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Volumn 49, Issue 7, 2015, Pages 825-842

Isavuconazole: A New Option for the Management of Invasive Fungal Infections

Author keywords

antifungal agents; aspergillosis; candidiasis; invasive fungal infections; isavuconazole; mold infections; Mucor; pharmacokinetics; triazole

Indexed keywords

AMPHOTERICIN B; ANIDULAFUNGIN; CASPOFUNGIN; FLUCONAZOLE; FLUCYTOSINE; ISAVUCONAZOLE; ISAVUCONAZONIUM; ITRACONAZOLE; MICAFUNGIN; POSACONAZOLE; RAVUCONAZOLE; VORICONAZOLE; ANTIFUNGAL AGENT; NITRILE; PYRIDINE DERIVATIVE; TRIAZOLE DERIVATIVE;

EID: 84931097019     PISSN: 10600280     EISSN: 15426270     Source Type: Journal    
DOI: 10.1177/1060028015581679     Document Type: Article
Times cited : (79)

References (98)
  • 1
    • 0035451130 scopus 로고    scopus 로고
    • Trends in mortality due to invasive mycotic diseases in the United States, 1980-1997
    • ,,, et al.. ;:-
    • McNeil MM,Nash SL,Hajjeh RA, et al.Trends in mortality due to invasive mycotic diseases in the United States, 1980-1997.Clin Infect Dis. 2001;33:641-647
    • (2001) Clin Infect Dis , vol.33 , pp. 641-647
    • McNeil, M.M.1    Nash, S.L.2    Hajjeh, R.A.3
  • 2
    • 84895064119 scopus 로고    scopus 로고
    • Clinical and economic burden of invasive fungal diseases in Europe: focus on pre-emptive and empirical treatment of Aspergillus and Candida species
    • ,,, et al.. ;:-
    • Drgona L,Khachatryan A,Stephens J, et al.Clinical and economic burden of invasive fungal diseases in Europe: focus on pre-emptive and empirical treatment of Aspergillus and Candida species.Eur J Clin Microbiol Infect Dis. 2014;33:7-21
    • (2014) Eur J Clin Microbiol Infect Dis , vol.33 , pp. 7-21
    • Drgona, L.1    Khachatryan, A.2    Stephens, J.3
  • 3
    • 84878342622 scopus 로고    scopus 로고
    • Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations
    • ,,, et al.. ;:-
    • Alexander BD,Johnson MD,Pfeiffer CD, et al.Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations.Clin Infect Dis. 2013;56:1724-1732
    • (2013) Clin Infect Dis , vol.56 , pp. 1724-1732
    • Alexander, B.D.1    Johnson, M.D.2    Pfeiffer, C.D.3
  • 4
    • 79960963679 scopus 로고    scopus 로고
    • Current concepts in antifungal pharmacology
    • Lewis RE.Current concepts in antifungal pharmacology.Mayo Clin Proc. 2011;86:805-817
    • (2011) Mayo Clin Proc , vol.86 , pp. 805-817
    • Lewis, R.E.1
  • 6
    • 29944441643 scopus 로고    scopus 로고
    • Single-ascending-dose pharmacokinetics and safety of the novel broad-spectrum antifungal triazole BAL4815 after intravenous infusions (50, 100, and 200 milligrams) and oral administrations (100, 200, and 400 milligrams) of its prodrug, BAL8557, in healthy volunteers
    • ,,, et al.. ;:-
    • Schmitt-Hoffmann A,Roos B,Heep M, et al.Single-ascending-dose pharmacokinetics and safety of the novel broad-spectrum antifungal triazole BAL4815 after intravenous infusions (50, 100, and 200 milligrams) and oral administrations (100, 200, and 400 milligrams) of its prodrug, BAL8557, in healthy volunteers.Antimicrob Agents Chemother. 2006;50:279-285
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 279-285
    • Schmitt-Hoffmann, A.1    Roos, B.2    Heep, M.3
  • 7
    • 17644440661 scopus 로고    scopus 로고
    • Design, synthesis and antifungal activity of a novel water soluble prodrug of antifungal triazole
    • ,,, et al.. ;:-
    • Ohwada J,Tsukazaki M,Hayase T, et al.Design, synthesis and antifungal activity of a novel water soluble prodrug of antifungal triazole.Bioorg Med Chem Lett. 2003;13:191-196
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 191-196
    • Ohwada, J.1    Tsukazaki, M.2    Hayase, T.3
  • 8
    • 0032882718 scopus 로고    scopus 로고
    • Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance
    • Ghannoum MA,Rice LB.Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance.Clin Microbiol Rev. 1999;12:501-517
    • (1999) Clin Microbiol Rev , vol.12 , pp. 501-517
    • Ghannoum, M.A.1    Rice, L.B.2
  • 9
    • 2442704002 scopus 로고    scopus 로고
    • Antifungal agents: in vitro susceptibility testing, pharmacodynamics, and prospects for combination therapy
    • Groll AH,Kolve H.Antifungal agents: in vitro susceptibility testing, pharmacodynamics, and prospects for combination therapy.Eur J Clin Microbiol Infect Dis. 2004;23:256-270
    • (2004) Eur J Clin Microbiol Infect Dis , vol.23 , pp. 256-270
    • Groll, A.H.1    Kolve, H.2
  • 10
    • 84879575734 scopus 로고    scopus 로고
    • The evolving role of antifungal susceptibility testing
    • Eschenauer GA,Carver PL.The evolving role of antifungal susceptibility testing.Pharmacotherapy. 2013;33:465-475
    • (2013) Pharmacotherapy , vol.33 , pp. 465-475
    • Eschenauer, G.A.1    Carver, P.L.2
  • 11
    • 65649120454 scopus 로고    scopus 로고
    • In vitro activity of Isavuconazole against Aspergillus species and zygomycetes according to the methodology of the European Committee on Antimicrobial Susceptibility Testing
