Attenuating effects of coenzyme Q10 and amlodipine in ulcerative colitis model in rats

Immunopharmacology and Immunotoxicology

Volumn 37, Issue 3, 2015, Pages 244-251

  El Morsy, Engy M ^a   Kamel, Rehab ^a   Ahmed, Maha A E ^b  

^a Helwan   (Egypt)

^b Misr University for Science and Technology   (Egypt)

Author keywords

Amlodipine; CoQ10; Inflammation; Oxidative stress; Ulcerative colitis

Indexed keywords

ACETIC ACID; ADENOSINE TRIPHOSPHATE; AMLODIPINE; HEAT SHOCK PROTEIN 70; INTERLEUKIN 10; INTERLEUKIN 1BETA; MALONALDEHYDE; MYELOPEROXIDASE; PROSTAGLANDIN E2; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UBIDECARENONE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; IL1B PROTEIN, RAT; PEROXIDASE; TUMOR NECROSIS FACTOR; UBIQUINONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; COLON; CONTROLLED STUDY; DRUG EFFICACY; ENZYME IMMUNOASSAY; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; ULCERATIVE COLITIS; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICALLY INDUCED; COLITIS, ULCERATIVE; DISEASE MODEL; DRUG EFFECTS; ENERGY METABOLISM; IMMUNOLOGY; PATHOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

AMLODIPINE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; COLITIS, ULCERATIVE; COLON; DINOPROSTONE; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; INTERLEUKIN-1BETA; MALE; MALONDIALDEHYDE; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA; UBIQUINONE;

EID: 84931052765     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2015.1021357     Document Type: Article

References (58)

