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Volumn 41, Issue 12, 2015, Pages 1954-1961

A comparative study of chitosan and poloxamer based thermosensitive hydrogel for the delivery of PEGylated melphalan conjugates

Author keywords

Anti cancer; Chitosan; Hydrogel; MCF; Melphalan; MTT; PEGylation; Poloxamer

Indexed keywords

CHITOSAN; DRUG CARRIER; MELPHALAN; POLOXAMER; HYDROGEL; MACROGOL DERIVATIVE;

EID: 84930941896     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2015.1011167     Document Type: Article
Times cited : (44)

References (51)
  • 1
    • 0023481976 scopus 로고
    • Metabolism and reactions of alkylating agents
    • Farmer PB. Metabolism and reactions of alkylating agents. Pharmacol Ther 1987;35:301-58.
    • (1987) Pharmacol Ther , vol.35 , pp. 301-358
    • Farmer, P.B.1
  • 2
    • 1842685155 scopus 로고    scopus 로고
    • Immunohistochemical detection of melphalan-DNA adducts in colon cancer cells in vitro and human colorectal liver tumours in vivo
    • Rothbarth J, Koevoets C, Tollenaar RA, et al. Immunohistochemical detection of melphalan-DNA adducts in colon cancer cells in vitro and human colorectal liver tumours in vivo. Biochem Pharmacol 2004;67:1771-8.
    • (2004) Biochem Pharmacol , vol.67 , pp. 1771-1778
    • Rothbarth, J.1    Koevoets, C.2    Tollenaar, R.A.3
  • 3
    • 0037374540 scopus 로고    scopus 로고
    • The discovery of a new potential anticancer drug: A case history
    • Cozzi P. The discovery of a new potential anticancer drug: a case history. Il Farmaco 2003;58:213-20.
    • (2003) Il Farmaco , vol.58 , pp. 213-220
    • Cozzi, P.1
  • 4
    • 0035046645 scopus 로고    scopus 로고
    • DNA minor groove alkylating agents
    • Denny WA. DNA minor groove alkylating agents. Curr Med Chem 2001;8:533-44.
    • (2001) Curr Med Chem , vol.8 , pp. 533-544
    • Denny, W.A.1
  • 5
    • 0035329177 scopus 로고    scopus 로고
    • Synthesis, molecular modelling, and antiproliferative and cytotoxic effects of carbocyclic derivatives of distamycin with chlorambucil moiety
    • Bartulewicz D, Bielawski K, Bielawska A, Rozanski A. Synthesis, molecular modelling, and antiproliferative and cytotoxic effects of carbocyclic derivatives of distamycin with chlorambucil moiety. Eur J Med Chem 2001;36:461-7.
    • (2001) Eur J Med Chem , vol.36 , pp. 461-467
    • Bartulewicz, D.1    Bielawski, K.2    Bielawska, A.3    Rozanski, A.4
  • 6
    • 0001286133 scopus 로고
    • Myleran in chronic myeloid leukaemia; chemical constitution and biological action
    • Haddow A, Timmis GM. Myleran in chronic myeloid leukaemia; chemical constitution and biological action. Lancet 1953;264:207-8.
    • (1953) Lancet , vol.264 , pp. 207-208
    • Haddow, A.1    Timmis, G.M.2
  • 7
    • 78651153913 scopus 로고
    • Newer anticancer agents
    • Knock FE. Newer anticancer agents. Med Clin N Am 1964;48:501-27.
    • (1964) Med Clin N Am , vol.48 , pp. 501-527
    • Knock, F.E.1
  • 8
    • 33750206776 scopus 로고    scopus 로고
    • The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks
    • Hanada K, Budzowska M, Modesti M, et al. The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks. EMBO J 2006;25:4921-32.
    • (2006) EMBO J , vol.25 , pp. 4921-4932
    • Hanada, K.1    Budzowska, M.2    Modesti, M.3
  • 9
    • 84866338504 scopus 로고    scopus 로고
    • Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines
    • Valdez BC, Nieto Y, Murray D, et al. Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines. Exp Hematol 2012;40:800-10.