    • Perkhofer S,Lechner V,Lass-Florl C.In vitro activity of Isavuconazole against Aspergillus species and zygomycetes according to the methodology of the European Committee on Antimicrobial Susceptibility Testing.Antimicrob Agents Chemother. 2009;53:1645-1647
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 1645-1647
    • Perkhofer, S.1    Lechner, V.2    Lass-Florl, C.3
  • 12
    • 30344449770 scopus 로고    scopus 로고
    • In vitro activity of a new triazole BAL4815, the active component of BAL8557 (the water-soluble prodrug), against Aspergillus spp
    • Warn PA,Sharp A,Denning DW.In vitro activity of a new triazole BAL4815, the active component of BAL8557 (the water-soluble prodrug), against Aspergillus spp.J Antimicrob Chemother. 2006;57:135-138
    • (2006) J Antimicrob Chemother , vol.57 , pp. 135-138
    • Warn, P.A.1    Sharp, A.2    Denning, D.W.3
  • 13
    • 84931044073 scopus 로고    scopus 로고
    • Isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex by the CLSI broth microdilution method (M27-A3 document): a multicenter study [published online October 15, 2014]
    • ,,, et al.. ;:
    • Espinel-Ingroff A,Chowdhary A,Gonzalez GM, et al.Isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex by the CLSI broth microdilution method (M27-A3 document): a multicenter study [published online October 15, 2014].Antimicrob Agents Chemother. 2014;:
    • (2014) Antimicrob Agents Chemother
    • Espinel-Ingroff, A.1    Chowdhary, A.2    Gonzalez, G.M.3
  • 14
    • 84920132563 scopus 로고    scopus 로고
    • Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method
    • ,,, et al.. ;:-
    • Espinel-Ingroff A,Chowdhary A,Gonzalez GM, et al.Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method.Antimicrob Agents Chemother. 2015;59:666-668
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 666-668
    • Espinel-Ingroff, A.1    Chowdhary, A.2    Gonzalez, G.M.3
  • 15
    • 84880255910 scopus 로고    scopus 로고
    • Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for Aspergillus spp. for the CLSI M38-A2 broth microdilution method
    • ,,, et al.. ;:-
    • Espinel-Ingroff A,Chowdhary A,Gonzalez GM, et al.Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for Aspergillus spp. for the CLSI M38-A2 broth microdilution method.Antimicrob Agents Chemother. 2013;57:3823-3828
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 3823-3828
    • Espinel-Ingroff, A.1    Chowdhary, A.2    Gonzalez, G.M.3
  • 17
    • 84900492654 scopus 로고    scopus 로고
    • Comparison of EUCAST and CLSI broth microdilution methods for the susceptibility testing of 10 systemically active antifungal agents when tested against Candida spp
    • Pfaller MA,Castanheira M,Messer SA,Rhomberg PR,Jones RN.Comparison of EUCAST and CLSI broth microdilution methods for the susceptibility testing of 10 systemically active antifungal agents when tested against Candida spp.Diagn Microbiol Infect Dis. 2014;79:198-204
    • (2014) Diagn Microbiol Infect Dis , vol.79 , pp. 198-204
    • Pfaller, M.A.1    Castanheira, M.2    Messer, S.A.3    Rhomberg, P.R.4    Jones, R.N.5
  • 18
    • 42049092525 scopus 로고    scopus 로고
    • In vitro antifungal activities of isavuconazole (BAL4815), voriconazole, and fluconazole against 1,007 isolates of zygomycete, Candida, Aspergillus, Fusarium, and Scedosporium species
    • Guinea J,Pelaez T,Recio S,Torres-Narbona M,Bouza E.In vitro antifungal activities of isavuconazole (BAL4815), voriconazole, and fluconazole against 1,007 isolates of zygomycete, Candida, Aspergillus, Fusarium, and Scedosporium species.Antimicrob Agents Chemother. 2008;52:1396-1400
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1396-1400
    • Guinea, J.1    Pelaez, T.2    Recio, S.3    Torres-Narbona, M.4    Bouza, E.5
  • 19
    • 34248379039 scopus 로고    scopus 로고
    • In vitro activities of isavuconazole and other antifungal agents against Candida bloodstream isolates
    • Seifert H,Aurbach U,Stefanik D,Cornely O.In vitro activities of isavuconazole and other antifungal agents against Candida bloodstream isolates.Antimicrob Agents Chemother. 2007;51:1818-1821
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1818-1821
    • Seifert, H.1    Aurbach, U.2    Stefanik, D.3    Cornely, O.4
  • 20
    • 77955920852 scopus 로고    scopus 로고
    • In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan
    • ,,, et al.. ;:-
    • Yamazaki T,Inagaki Y,Fujii T, et al.In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan.Int J Antimicrob Agents. 2010;36:324-331
    • (2010) Int J Antimicrob Agents , vol.36 , pp. 324-331
    • Yamazaki, T.1    Inagaki, Y.2    Fujii, T.3
  • 21
    • 84880613296 scopus 로고    scopus 로고
    • In vitro activities of isavuconazole and comparator antifungal agents tested against a global collection of opportunistic yeasts and molds
