • (2012) Nature , vol.488 , pp. 471-475
    • Kong, A.1
  • 32
    • 84860741138 scopus 로고    scopus 로고
    • Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
    • O'Roak B.J., et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature 2012, 485:246-250.
    • (2012) Nature , vol.485 , pp. 246-250
    • O'Roak, B.J.1
  • 33
    • 84860780495 scopus 로고    scopus 로고
    • De novo mutations revealed by whole-exome sequencing are strongly associated with autism
    • Sanders S.J., et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature 2012, 485:237-241.
    • (2012) Nature , vol.485 , pp. 237-241
    • Sanders, S.J.1
  • 34
    • 84907982955 scopus 로고    scopus 로고
    • De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder
    • Dong S., et al. De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder. Cell Rep. 2014, 9:16-23.
    • (2014) Cell Rep. , vol.9 , pp. 16-23
    • Dong, S.1
  • 35
    • 84871595000 scopus 로고    scopus 로고
    • Whole-genome sequencing in autism identifies hot spots for de novo germline mutation
    • Michaelson J.J., et al. Whole-genome sequencing in autism identifies hot spots for de novo germline mutation. Cell 2012, 151:1431-1442.
    • (2012) Cell , vol.151 , pp. 1431-1442
    • Michaelson, J.J.1
  • 36
    • 84912101541 scopus 로고    scopus 로고
    • The contribution of de novo coding mutations to autism spectrum disorder
    • Iossifov I., et al. The contribution of de novo coding mutations to autism spectrum disorder. Nature 2014, 515:216-221.
    • (2014) Nature , vol.515 , pp. 216-221
    • Iossifov, I.1
  • 37
    • 84876465705 scopus 로고    scopus 로고
    • Increased paternal age and the influence on burden of genomic copy number variation in the general population
    • Buizer-Voskamp J.E., et al. Increased paternal age and the influence on burden of genomic copy number variation in the general population. Hum. Genet. 2013, 132:443-450.
    • (2013) Hum. Genet. , vol.132 , pp. 443-450
    • Buizer-Voskamp, J.E.1
  • 38
    • 79958074870 scopus 로고    scopus 로고
    • Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism
    • Sanders S.J., et al. Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron 2011, 70:863-885.
    • (2011) Neuron , vol.70 , pp. 863-885
    • Sanders, S.J.1
  • 39
    • 84897400595 scopus 로고    scopus 로고
    • The rate of nonallelic homologous recombination in males is highly variable, correlated between monozygotic twins and independent of age
    • MacArthur J.A., et al. The rate of nonallelic homologous recombination in males is highly variable, correlated between monozygotic twins and independent of age. PLoS Genet. 2014, 10:e1004195.
    • (2014) PLoS Genet. , vol.10 , pp. e1004195
    • MacArthur, J.A.1
  • 40
    • 81055157730 scopus 로고    scopus 로고
    • De novo copy number variants associated with intellectual disability have a paternal origin and age bias
    • Hehir-Kwa J.Y., et al. De novo copy number variants associated with intellectual disability have a paternal origin and age bias. J. Med. Genet. 2011, 48:776-778.
    • (2011) J. Med. Genet. , vol.48 , pp. 776-778
    • Hehir-Kwa, J.Y.1
  • 41
    • 79960767506 scopus 로고    scopus 로고
    • Decanalization, brain development and risk of schizophrenia
    • McGrath J., et al. Decanalization, brain development and risk of schizophrenia. Transl. Psychiatry 2011, 1:e14.
    • (2011) Transl. Psychiatry , vol.1 , pp. e14
    • McGrath, J.1
  • 42
    • 84856922362 scopus 로고    scopus 로고
    • Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease
    • Goriely A., Wilkie A.O.M. Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease. Am. J. Hum. Genet. 2012, 90:175-200.