    • (2012) Exp Hematol , vol.40 , pp. 800-810
    • Valdez, B.C.1    Nieto, Y.2    Murray, D.3
  • 10
    • 84895329009 scopus 로고
    • Reaction of some mutagenic and carcinogenic compounds with nucleic acids
    • Brookes P, Lawley PD. Reaction of some mutagenic and carcinogenic compounds with nucleic acids. J Cell Comp Physiol 1964;64:111-28.
    • (1964) J Cell Comp Physiol , vol.64 , pp. 111-128
    • Brookes, P.1    Lawley, P.D.2
  • 11
    • 84882488326 scopus 로고    scopus 로고
    • Design and synthesis of novel quinazoline nitrogen mustard derivatives as potential therapeutic agents for cancer
    • Li S, Wang X, He Y, et al. Design and synthesis of novel quinazoline nitrogen mustard derivatives as potential therapeutic agents for cancer. Eur J Med Chem 2013;67:293-301.
    • (2013) Eur J Med Chem , vol.67 , pp. 293-301
    • Li, S.1    Wang, X.2    He, Y.3
  • 12
    • 77952524536 scopus 로고    scopus 로고
    • Chitosan nanoparticles as a new delivery system for the chemotherapy agent tegafur
    • Arias JL, López-Viota M, Gallardo V, Ruiz MA. Chitosan nanoparticles as a new delivery system for the chemotherapy agent tegafur. Drug Dev Ind Pharm 2010;36:744-50.
    • (2010) Drug Dev Ind Pharm , vol.36 , pp. 744-750
    • Arias, J.L.1    López-Viota, M.2    Gallardo, V.3    Ruiz, M.A.4
  • 13
    • 59249097880 scopus 로고    scopus 로고
    • Cytotoxic effects of butanolic extract from Pfaffia paniculata (Brazilian ginseng) on cultured human breast cancer cell line MCF-7
    • Nagamine MK, Da Silva TC, Matsuzaki P, et al. Cytotoxic effects of butanolic extract from Pfaffia paniculata (Brazilian ginseng) on cultured human breast cancer cell line MCF-7. Exp Toxicol Pathol 2009;61:75-82.
    • (2009) Exp Toxicol Pathol , vol.61 , pp. 75-82
    • Nagamine, M.K.1    Da Silva, T.C.2    Matsuzaki, P.3
  • 14
    • 84964222364 scopus 로고    scopus 로고
    • Fusogenic liposomal formulation of sirolimus: Improvement of drug anti-proliferative effect on human T-cells
    • Epub ahead of print
    • Valizadeh H, Ghanbarzadeh S, Zakeri-Milani P. Fusogenic liposomal formulation of sirolimus: improvement of drug anti-proliferative effect on human T-cells. Drug Dev Ind Pharm 2014. [Epub ahead of print]. doi:10.3109/03639045.2014.971032.
    • (2014) Drug Dev Ind Pharm
    • Valizadeh, H.1    Ghanbarzadeh, S.2    Zakeri-Milani, P.3
  • 15
    • 0015762456 scopus 로고
    • A human cell line from a pleural effusion derived from a breast carcinoma
    • Soule HD, Vazguez J, Long A, et al. A human cell line from a pleural effusion derived from a breast carcinoma. J Natl Cancer Inst 1973;51:1409-16.
    • (1973) J Natl Cancer Inst , vol.51 , pp. 1409-1416
    • Soule, H.D.1    Vazguez, J.2    Long, A.3
  • 16
    • 83655203192 scopus 로고    scopus 로고
    • Effect of flavonone hesperidin on the apoptosis of human mammary carcinoma cell line MCF-7
    • Natarajan N, Thamaraiselvan R, Lingaiah H, et al. Effect of flavonone hesperidin on the apoptosis of human mammary carcinoma cell line MCF-7. Biomed Prev Nutr 2011;1:207-15.
    • (2011) Biomed Prev Nutr , vol.1 , pp. 207-215
    • Natarajan, N.1    Thamaraiselvan, R.2    Lingaiah, H.3
  • 17
    • 84870255850 scopus 로고    scopus 로고
    • Novel crosslinking methods to design hydrogels
    • Hennink WE, Van Nostrum CF. Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev 2012;64:223-36.
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 223-236
    • Hennink, W.E.1    Van Nostrum, C.F.2