    • Pfaller MA,Messer SA,Rhomberg PR,Jones RN,Castanheira M.In vitro activities of isavuconazole and comparator antifungal agents tested against a global collection of opportunistic yeasts and molds.J Clin Microbiol. 2013;51:2608-2616
    • (2013) J Clin Microbiol , vol.51 , pp. 2608-2616
    • Pfaller, M.A.1    Messer, S.A.2    Rhomberg, P.R.3    Jones, R.N.4    Castanheira, M.5
  • 22
    • 84897561300 scopus 로고    scopus 로고
    • Epidemiology of candidemia in Qatar, the Middle East: performance of MALDI-TOF MS for the identification of Candida species, species distribution, outcome, and susceptibility pattern
    • ,,, et al.. ;:-
    • Taj-Aldeen SJ,Kolecka A,Boesten R, et al.Epidemiology of candidemia in Qatar, the Middle East: performance of MALDI-TOF MS for the identification of Candida species, species distribution, outcome, and susceptibility pattern.Infection. 2014;42:393-404
    • (2014) Infection , vol.42 , pp. 393-404
    • Taj-Aldeen, S.J.1    Kolecka, A.2    Boesten, R.3
  • 24
    • 84876734548 scopus 로고    scopus 로고
    • Candida nivariensis as an etiologic agent of vulvovaginal candidiasis in a tertiary care hospital of New Delhi, India
    • ,,, et al.. ;:-
    • Sharma C,Wankhede S,Muralidhar S, et al.Candida nivariensis as an etiologic agent of vulvovaginal candidiasis in a tertiary care hospital of New Delhi, India.Diagn Microbiol Infect Dis. 2013;76:46-50
    • (2013) Diagn Microbiol Infect Dis , vol.76 , pp. 46-50
    • Sharma, C.1    Wankhede, S.2    Muralidhar, S.3
  • 28
    • 80052794427 scopus 로고    scopus 로고
    • In vitro susceptibility of 188 clinical and environmental isolates of Aspergillus flavus for the new triazole isavuconazole and seven other antifungal drugs
    • Shivaprakash MR,Geertsen E,Chakrabarti A,Mouton JW,Meis JF.In vitro susceptibility of 188 clinical and environmental isolates of Aspergillus flavus for the new triazole isavuconazole and seven other antifungal drugs.Mycoses. 2011;54:e583-e589
    • (2011) Mycoses , vol.54 , pp. e583-e589
    • Shivaprakash, M.R.1    Geertsen, E.2    Chakrabarti, A.3    Mouton, J.W.4    Meis, J.F.5
  • 29
    • 84908409029 scopus 로고    scopus 로고
    • EUCAST isavuconazole susceptibility testing of Aspergillus: comparison of results for inoculum standardisation using conidia counting versus optical density [published online August 20, 2014]
    • Arendrup MC,Howard S,Lass-Florl C,Mouton JW,Meletiadis J,Cuenca-Estrella M.EUCAST isavuconazole susceptibility testing of Aspergillus: comparison of results for inoculum standardisation using conidia counting versus optical density [published online August 20, 2014].Antimicrob Agents Chemother.:
    • Antimicrob Agents Chemother
    • Arendrup, M.C.1    Howard, S.2    Lass-Florl, C.3    Mouton, J.W.4    Meletiadis, J.5    Cuenca-Estrella, M.6
  • 30
    • 84882742698 scopus 로고    scopus 로고
    • Isavuconazole activity against Aspergillus lentulus, Neosartorya udagawae, and Cryptococcus gattii: emerging fungal pathogens with reduced azole susceptibility
    • ,,, et al.. ;:-
    • Datta K,Rhee P,Byrnes E, et al.Isavuconazole activity against Aspergillus lentulus, Neosartorya udagawae, and Cryptococcus gattii: emerging fungal pathogens with reduced azole susceptibility.J Clin Microbiol. 2013;51:3090-3093
    • (2013) J Clin Microbiol , vol.51 , pp. 3090-3093
    • Datta, K.1    Rhee, P.2    Byrnes, E.3
  • 31
    • 82555166966 scopus 로고    scopus 로고
    • In vitro activity of isavuconazole against 208 Aspergillus flavus isolates in comparison with 7 other antifungal agents: assessment according to the methodology of the European Committee on Antimicrobial Susceptibility Testing
    • Rudramurthy SM,Chakrabarti A,Geertsen E,Mouton JW,Meis JF.In vitro activity of isavuconazole against 208 Aspergillus flavus isolates in comparison with 7 other antifungal agents: assessment according to the methodology of the European Committee on Antimicrobial Susceptibility Testing.Diagn Microbiol Infect Dis. 2011;71:370-377
    • (2011) Diagn Microbiol Infect Dis , vol.71 , pp. 370-377
    • Rudramurthy, S.M.1    Chakrabarti, A.2    Geertsen, E.3    Mouton, J.W.4    Meis, J.F.5
  • 32
    • 42049109270 scopus 로고    scopus 로고
    • In vitro activity of the new azole isavuconazole (BAL4815) compared with six other antifungal agents against 162 Cryptococcus neoformans isolates from Cuba
    • Illnait-Zaragozi MT,Martinez GF,Curfs-Breuker I,Fernandez CM,Boekhout T,Meis JF.In vitro activity of the new azole isavuconazole (BAL4815) compared with six other antifungal agents against 162 Cryptococcus neoformans isolates from Cuba.Antimicrob Agents Chemother. 2008;52:1580-1582
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1580-1582
    • Illnait-Zaragozi, M.T.1    Martinez, G.F.2    Curfs-Breuker, I.3    Fernandez, C.M.4    Boekhout, T.5    Meis, J.F.6
  • 33
    • 84876299820 scopus 로고    scopus 로고
    • First environmental isolation of Cryptococcus gattii, genotype AFLP5, from India and a global review
    • ,,, et al.. ;:-