    • (2012) Am. J. Hum. Genet. , vol.90 , pp. 175-200
    • Goriely, A.1    Wilkie, A.O.M.2
  • 43
    • 84882284132 scopus 로고    scopus 로고
    • 'Selfish spermatogonial selection': a novel mechanism for the association between advanced paternal age and neurodevelopmental disorders
    • Goriely A., et al. 'Selfish spermatogonial selection': a novel mechanism for the association between advanced paternal age and neurodevelopmental disorders. Am. J. Psychiatry 2013, 170:599-608.
    • (2013) Am. J. Psychiatry , vol.170 , pp. 599-608
    • Goriely, A.1
  • 44
    • 33745476745 scopus 로고    scopus 로고
    • Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm
    • Wyrobek A.J., et al. Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:9601-9606.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 9601-9606
    • Wyrobek, A.J.1
  • 46
    • 84905454836 scopus 로고    scopus 로고
    • Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility
    • Jenkins T.G., et al. Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility. PLoS Genet. 2014, 10:e1004458.
    • (2014) PLoS Genet. , vol.10 , pp. e1004458
    • Jenkins, T.G.1
  • 47
    • 79961098041 scopus 로고    scopus 로고
    • Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies
    • Selesniemi K., et al. Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:12319-12324.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 12319-12324
    • Selesniemi, K.1
  • 48
    • 35748971012 scopus 로고    scopus 로고
    • Crossover interference underlies sex differences in recombination rates
    • Petkov P.M., et al. Crossover interference underlies sex differences in recombination rates. Trends Genet. 2007, 23:539-542.
    • (2007) Trends Genet. , vol.23 , pp. 539-542
    • Petkov, P.M.1
  • 49
    • 40749089626 scopus 로고    scopus 로고
    • Structural variation of chromosomes in autism spectrum disorder
    • Marshall C.R., et al. Structural variation of chromosomes in autism spectrum disorder. Am. J. Hum. Genet. 2008, 82:477-488.
    • (2008) Am. J. Hum. Genet. , vol.82 , pp. 477-488
    • Marshall, C.R.1
  • 50
    • 0025921769 scopus 로고
    • Chromosome abnormalities found among 34910 newborn children: results from a 13-year incidence study in Århus, Denmark
    • Nielsen J., Wohlert M. Chromosome abnormalities found among 34910 newborn children: results from a 13-year incidence study in Århus, Denmark. Hum. Genet. 1991, 87:81-83.
    • (1991) Hum. Genet. , vol.87 , pp. 81-83
    • Nielsen, J.1    Wohlert, M.2
  • 51
    • 84863892710 scopus 로고    scopus 로고
    • Human aneuploidy: mechanisms and new insights into an age-old problem
    • Nagaoka S.I., et al. Human aneuploidy: mechanisms and new insights into an age-old problem. Nat. Rev. Genet. 2012, 13:493-504.
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 493-504
    • Nagaoka, S.I.1
  • 52
    • 84867076609 scopus 로고    scopus 로고
    • Dosage effects of X and Y chromosomes on language and social functioning in children with supernumerary sex chromosome aneuploidies: implications for idiopathic language impairment and autism spectrum disorders
    • Lee N.R., et al. Dosage effects of X and Y chromosomes on language and social functioning in children with supernumerary sex chromosome aneuploidies: implications for idiopathic language impairment and autism spectrum disorders. J. Child Psychol. Psychiatry 2012, 53:1072-1081.
    • (2012) J. Child Psychol. Psychiatry , vol.53 , pp. 1072-1081
    • Lee, N.R.1
  • 53
    • 34548225995 scopus 로고    scopus 로고
    • Unexplained autism is frequently associated with low-level mosaic aneuploidy
    • Yurov Y.B., et al. Unexplained autism is frequently associated with low-level mosaic aneuploidy. J. Med. Genet. 2007, 44:521-525.