1. Puneet KR, Kavinder S, Nirmal S, Amteshwar SJ A review on chemical-induced inflammatory bowel disease models in rodents. Korean J Physiol Pharmacol. 2014; 18: 279-288
2. Niu X, Fan T, Li W, et al. Protective effect of sanguinarine against acetic acid-induced ulcerative colitis in mice. Toxicol Appl Pharmacol. 2013; 267: 256-265
3. Neurath MF, Fuss I, Pasparakis M, et al. Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice. Eur J Immunol. 1997; 27: 1743-1750
4. Yao J, Wang JY, Liu L, et al. Anti-oxidant effects of resveratrol on mice with DSS-induced ulcerative colitis. Arch Med Res. 2010; 41: 288-294
5. Zhao L, Wu H, Zhao A, et al. The in vivo and in vitro study of polysaccharides from a two-herb formula on ulcerative colitis and potential mechanism of action. J Ethnopharmacol. 2014; 153: 151-159
6. Mustafa A, El-Medany A, Hagar HH, El-Medany G. Ginkgo biloba attenuates mucosal damage in a rat model of ulcerative colitis. Pharmacol Res. 2006; 53: 324-330
7. Tran MT, Mitchell TM, Kennedy DT, Gilles JT. Role of coenzyme Q10 in chronic heart failure, angina, and hypertension. Pharmacotherapy. 2001; 21: 797-806
8. Crane F. Biochemical functions of coenzyme Q10. J Am Coll Nutr. 2001; 20: 591-598
9. Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007; 7: S78-S88
10. Kucharská J, Braunová Z, Ulicná O, et al. Deficit of coenzyme Q in heart and liver mitochondria of rats with streptozotocin-induced diabetes. Physiol Res. 2000; 49: 411-418
11. El-Abhar HS. Coenzyme Q10: a novel gastroprotective effect via modulation of vascular permeability, prostaglandin E2, nitric oxide and redox status in indomethacin-induced gastric ulcer model. Eur J Pharmacol. 2010; 649: 314-319
12. Lee J, Hong YS, Jeong JH, et al. Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines. PLoS One. 2013; 8: e69362
13. Kaplan NM. Amlodipine in the treatment of hypertension. Postgrad Med J. 1991; 67: 15-19
14. Pronobesh C, Dagagi AV, Pallab C, Kumar WA. Protective role of the calcium channel blocker amlodipine against mitochondrial injury in ischemia and reperfusion injury of rat liver. Acta Pharm. 2008; 58: 421-428
15. Li XQ, Cao W, Li T, et al. Amlodipine inhibits TNF-Alpha production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway. Int Immunopharmacol. 2009; 9: 1032-1041
16. Salehi I, Mohammadi M, Mirzaei F, Soufi FG. Amlodipine attenuates oxidative stress in the heart and blood of high-cholesterol diet rabbits. Cardiovasc J Afr. 2012; 23: 18-22
17. Patil AN, Advani MG, Mali SN, et al. Evaluation of anti-ulcer effect of amlodipine in gastric ulcer models in rats. Indian J Pharmacol. 2012; 44: 387-389
18. Fouad AA, Al-Sultan AI, Refaie SM, Yacoubi MT. Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice. Toxicology. 2010; 274: 49-56
19. Kawai H, Deguchi S, Deguchi K, et al. Synergistic benefit of combined amlodipine plus atorvastatin on neuronal damage after stroke in Zucker metabolic rat. Brain Res. 2011; 1368: 317-323
20. Millar AD, Rampton DS, Chander CL, et al. Evaluating the antioxidant potential of new treatments for inflammatory bowel disease using a rat model of colitis. Gut. 1996; 39: 407-415
21. Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem. 1978; 86: 271-278
22. Ukeda H, Maeda S, Ishii T, Sawamura M. Spectrophotometric assay for superoxide dismutase based on tetrazolium salt 30-{1-[(phenylamino)-carbonyl]-3,4-Tetrazolium}-bis(4-methoxy-6- nitro)benzenesulfonic acid hydrate reduction by xanthine-xanthine oxidase. Anal Biochem. 1997; 251: 206-209
23. Elson CO, Sartor RB, Tennyson GS, Riddell RH. Experimental models of inflammatory bowel disease. Gastroenterology. 1995; 109: 1344-1367
24. Narayanan K, Chandrasekharan G. Protective effect of Bauhinia tomentosa on acetic acid induced ulcerative colitis by regulating antioxidant and inflammatory mediators. Int Immunopharmacol. 2013; 16: 57-66
25. Krieglstein CF, Cerwinka WH, Laroux FS, et al. Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide. J Exp Med. 2001; 194: 1207-1218
26. Barazzone C, White CW. Mechanisms of cell injury and death in hyperoxia: role of cytokines and Bcl-2 family proteins. Am J Respir Cell Mol Biol. 2000; 22: 517-519
27. Nulton-Persson AC, Szweda LI. Modulation of mitochondrial function by hydrogen peroxide. J Biol Chem. 2001; 276: 23357-23361
28. Panov A, Dikalov S, Shalbuyeva N, et al. Species-And tissue specific relationships between mitochondrial permeability transition and generation of ROS in brain and liver mitochondria of rats and mice. Am J Physiol Cell Physiol. 2007; 292: C708-C718
29. Singh RB, Niaz MA, Vipul R, Raj K. Coenzyme Q10 and the heart. Pak Heart J. 1998; 31: 3-4
30. Dogan Z, Ergul B, Sarikaya M, et al. The protective effect of Echinacea spp. (Echinacea angustifolia and Echinacea purpurea) in a rat colitis model induced by acetic acid. Pak J Pharm Sci. 2014; 27: 1827-1835
