Methoxylated flavones from Salvia Mirzayanii Rech. F. and esfand with immunosuppressive properties

Iranian Journal of Pharmaceutical Research

Volumn 14, Issue 3, 2015, Pages 955-960

  Ayatollahi, Abdul Majid ^a,b   Ghanadian, Mustafa ^c   Att Ur Rahman, Rahman ^d   Mesaik, M Ahmed ^d   Khalid, Ahmad Shukralla ^d   Adeli, Fateme ^b  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

Immunosuppressive; Methoxylated flavones; Oxidative burst; Salvia Mirzayanii; T cell proliferation

Indexed keywords

FLAVONE DERIVATIVE; PLANT EXTRACT; REACTIVE NITROGEN SPECIES; SALVIA MIRZAYANII EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION ASSAY; CHEMILUMINESCENCE IMMUNOASSAY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IC50; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; OXIDATION KINETICS; PERIPHERAL BLOOD MONONUCLEAR CELL; QUANTITATIVE ASSAY; T LYMPHOCYTE ACTIVATION;

EID: 84931053925     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Firuzi O, Miri R, Asadollahi M, Eslami S and Jassbi AR. Cytotoxic, antioxidant and antimicrobial activities and phenolic contents of eleven salvia species from Iran. Iran. J. Pharm. Res. (2013) 12: 801-810.
2. Mehrabani M, Heydari MR and Mehrabani M. Study of acute and chronic antihyperglycemic activity of methanolic extract of Salvia mirzayanii Rech. & Esfand. in rats. J. Med. Plants (2010) 9: 106-116.
3. Amirghofran Z, Bahmani M, Azadmehr A, Javidnia K, Ramazani M and Ziaei A. Effect of Salvia mirzayanii on the immune system and induction of apoptosis in peripheral blood lymphocytes. Nat. Prod. Res. (2010) 24: 500-508.
4. Amirghofran Z. Medicinal plants as immunosuppressive agents in traditional Iranian medicine. Iran. J. Immunol. (2010) 7: 65-73.
5. Moghaddam FM, Amiri R, Alam M, Hossain MB and van der Helm D. Structure and absolute stereochemistry of salvimirzacolide, a new sesterterpene from Salvia mirzayanii. J. Nat. Prod. (1998) 61: 279-281.
6. Javidnia K, Miri R, Kamalinejad M and Nasiri A. Composition of the essential oil of Salvia mirzayanii Rech. f. & Esfand from Iran. Flavour Fragr. J. (2002) 17: 465-467.
7. Ziaei A, Ramezani M, Wright L, Paetz C, Schneider B and Amirghofran Z. Identification of spathulenol in Salvia mirzayanii and the immunomodulatory effects. Phytother. Res. (2011) 25: 557-562.
8. Liu S, Guo C, Guo Y, Yu H, Greenaway F and Sun MZ. Comparative binding affinities of favonoid phytochemicals with bovine serum albumin. Iran. J. Pharm. Res. (2014) 13: 1019-1028.
9. Wudtiwai B, Sripanidkulchai B, Kongtawelert P and Banjerdpongchai R. Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines. J. Hematol. Oncol. (2011) 4: 52.
10. Li S, Pan MH, Lai CS, Lo CY, Dushenkov S and Ho CT. Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines. Bioorg. Med. Chem. (2007) 5: 3381-3389.
11. Nagao T, Abe F, Kinjo J and Okabe H. Antiproliferative constituents in plants. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure–activity relationship. Biol. Pharm. Bull. (2002) 25: 875-879.
12. Ghanadian SM, Ayatollahi AM, Mesaik MA and Abdalla OM. New immunosuppressive cyclomyrsinol diterpenes from Euphorbia kopetdaghi Prokh. Nat. Prod. Res. (2013) 27: 246-254.
13. Ghanadian SM, Ayatollahi AM, Afsharypour S, Hareem S, Abdalla OM and Bankeu JJK. Flavonol Glycosides from Euphorbia microsciadia Bioss. with their Immunomodulatory Activities. Iran. J. Pharm. Res. (2012) 11: 925-930.
14. Shahlaei M, Ghanadian SM, Ayatollahi AM, Mesaik MA, Abdalla OM, Afsharypour S and Rabbani M. Molecular modeling, structure activity relationship and immunomodulatory properties of some lupeol derivatives. Med. Chem. Res. (2013) 22: 1795-1803.
15. Moradkhani S, Ayatollahi AM, Ghanadian M, Moin MR, Razavizadeh M and Shahlaei M. Phytochemical analysis and metal-chelation activity of achillea tenuifolia lam. Iran. J. Pharm. Res. (2012) 11: 177-183.
16. Budzikiewicz H, Djerassi C and Williams DH. Structure Elucidation of Natural Products by Mass Spectrometry. Holden day INC, San Francisco (1964) 150-250.
17. Horie T, Ohtsuru Y, Shibata K, Yamashita K, Tsukayama M and Kawamura Y. 13C NMR spectral assignment of the A-ring of polyoxygenated flavones. Phytochem. (1998) 47: 865-874.
18. Martínez V, Barberá O, Sanchez-Parareda J and Alberto Marco J. Phenolic and acetylenic metabolites from Artemisia assoana. Phytochem. (1987) 26: 2619-2624.
19. Park Y, Moon BH, Yang H, Lee Y, Lee E and Lim Y. Complete assignments of NMR data of 13 hydroxymethoxyflavones. Magn. Reson. Chem. (2007) 45: 1072-1075.
20. Mesaik MA, Murad S, Khan KM, Tareen RB, Ahmed A and Choudhary MI. Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus‐castus. Phytother. Res. (2009) 23: 1516-1520.
21. Hung K, Hayashi R, Lafond-Walker A, Lowenstein C, Pardoll D and Levitsky H. The Central Role of CD4(+) T Cells in the Antitumor Immune Response. J. Exp. Med. (1998) 188: 2357-2368.
22. von Knethen A, Tautenhahn A, Link H, Lindemann D and Brüne B. Activation-induced depletion of protein kinase Cα provokes desensitization of monocytes/macrophages in sepsis. J. Immunol. (2005) 174: 4960-4965.
23. Beutler JA, Hamel E, Vlietinck, AJ, Haemers A, Rajan P, Roitman JN, Cardellina JH and Boyd MR. Structure-activity requirements for flavone cytotoxicity and binding to tubulin. J. Med. Chem. (1998) 41: 2333-2338.