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Volumn 46, Issue 1, 2015, Pages

The long subclinical phase of Mycobacterium avium ssp. Paratuberculosis infections explained without adaptive immunity Modeling Johne's disease: From the inside out Dr Ad Koets and Prof Yrjo Grohn

Author keywords

[No Author keywords available]

Indexed keywords

MYCOBACTERIUM AVIUM;

EID: 84931025272     PISSN: 09284249     EISSN: 12979716     Source Type: Journal    
DOI: 10.1186/s13567-015-0202-3     Document Type: Article
Times cited : (13)

References (47)
  • 1
    • 84455194826 scopus 로고    scopus 로고
    • A meta-analysis of the effect of dose and age at exposure on shedding of Mycobacterium avium subspecies paratuberculosis (MAP) in experimentally infected calves and cows
    • 1:STN:280:DC%2BC38%2FosVWqsQ%3D%3D 21524342
    • Mitchell RM, Medley GF, Collins MT, Schukken YH (2012) A meta-analysis of the effect of dose and age at exposure on shedding of Mycobacterium avium subspecies paratuberculosis (MAP) in experimentally infected calves and cows. Epidemiol Infect 140:231-246
    • (2012) Epidemiol Infect , vol.140 , pp. 231-246
    • Mitchell, R.M.1    Medley, G.F.2    Collins, M.T.3    Schukken, Y.H.4
  • 2
    • 0016651734 scopus 로고
    • Age of cattle as related to resistance to infection with Mycobactierium paratuberculosis
    • 1:STN:280:DyaE2M7gslensA%3D%3D 1115424
    • Larsen AB, Merkal RS, Cutlip RC (1975) Age of cattle as related to resistance to infection with Mycobactierium paratuberculosis. Am J Vet Res 36:255-257
    • (1975) Am J Vet Res , vol.36 , pp. 255-257
    • Larsen, A.B.1    Merkal, R.S.2    Cutlip, R.C.3
  • 4
    • 0032113583 scopus 로고    scopus 로고
    • Interferon-gamma and interleukin 4 gene expression in cows infected with Mycobacterium paratuberculosis
    • 1:CAS:528:DyaK1cXntFSqtLc%3D 9659548
    • Sweeney RW, Jones DE, Habecker P, Scott P (1998) Interferon-gamma and interleukin 4 gene expression in cows infected with Mycobacterium paratuberculosis. Am J Vet Res 59:842-847
    • (1998) Am J Vet Res , vol.59 , pp. 842-847
    • Sweeney, R.W.1    Jones, D.E.2    Habecker, P.3    Scott, P.4
  • 5
    • 0034695118 scopus 로고    scopus 로고
    • Transitions in immune responses to Mycobacterium paratuberculosis
    • 1:CAS:528:DC%2BD3cXoslKnu70%3D 11118731
    • Stabel JR (2000) Transitions in immune responses to Mycobacterium paratuberculosis. Vet Microbiol 77:465-473
    • (2000) Vet Microbiol , vol.77 , pp. 465-473
    • Stabel, J.R.1
  • 6
    • 0036084074 scopus 로고    scopus 로고
    • Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gamma delta T cells, and related changes in T-cell function
    • 1:CAS:528:DC%2BD38XkvV2ksb4%3D 128076 12065529
    • Koets A, Rutten V, Hoek A, van Mil F, Müller K, Bakker D, Gruys E, van Eden W (2002) Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gamma delta T cells, and related changes in T-cell function. Infect Immun 70:3856-3864
    • (2002) Infect Immun , vol.70 , pp. 3856-3864
    • Koets, A.1    Rutten, V.2    Hoek, A.3    Van Mil, F.4    Müller, K.5    Bakker, D.6    Gruys, E.7    Van Eden, W.8
  • 7
    • 0039890174 scopus 로고    scopus 로고
