Blood-brain barrier permeability in the periventricular areas of the normal mouse brain

Acta Neuropathologica

Volumn 99, Issue 4, 2000, Pages 385-392

  Ueno, Masaki ^a   Akiguchi, Ichiro ^b   Hosokawa, Masanori ^c   Kotani, Hirokazu ^a   Kanenishi, Kenji ^a   Sakamoto, Haruhiko ^a  

^a KAGAWA UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Blood brain barrier; Horseradish peroxidase; Perivascular cells; Periventricular area; Virchow Robin space

Indexed keywords

HORSERADISH PEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN INJURY; CHOROID PLEXUS; CYTOPLASM; ELECTRON MICROSCOPY; ENDOSOME; ENDOTHELIUM CELL; EPENDYMA; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; LATERAL BRAIN VENTRICLE; MACROMOLECULE; MEMBRANE VESICLE; MICROSCOPY; MOUSE; NONHUMAN; OPTIC TRACT; PRIORITY JOURNAL; STAINING; THEORY; ULTRASTRUCTURE; WHITE MATTER;

EID: 0034112249     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010051140     Document Type: Article

References (37)

1. Akiguchi I, Tomimoto H, Suenaga T, Wakita H, Budka H (1998) Blood-brain barrier dysfunction in Binswanger's disease; an immunohistochemical study. Acta Neuropathol 95 : 78-84
2. Balin BJ, Broadwell RD, Salcman M, El-Kalliny M (1986) Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey. J Comp Neurol 251 : 260-280
3. Banks WA, Broadwell RD (1994) Blood to brain and brain to blood passage of native horseradish peroxidase, wheat germ agglutinin, and albumin: pharmacokinetic and morphological assessments. J Neurochem 62 : 2404-2419
4. Becker NH, Zimmerman HM (1968) Observations of the distribution of exogenous peroxidase in the rat cerebrum. J Neuropathol Exp Neurol 27 : 439-452
5. Brightman MW, Reese TS (1969) Junctions between intimately apposed cell membranes in the vertebrate brain. J Cell Biol 40 : 648-677
6. Brightman MW, Klatzo I, Olsson Y, Reese TS (1970) The blood-brain barrier to proteins under normal and pathological conditions. J Neurol Sci 10 : 215-239
7. Broadwell RD, Banks WA (1993) A cell biological perspective for the transcytosis of peptides and proteins through the mammalian blood-brain fluid barriers. In: Pardridge WM (ed) The blood-brain barrier cellular and molecular biology. Raven Press, New York, pp 165-199
8. Broadwell RD, Brightman MW (1976) Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood. J Comp Neurol 166 : 257-284
9. Broadwell RD, Sofroniew MV (1993) Serum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous system. Exp Neurol 120 : 245-263
10. Brun A, Englund E (1986) A white matter disorder in dementia of the Alzheimer type: a patho-anatomical study. Ann Neurol 19 : 253-262
11. Esiri MM, Gay D (1990) Immunological and neuropathological significance of the Virchow-Robin space. J Neurol Sci 100 : 3-8
12. Feigin I, Popoff N (1963) Neuropathological changes late in cerebral edema: the relationship to trauma, hypertensive disease and Binswanger's encephalopathy. J Neuropathol Exp Neurol 22 : 500-511
13. Feigin I, Budzilovich G, Weinberg S (1973) Degeneration of white matter in hypoxia, acidosis and edema. J Neuropathol Exp Neurol 32 : 125-143
14. Ferrer I, Bella R, Serrano MT, Marti E, Guionnet N (1990) Arteriosclerotic leucoencephalopathy in the elderly and its relation to white matter lesions in Binswanger's disease, multi-infarct encephalopathy and Alzheimer's disease. J Neurol Sci 98 : 37-50
15. Graeber MB, Streit WJ, Buringer D, Sparks DL, Kreutzberg GW (1992) Ultrastructural location of major histocompatibility complex (MHC) class II positive perivascular cells in histologically normal human brain. J Neuropathol Exp Neurol 51 : 303-311
16. Hachinski VC, Potter P, Merskey H (1987) Leuko-araiosis. Arch Neurol 44 : 21-23
17. Hickey WF, Kimura H (1988) Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 239 : 290-292
18. Ichimura T, Fraser PA, Cserr HF (1991) Distribution of extracellular tracers in perivascular spaces of the rat brain. Brain Res 545 : 103-113
