Mechanism of fluconazole resistance in Candida krusei

Antimicrobial Agents and Chemotherapy

Volumn 42, Issue 10, 1998, Pages 2645-2649

  Orozco, Alison S ^a   Higginbotham, Lindsey M ^a   Hitchcock, Christopher A ^b   Parkinson, Tanya ^b   Falconer, Derek ^b   Ibrahim, Ashraf S ^a   Ghannoum, Mahmoud A ^a,c,e   Filler, Scott G ^a,c,d  

^a St John's Cardiovascular Research Center   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; CELL EXTRACT; FLUCONAZOLE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIBIOTIC RESISTANCE; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDA KRUSEI; DISEASE ACTIVITY; DISEASE PREDISPOSITION; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME INHIBITION; MEMBRANE STRUCTURE; MICROSOME; PRIORITY JOURNAL; QUALITATIVE DIAGNOSIS; SPECIES DIFFERENCE; STEROL SYNTHESIS;

EID: 0031665185     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.10.2645     Document Type: Article

References (33)

1. Borg-von Zepelin, M., H. Eiffert, M. Kann, and R. Rüchel. 1093. Changes in the spectrum of fungal isolates: results from clinical specimens gathered in 1987/88 compared with those in 1991/92 in the University Hospital Göttingen, Germany. Mycoses 36:247-253.
2. Burgener-Kairuz, P., J.-P. Zuber, P. Jaunin, T. G. Buchman, J. Bille, and M. Rossier. 1994. Rapid detection and identification of Candida albicans and Torulopsis (Candida) glabrata in clinical specimens by species-specific nested PCR amplification of a cytochrome P-450 lanosterol-α-demethylase (L1A1) gene fragment. J. Clin. Microbiol. 32:1902-1907.
3. Dermoumi, H. 1992. In vitro susceptibility of yeast isolates from the blood to fluconazole and amphotericin B. Chemotherapy 38:112-117.
4. Fisher, M. A., S.-H. Shen, J. Haddad, and W. F. Tarry. 1989. Comparison of in vivo activity of fluconazole with that of amphotericin B against Candida tropicalis, Candida glabrata, and Candida krusei. Antimicrob. Agents Chemother. 33:1443-1446.
5. Geber, A., C. A. Hitchcock, J. E. Swartz, F. S. Pullen, K. E. Marsden, K. J. Kwon-Chung, and J. E. Bennett. 1995. Deletion of the Candida glabrata ERG3 and ERG11 genes: effect on cell viability, cell growth, sterol composition, and antifungal susceptibility. Antimicrob. Agents Chemother. 39:2708-2717.
6. Ghannoum, M. A., G. Janini, L. Khamis, and S. S. Radwan. 1986. Dimorphism-associated variations in the lipid composition of Candida albicans. J. Gen. Microbiol. 132:2367-2375.
7. Ghannoum, M. A., I. Swairjo, and D. R. Soll. 1990. Variation in lipid and sterol contents in Candida albicans white and opaque phenotypes. J. Med. Vet. Mycol. 28:103-115.
8. Goldman, M., J. C. Pottage, and D. C. Weaver. 1993. Candida krusei fungemia. Report of 4 cases and review of the literature. Medicine 72:143-150.
9. Hitchcock, C. A. 1993. Resistance of Candida albicans to azole antifungal agents. Biochem. Soc. Trans. 21:1039-1047.
10. Hitchcock, C. A., S. B. Brown, E. G. V. Evans, and D. J. Adams. 1989. Cytochrome P-450-dependent 14α-demethylation of lanosterol in Candida albicans. Biochem. J. 260:549-556.
11. Hitchcock, C. A., K. Dickinson, S. B. Brown, E. G. V. Evans, and D. J. Adams. 1990. Interaction of azole antifungal antibiotics with cytochrome P-450-dependent 14α-sterol demethylase purified from Candida albicans. Biochem. J. 266:475-480.
12. Hitchcock, C. A., K. Dickinson, S. B. Brown, E. G. V. Evans, and D. J. Adams. 1989. Purification and properties of cytochrome P-450-dependent 14α-sterol demethylase from Candida albicans. Biochem. J. 263:573-579.
13. Käppeli, O., M. Sauer, and A. Fiecther. 1982. Convenient procedure for the isolation of highly enriched, cytochrome P-450-containing microsomal fraction from Candida tropicalis. Anal. Biochem. 126:179-182.
14. 5,6-desaturation. FEBS Lett. 400:80-82.