    • Mycobacterium avium subsp. Paratuberculosis: Pathogen, pathogenesis and diagnosis
    • 1:STN:280:DC%2BD3M7pvFKlsQ%3D%3D 11288509
    • Manning EJB, Colline MT (2001) Mycobacterium avium subsp. Paratuberculosis: pathogen, pathogenesis and diagnosis. Rev Sci Tech 20:133-150
    • (2001) Rev Sci Tech , vol.20 , pp. 133-150
    • Manning, E.J.B.1    Colline, M.T.2
  • 8
    • 58149252446 scopus 로고    scopus 로고
    • Review paper: Modulation of mononuclear phagocyte function by Mycobacterium avium subsp. Paratuberculosis
    • 1:CAS:528:DC%2BD1cXhsVKjtL%2FI 18984786
    • Weiss DJ, Souza CD (2008) Review paper: modulation of mononuclear phagocyte function by Mycobacterium avium subsp. Paratuberculosis. Vet Pathol 45:829-841
    • (2008) Vet Pathol , vol.45 , pp. 829-841
    • Weiss, D.J.1    Souza, C.D.2
  • 9
    • 33645037866 scopus 로고    scopus 로고
    • Mucosal immune response in cattle with subclinical Johne's disease
    • 1:CAS:528:DC%2BD28Xjt12msb4%3D 16537930
    • Weiss DJ, Evanson OA, Souza CD (2006) Mucosal immune response in cattle with subclinical Johne's disease. Vet Pathol 43:127-135
    • (2006) Vet Pathol , vol.43 , pp. 127-135
    • Weiss, D.J.1    Evanson, O.A.2    Souza, C.D.3
  • 12
    • 12144288927 scopus 로고    scopus 로고
    • Neutralization of interleukin-10 significantly enhances gamma interferon expression in peripheral blood by stimulation with Johnin purified protein derivative and by infection with Mycobacterium avium subsp. Paratuberculosis in experimentally infected cattle with paratuberculosis
    • 1:CAS:528:DC%2BD2cXjt1eku70%3D 375198 15039374
    • Buza JJ, Hikono H, Mori Y, Nagata R, Hirayama S, Bari AM, Shu Y, Tsuji NM, Momotani E (2004) Neutralization of interleukin-10 significantly enhances gamma interferon expression in peripheral blood by stimulation with Johnin purified protein derivative and by infection with Mycobacterium avium subsp. Paratuberculosis in experimentally infected cattle with paratuberculosis. Infect Immun 72:2425-2428
    • (2004) Infect Immun , vol.72 , pp. 2425-2428
    • Buza, J.J.1    Hikono, H.2    Mori, Y.3    Nagata, R.4    Hirayama, S.5    Bari, A.M.6    Shu, Y.7    Tsuji, N.M.8    Momotani, E.9
  • 14
    • 79957589021 scopus 로고    scopus 로고
    • Does a Th1 over Th2 dominancy really exist in the early stages of Mycobacterium avium subspecies paratuberculosis infections?
    • 1:CAS:528:DC%2BC3MXmvVehtr4%3D 21281979
    • Begg DJ, De Silva K, Carter N, Plain KM, Purdie A, Whittington RJ (2011) Does a Th1 over Th2 dominancy really exist in the early stages of Mycobacterium avium subspecies paratuberculosis infections? Immunobiology 216:840-846
    • (2011) Immunobiology , vol.216 , pp. 840-846
    • Begg, D.J.1    De Silva, K.2    Carter, N.3    Plain, K.M.4    Purdie, A.5    Whittington, R.J.6
  • 15
    • 84931043273 scopus 로고    scopus 로고
    • Evaluating the contribution of the cellular and humoral immune responses to the control of shedding of Mycobacterium avium ssp
    • Vet Res (in press)
    • Ganusov VV, Klinkenberg D, Bakker D, Koets AP (2015) Evaluating the contribution of the cellular and humoral immune responses to the control of shedding of Mycobacterium avium ssp. Paratuberculosis in cattle. Vet Res (in press).