    • (2007) J. Med. Genet. , vol.44 , pp. 521-525
    • Yurov, Y.B.1
  • 54
    • 84901585347 scopus 로고    scopus 로고
    • Mosaic epigenetic dysregulation of ectodermal cells in autism spectrum disorder
    • Berko E.R., et al. Mosaic epigenetic dysregulation of ectodermal cells in autism spectrum disorder. PLoS Genet. 2014, 10:e1004402.
    • (2014) PLoS Genet. , vol.10 , pp. e1004402
    • Berko, E.R.1
  • 55
    • 84905924731 scopus 로고    scopus 로고
    • Parental somatic mosaicism is underrecognized and influences recurrence risk of genomic disorders
    • Campbell I.M., et al. Parental somatic mosaicism is underrecognized and influences recurrence risk of genomic disorders. Am. J. Hum. Genet. 2014, 95:173-182.
    • (2014) Am. J. Hum. Genet. , vol.95 , pp. 173-182
    • Campbell, I.M.1
  • 56
    • 84879770369 scopus 로고    scopus 로고
    • Autism and mental retardation among offspring born after in vitro fertilization
    • Sandin S., et al. Autism and mental retardation among offspring born after in vitro fertilization. JAMA 2013, 310:75-84.
    • (2013) JAMA , vol.310 , pp. 75-84
    • Sandin, S.1
  • 57
    • 25844455213 scopus 로고    scopus 로고
    • Intracytoplasmic sperm injection: a review of risks and complications
    • Woldringh G.H., et al. Intracytoplasmic sperm injection: a review of risks and complications. BJU Int. 2005, 96:749-753.
    • (2005) BJU Int. , vol.96 , pp. 749-753
    • Woldringh, G.H.1
  • 58
    • 7944227877 scopus 로고    scopus 로고
    • Advanced maternal age and adverse perinatal outcome
    • Jacobsson B., et al. Advanced maternal age and adverse perinatal outcome. Obstet. Gynecol. 2004, 104:727-733.
    • (2004) Obstet. Gynecol. , vol.104 , pp. 727-733
    • Jacobsson, B.1
  • 59
    • 0028842345 scopus 로고
    • Pregnancy outcome in nulliparous women 35 years and older
    • Prysak M., et al. Pregnancy outcome in nulliparous women 35 years and older. Obstet. Gynecol. 1995, 85:65-70.
    • (1995) Obstet. Gynecol. , vol.85 , pp. 65-70
    • Prysak, M.1
  • 60
    • 20244379701 scopus 로고    scopus 로고
    • Impact of maternal age on obstetric outcome
    • Cleary-Goldman J., et al. Impact of maternal age on obstetric outcome. Obstet. Gynecol. 2005, 105:983-990.
    • (2005) Obstet. Gynecol. , vol.105 , pp. 983-990
    • Cleary-Goldman, J.1
  • 61
    • 40949113792 scopus 로고    scopus 로고
    • Births: final data for 2005
    • Martin J.A., et al. Births: final data for 2005. Natl. Vital Stat. Rep. 2007, 56:1-103.
    • (2007) Natl. Vital Stat. Rep. , vol.56 , pp. 1-103
    • Martin, J.A.1
  • 62
    • 84860598358 scopus 로고    scopus 로고
    • Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders
    • Krakowiak P., et al. Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. Pediatrics 2012, 129:e1121-e1128.
    • (2012) Pediatrics , vol.129 , pp. e1121-e1128
    • Krakowiak, P.1
  • 63
    • 80051539002 scopus 로고    scopus 로고
    • Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis
    • Gardener H., et al. Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis. Pediatrics 2011, 128:344-355.
    • (2011) Pediatrics , vol.128 , pp. 344-355
    • Gardener, H.1
  • 64
    • 84857550472 scopus 로고    scopus 로고
    • Pregnancy complications and obstetric suboptimality in association with autism spectrum disorders in children of the Nurses' Health Study II
    • Lyall K., et al. Pregnancy complications and obstetric suboptimality in association with autism spectrum disorders in children of the Nurses' Health Study II. Autism Res. 2012, 5:21-30.
