Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor

Angiogenesis

Volumn 14, Issue 4, 2011, Pages 533-544

  Wyder, Lorenza ^a,b   Suply, Thomas ^a   Ricoux, Bérangère ^a   Billy, Eric ^a   Schnell, Christian ^a   Baumgarten, Birgit U ^a   Maira, Sauveur Michel ^a   Koelbing, Claudia ^a   Ferretti, Mireille ^a   Kinzel, Bernd ^a   Müller, Matthias ^a   Seuwen, Klaus ^a   Ludwig, Marie Gabrielle ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b ACTELION PHARMACEUTICALS LTD   (Switzerland)

Author keywords

Acidosis; Angiogenesis; Endothelium; Hypoxia; Tumor

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 4; MESSENGER RNA; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ACIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL DENSITY; BLOOD VESSEL LENGTH; BLOOD VESSEL PARAMETERS; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; FEMALE; GENE EXPRESSION; HISTOLOGY; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MALE; MARKER GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR VOLUME;

ANIMALS; BLOTTING, WESTERN; CELL PROLIFERATION; COMPUTATIONAL BIOLOGY; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLAST GROWTH FACTOR 2; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HELA CELLS; HUMANS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

ANIMALIA; MUS;

EID: 84855188299     PISSN: 09696970     EISSN: 15737209     Source Type: Journal    
DOI: 10.1007/s10456-011-9238-9     Document Type: Article

References (35)