31. Jainu M, Mohan KV, Devi CS. Protective effect of Cissus quadrangularis on neutrophil mediated tissue injury induced by aspirin in rats. J Ethnopharmacol. 2006; 104: 302-305
32. Kettle AJ, Gedye CA, Winterbourn CC. Mechanism of inactivation of myeloperoxidase by 4-Aminobenzoic acid hydrazide. Biochem J. 1997; 15: 503-508
33. Eigler A, Sinha B, Hartmann G, Endres S. Taming TNF: strategies to restrain this proinflammatory cytokine. Immunol Today. 1997; 18: 487-492
34. Seiko N, Douglas RS, Larry WO, et al. Evidence for oxidative stress in NSAID-induced colitis in IL10/ mice. Free Radic Biol Med. 2003; 34: 1153-1166
35. Fiorentino DF, Zlotnik A, Mosmann TR, et al. IL-10 inhibits cytokine production by activated macrophages. J Immunol. 1991; 147: 3815-3822
36. Laichalk LL, Danforth JM, Standiford TJ. Interleukin-10 inhibits neutrophil phagocytic and bactericidal activity. FEMS Immunol Med Microbiol. 1996; 15: 181-187
37. Akagi R, Ohno M, Matsubara K, et al. Glutamine protects intestinal barrier function of colon epithelial cells from ethanol by modulating Hsp70 expression. Pharmacology. 2013; 91: 104-111
38. El Golli-Bennour E, Bacha H. Hsp70 expression as biomarkers of oxidative stress: mycotoxins' exploration. Toxicology. 2011; 287: 1-7
39. Gotoh T, Terada K, Oyadomari S, Mori M. hsp70-DnaJ chaperone pair prevents nitric oxide- And CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. Cell Death Differ. 2004; 11: 390-402
40. Sohet FM, Neyrinck AM, Pachikian BD, et al. Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice. Biochem Pharmacol. 2009; 78: 1391-1400
41. Tsuneki H, Sekizaki N, Suzuki T, et al. Coenzyme Q10 prevents high glucose-induced oxidative stress in human umbilical vein endothelial cells. Eur J Pharmacol. 2007; 566: 1-10
42. James AM, Smith RA, Murphy MP. Antioxidant and prooxidant properties of mitochondrial coenzyme Q. Arch Biochem Biophys. 2004; 423: 47-56
43. Beal MF. Coenzyme Q10 as a possible treatment for neurodegenerative diseases. Free Radic Res. 2002; 36: 455-460
44. Beal MF, Henshaw DR, Jenkins BG, et al. Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate. Ann Neurol. 1994; 36: 882-888
45. Bonakdar RA, Guarneri E. Coenzyme Q10. Am Fam Physician. 2005; 72: 1065-1070
46. Chang Y, Huang SK, Wang SJ. Coenzyme Q10 inhibits the release of glutamate in rat cerebrocortical nerve terminals by suppression of voltage dependent calcium influx and mitogen-Activated protein kinase signaling pathway. J Agric Food Chem. 2012; 60: 11909-11918
47. Kikuya M, Hozawa A, Ohokubo T, et al. Prognostic significance of blood pressure and heart rate variabilities: the Ohasama study. Hypertension. 2000; 36: 901-906
48. Mason RP. Mechanisms of plaque stabilization for the dihydropyridine calcium channel blocker amlodipine: review of the evidence. Atherosclerosis. 2002; 165: 191-199
49. Zhang X, Deguchi S, Deguchi K, et al. Amlodipine and atorvastatin exert protective and additive effects via antiapoptotic and antiautophagic mechanisms after transient middle cerebral artery occlusion in Zucker metabolic syndrome rats. J Neurosci Res. 2011; 89: 1228-1234
50. Pronobesh C, Dagagi AV, Pallab C, Kumar WA. Protective role of the calcium channel blocker amlodipine against mitochondrial injury in ischemia and reperfusion injury of rat liver. Acta Pharm. 2008; 58: 421-428
51. Sathish V, Ebenezar KK, Devaki T. Biochemical changes on the cardioprotective effect of nicorandil and amlodipine during experimental myocardial infarction in rats. Pharmacol Res. 2003; 48: 565-570
52. Kim JM, Park E. Coenzyme Q10 attenuated DMH-induced precancerous lesions in SD rats. J Nutr Sci Vitaminol. 2010; 56: 139-144
53. Kunitomo M, Yamaguchi Y, Kagota S, Otsubo K. Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual metabolic components developing in a rat model of metabolic syndrome. J Pharmacol Sci. 2008; 107: 128-137
54. Choi BS, Song HS, Kim HR, et al. Effect of coenzyme Q10 on cutaneous healing in skin-incised mice. Arch Pharm Res. 2009; 32: 907-913
55. Jin HJ, Xue Y, Chen G, Wu ZY. Effect of coenzyme Q10 on the expression of tumor necrosis factor-A and interleukin-10 in gingival tissue of experimental periodontitis in rats. Zhonghua Kou Qiang Yi Xue Za Zhi. 2013; 48: 660-663
56. Ishikawa J, Ohga K, Yoshino T, et al A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes. J Immunol. 2003; 1: 4441-4449
57. Ben-Sreti MM, Gonzalez JP, Sewell RD. Effects of elevated calcium and calcium antagonists on 6, 7-benzomorphan-induced analgesia. Eur J Pharmacol. 1983; 90: 385-391
58. Otani T, Yamaguchi K, Scherl E, et al. Levels of NAD(+)- dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNFalpha. Am J Physiol Gastrointestinal Liver Physiol. 2006; 290: G361-G368