    • (2012) Autism Res. , vol.5 , pp. 21-30
    • Lyall, K.1
  • 65
    • 85027934253 scopus 로고    scopus 로고
    • Environmental chemical exposures and autism spectrum disorders: a review of the epidemiological evidence
    • Kalkbrenner A.E., et al. Environmental chemical exposures and autism spectrum disorders: a review of the epidemiological evidence. Curr. Probl. Pediatr. Adolesc. Health Care 2014, 44:277-318.
    • (2014) Curr. Probl. Pediatr. Adolesc. Health Care , vol.44 , pp. 277-318
    • Kalkbrenner, A.E.1
  • 66
    • 84867401557 scopus 로고    scopus 로고
    • Levels of select PCB and PBDE congeners in humanpostmortem brain reveal possible environmental involvement in 15q11-q13 duplication autism spectrum disorder
    • Mitchell M.M., et al. Levels of select PCB and PBDE congeners in humanpostmortem brain reveal possible environmental involvement in 15q11-q13 duplication autism spectrum disorder. Environ. Mol. Mutagen. 2012, 53:589-598.
    • (2012) Environ. Mol. Mutagen. , vol.53 , pp. 589-598
    • Mitchell, M.M.1
  • 67
    • 84878808578 scopus 로고    scopus 로고
    • Autism and the broad autism phenotype: familial patterns and intergenerational transmission
    • Sasson N.J., et al. Autism and the broad autism phenotype: familial patterns and intergenerational transmission. J. Neurodev. Disord. 2013, 5:11.
    • (2013) J. Neurodev. Disord. , vol.5 , pp. 11
    • Sasson, N.J.1
  • 68
    • 39449109457 scopus 로고    scopus 로고
    • Do autism-related personality traits explain higher paternal age in autism?
    • Puleo C., et al. Do autism-related personality traits explain higher paternal age in autism?. Mol. Psychiatry 2008, 13:243-244.
    • (2008) Mol. Psychiatry , vol.13 , pp. 243-244
    • Puleo, C.1
  • 69
    • 44449090109 scopus 로고    scopus 로고
    • Parental psychiatric disorders associated with autism spectrum disorders in the offspring
    • Daniels J.L., et al. Parental psychiatric disorders associated with autism spectrum disorders in the offspring. Pediatrics 2008, 121:e1357-e1362.
    • (2008) Pediatrics , vol.121 , pp. e1357-e1362
    • Daniels, J.L.1
  • 70
    • 77952818259 scopus 로고    scopus 로고
    • Genetic overlap between autism, schizophrenia and bipolar disorder
    • Carroll L.S., Owen M.J. Genetic overlap between autism, schizophrenia and bipolar disorder. Genome Med. 2009, 1:102.
    • (2009) Genome Med. , vol.1 , pp. 102
    • Carroll, L.S.1    Owen, M.J.2
  • 71
    • 84873038290 scopus 로고    scopus 로고
    • Characteristics of first-time fathers of advanced age: a Norwegian population-based study
    • Nilsen A.B., et al. Characteristics of first-time fathers of advanced age: a Norwegian population-based study. BMC Pregnancy Childbirth 2013, 13:29.
    • (2013) BMC Pregnancy Childbirth , vol.13 , pp. 29
    • Nilsen, A.B.1
  • 72
    • 57149100947 scopus 로고    scopus 로고
    • Advanced parental age and the risk of autism spectrum disorder
    • Durkin M.S., et al. Advanced parental age and the risk of autism spectrum disorder. Am. J. Epidemiol. 2008, 168:1268-1276.
    • (2008) Am. J. Epidemiol. , vol.168 , pp. 1268-1276
    • Durkin, M.S.1
  • 73
    • 83355174305 scopus 로고    scopus 로고
    • Shifting parenthood to advanced reproductive ages: trends, causes and consequences
    • Springer, J. Tremmel (Ed.)