  • 18
    • 84918774908 scopus 로고    scopus 로고
    • An insight on human skin penetration of diflunisal: Lipogel versus hydrogel microemulsion
    • Sallam MA, Motawaa AM, Mortada SM. An insight on human skin penetration of diflunisal: lipogel versus hydrogel microemulsion. Drug Dev Ind Pharm 2015;41:141-7.
    • (2015) Drug Dev Ind Pharm , vol.41 , pp. 141-147
    • Sallam, M.A.1    Motawaa, A.M.2    Mortada, S.M.3
  • 19
    • 0035385135 scopus 로고    scopus 로고
    • Hydrogels for tissue engineering
    • Lee KY, Mooney DJ. Hydrogels for tissue engineering. Chem Rev 2001;101:1869-79.
    • (2001) Chem Rev , vol.101 , pp. 1869-1879
    • Lee, K.Y.1    Mooney, D.J.2
  • 20
    • 70350676968 scopus 로고    scopus 로고
    • Hydrogels from soft contact lenses and implants to self-assembled nanomaterials
    • Kopecek J. Hydrogels from soft contact lenses and implants to self-assembled nanomaterials. J Polym Sci Part A, Polym Chem 2009;47:5929-46.
    • (2009) J Polym Sci Part A, Polym Chem , vol.47 , pp. 5929-5946
    • Kopecek, J.1
  • 21
    • 33645016622 scopus 로고    scopus 로고
    • The influence of variation of gastric pH on the gelation and release characteristics of in situ gelling pectin formulations
    • Itoh K, Kubo W, Fujiwara M, et al. The influence of variation of gastric pH on the gelation and release characteristics of in situ gelling pectin formulations. Int J Pharm 2006;312:37-42.
    • (2006) Int J Pharm , vol.312 , pp. 37-42
    • Itoh, K.1    Kubo, W.2    Fujiwara, M.3
  • 22
    • 33846573824 scopus 로고    scopus 로고
    • Ph- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel
    • Shim WS, Kim J-H, Kim K, et al. pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel. Int J Pharm 2007;331:11-18.
    • (2007) Int J Pharm , vol.331 , pp. 11-18
    • Shim, W.S.1    Kim, J.-H.2    Kim, K.3
  • 23
    • 84874373115 scopus 로고    scopus 로고
    • Recent progress of in situ formed gels for biomedical applications
    • Ko DY, Shinde UP, Yeon B, Jeong B. Recent progress of in situ formed gels for biomedical applications. Prog Polym Sci 2013;38:672-701.
    • (2013) Prog Polym Sci , vol.38 , pp. 672-701
    • Ko, D.Y.1    Shinde, U.P.2    Yeon, B.3    Jeong, B.4
  • 24
    • 84906879174 scopus 로고    scopus 로고
    • Stimuliresponsive bacterial cellulose-g-poly (acrylic acid-co-acrylamide) hydrogels for oral controlled release drug delivery
    • Mohd Amin MCI, Ahmad N, Pandey M, Jue Xin C. Stimuliresponsive bacterial cellulose-g-poly (acrylic acid-co-acrylamide) hydrogels for oral controlled release drug delivery. Drug Dev Ind Pharm 2014;40:1340-9.
    • (2014) Drug Dev Ind Pharm , vol.40 , pp. 1340-1349
    • Mohd Amin, M.C.I.1    Ahmad, N.2    Pandey, M.3    Jue Xin, C.4
  • 25
    • 84906212627 scopus 로고    scopus 로고
    • Synthesis, characterization, biodegradability and biocompatibility of a temperature-sensitive PBLA-PEG-PBLA hydrogel as protein delivery system with low critical gelation concentration
    • Xu Y, Shen Y, Xiong Y, et al. Synthesis, characterization, biodegradability and biocompatibility of a temperature-sensitive PBLA-PEG-PBLA hydrogel as protein delivery system with low critical gelation concentration. Drug Dev Ind Pharm 2014;40:1264-75.
    • (2014) Drug Dev Ind Pharm , vol.40 , pp. 1264-1275
    • Xu, Y.1    Shen, Y.2    Xiong, Y.3
  • 26
    • 0023581602 scopus 로고
    • Applications of thermally reversible polymers and hydrogels in therapeutics and diagnostics