19. Kida S, Pantazis A, Weller RO (1993) CSF drains directly from the subarachnoid space into nasal lymphatics in the rat. Anatomy, histology and immunological significance. Neuropathol Appl Neurobiol 19 : 480-488
20. Kida S, Steart PV, Zhang E-T, Weller RO (1993) Perivascular cells act as scavengers in the cerebral perivascular spaces and remain distinct from pericytes, microglia and macrophages. Acta Neuropathol 85 : 646-652
21. Klatzo I, Miquel J, Ferris PJ, Prokop JD, Smith DE (1964) Observations on the passage of the fluorescein-labeled serum proteins (FLSP) from the cerebrospinal fluid. J Neuropathol Exp Neurol 23 : 18-35
22. Ma K-C, Lundberg PO, Lilja A, Olsson Y (1992) Binswanger's disease in the absence of chronic arterial hypertension. Acta Neuropathol 83 : 434-439
23. Mato M, Ookawara S, Mato TK, Namiki T (1985) An attempt to differentiate further between microglia and fluorescent granular perithelial (FGP) cells by their capacity to incorporate exogenous protein. Am J Anat 172 : 125-140
24. Mato M, Ookawara S, Sakamoto A, Aikawa E, Ogawa T, Mitsuhashi U, Masuzawa T, Suzuki H, Honda M, Yazaki Y, Watanabe E, Luoma J, Yla-Herttuala S, Fraser I, Gordon S, Kodama T (1996) Involvement of specific macrophage-lineage cells surrounding arterioles in harrier and scavenger function in brain cortex. Proc Natl Acad Sci USA 93 : 3269-3274
25. Mesulam M-M (1978) Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction-product with superior sensitivity for visualizing neural afferents and efferents. J Histochem Cytochem 26 : 106-117
26. Pantoni L, Garcia JH (1995) The significance of cerebral white matter abnormalities 100 years after Binswanger's report. A review. Stroke 26 : 1293-1301
27. Reese TS, Karnovsky MJ (1967) Fine structural localization of a blood-brain barrier for exogenous peroxidase. J Cell Biol 34 : 207-217
28. Tomimoto H, Akiguchi I, Suenaga T, Nishimura M, Wakita H, Nakamura S, Kimura J (1996) Alterations of the blood-brain barrier and glial cells in white-matter lesions in cerebrovascular and Alzheimer's disease patients. Stroke 27 : 2069-2074
29. Ueno M, Akiguchi I, Hosokawa M, Yagi H, Takemura M, Kimura J, Takeda T (1994) Accumulation of blood-borne horseradish peroxidase in medial portions of the mouse hippocampus. Acta Neurol Scand 90 : 400-404
30. Ueno M, Akiguchi I, Hosokawa M, Shinnou M, Sakamoto H, Takemura M. Higuchi K (1997) Age-related changes in the brain transfer of blood-borne horseradish peroxidase in the hippocampus of senescence-accelerated mouse. Acta Neuropathol 93 : 233-240
31. Ueno M, Akiguchi I, Hosokawa M, Shinnou M, Sakamoto H, Takemura M, Higuchi K (1998) Ultrastructural and permeability features of microvessels in the olfactory bulbs of SAM mice. Acta Neuropathol 96 : 261-270
32. Van Deurs B (1976) Observations on the blood-brain barrier in hypertensive rats, with particular reference to phagocytic pericytes. J Ultrastruct Res 56 : 65-77
33. Vorbrodt AW, Lossinsky AS, Wisniewski HM, Suzuki R, Yamaguchi T, Masaoka H, Klatzo I (1985) Ultrastructural observations on the transvascular route of protein removal in vasogenic brain edema. Acta Neuropathol (Berl) 66 : 265-273
34. Wagner HJ, Pilgrim C, Brandl J (1974) Penetration and removal of horseradish peroxidase injected into the cerebrospinal fluid: role of cerebral perivascular spaces, endothelium and microglia. Acta Neuropathol (Berl) 27 : 299-315
35. Weller RO (1998) Pathology of cerebrospinal fluid and interstitial fluid of the CNS: significance for Alzheimer disease, prion disorders and multiple sclerosis. J Neuropathol Exp Neurol 57 : 885-894
36. Westergaard RD, Brightman MW (1973) Transport of proteins across normal cerebral arterioles. J Comp Neurol 152 : 17-44
37. Zhang ET, Richards HK, Kida S, Weller RO (1992) Directional and compartmentalised drainage of interstitial fluid and cerebrospinal fluid from the rat brain. Acta Neuropathol 83 : 233-239