    • (2015) Paratuberculosis in Cattle
    • Ganusov, V.V.1    Klinkenberg, D.2    Bakker, D.3    Koets, A.P.4
  • 18
    • 27944470003 scopus 로고    scopus 로고
    • Advanced granulomatous lesions in Mycobacterium bovis-infected cattle are associated with increased expression of type i procollagen, gammadelta (WC1+) T cells and CD 68+ cells
    • 1:CAS:528:DC%2BD2MXhtFOmtL3O 16154140
    • Wangoo A, Johnson L, Gough J, Ackbar R, Inglut S, Hicks D, Spencer Y, Hewinson G, Vordermeier M (2005) Advanced granulomatous lesions in Mycobacterium bovis-infected cattle are associated with increased expression of type I procollagen, gammadelta (WC1+) T cells and CD 68+ cells. J Comp Pathol 133:223-234
    • (2005) J Comp Pathol , vol.133 , pp. 223-234
    • Wangoo, A.1    Johnson, L.2    Gough, J.3    Ackbar, R.4    Inglut, S.5    Hicks, D.6    Spencer, Y.7    Hewinson, G.8    Vordermeier, M.9
  • 20
    • 0023782059 scopus 로고
    • Effect of glucocorticoids on cows suspected of subclinical infection with M. Paratuberculosis
    • 1:STN:280:DyaL1c3jslWqtQ%3D%3D 3376411
    • Wentink GH, Rutten VP, Jaartsveld FH, Zeeuwen AA, Van Kooten PJ (1988) Effect of glucocorticoids on cows suspected of subclinical infection with M. Paratuberculosis. Vet Q 10:57-62
    • (1988) Vet Q , vol.10 , pp. 57-62
    • Wentink, G.H.1    Rutten, V.P.2    Jaartsveld, F.H.3    Zeeuwen, A.A.4    Van Kooten, P.J.5
  • 21
    • 0345714672 scopus 로고    scopus 로고
    • Mycobacterium avium aubsp. Paratuberculosis infection causes suppression of RANTES, monocyte chemoattractant protein 1, and tumor necrosis factor alpha expression in peripheral blood of experimentally infected cattle
    • 1:CAS:528:DC%2BD3sXpsFGnurY%3D 308884 14638822
    • Buza JJ, Mori Y, Bari AM, Hikono H, Aodon G, Hirayama S, Shu Y, Momotani E (2003) Mycobacterium avium aubsp. Paratuberculosis infection causes suppression of RANTES, monocyte chemoattractant protein 1, and tumor necrosis factor alpha expression in peripheral blood of experimentally infected cattle. Infect Immun 71:7223-7227
    • (2003) Infect Immun , vol.71 , pp. 7223-7227
    • Buza, J.J.1    Mori, Y.2    Bari, A.M.3    Hikono, H.4    Aodon, G.5    Hirayama, S.6    Shu, Y.7    Momotani, E.8
  • 22
    • 60549093834 scopus 로고    scopus 로고
    • Mycobacterium avium subspecies paratuberculosis suppresses expression of IL-12p40 and iNOS genes induced by signalling through CD40 in bovine monocyte-derived macrophages
    • 1:CAS:528:DC%2BD1MXisVOgurk%3D 19022505
    • Sommer S, Pudrith CB, Colvin CJ, Coussens PM (2009) Mycobacterium avium subspecies paratuberculosis suppresses expression of IL-12p40 and iNOS genes induced by signalling through CD40 in bovine monocyte-derived macrophages. Vet Immunol Immunopathol 128:44-52
    • (2009) Vet Immunol Immunopathol , vol.128 , pp. 44-52
    • Sommer, S.1    Pudrith, C.B.2    Colvin, C.J.3    Coussens, P.M.4
  • 23
    • 84857038209 scopus 로고    scopus 로고
    • Expression of genes associated with the antigen presentation and processing pathway are consistently regulated in early Mycobacterium avium subsp. Paratuberculosis infection
    • 22239946
    • Purdie AC, Plain KM, Begg DJ, De Silva K, Whittington RJ (2012) Expression of genes associated with the antigen presentation and processing pathway are consistently regulated in early Mycobacterium avium subsp. Paratuberculosis infection. Comp Immunol Microbiol Infect Dis 35:151-162
    • (2012) Comp Immunol Microbiol Infect Dis , vol.35 , pp. 151-162
    • Purdie, A.C.1    Plain, K.M.2    Begg, D.J.3    De Silva, K.4    Whittington, R.J.5
  • 24
    • 34247098883 scopus 로고    scopus 로고
