Intravenous levetiracetam treatment in status epilepticus: A prospective study

Epilepsy Research

Volumn 114, Issue , 2015, Pages 13-22

  Atmaca, Murat Mert ^a   Orhan, Elif Kocasoy ^a   Bebek, Nerses ^a   Gurses, Candan ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Efficacy; Intravenous levetiracetam; Prospective; Status epilepticus; Systemic disease

Indexed keywords

BENZODIAZEPINE; CARBAMAZEPINE; CLONAZEPAM; DIAZEPAM; ETIRACETAM; MIDAZOLAM; PHENYTOIN; TOPIRAMATE; VALPROIC ACID; ANTICONVULSIVE AGENT; PIRACETAM;

ADOLESCENT; ADULT; ADVERSE OUTCOME; AGED; ARTICLE; BRAIN TUMOR; CEREBROVASCULAR DISEASE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DRUG EFFICACY; DRUG TREATMENT FAILURE; EMERGENCY WARD; EPILEPTIC STATE; FEMALE; HEADACHE; HOSPITAL SERVICE; HUMAN; INTENSIVE CARE UNIT; MALE; MENINGOENCEPHALITIS; MIDDLE AGED; MUSCLE SPASM; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; RISK FACTOR; SOMNOLENCE; TREATMENT OUTCOME; TREATMENT RESPONSE; VERY ELDERLY; YOUNG ADULT; ANALOGS AND DERIVATIVES; COMPLICATION; DRUG RESISTANT EPILEPSY; ELECTROENCEPHALOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; STATUS EPILEPTICUS; TREATMENT FAILURE;

ADMINISTRATION, INTRAVENOUS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTICONVULSANTS; DIAZEPAM; DRUG RESISTANT EPILEPSY; ELECTROENCEPHALOGRAPHY; FEMALE; HUMANS; MALE; MIDDLE AGED; PIRACETAM; PROSPECTIVE STUDIES; STATUS EPILEPTICUS; TREATMENT FAILURE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84931025185     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2015.04.003     Document Type: Article

References (34)

