Interleukin-9 is associated with elevated anti–double-stranded DNA antibodies in lupus-prone mice

Molecular Medicine

Volumn 21, Issue , 2015, Pages 364-370

  Yang, Ji ^a   Li, Qiao ^b   Yang, Xue ^b,c   Li, Ming ^a  

^a ZHONGSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA ANTIBODY; INTERLEUKIN 17; INTERLEUKIN 9; NEUTRALIZING ANTIBODY; STAT3 PROTEIN; ANTINUCLEAR ANTIBODY; CYTOKINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CONTROLLED STUDY; FEMALE; GERMINAL CENTER; IN VIVO STUDY; INHIBITION KINETICS; LUPUS ERYTHEMATOSUS NEPHRITIS; LUPUS VULGARIS; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PATHOGENESIS; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TH9 CELL; ANIMAL; DISEASE MODEL; HELPER CELL; IMMUNOLOGY; METABOLISM; MURPHY ROTHS LARGE LYMPHOPROLIFERATIVE MOUSE; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, NEUTRALIZING; ANTIBODY FORMATION; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GERMINAL CENTER; INTERLEUKIN-17; INTERLEUKIN-9; LUPUS ERYTHEMATOSUS, SYSTEMIC; LUPUS NEPHRITIS; MICE; MICE, INBRED MRL LPR; STAT3 TRANSCRIPTION FACTOR; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84930955076     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2014.00237     Document Type: Article

References (28)

1. Arbuckle MR, et al. (2003) Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N. Engl. J. Med. 349:1526-33.
2. Veldhoen M, et al. (2008) Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9- producing subset. Nat. Immunol. 9:1341-6.
3. Dardalhon V, et al. (2008) IL-4 inhibits TGF-betainduced Foxp3+ T cells and, together with TGFbeta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat. Immunol. 9:1347-55.
4. Putheti P, et al. (2010) Human CD4 memory T cells can become CD4+IL-9+ T cells. PLoS One. 5:e8706.
5. Yao W, et al. (2013) Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP. Immunity. 38:360-72.
6. Schmitt E, Klein M, Bopp T. (2014) Th9 cells, new players in adaptive immunity. Trends Immunol. 35:61-8.
7. Kaplan MH. (2013) Th9 cells: differentiation and disease. Immunol. Rev. 252:104-15.
8. Ouyang H, et al. (2013) Increased interleukin-9 and CD4+IL-9+ T cells in patients with systemic lupus erythematosus. Mol. Med. Rep. 7:1031-7.
9. Yang J, et al. (2009) Th17 and natural Treg cell population dynamics in systemic lupus erythematosus. Arthritis Rheum. 60:1472-83.
10. Yang J, et al. (2011) Recovery of the immune balance between Th17 and regulatory T cells as a treatment for systemic lupus erythematosus. Rheumatology. 50:1366-72.
11. Crispin JC, Tsokos GC. (2010) Interleukin-17- producing T cells in lupus. Curr. Opin. Rheumatol. 22:499-503.
12. Doreau A, et al. (2009) Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus. Nat. Immunol. 10:778-85.
13. Elyaman W, et al. (2009) IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc. Natl. Acad. Sci. U. S. A. 106:12885-90.
14. Soroosh P, Doherty TA. (2009) Th9 and allergic disease. Immunology. 127:450-8.
15. Kim MS, et al. (2013) Effects of interleukin-9 blockade on chronic airway inflammation in murine asthma models. Allergy Asthma Immunol. Res. 5:197-206.
16. Kezic JM, et al. (2012) Neutralization of IL-17 ameliorates uveitis but damages photoreceptors in a murine model of spondyloarthritis. Arthritis Res. Ther. 14:R18.
17. Watson ML, et al. (1992) Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal diseasemodifying loci. J. Exp. Med. 176:1645-56.
18. Nowak EC, Noelle RJ. (2010) Interleukin-9 as a T helper type 17 cytokine. Immunology. 131:169-73.
19. Lu Y, et al. (2014) Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers. Proc. Natl. Acad. Sci. U. S. A. 111:2265-70.
20. Kim HS, Chung DH. (2013) IL-9-producing invariant NKT cells protect against DSS-induced colitis in an IL-4-dependent manner. Mucosal Immunol. 6:347-57.
21. Fawaz LM, et al. (2007) Expression of IL-9 receptor alpha chain on human germinal center B cells modulates IgE secretion. J. Allergy Clin. Immunol. 120:1208-15.
22. Avery DT, et al. (2010) B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J. Exp. Med. 207:155-71.
23. Liu J, et al. (2014) IL-9 regulates allergen-specific Th1 responses in allergic contact dermatitis. J. Invest. Dermatol. 134:1903-11.
24. Ma L, et al. (2014) Possible pathogenic role of T helper type 9 cells and interleukin (IL)-9 in atopic dermatitis. Clin. Exp. Immunol. 175:25-31.
25. Yanaba K, et al. (2011) Serum interleukin 9 levels are increased in patients with systemic sclerosis: association with lower frequency and severity of pulmonary fibrosis. J. Rheumatol. 38:2193-7.
26. Leng RX, et al. (2012) Potential roles of IL-9 in the pathogenesis of systemic lupus erythematosus. Am. J. Clin. Exp. Immunol. 1:28-32.
27. Wang L, et al. (2009) IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J. Exp. Med. 206:1457-64.
28. Goswami R, Kaplan MH. (2011) A brief history of IL-9. J. Immunol. 186:3283-8.