1. MG Ludwig M Vanek D Guerini JA Gasser CE Jones U Junker H Hofstetter RM Wolf K Seuwen 2003 Proton-sensing G-protein-coupled receptors Nature 425 93 98 12955148 10.1038/nature01905 1:CAS:528:DC%2BD3sXmvFansrw%3D (Pubitemid 37101724)
2. JQ Wang J Kon C Mogi M Tobo A Damirin K Sato M Komachi E Malchinkhuu N Murata T Kimura A Kuwabara K Wakamatsu H Koizumi T Uede G Tsujimoto H Kurose T Sato A Harada N Misawa H Tomura F Okajima 2004 TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor J Biol Chem 279 45626 456633 15326175 10.1074/jbc.M406966200 1:CAS:528:DC%2BD2cXovVCns7s%3D (Pubitemid 39491550)
3. S Ishii Y Kihara T Shimizu 2005 Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor J Biol Chem 280 9083 9087 15618224 10.1074/jbc.M407832200 1:CAS:528:DC%2BD2MXitVCitL8%3D (Pubitemid 40409602)
4. K Seuwen MG Ludwig RM Wolf 2006 Receptors for protons or lipid messengers or both? J Recept Signal Transduct Res 26 599 610 17118800 10.1080/ 10799890600932220 1:CAS:528:DC%2BD28XhtF2rt7nE (Pubitemid 44849907)
5. H Lum J Qiao RJ Walter F Huang PV Subbaiah KS Kim O Holian 2003 Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells Am J Physiol Heart Circ Physiol 285 1786 1789
6. KS Kim J Ren Y Jiang Q Ebrahem R Tipps K Cristina YJ Xiao J Qiao KL Taylor H Lum B Anand-Apte Y Xu 2005 GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine FASEB J 19 819 821 15857892 1:CAS:528:DC%2BD2MXktVKmsbk%3D (Pubitemid 40617395)
7. J Qiao F Huang RP Naikawadi KS Kim T Said H Lum 2006 Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4 Am J Physiol Lung Cell Mol Physiol 291 91 101 10.1152/ajplung.00508.2005
8. F Huang D Mehta S Predescu KS Kim H Lum 2007 A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration Endothelium 14 25 34 17364894 10.1080/10623320601177288 1:CAS:528:DC%2BD2sXkvFWmsrs%3D (Pubitemid 46978767)
9. Y Zou CH Kim JH Chung JY Kim SW Chung MK Kim DS Im J Lee BP Yu HY Chung 2007 Upregulation of endothelial adhesion molecules by lysophosphatidylcholine. Involvement of G protein-coupled receptor GPR4 FEBS J 274 2573 2584 17437524 10.1111/j.1742-4658.2007.05792.x 1:CAS:528:DC%2BD2sXmtFGltr0%3D (Pubitemid 46669342)
10. LV Yang CG Radu M Roy S Lee J McLaughlin MA Teitell ML Iruela-Arispe ON Witte 2007 Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor Mol Cell Biol 27 1334 1347 17145776 10.1128/MCB.01909-06 1:CAS:528:DC%2BD2sXit1amsrk%3D (Pubitemid 46239816)
11. G Bergers LE Benjamin 2003 Tumorigenesis and the angiogenic switch Nat Rev Cancer 3 401 410 12778130 10.1038/nrc1093 1:CAS:528:DC%2BD3sXktFOnsb8%3D (Pubitemid 37328844)
12. VL Heath R Bicknell 2009 Anticancer strategies involving the vasculature Nat Rev Clin Oncol 6 395 404 19424102 10.1038/nrclinonc.2009.52 1:CAS:528:DC%2BD1MXnslKks78%3D
13. JR Griffiths 1991 Are cancer cells acidic ? Br J Cancer 64 425 427 1911181 10.1038/bjc.1991.326 1:CAS:528:DyaK38XotFahtw%3D%3D
14. RA Gatenby RJ Gillies 2004 Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4 891 899 15516961 10.1038/nrc1478 1:CAS:528:DC%2BD2cXptFegt7w%3D (Pubitemid 39472955)
15. J Chiche MC Brahimi-Horn J Pouyssegur 2010 Tumor hypoxia induces a metabolic shift causing acidosis: a common feature in cancer J Cell Mol Med 14 771 794 20015196 10.1111/j.1582-4934.2009.00994.x 1:CAS:528:DC%2BC3cXnvVagtr0%3D
16. SS Gambhir 2002 Molecular imaging of cancer with positron emission tomography Nat Rev Cancer 2 683 693 12209157 10.1038/nrc882 1:CAS:528: DC%2BD38Xmslanu7c%3D (Pubitemid 37328919)
17. MG Vander Heiden LC Cantley CB Thompson 2009 Understanding the Warburg effect: the metabolic requirements of cell proliferation Science 324 1029 1033 19460998 10.1126/science.1160809 1:CAS:528:DC%2BD1MXmtVKlsbg%3D
18. HJ Park JC Lyons T Ohtsubo CW Song 1999 Acidic environment causes apoptosis by increasing caspase activity Br J Cancer 80 1892 1897 10471036 10.1038/sj.bjc.6690617 1:CAS:528:DyaK1MXlvVaisrw%3D (Pubitemid 29391271)
19. EK Rofstad B Mathiesen K Kindem K Galappathi 2006 Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice Cancer Res 66 6699 6707 16818644 10.1158/0008-5472.CAN-06-0983 1:CAS:528:DC%2BD28XmsVamu74%3D (Pubitemid 44085627)
