Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons

Science

Volumn 348, Issue 6240, 2015, Pages 1255-1260

  Kumar, Natasha N ^a   Velic, Ana ^b   Soliz, Jorge ^b,c   Shi, Yingtang ^a   Li, Keyong ^a   Wang, Sheng ^a,d   Weaver, Janelle L ^a   Sen, Josh ^a   Abbott, Stephen B G ^a,e,f   Lazarenko, Roman M ^a   Ludwig, Marie Gabrielle ^g   Perez Reyes, Edward ^a   Mohebbi, Nilufar ^b   Bettoni, Carla ^b   Gassmann, Max ^b   Suply, Thomas ^g   Seuwen, Klaus ^g   Guyenet, Patrice G ^a   Wagner, Carsten A ^b   Bayliss, Douglas A ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c LAVAL UNIVERSITY   (Canada)

^d HEBEI MEDICAL UNIVERSITY   (China)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

^f HARVARD MEDICAL SCHOOL   (United States)

^g NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; G PROTEIN COUPLED RECEPTOR; POTASSIUM CHANNEL; GPR4 PROTEIN, MOUSE; KCNK5 PROTEIN, MOUSE; TANDEM PORE DOMAIN POTASSIUM CHANNEL;

BLOOD; BRAIN; CARBON DIOXIDE; HOMEOSTASIS; NERVOUS SYSTEM; PH; RESPIRATION;

ANIMAL CELL; APNEA; ARTICLE; CELL ACTIVATION; GENE DELETION; GENE DISRUPTION; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RESPIRATION CONTROL; RETROTRAPEZOID NUCLEUS NEURON; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BREATHING; C57BL MOUSE; CYTOLOGY; FEMALE; GENETICS; MALE; METABOLISM; MUTANT MOUSE STRAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; RESPIRATORY ACIDOSIS; TRAPEZOID BODY;

ACIDOSIS, RESPIRATORY; ANIMALS; CARBON DIOXIDE; FEMALE; GENE DELETION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEURONS; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; RECEPTORS, G-PROTEIN-COUPLED; RESPIRATION; TRAPEZOID BODY;

EID: 84931034183     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaa0922     Document Type: Article

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