    • The associations between culling due to clinical Johne's disease or the detection of Mycobacterium avium subsp paratuberculosis fecal shedding and the diagnosis of clinical or subclinical disease in two dairy herds in Minnesota, USA
    • 17368838
    • Raizman EA, Wells SJ, Godden SM, Fetrow J, Oakes JM (2007) The associations between culling due to clinical Johne's disease or the detection of Mycobacterium avium subsp paratuberculosis fecal shedding and the diagnosis of clinical or subclinical disease in two dairy herds in Minnesota, USA. Prev Vet Med 80:166-178
    • (2007) Prev Vet Med , vol.80 , pp. 166-178
    • Raizman, E.A.1    Wells, S.J.2    Godden, S.M.3    Fetrow, J.4    Oakes, J.M.5
  • 25
    • 33846344343 scopus 로고    scopus 로고
    • The association between Mycobacterium acium subsp. Paratuberculosis fecal shedding or clinical Johne's disease and lactation performance on two Minnesota, USA dairy farms
    • 17118473
    • Raizman EA, Fetrow J, Wells SJ, Godden SM, Oakes MJ, Vazquez G (2007) The association between Mycobacterium acium subsp. Paratuberculosis fecal shedding or clinical Johne's disease and lactation performance on two Minnesota, USA dairy farms. Prev Vet Med 78:179-195
    • (2007) Prev Vet Med , vol.78 , pp. 179-195
    • Raizman, E.A.1    Fetrow, J.2    Wells, S.J.3    Godden, S.M.4    Oakes, M.J.5    Vazquez, G.6
  • 26
    • 0040756400 scopus 로고    scopus 로고
    • Control of Mycobacterium avium subsp. Paratuberculosis infection in agricultural species
    • 1:STN:280:DC%2BD3M7pvFKltg%3D%3D 11288510
    • Kennedy DJ, Benedictus G (2001) Control of Mycobacterium avium subsp. Paratuberculosis infection in agricultural species. Rev Sci Tech 20:151-179
    • (2001) Rev Sci Tech , vol.20 , pp. 151-179
    • Kennedy, D.J.1    Benedictus, G.2
  • 27
    • 62149147607 scopus 로고    scopus 로고
    • Mathematical and computational approaches can complement experimental studies of host-pathogen interactions
    • 1:CAS:528:DC%2BD1MXktVajsrg%3D 2720090 19134115
    • Kirschner DE, Linderman JJ (2009) Mathematical and computational approaches can complement experimental studies of host-pathogen interactions. Cell Microbiol 11:531-539
    • (2009) Cell Microbiol , vol.11 , pp. 531-539
    • Kirschner, D.E.1    Linderman, J.J.2
  • 28
    • 79956287702 scopus 로고    scopus 로고
    • Predicting fadeout versus persistence of paratuberculosis in a dairy cattle herd for management and control purposes: A modelling study
    • 3053233 21324117
    • Marce C, Ezanno P, Seegers H, Pfeiffer DU, Fourichon C (2011) Predicting fadeout versus persistence of paratuberculosis in a dairy cattle herd for management and control purposes: a modelling study. Vet Res 42:36
    • (2011) Vet Res , vol.42 , pp. 36
    • Marce, C.1    Ezanno, P.2    Seegers, H.3    Pfeiffer, D.U.4    Fourichon, C.5
  • 29
    • 84871659437 scopus 로고    scopus 로고
    • Impact of imperfect Mycobacterium avium subsp paratuberculosis vaccines in dairy herds: A mathematical modeling approach
    • 22921715
    • Lu Z, Schukken YH, Smith RL, Mitchell RM, Grohn YT (2013) Impact of imperfect Mycobacterium avium subsp paratuberculosis vaccines in dairy herds: a mathematical modeling approach. Prev Vet Med 108:148-158
    • (2013) Prev Vet Med , vol.108 , pp. 148-158
    • Lu, Z.1    Schukken, Y.H.2    Smith, R.L.3    Mitchell, R.M.4    Grohn, Y.T.5
  • 30
    • 84896738474 scopus 로고    scopus 로고
    • Competition for antigen between Th1 and Th2 responses determines the timing of the immune response switch during Mycobacterium avium subspecies paratuberculosis infection in ruminants
    • e1003414 3886887 24415928
    • Magombedze G, Eda S, Ganusov VV (2014) Competition for antigen between Th1 and Th2 responses determines the timing of the immune response switch during Mycobacterium avium subspecies paratuberculosis infection in ruminants. PLoS Comput Biol 10:e1003414