    • Chowdhary A,Prakash A,Randhawa HS, et al.First environmental isolation of Cryptococcus gattii, genotype AFLP5, from India and a global review.Mycoses. 2013;56:222-228
    • (2013) Mycoses , vol.56 , pp. 222-228
    • Chowdhary, A.1    Prakash, A.2    Randhawa, H.S.3
  • 34
    • 84931058235 scopus 로고    scopus 로고
    • Isavuconazole activity against emerging fungal pathogens with reduced azole-susceptibility: Aspergillus lentulus, Neosartorya udagawae and Cryptococcus gattii [published online June 28, 2013]
    • Datta K,Rhee P,Byrnes E.Isavuconazole activity against emerging fungal pathogens with reduced azole-susceptibility: Aspergillus lentulus, Neosartorya udagawae and Cryptococcus gattii [published online June 28, 2013].J Clin Microbiol.:
    • J Clin Microbiol
    • Datta, K.1    Rhee, P.2    Byrnes, E.3
  • 35
    • 84868036936 scopus 로고    scopus 로고
    • Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for fluconazole, itraconazole, posaconazole, and voriconazole
    • ,,, et al.. ;:-
    • Espinel-Ingroff A,Aller AI,Canton E, et al.Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for fluconazole, itraconazole, posaconazole, and voriconazole.Antimicrob Agents Chemother. 2012;56:5898-5906
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 5898-5906
    • Espinel-Ingroff, A.1    Aller, A.I.2    Canton, E.3
  • 36
    • 84861125770 scopus 로고    scopus 로고
    • Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine
    • ,,, et al.. ;:-
    • Espinel-Ingroff A,Chowdhary A,Cuenca-Estrella M, et al.Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine.Antimicrob Agents Chemother. 2012;56:3107-3113
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 3107-3113
    • Espinel-Ingroff, A.1    Chowdhary, A.2    Cuenca-Estrella, M.3
  • 37
    • 77957735262 scopus 로고    scopus 로고
    • Antifungal susceptibility, serotyping, and genotyping of clinical Cryptococcus neoformans isolates collected during 18 years in a single institution in Madrid, Spain
    • ,,, et al.. ;:-
    • Guinea J,Hagen F,Pelaez T, et al.Antifungal susceptibility, serotyping, and genotyping of clinical Cryptococcus neoformans isolates collected during 18 years in a single institution in Madrid, Spain.Med Mycol. 2010;48:942-948
    • (2010) Med Mycol , vol.48 , pp. 942-948
    • Guinea, J.1    Hagen, F.2    Pelaez, T.3
  • 38
    • 78649651789 scopus 로고    scopus 로고
    • In vitro antifungal susceptibilities and amplified fragment length polymorphism genotyping of a worldwide collection of 350 clinical, veterinary, and environmental Cryptococcus gattii isolates
    • ,,, et al.. ;:-
    • Hagen F,Illnait-Zaragozi MT,Bartlett KH, et al.In vitro antifungal susceptibilities and amplified fragment length polymorphism genotyping of a worldwide collection of 350 clinical, veterinary, and environmental Cryptococcus gattii isolates.Antimicrob Agents Chemother. 2010;54:5139-5145
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 5139-5145
    • Hagen, F.1    Illnait-Zaragozi, M.T.2    Bartlett, K.H.3
  • 39
    • 84861179478 scopus 로고    scopus 로고
    • Extensive genetic diversity within the Dutch clinical Cryptococcus neoformans population
    • ,,, et al.. ;:-
    • Hagen F,Illnait-Zaragozi MT,Meis JF, et al.Extensive genetic diversity within the Dutch clinical Cryptococcus neoformans population.J Clin Microbiol. 2012;50:1918-1926
    • (2012) J Clin Microbiol , vol.50 , pp. 1918-1926
    • Hagen, F.1    Illnait-Zaragozi, M.T.2    Meis, J.F.3
  • 40
    • 77957277084 scopus 로고    scopus 로고
    • Microsatellite typing and susceptibilities of serial Cryptococcus neoformans isolates from Cuban patients with recurrent cryptococcal meningitis
    • ,,, et al.. ;:
    • Illnait-Zaragozi MT,Martinez-Machin GF,Fernandez-Andreu CM, et al.Microsatellite typing and susceptibilities of serial Cryptococcus neoformans isolates from Cuban patients with recurrent cryptococcal meningitis.BMC Infect Dis. 2010;10:
    • (2010) BMC Infect Dis , vol.10
    • Illnait-Zaragozi, M.T.1    Martinez-Machin, G.F.2    Fernandez-Andreu, C.M.3
  • 43
  • 44
    • 66749159129 scopus 로고    scopus 로고
    • Molecular identification and susceptibility of Trichosporon species isolated from clinical specimens in Qatar: isolation of Trichosporon dohaense Taj-Aldeen, Meis & Boekhout sp. nov
    • ,,, et al.. ;:-
    • Taj-Aldeen SJ,Al-Ansari N,El Shafei S, et al.Molecular identification and susceptibility of Trichosporon species isolated from clinical specimens in Qatar: isolation of Trichosporon dohaense Taj-Aldeen, Meis & Boekhout sp. nov.J Clin Microbiol. 2009;47:1791-1799
    • (2009) J Clin Microbiol , vol.47 , pp. 1791-1799
    • Taj-Aldeen, S.J.1    Al-Ansari, N.2    El Shafei, S.3
  • 45
    • 67249103186 scopus 로고    scopus 로고
    • In vitro activity of isavuconazole against Trichosporon, Rhodotorula, Geotrichum, Saccharomyces and Pichia species