15. Lamb, D. C., D. E. Kelly, W. H. Schunck, A. Z. Shyadehi, M. Akhtar, D. J. Lowe, B. C. Baldwin, and S. L. Kelly. 1997. The mutation T315A in Candida albicans sterol 14α-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity. J. Biol. Chem. 272:5682-5688.
16. Loeffler, R. S. T., and A. L. Hayes. 1990. Sterols of the plant pathogenic fungi Botrytis cinera and pyrenophora teres. Phytochemistry 29:3424-3425.
17. Loeffler, R. S. T., and A. L. Hayes. 1992. Effects of sterols biosynthesis inhibitor fungicides on growth and sterol composition of Ustilago maydis, Botrytis cinera and pyrenophora teres. Pestic. Sci. 35:7-17
18. Marichal, P., J. Gorrens, M.-C. Coene, L. LeJeune, and H. Vanden Bossche. 1995. Origin in differences in susceptibility of Candida krusei to azole antifungal agents. Mycoses 38:111-117.
19. McQuillen, D. P., B. S. Zingman, F. Meunier, and S. M. Levitz. Invasive infections due to Candida krusei: report of ten cases of fungemia that include three cases of endophthalmitis. Clin. Infect. Dis. 14:472-478.
20. National Committee for Clinical Laboratory Standards. 1995. Reference method for broth dilution antifungal susceptibility testing of yeast. Tentative standard. Document M27-T. National Committee for Clinical Laboratory Standards, Villanova, Pa.
21. Omura, T., and R. Sato. 1964. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 239:370-2378.
22. Parkinson, T., D. J. Falconer, and C. A. Hitchcock. 1995. Fluconazole resistance due to energy-dependent drug efflux in Candida glabrata. Antimicrob. Agents Chemother. 39:1696-1699.
23. Quail, M. A., A. Arnoldi, D. J. Moore, M. W. Goosey, and S. L. Kelly. 1993. Ketoconazole mediated growth inhibition in Botrytis cinera and Saccharomyces cerevisiae. Phytochemistry 32:273-280.
24. Sanglard, D., F. Ischer, I. Koymans, and J. Bille. 1998. Amino acid substitutions in the cytochrome P-450 lanosterol 14α-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents. Antimicrob. Agents Chemother. 42:241-253.
25. Sanglard, D., O. Käppeli, and A. Fiecther. 1986. The distinction of different types of cytochromes P-450 from the yeasts Candida tropicalis and Saccharomyces uvarum. Arch. Biochem. Biophys. 251:276-286.
26. Sanglard, D., K. Kuchler, F. Ischer, J.-L. Pagani, M. Monod, and J. Bille. 1995. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob. Agents Chemother. 39:2378-2386.
27. Sorkhoh, N. A., M. A. Ghannoum, A. S. Ibrahim, R. J. Stretton and S. S. Radwan. 1991. Growth of Candida albicans in the presence of hydrocarbons: a correlation between sterol concentration and hydrocarbon uptake. App. Microbiol. Biotechnol. 34:509-512.
28. Vandenheuvel, F. A., and A. S. Court. 1968. Reference high-efficiency non-polar packed column for the gas-liquid chromatography of nanogram amounts of sterols. Part I. Retention time data. J. Chromatogr. 38:439-459.
29. Venkateswarlu, K., D. W. Denning, and S. L. Kelly. 1997. Inhibition and interaction of cytochrome P450 of Candida krusei with azole antifungal drugs. J. Med. Vet. Mycol. 35:19-25.
30. Venkateswarlu, K., D. W. Denning, N. J. Manning, and S. L. Kelly. 1996. Comparison of D0870, a new triazole antifungal agent, to fluconazole for inhibition of Candida albicans cytochrome P-450 by using in vitro assays. Antimicrob. Agents Chemother. 40:1382-1386.
31. Venkateswarlu, K., D. W. Denning, N. J. Manning, and S. L. Kelly. 1996. Reduced accumulation of drug in Candida krusei accounts for itraconazole resistance. Antimicrob. Agents Chemother. 40:2443-2446.
32. White, T. C. 1997. The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14α demethylase in Candida albicans. Antimicrob. Agents Chemother. 41:1488-1494.
33. Wingard, J. R., W. G. Merz, M. G. Rinaldi, T. K. Johnson, J. E. Karp, and R. Saral. 1991. Increase in Candida krusei infection among patients with hone marrow transplantation and neutropenia treated prophylactically with fluconazole. N. Engl. J. Med. 325:1274-1277.