    • (2014) PLoS Comput Biol , vol.10
    • Magombedze, G.1    Eda, S.2    Ganusov, V.V.3
  • 31
    • 0035253576 scopus 로고    scopus 로고
    • A model to predict cell-mediated immune regulatory mechanisms during human infection with Mycobacterium tuberculosis
    • 1:CAS:528:DC%2BD3MXhtVSis7c%3D 11160244
    • Wigginton JE, Kirschner D (2001) A model to predict cell-mediated immune regulatory mechanisms during human infection with Mycobacterium tuberculosis. J Immunol 166:1951-1967
    • (2001) J Immunol , vol.166 , pp. 1951-1967
    • Wigginton, J.E.1    Kirschner, D.2
  • 32
    • 77954465946 scopus 로고    scopus 로고
    • TNF and IL-10 are major factors in modulation of the phagocytic cell environment in lung and lymph node in tuberculosis: A next generation two-compartmental model
    • 1:CAS:528:DC%2BC3cXovFCitb4%3D 3150786 20510249
    • Marino S, Myers A, Flynn JL, Kirschner DE (2010) TNF and IL-10 are major factors in modulation of the phagocytic cell environment in lung and lymph node in tuberculosis: a next generation two-compartmental model. J Theor Biol 265:586-598
    • (2010) J Theor Biol , vol.265 , pp. 586-598
    • Marino, S.1    Myers, A.2    Flynn, J.L.3    Kirschner, D.E.4
  • 33
    • 67650433616 scopus 로고    scopus 로고
    • Modeling the immune rheostat of macrophages in the lung in response to infection
    • 1:CAS:528:DC%2BD1MXptVWlsL0%3D 2708732 19549875
    • Day J, Friedman A, Schlesinger LS (2009) Modeling the immune rheostat of macrophages in the lung in response to infection. Proc Natl Acad Sci U S A 106:11246-11251
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 11246-11251
    • Day, J.1    Friedman, A.2    Schlesinger, L.S.3
  • 34
    • 77958518502 scopus 로고    scopus 로고
    • Mathematical modeling of tuberculosis bacillary counts and cellular populations in the organs of infected mice
    • e12985 2944881 20886087
    • Bru A, Cardona PJ (2010) Mathematical modeling of tuberculosis bacillary counts and cellular populations in the organs of infected mice. PLoS One 5:e12985
    • (2010) PLoS One , vol.5
    • Bru, A.1    Cardona, P.J.2
  • 35
    • 16544371664 scopus 로고    scopus 로고
    • Macrophage response to Mycobacterium tuberculosis infection
    • 1:STN:280:DC%2BD2c%2FksVKitQ%3D%3D 14745511
    • Gammack D, Doering CR, Kirschner DE (2004) Macrophage response to Mycobacterium tuberculosis infection. J Math Biol 48:218-242
    • (2004) J Math Biol , vol.48 , pp. 218-242
    • Gammack, D.1    Doering, C.R.2    Kirschner, D.E.3
  • 36
    • 0014325451 scopus 로고
    • The origin and kinetics of mononuclear phagocytes
    • 2138527 5666958
    • Van Furth R, Cohn ZA (1968) The origin and kinetics of mononuclear phagocytes. J Exp Med 128:415-435
    • (1968) J Exp Med , vol.128 , pp. 415-435
    • Van Furth, R.1    Cohn, Z.A.2
  • 37
    • 0017814744 scopus 로고
    • The origin, kinetics, and characteristics of the Kupffer cells in the normal steady state
    • 1:CAS:528:DyaE1cXlt1Kqtrg%3D 2184923 670884
    • Crofton RW, Diesselhoff-den Dulk MM, Van Furth R (1978) The origin, kinetics, and characteristics of the Kupffer cells in the normal steady state. J Exp Med 148:1-17
    • (1978) J Exp Med , vol.148 , pp. 1-17
    • Crofton, R.W.1    Diesselhoff-Den Dulk, M.M.2    Van Furth, R.3
  • 38
    • 0018762078 scopus 로고
    • Origin, kinetics, and characteristics of pulmonary macrophages in the normal steady state
    • 1:STN:280:DyaE1M7psFOlsg%3D%3D 448291
    • van oud Alblas AB, van Furth R (1979) Origin, kinetics, and characteristics of pulmonary macrophages in the normal steady state. J Exp Med 149:1504-1518
    • (1979) J Exp Med , vol.149 , pp. 1504-1518