    • Thompson GR,Wiederhold NP,Sutton DA,Fothergill A,Patterson TF.In vitro activity of isavuconazole against Trichosporon, Rhodotorula, Geotrichum, Saccharomyces and Pichia species.J Antimicrob Chemother. 2009;64:79-83
    • (2009) J Antimicrob Chemother , vol.64 , pp. 79-83
    • Thompson, G.R.1    Wiederhold, N.P.2    Sutton, D.A.3    Fothergill, A.4    Patterson, T.F.5
  • 46
    • 68349106776 scopus 로고    scopus 로고
    • In vitro antifungal activity of isavuconazole against 345 mucorales isolates collected at study centers in eight countries
    • ,,, et al.. ;:-
    • Verweij PE,Gonzalez GM,Wiedrhold NP, et al.In vitro antifungal activity of isavuconazole against 345 mucorales isolates collected at study centers in eight countries.J Chemother. 2009;21:272-281
    • (2009) J Chemother , vol.21 , pp. 272-281
    • Verweij, P.E.1    Gonzalez, G.M.2    Wiedrhold, N.P.3
  • 47
    • 58149197661 scopus 로고    scopus 로고
    • In vitro activities of isavuconazole against opportunistic filamentous and dimorphic fungi
    • Gonzalez GM.In vitro activities of isavuconazole against opportunistic filamentous and dimorphic fungi.Med Mycol. 2009;47:71-76
    • (2009) Med Mycol , vol.47 , pp. 71-76
    • Gonzalez, G.M.1
  • 48
    • 84913611314 scopus 로고    scopus 로고
    • Molecular characterization and in vitro antifungal susceptibility of 80 clinical isolates of mucormycetes in Delhi, India
    • ,,, et al.. ;:-
    • Chowdhary A,Kathuria S,Singh PK, et al.Molecular characterization and in vitro antifungal susceptibility of 80 clinical isolates of mucormycetes in Delhi, India.Mycoses. 2014;57:97-107
    • (2014) Mycoses , vol.57 , pp. 97-107
    • Chowdhary, A.1    Kathuria, S.2    Singh, P.K.3
  • 49
    • 78650066193 scopus 로고    scopus 로고
    • Apophysomyces elegans: epidemiology, amplified fragment length polymorphism typing, and in vitro antifungal susceptibility pattern
    • Chakrabarti A,Shivaprakash MR,Curfs-Breuker I,Baghela A,Klaassen CH,Meis JF.Apophysomyces elegans: epidemiology, amplified fragment length polymorphism typing, and in vitro antifungal susceptibility pattern.J Clin Microbiol. 2010;48:4580-4585
    • (2010) J Clin Microbiol , vol.48 , pp. 4580-4585
    • Chakrabarti, A.1    Shivaprakash, M.R.2    Curfs-Breuker, I.3    Baghela, A.4    Klaassen, C.H.5    Meis, J.F.6
  • 50
    • 84897500774 scopus 로고    scopus 로고
    • Successful isavuconazole salvage therapy in a patient with invasive mucormycosis
    • Ervens J,Ghannoum M,Graf B,Schwartz S.Successful isavuconazole salvage therapy in a patient with invasive mucormycosis.Infection. 2014;42:429-432
    • (2014) Infection , vol.42 , pp. 429-432
    • Ervens, J.1    Ghannoum, M.2    Graf, B.3    Schwartz, S.4
  • 51
    • 84860150319 scopus 로고    scopus 로고
    • Species-specific antifungal susceptibility patterns of Scedosporium and Pseudallescheria species
    • ,,, et al.. ;:-
    • Lackner M,de Hoog GS,Verweij PE, et al.Species-specific antifungal susceptibility patterns of Scedosporium and Pseudallescheria species.Antimicrob Agents Chemother. 2012;56:2635-2642
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 2635-2642
    • Lackner, M.1    de Hoog, G.S.2    Verweij, P.E.3
  • 56
    • 80054686167 scopus 로고    scopus 로고
    • Microdilution in vitro antifungal susceptibility of Exophiala dermatitidis, a systemic opportunist
    • Badali H,de Hoog GS,Sudhadham M,Meis JF.Microdilution in vitro antifungal susceptibility of Exophiala dermatitidis, a systemic opportunist.Med Mycol. 2011;49:819-824
    • (2011) Med Mycol , vol.49 , pp. 819-824
    • Badali, H.1    de Hoog, G.S.2    Sudhadham, M.3    Meis, J.F.4
  • 60
    • 0037417050 scopus 로고    scopus 로고
    • A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus
    • Diaz-Guerra TM,Mellado E,Cuenca-Estrella M,Rodriguez-Tudela JL.A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus.Antimicrob Agents Chemother. 2003;47:1120-1124
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 1120-1124
    • Diaz-Guerra, T.M.1    Mellado, E.2    Cuenca-Estrella, M.3    Rodriguez-Tudela, J.L.4
  • 61
    • 33644832215 scopus 로고    scopus 로고
    • Update on antifungal drug resistance mechanisms of Aspergillus fumigatus
    • Chamilos G,Kontoyiannis DP.Update on antifungal drug resistance mechanisms of Aspergillus fumigatus.Drug Resist Updat. 2005;8:344-358
    • (2005) Drug Resist Updat , vol.8 , pp. 344-358
    • Chamilos, G.1    Kontoyiannis, D.P.2
  • 62
    • 3042531281 scopus 로고    scopus 로고
    • Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs
    • Mellado E,Garcia-Effron G,Alcazar-Fuoli L,Cuenca-Estrella M,Rodriguez-Tudela JL.Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs.Antimicrob Agents Chemother. 2004;48:2747-2750
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 2747-2750
    • Mellado, E.1    Garcia-Effron, G.2    Alcazar-Fuoli, L.3    Cuenca-Estrella, M.4    Rodriguez-Tudela, J.L.5
  • 63
    • 84931091222 scopus 로고    scopus 로고
    • A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations
    • ,,, et al.; 2007; 2007. 1897.