    • Sobotka T. Shifting parenthood to advanced reproductive ages: trends, causes and consequences. A Young Generation Under Pressure? 2010, 129-154. Springer. J. Tremmel (Ed.).
    • (2010) A Young Generation Under Pressure? , pp. 129-154
    • Sobotka, T.1
  • 74
    • 77955371018 scopus 로고    scopus 로고
    • Socioeconomic inequality in the prevalence of autism spectrum disorder: evidence from a US cross-sectional study
    • Durkin M.S., et al. Socioeconomic inequality in the prevalence of autism spectrum disorder: evidence from a US cross-sectional study. PLoS ONE 2010, 5:e11551.
    • (2010) PLoS ONE , vol.5 , pp. e11551
    • Durkin, M.S.1
  • 75
    • 84896808343 scopus 로고    scopus 로고
    • Parental age and the risk of autism spectrum disorders: findings from a Swedish population-based cohort
    • Idring S., et al. Parental age and the risk of autism spectrum disorders: findings from a Swedish population-based cohort. Int. J. Epidemiol. 2014, 43:107-115.
    • (2014) Int. J. Epidemiol. , vol.43 , pp. 107-115
    • Idring, S.1
  • 76
    • 84905819005 scopus 로고    scopus 로고
    • Evidence of reproductive stoppage in families with autism spectrum disorder: a large, population-based cohort study
    • Hoffmann T.J., et al. Evidence of reproductive stoppage in families with autism spectrum disorder: a large, population-based cohort study. JAMA 2014, 71:943-951.
    • (2014) JAMA , vol.71 , pp. 943-951
    • Hoffmann, T.J.1
  • 77
    • 84863980709 scopus 로고    scopus 로고
    • Genetic architectures of psychiatric disorders: the emerging picture and its implications
    • Sullivan P.F., et al. Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat. Rev. Genet. 2012, 13:537-551.
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 537-551
    • Sullivan, P.F.1
  • 78
    • 84892799819 scopus 로고    scopus 로고
    • The role of de novo mutations in the genetics of autism spectrum disorders
    • Ronemus M., et al. The role of de novo mutations in the genetics of autism spectrum disorders. Nat. Rev. Genet. 2014, 15:133-141.
    • (2014) Nat. Rev. Genet. , vol.15 , pp. 133-141
    • Ronemus, M.1
  • 79
    • 84860712363 scopus 로고    scopus 로고
    • Patterns and rates of exonic de novo mutations in autism spectrum disorders
    • Neale B.M., et al. Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature 2012, 485:242-245.
    • (2012) Nature , vol.485 , pp. 242-245
    • Neale, B.M.1
  • 80
    • 84899918742 scopus 로고    scopus 로고
    • Convergence of genes and cellular pathways dysregulated in autism spectrum disorders
    • Pinto D., et al. Convergence of genes and cellular pathways dysregulated in autism spectrum disorders. Am. J. Hum. Genet. 2014, 94:677-694.
    • (2014) Am. J. Hum. Genet. , vol.94 , pp. 677-694
    • Pinto, D.1
  • 81
    • 84912144889 scopus 로고    scopus 로고
    • Synaptic, transcriptional and chromatin genes disrupted in autism
    • De Rubeis S., et al. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature 2014, 515:209-215.
    • (2014) Nature , vol.515 , pp. 209-215
    • De Rubeis, S.1
  • 82
    • 84904635209 scopus 로고    scopus 로고
    • Disruptive CHD8 mutations define a subtype of autism early in development
    • Bernier R., et al. Disruptive CHD8 mutations define a subtype of autism early in development. Cell 2014, 158:263-276.
    • (2014) Cell , vol.158 , pp. 263-276
    • Bernier, R.1
  • 83
    • 84905582433 scopus 로고    scopus 로고
    • Most genetic risk for autism resides with common variation
    • Gaugler T., et al. Most genetic risk for autism resides with common variation. Nat. Genet. 2014, 46:881-885.