    • Van Oud Alblas, A.B.1    Van Furth, R.2
  • 39
    • 77956112107 scopus 로고    scopus 로고
    • The puzzle of intestinal lamina propria dendritic cells and macrophages
    • 1:CAS:528:DC%2BC3cXpsF2rsL0%3D 20853495
    • Pabst O, Bernhardt G (2010) The puzzle of intestinal lamina propria dendritic cells and macrophages. Eur J Immunol 40:2107-2111
    • (2010) Eur J Immunol , vol.40 , pp. 2107-2111
    • Pabst, O.1    Bernhardt, G.2
  • 41
    • 40449106691 scopus 로고    scopus 로고
    • The immune status of the bovine uterus during the peripartum period
    • 1:CAS:528:DC%2BD1cXjtlOqurk%3D 17400489
    • Singh J, Murray RD, Mshelia G, Woldehiwet Z (2008) The immune status of the bovine uterus during the peripartum period. Vet J 175:301-309
    • (2008) Vet J , vol.175 , pp. 301-309
    • Singh, J.1    Murray, R.D.2    Mshelia, G.3    Woldehiwet, Z.4
  • 42
    • 2542637276 scopus 로고    scopus 로고
    • Model for immune responses to Mycobacterium avium subspecies paratuberculosis in cattle
    • 1:CAS:528:DC%2BD2cXkslCitbc%3D 415675 15155609
    • Coussens PM (2004) Model for immune responses to Mycobacterium avium subspecies paratuberculosis in cattle. Infect Immun 72:3089-3096
    • (2004) Infect Immun , vol.72 , pp. 3089-3096
    • Coussens, P.M.1
  • 43
    • 77649126707 scopus 로고    scopus 로고
    • Dissecting cancer through mathematics: From the cell to the animal model
    • 1:CAS:528:DC%2BC3cXitlait7Y%3D 20179714
    • Byrne HM (2010) Dissecting cancer through mathematics: from the cell to the animal model. Nat Rev Cancer 10:221-230
    • (2010) Nat Rev Cancer , vol.10 , pp. 221-230
    • Byrne, H.M.1
  • 44
    • 84874284985 scopus 로고    scopus 로고
    • The granuloma in tuberculosis: Dynamics of a host-pathogen collusion
    • 3538277 23308075
    • Ehlers S, Schaible UE (2013) The granuloma in tuberculosis: dynamics of a host-pathogen collusion. Front Immunol 3:411
    • (2013) Front Immunol , vol.3 , pp. 411
    • Ehlers, S.1    Schaible, U.E.2
  • 45
    • 84891853921 scopus 로고    scopus 로고
    • Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing
    • 1:CAS:528:DC%2BC3sXhvFensLrN 3947310 24336248
    • Lin PL, Ford CB, Coleman MT, Myers AJ, Gawande R, Ioerger T, Sacchettini J, Fortune SM, Flynn JL (2014) Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing. Nat Med 20:75-79
    • (2014) Nat Med , vol.20 , pp. 75-79
    • Lin, P.L.1    Ford, C.B.2    Coleman, M.T.3    Myers, A.J.4    Gawande, R.5    Ioerger, T.6    Sacchettini, J.7    Fortune, S.M.8    Flynn, J.L.9
  • 46
    • 84906538047 scopus 로고    scopus 로고
    • Shedding patterns of dairy calves experimentally infected with Mycobacterium avium subspecies paratuberculosis
    • 4347591 25224905
    • Mortier RAR, Barkema HW, Orsel K, Wolf R, De Buck J (2014) Shedding patterns of dairy calves experimentally infected with Mycobacterium avium subspecies paratuberculosis. Vet Res 45:71
    • (2014) Vet Res , vol.45 , pp. 71
    • Mortier, R.A.R.1    Barkema, H.W.2    Orsel, K.3    Wolf, R.4    De Buck, J.5
  • 47
    • 34248545639 scopus 로고    scopus 로고
    • Horizontal transmission of Mycobacterium avium subsp paratuberculosis in cattle in an experimental setting: Calves can transmit the infection to other calves
    • 17317041
    • Van Roermund HJW, Bakker D, Willernsen PTJ, de Jong MCM (2007) Horizontal transmission of Mycobacterium avium subsp paratuberculosis in cattle in an experimental setting: Calves can transmit the infection to other calves. Vet Microbiol 122:270-279
    • (2007) Vet Microbiol , vol.122 , pp. 270-279
    • Van Roermund, H.J.W.1    Bakker, D.2    Willernsen, P.T.J.3    De Jong, M.C.M.4


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