    • Mellado E,Garcia-Effron G,Alcazar-Fuoli L, et al.A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.; 2007; 2007. 1897.
    • Mellado, E.1    Garcia-Effron, G.2    Alcazar-Fuoli, L.3
  • 64
    • 84855860621 scopus 로고    scopus 로고
    • Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India
    • Chowdhary A,Kathuria S,Randhawa HS,Gaur SN,Klaassen CH,Meis JF.Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India.J Antimicrob Chemother. 2012;67:362-366
    • (2012) J Antimicrob Chemother , vol.67 , pp. 362-366
    • Chowdhary, A.1    Kathuria, S.2    Randhawa, H.S.3    Gaur, S.N.4    Klaassen, C.H.5    Meis, J.F.6
  • 65
    • 79955544138 scopus 로고    scopus 로고
    • Azole resistance of Aspergillus fumigatus biofilms is partly associated with efflux pump activity
    • ,,, et al.. ;:-
    • Rajendran R,Mowat E,McCulloch E, et al.Azole resistance of Aspergillus fumigatus biofilms is partly associated with efflux pump activity.Antimicrob Agents Chemother. 2011;55:2092-2097
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 2092-2097
    • Rajendran, R.1    Mowat, E.2    McCulloch, E.3
  • 66
    • 84887454188 scopus 로고    scopus 로고
    • Isavuconazole (BAL4815) pharmacodynamic target determination in an in vivo murine model of invasive pulmonary aspergillosis against wild-type and cyp51 mutant isolates of Aspergillus fumigatus
    • Lepak AJ,Marchillo K,Vanhecker J,Andes DR.Isavuconazole (BAL4815) pharmacodynamic target determination in an in vivo murine model of invasive pulmonary aspergillosis against wild-type and cyp51 mutant isolates of Aspergillus fumigatus.Antimicrob Agents Chemother. 2013;57:6284-6289
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 6284-6289
    • Lepak, A.J.1    Marchillo, K.2    Vanhecker, J.3    Andes, D.R.4
  • 67
    • 84885942197 scopus 로고    scopus 로고
    • Isavuconazole pharmacodynamic target determination for Candida species in an in vivo murine disseminated candidiasis model
    • Lepak AJ,Marchillo K,Vanhecker J,Diekema D,Andes DR.Isavuconazole pharmacodynamic target determination for Candida species in an in vivo murine disseminated candidiasis model.Antimicrob Agents Chemother. 2013;57:5642-5648
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 5642-5648
    • Lepak, A.J.1    Marchillo, K.2    Vanhecker, J.3    Diekema, D.4    Andes, D.R.5
  • 68
    • 84874100340 scopus 로고    scopus 로고
    • Evaluation of the in vitro activity of voriconazole as predictive of in vivo outcome in a murine Aspergillus fumigatus infection model
    • Salas V,Pastor FJ,Calvo E,Sutton DA,Fothergill AW,Guarro J.Evaluation of the in vitro activity of voriconazole as predictive of in vivo outcome in a murine Aspergillus fumigatus infection model.Antimicrob Agents Chemother. 2013;57:1404-1408
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 1404-1408
    • Salas, V.1    Pastor, F.J.2    Calvo, E.3    Sutton, D.A.4    Fothergill, A.W.5    Guarro, J.6
  • 70
    • 84931094466 scopus 로고    scopus 로고
    • In vitro post antibiotic effect of isavuconazole, voriconazole and amphotericin against a strain of C. albicans with concentration dependent pharmacokinetics in a murine model and susceptibility of strains from mouse kidneys post infection
    • ,,,,.; 2008Barcelona, Spain; 2008.
    • Warn PA,Sharp A,Majithiya JB,Parmar A,Denning DW.In vitro post antibiotic effect of isavuconazole, voriconazole and amphotericin against a strain of C. albicans with concentration dependent pharmacokinetics in a murine model and susceptibility of strains from mouse kidneys post infection.Paper presented at: 18th European Congress of Clinical Microbiology and Infectious Diseases, ECCMID; 2008Barcelona, Spain; 2008.