20. K DeClerck RC Eble 2010 The role of hypoxia and acidosis in promoting metastasis and resistance to chemotherapy Front Biosci 15 213 225 20036816 10.2741/3616 1:CAS:528:DC%2BC3cXovFamtrs%3D
21. MC Brahimi-Horn J Pouyssegur 2007 Hypoxia in cancer cell metabolism and pH regulation Essays Biochem 43 165 178 17705800 10.1042/BSE0430165 1:CAS:528:DC%2BD2sXhtFGqtbfP
22. Y Salomon 1979 Adenylate cyclase assay Adv Cyclic Nucleotide Res 10 35 55 222124 1:CAS:528:DyaE1MXksFWlsL4%3D
23. D Hüsken F Asselbergs B Kinzel F Natt J Weiler P Martin R Häner J Hall 2003 mRNA fusion constructs serve in a general cell-based assay to profile oligonucleotide activity Nucleic Acids Res 31 102 10.1093/nar/gng103
24. J Wood K Bonjean S Ruetz A Bellahcène L Devy JM Foidart V Castronovo JR Green 2002 Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid J Pharmacol Exp Ther 302 1055 1061 12183663 10.1124/jpet.102.035295 1:CAS:528:DC%2BD38XmsF2hsbc%3D (Pubitemid 34920226)
25. JM Wood G Bold E Buchdunger R Cozens S Ferrari J Frei F Hofmann J Mestan H Mett T O'Reilly E Persohn J Rosel C Schnell D Stover A Theuer H Towbin F Wenger K Woods-Cook A Menrad G Siemeister M Schirner KH Thierauch MR Schneider J Drevs G Martiny-Baron F Totzke 2000 PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration Cancer Res 60 2178 2189 10786682 1:CAS:528: DC%2BD3cXivVaksb0%3D (Pubitemid 30225181)
26. G Martiny-Baron P Holzer E Billy C Schnell J Brueggen M Ferretti N Schmiedeberg JM Wood P Furet P Imbach 2010 The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis Angiogenesis 13 259 267 20803239 10.1007/s10456-010-9183-z 1:CAS:528:DC%2BC3cXhtFyis7fN
27. M Ehrbar VG Djonov C Schnell SA Tschanz G Martiny-Baron U Schenk J Wood PH Burri JA Hubbell AH Zisch 2004 Cell-demanded liberation of VEGF121 from fibrin implants induces local and controlled blood vessel growth Circ Res 94 1124 1132 15044320 10.1161/01.RES.0000126411.29641.08 1:CAS:528: DC%2BD2cXjt1ylu7Y%3D (Pubitemid 38579708)
28. SS Chae JH Paik H Furneaux T Hla 2004 Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference J Clin Invest 114 1082 1089 15489955 1:CAS:528:DC%2BD2cXovVensrs%3D (Pubitemid 39578697)
29. W Fiedler H Serve H Döhner M Schwittay OG Ottmann AM O'Farrell CL Bello R Allred WC Manning JM Cherrington SG Louie W Hong NM Brega G Massimini P Scigalla WE Berdel DK Hossfeld 2005 A phase 1 study of SU11248 in the treatment of patients withrefractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease Blood 105 986 993 15459012 10.1182/blood-2004-05-1846 1:CAS:528:DC%2BD2MXhtFCgsLY%3D (Pubitemid 40170865)
30. SB Wedam JA Low SX Yang CK Chow P Choyke D Danforth SM Hewitt A Berman SM Steinberg DJ Liewehr J Plehn A Doshi D Thomasson N McCarthy H Koeppen M Sherman J Zujewski K Camphausen H Chen SM Swain 2006 Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer J Clin Oncol 24 769 777 16391297 10.1200/JCO.2005.03.4645 1:CAS:528:DC%2BD28XitVGisbY%3D (Pubitemid 46622044)
31. M Grunewald I Avraham Y Dor E Bachar-Lustig A Itin S Jung S Chimenti L Landsman R Abramovitch E Keshet 2006 VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells Cell 124 175 189 16413490 10.1016/j.cell.2005.10.036 1:CAS:528:DC%2BD28XntVGkug%3D%3D (Pubitemid 43069318)
32. SB Coffelt CE Lewis L Naldini JM Brown N Ferrara M De Palma 2010 Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors Am J Pathol 176 1564 1576 20167863 10.2353/ajpath.2010.090786
33. S Tazzyman CE Lewis C Murdoch 2009 Neutrophils: key mediators of tumour angiogenesis Int J Exp Pathol 90 222 231 19563607 10.1111/j.1365-2613.2009. 00641.x 1:CAS:528:DC%2BD1MXotV2ju7g%3D
34. C Murdoch M Muthana SB Coffelt CE Lewis 2008 The role of myeloid cells in the promotion of tumour angiogenesis Nat Rev Cancer 8 618 631 18633355 10.1038/nrc2444 1:CAS:528:DC%2BD1cXovV2lsrY%3D
35. SB Coffelt R Hughes CE Lewis 2009 Tumor-associated macrophages: effectors of angiogenesis and tumor progression Biochim Biophys Acta 1796 11 18 19269310 1:CAS:528:DC%2BD1MXhtVenurvN