1. Aiguabella M., Falip M., Villanueva V., de la Pena P., Molins A., Garcia-Morales I., Saiz R.A., Pardo J., Tortosa D., Sansa G., Miro J. Efficacy of intravenous levetiracetam as an add-on treatment in status epilepticus: a multicentric observational study. Seizure 2011, 20:60-64.
2. Alvarez V., Januel J.M., Burnand B., Rossetti A.O. Second-line status epilepticus treatment: comparison of phenytoin, valproate, and levetiracetam. Epilepsia 2011, 52:1292-1296.
3. Berning S., Boesebeck F., van Baalen A., Kellinghaus C. Intravenous levetiracetam as treatment for status epilepticus. J. Neurol. 2009, 256:1634-1642.
4. Beyenburg S., Reuber M., Maraite N. Intravenous levetiracetam for epileptic seizure emergencies in older people. Gerontology 2009, 55:27-31.
5. Brevoord J.C., Joosten K.F., Arts W.F., van Rooij R.W., de Hoog M. Status epilepticus: clinical analysis of a treatment protocol based on midazolam and phenytoin. J. Child Neurol. 2005, 20:476-481.
6. Chen L., Zhou B., Li J.M., Zhu Y., Wang J.H., Sander J.W., Stefan H., Zhou D. Clinical features of convulsive status epilepticus: a study of 220 cases in western China. Eur. J. Neurol. 2009, 16:444-449.
7. Claassen J., Lokin J.K., Fitzsimmons B.F., Mendelsohn F.A., Mayer S.A. Predictors of functional disability and mortality after status epilepticus. Neurology 2002, 58:139-142.
8. Cockerell O.C., Rothwell J., Thompson P.D., Marsden C.D., Shorvon S.D. Clinical and physiological features of epilepsia partialis continua. Cases ascertained in the UK. Brain 1996, 119(Pt 2):393-407.
9. Crepeau A.Z., Treiman D.M. Levetiracetam: a comprehensive review. Expert Rev. Neurother. 2010, 10:159-171.
10. Dudra-Jastrzebska M., Andres-Mach M.M., Ratnaraj N., Patsalos P.N., Czuczwar S.J., Luszczki J.J. Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model. Seizure 2009, 18:607-614.
11. Eue S., Grumbt M., Muller M., Schulze A. Two years of experience in the treatment of status epilepticus with intravenous levetiracetam. Epilepsy Behav. 2009, 15:467-469.
12. Gamez-Leyva G., Aristin J.L., Fernandez E., Pascual J. Experience with intravenous levetiracetam in status epilepticus: a retrospective case series. CNS Drugs 2009, 23:983-987.
13. Holmes G.L. Seizure-induced neuronal injury: animal data. Neurology 2002, 59:S3-S6.
14. Kaplan P.W. The EEG of status epilepticus. J. Clin. Neurophysiol. 2006, 23:221-229.
15. Knake S., Gruener J., Hattemer K., Klein K.M., Bauer S., Oertel W.H., Hamer H.M., Rosenow F. Intravenous levetiracetam in the treatment of benzodiazepine refractory status epilepticus. J. Neurol. Neurosurg. Psychiatry 2008, 79:588-589.
16. Lynch B.A., Lambeng N., Nocka K., Kensel-Hammes P., Bajjalieh S.M., Matagne A., Fuks B. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:9861-9866.
17. Mazarati A.M., Baldwin R., Klitgaard H., Matagne A., Wasterlain C.G. Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus. Epilepsy Res. 2004, 58:167-174.
18. Misra U.K., Kalita J., Maurya P.K. Levetiracetam versus lorazepam in status epilepticus: a randomized, open labeled pilot study. J. Neurol. 2012, 259:645-648.
19. Moddel G., Bunten S., Dobis C., Kovac S., Dogan M., Fischera M., Dziewas R., Schabitz W.R., Evers S., Happe S. Intravenous levetiracetam: a new treatment alternative for refractory status epilepticus. J. Neurol. Neurosurg. Psychiatry 2009, 80:689-692.
20. Obeso J.A., Rothwell J.C., Marsden C.D. The spectrum of cortical myoclonus. From focal reflex jerks to spontaneous motor epilepsy. Brain 1985, 108(Pt 1):193-1124.
21. Ramael S., Daoust A., Otoul C., Toublanc N., Troenaru M., Lu Z.S., Stockis A. Levetiracetam intravenous infusion: a randomized, placebo-controlled safety and pharmacokinetic study. Epilepsia 2006, 47:1128-1135.
22. Rigo J.M., Hans G., Nguyen L., Rocher V., Belachew S., Malgrange B., Leprince P., Moonen G., Selak I., Matagne A., Klitgaard H. The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents. Br. J. Pharmacol. 2002, 136:659-672.
23. Rossetti A.O., Bromfield E.B. Levetiracetam in the treatment of status epilepticus in adults: a study of 13 episodes. Eur. Neurol. 2005, 54:34-38.
24. Rossetti A.O., Hurwitz S., Logroscino G., Bromfield E.B. Prognosis of status epilepticus: role of aetiology, age, and consciousness impairment at presentation. J. Neurol. Neurosurg. Psychiatry 2006, 77:611-615.
25. Rossetti A.O., Logroscino G., Milligan T.A., Michaelides C., Ruffieux C., Bromfield E.B. Status Epilepticus Severity Score (STESS): a tool to orient early treatment strategy. J. Neurol. 2008, 255:1561-1566.
26. Ruegg S., Naegelin Y., Hardmeier M., Winkler D.T., Marsch S., Fuhr P. Intravenous levetiracetam: treatment experience with the first 50 critically ill patients. Epilepsy Behav. 2008, 12:477-480.
27. Rupprecht S., Franke K., Fitzek S., Witte O.W., Hagemann G. Levetiracetam as a treatment option in non-convulsive status epilepticus. Epilepsy Res. 2007, 73:238-244.
28. Shorvon S., Baulac M., Cross H., Trinka E., Walker M. The drug treatment of status epilepticus in Europe: consensus document from a workshop at the first London Colloquium on Status Epilepticus. Epilepsia 2008, 49:1277-1285.
29. Stefan H., Feuerstein T.J. Novel anticonvulsant drugs. Pharmacol. Ther. 2007, 113:165-183.
30. Thomas J.E., Reagan T.J., Klass D.W. Epilepsia partialis continua. A review of 32 cases. Arch. Neurol. 1977, 34:266-275.
31. Trinka E., Dobesberger J. New treatment options in status epilepticus: a critical review on intravenous levetiracetam. Ther. Adv. Neurol. Disord. 2009, 2:79-91.
32. Tsuchida T.N., Barkovich A.J., Bollen A.W., Hart A.P., Ferriero D.M. Childhood status epilepticus and excitotoxic neuronal injury. Pediatr. Neurol. 2007, 36:253-257.
33. Uges J.W., van Huizen M.D., Engelsman J., Wilms E.B., Touw D.J., Peeters E., Vecht C.J. Safety and pharmacokinetics of intravenous levetiracetam infusion as add-on in status epilepticus. Epilepsia 2009, 50:415-421.
34. Wieser H.G., Chauvel P. Simple partial status epilepticus and epilepsia partialis continua of Kozhevnikov. Epilepsy: A Comprehensive Textbook 2008, 705-723. Wolters Kluwer, Philadelphia. 2nd ed. J. Engel, T.A. Pedley (Eds.).