    • Paper presented at: 18th European Congress of Clinical Microbiology and Infectious Diseases, ECCMID
    • Warn, P.A.1    Sharp, A.2    Majithiya, J.B.3    Parmar, A.4    Denning, D.W.5
  • 71
    • 67749102126 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of a novel triazole, isavuconazole: mathematical modeling, importance of tissue concentrations, and impact of immune status on antifungal effect
    • Warn PA,Sharp A,Parmar A,Majithiya J,Denning DW,Hope WW.Pharmacokinetics and pharmacodynamics of a novel triazole, isavuconazole: mathematical modeling, importance of tissue concentrations, and impact of immune status on antifungal effect.Antimicrob Agents Chemother. 2009;53:3453-3461
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 3453-3461
    • Warn, P.A.1    Sharp, A.2    Parmar, A.3    Majithiya, J.4    Denning, D.W.5    Hope, W.W.6
  • 72
    • 29944445355 scopus 로고    scopus 로고
    • Multiple-dose pharmacokinetics and safety of the new antifungal triazole BAL4815 after intravenous infusion and oral administration of its prodrug, BAL8557, in healthy volunteers
    • ,,, et al.. ;:-
    • Schmitt-Hoffmann A,Roos B,Maares J, et al.Multiple-dose pharmacokinetics and safety of the new antifungal triazole BAL4815 after intravenous infusion and oral administration of its prodrug, BAL8557, in healthy volunteers.Antimicrob Agents Chemother. 2006;50:286-293
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 286-293
    • Schmitt-Hoffmann, A.1    Roos, B.2    Maares, J.3
  • 73
    • 70350313475 scopus 로고    scopus 로고
    • Effect of mild and moderate liver disease on the pharmacokinetics of isavuconazole after intravenous and oral administration of a single dose of the prodrug BAL8557
    • ,,, et al.. ;:-
    • Schmitt-Hoffmann A,Roos B,Spickermann J, et al.Effect of mild and moderate liver disease on the pharmacokinetics of isavuconazole after intravenous and oral administration of a single dose of the prodrug BAL8557.Antimicrob Agents Chemother. 2009;53:4885-4890
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 4885-4890
    • Schmitt-Hoffmann, A.1    Roos, B.2    Spickermann, J.3
  • 74
    • 84929821439 scopus 로고    scopus 로고
    • Pharmacokinetics of oral isavuconazole in a patient after Roux-en-Y gastric bypass surgery
    • Knoll BM.Pharmacokinetics of oral isavuconazole in a patient after Roux-en-Y gastric bypass surgery.J Antimicrob Chemother. 2014;69:3441-3443
    • (2014) J Antimicrob Chemother , vol.69 , pp. 3441-3443
    • Knoll, B.M.1
  • 75
    • 84949115259 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of isavuconazole as antifungal prophylaxis in acute myeloid leukemia patients with neutropenia: results of a phase 2, dose escalation study
    • Cornely OA,Bohme A,Schmitt-Hoffmann A,Ullmann AJ.Safety and pharmacokinetics of isavuconazole as antifungal prophylaxis in acute myeloid leukemia patients with neutropenia: results of a phase 2, dose escalation study.Antimicrob Agents Chemother. 2015;59:2078-2085
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 2078-2085
    • Cornely, O.A.1    Bohme, A.2    Schmitt-Hoffmann, A.3    Ullmann, A.J.4
  • 76
    • 84931091649 scopus 로고    scopus 로고
    • Advisory Committee Briefing Document. Isavuconazonium: invasive aspergillosis and invasive mucormycosis. Accessed March 29, 2015
    • Advisory Committee Briefing Document. Isavuconazonium: invasive aspergillosis and invasive mucormycosis. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/Anti-InfectiveDrugsAdvisoryCommittee/UCM430748.pdf. Accessed March 29, 2015.
  • 78
    • 84931098807 scopus 로고    scopus 로고
    • No relevant food effect in man on isavuconazole oral pharmacokinetics preliminary data
    • ,,, et al.; 2008Paper presented at: 41st Interscience Conference on Antimicrobial Agents and Chemotherapy American Society for Microbiology; 2008.
    • Schmitt-Hoffmann A,Roos B,Roerhle M, et al.No relevant food effect in man on isavuconazole oral pharmacokinetics preliminary data.; 2008Paper presented at: 41st Interscience Conference on Antimicrobial Agents and Chemotherapy American Society for Microbiology; 2008.
    • Schmitt-Hoffmann, A.1    Roos, B.2    Roerhle, M.3
  • 82
    • 56649106673 scopus 로고    scopus 로고
    • Posaconazole concentrations in the central nervous system
    • ,,, et al.. ;:-
    • Ruping MJ,Albermann N,Ebinger F, et al.Posaconazole concentrations in the central nervous system.J Antimicrob Chemother. 2008;62:1468-1470
    • (2008) J Antimicrob Chemother , vol.62 , pp. 1468-1470
    • Ruping, M.J.1    Albermann, N.2    Ebinger, F.3
  • 83
    • 84931064877 scopus 로고    scopus 로고
    • FDA briefing document: Anti-infective Drugs Advisory Committee Meeting January 22, 2015. Accessed March 29, 2015
    • FDA briefing document: Anti-infective Drugs Advisory Committee Meeting January 22, 2015. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/Anti-InfectiveDrugsAdvisoryCommittee/UCM430747.pdf. Accessed March 29, 2015.