    • (2014) Nat. Genet. , vol.46 , pp. 881-885
    • Gaugler, T.1
  • 84
    • 84899784475 scopus 로고    scopus 로고
    • The familial risk of autism
    • Sandin S., et al. The familial risk of autism. JAMA 2014, 311:1770-1777.
    • (2014) JAMA , vol.311 , pp. 1770-1777
    • Sandin, S.1
  • 86
    • 77249095480 scopus 로고    scopus 로고
    • Independent and dependent contributions of advanced maternal and paternal ages to autism risk
    • Shelton J.F., et al. Independent and dependent contributions of advanced maternal and paternal ages to autism risk. Autism Res. 2010, 3:30-39.
    • (2010) Autism Res. , vol.3 , pp. 30-39
    • Shelton, J.F.1
  • 87
    • 69049119214 scopus 로고    scopus 로고
    • Estimated autism risk and older reproductive age
    • King M.D., et al. Estimated autism risk and older reproductive age. Am. J. Public Health 2009, 99:1673.
    • (2009) Am. J. Public Health , vol.99 , pp. 1673
    • King, M.D.1
  • 88
    • 70349856176 scopus 로고    scopus 로고
    • Diagnostic change and the increased prevalence of autism
    • King M., Bearman P. Diagnostic change and the increased prevalence of autism. Int. J. Epidemiol. 2009, 38:1224-1234.
    • (2009) Int. J. Epidemiol. , vol.38 , pp. 1224-1234
    • King, M.1    Bearman, P.2
  • 89
    • 81955164228 scopus 로고    scopus 로고
    • Advanced paternal and grandpaternal age and schizophrenia: a three-generation perspective
    • Frans E.M., et al. Advanced paternal and grandpaternal age and schizophrenia: a three-generation perspective. Schizophr. Res. 2011, 133:120-124.
    • (2011) Schizophr. Res. , vol.133 , pp. 120-124
    • Frans, E.M.1
  • 90
    • 84876908483 scopus 로고    scopus 로고
    • Autism risk across generations: a population-based study of advancing grandpaternal and paternal age
    • Frans E.M., et al. Autism risk across generations: a population-based study of advancing grandpaternal and paternal age. JAMA Psychiatry 2013, 70:516-521.
    • (2013) JAMA Psychiatry , vol.70 , pp. 516-521
    • Frans, E.M.1
  • 91
    • 77956337379 scopus 로고    scopus 로고
    • Parental and grandparental ages in the autistic spectrum disorders: a birth cohort study
    • Golding J., et al. Parental and grandparental ages in the autistic spectrum disorders: a birth cohort study. PLoS ONE 2010, 5:e9939.
    • (2010) PLoS ONE , vol.5 , pp. e9939
    • Golding, J.1
  • 92
    • 84925286111 scopus 로고    scopus 로고
    • Grand-paternal age and the development of autism-like symptoms in mice progeny
    • Sampino S., et al. Grand-paternal age and the development of autism-like symptoms in mice progeny. Transl. Psychiatry 2014, 4:e386.
    • (2014) Transl. Psychiatry , vol.4 , pp. e386
    • Sampino, S.1
  • 93
    • 34848926219 scopus 로고    scopus 로고
    • The use of genetic epidemiology to guide classification in child and adult psychopathology
    • Szatmari P., et al. The use of genetic epidemiology to guide classification in child and adult psychopathology. Int. Rev. Psychiatry 2007, 19:483-496.
    • (2007) Int. Rev. Psychiatry , vol.19 , pp. 483-496
    • Szatmari, P.1
  • 94
    • 84905836979 scopus 로고    scopus 로고
    • Parental social responsiveness and risk of autism spectrum disorder in offspring
    • Lyall K., et al. Parental social responsiveness and risk of autism spectrum disorder in offspring. JAMA Psychiatry 2014, 71:936-942.
    • (2014) JAMA Psychiatry , vol.71 , pp. 936-942
    • Lyall, K.1


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