  • 84
    • 33845365814 scopus 로고    scopus 로고
    • Factors influencing the magnitude and clinical significance of drug interactions between azole antifungals and select immunosuppressants
    • Saad AH,DePestel DD,Carver PL.Factors influencing the magnitude and clinical significance of drug interactions between azole antifungals and select immunosuppressants.Pharmacotherapy. 2006;26:1730-1744
    • (2006) Pharmacotherapy , vol.26 , pp. 1730-1744
    • Saad, A.H.1    DePestel, D.D.2    Carver, P.L.3
  • 85
    • 47149112547 scopus 로고    scopus 로고
    • Concurrent administration of sirolimus and voriconazole: a pilot study assessing safety and approaches to appropriate management
    • Surowiec D,DePestel DD,Carver PL.Concurrent administration of sirolimus and voriconazole: a pilot study assessing safety and approaches to appropriate management.Pharmacotherapy. 2008;28:719-729
    • (2008) Pharmacotherapy , vol.28 , pp. 719-729
    • Surowiec, D.1    DePestel, D.D.2    Carver, P.L.3
  • 86
    • 57649180452 scopus 로고    scopus 로고
    • Efficacy of isavuconazole, voriconazole and fluconazole in temporarily neutropenic murine models of disseminated Candida tropicalis and Candida krusei
    • Majithiya J,Sharp A,Parmar A,Denning DW,Warn PA.Efficacy of isavuconazole, voriconazole and fluconazole in temporarily neutropenic murine models of disseminated Candida tropicalis and Candida krusei.J Antimicrob Chemother. 2009;63:161-166
    • (2009) J Antimicrob Chemother , vol.63 , pp. 161-166
    • Majithiya, J.1    Sharp, A.2    Parmar, A.3    Denning, D.W.4    Warn, P.A.5
  • 90
    • 84890788343 scopus 로고    scopus 로고
    • First neonatal case of fungaemia due to Pseudozyma aphidis and a global literature review
    • ,,, et al.. ;:-
    • Prakash A,Wankhede S,Singh PK, et al.First neonatal case of fungaemia due to Pseudozyma aphidis and a global literature review.Mycoses. 2014;57:64-68
    • (2014) Mycoses , vol.57 , pp. 64-68
    • Prakash, A.1    Wankhede, S.2    Singh, P.K.3
  • 91
    • 84894541569 scopus 로고    scopus 로고
    • Isavuconazole treatment of a patient with disseminated mucormycosis
    • ,,, et al.. ;:-
    • Peixoto D,Gagne LS,Hammond SP, et al.Isavuconazole treatment of a patient with disseminated mucormycosis.J Clin Microbiol. 2014;52:1016-1019
    • (2014) J Clin Microbiol , vol.52 , pp. 1016-1019
    • Peixoto, D.1    Gagne, L.S.2    Hammond, S.P.3
  • 92
    • 84923240054 scopus 로고    scopus 로고
    • A phase 2, randomized, double-blind, multicenter trial to evaluate the safety and efficacy of three dosing regimens of isavuconazole compared with fluconazole in patients with uncomplicated esophageal candidiasis
    • Viljoen J,Azie N,Schmitt-Hoffmann AH,Ghannoum M.A phase 2, randomized, double-blind, multicenter trial to evaluate the safety and efficacy of three dosing regimens of isavuconazole compared with fluconazole in patients with uncomplicated esophageal candidiasis.Antimicrob Agents Chemother. 2015;59:1671-1679
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 1671-1679
    • Viljoen, J.1    Azie, N.2    Schmitt-Hoffmann, A.H.3    Ghannoum, M.4
  • 93
    • 84931096554 scopus 로고    scopus 로고
    • Astellas Pharma Inc. Isavuconazole (BAL8557) in the treatment of candidemia and other invasive candida infections. Accessed March 29, 2015
    • Astellas Pharma Inc. Isavuconazole (BAL8557) in the treatment of candidemia and other invasive candida infections. http://clinicaltrials.gov/ct2/show/NCT00413218?term=NCT00444366&rank=1. Accessed March 29, 2015.
  • 94
    • 84931076014 scopus 로고    scopus 로고
    • Basilea Pharmaceutica. Press release. Accessed March 29, 2015
    • Basilea Pharmaceutica. Press release. http://www.basilea.com/News-and-Media/Basilea-and-Astellas-update-isavuconazole-phase-III-trial-in-consultation-with-FDA/385. Accessed March 29, 2015.
  • 96
    • 84931080230 scopus 로고    scopus 로고
    • Astellas Pharma Inc. Isavuconazole in the treatment of renally impaired aspergillosis and rare fungi. Accessed March 29, 2015
    • Astellas Pharma Inc. Isavuconazole in the treatment of renally impaired aspergillosis and rare fungi. http://clinicaltrials.gov/ct2/show/NCT00634049?term=NCT00634049&rank=1. Accessed March 29, 2015.
  • 97
    • 84876927815 scopus 로고    scopus 로고
    • Optimizing antifungal choice and administration
    • Andes D.Optimizing antifungal choice and administration.Curr Med Res Opin. 2013;29:13-18
    • (2013) Curr Med Res Opin , vol.29 , pp. 13-18
    • Andes, D.1
  • 98
    • 84858111081 scopus 로고    scopus 로고
    • Resistance of Asian Cryptococcus neoformans serotype A is confined to few microsatellite genotypes
    • ,,, et al.. ;:
    • Pan W,Khayhan K,Hagen F, et al.Resistance of Asian Cryptococcus neoformans serotype A is confined to few microsatellite genotypes.PLoS One. 2012;7:e32868
    • (2012) PLoS One , vol.7 , pp. e32868
    • Pan, W.1    Khayhan, K.2    Hagen, F.3


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