    • Hoffman AS. Applications of thermally reversible polymers and hydrogels in therapeutics and diagnostics. J Control Release 1987;6:297-305.
    • (1987) J Control Release , vol.6 , pp. 297-305
    • Hoffman, A.S.1
  • 27
    • 0025847713 scopus 로고
    • Controlled release by using poly (methacrylic acid-g-ethylene glycol) hydrogels
    • Peppas NA, Klier J. Controlled release by using poly (methacrylic acid-g-ethylene glycol) hydrogels. J Control Release 1991;16:203-14.
    • (1991) J Control Release , vol.16 , pp. 203-214
    • Peppas, N.A.1    Klier, J.2
  • 28
    • 0029635983 scopus 로고
    • Graft copolymers that exhibit temperatureinduced phase transitions over a wide range of pH
    • Chen G, Hoffman AS. Graft copolymers that exhibit temperatureinduced phase transitions over a wide range of pH. Nature 1995;373:49-52.
    • (1995) Nature , vol.373 , pp. 49-52
    • Chen, G.1    Hoffman, A.S.2
  • 29
    • 84869779017 scopus 로고    scopus 로고
    • Advancement in stimuli triggered in situ gelling delivery for local and systemic route
    • Ajazuddin, Alexander A, Khan J, et al. Advancement in stimuli triggered in situ gelling delivery for local and systemic route. Expert Opin Drug Deliv 2012;9:1573-92.
    • (2012) Expert Opin Drug Deliv , vol.9 , pp. 1573-1592
    • Ajazuddin1    Alexander, A.2    Khan, J.3
  • 30
    • 0033908076 scopus 로고    scopus 로고
    • Multilayer hydrogels as muscle-like actuators
    • Liu Z, Calvert P. Multilayer hydrogels as muscle-like actuators. Adv Mater 2000;12:288-91.
    • (2000) Adv Mater , vol.12 , pp. 288-291
    • Liu, Z.1    Calvert, P.2
  • 31
    • 0037429126 scopus 로고    scopus 로고
    • Electrical sensitive behavior of poly (vinyl alcohol)/poly (diallyldimethylammonium chloride) IPN hydrogel
    • Kim SJ, Yoon SG, Lee YM, Kim SI. Electrical sensitive behavior of poly (vinyl alcohol)/poly (diallyldimethylammonium chloride) IPN hydrogel. Sensor Actuat B: Chem 2003;88:286-91.
    • (2003) Sensor Actuat B: Chem , vol.88 , pp. 286-291
    • Kim, S.J.1    Yoon, S.G.2    Lee, Y.M.3    Kim, S.I.4
  • 32
    • 0032482152 scopus 로고    scopus 로고
    • Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery
    • Bromberg LE, Ron ES. Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery. Adv Drug Deliv Rev 1998;31:197-221.
    • (1998) Adv Drug Deliv Rev , vol.31 , pp. 197-221
    • Bromberg, L.E.1    Ron, E.S.2
  • 33
    • 84912571281 scopus 로고    scopus 로고
    • Polyethylene glycol (PEG) - Poly (N-isopropylacrylamide) (PNIPAAm) based thermosensitive injectable hydrogels for biomedical applications
    • Alexander A, Ajazuddin, Khan J, et al. Polyethylene glycol (PEG) - poly (N-isopropylacrylamide) (PNIPAAm) based thermosensitive injectable hydrogels for biomedical applications. Eur J Pharm Biopharm 2014;88:575-85.
    • (2014) Eur J Pharm Biopharm , vol.88 , pp. 575-585
    • Alexander, A.1    Ajazuddin2    Khan, J.3
  • 34
    • 84887134441 scopus 로고    scopus 로고
    • Poly (ethylene glycol) - Poly (lactic-co-glycolic acid) based thermosensitive injectable hydrogels for biomedical applications
    • Alexander A, Ajazuddin, Khan J, et al. Poly (ethylene glycol) - poly (lactic-co-glycolic acid) based thermosensitive injectable hydrogels for biomedical applications. J Control Release 2013;172:715-29.
    • (2013) J Control Release , vol.172 , pp. 715-729
    • Alexander, A.1    Ajazuddin2    Khan, J.3
  • 35
    • 0034879035 scopus 로고    scopus 로고
    • Chitosan: Some pharmaceutical and biological aspects - An update
    • Singla AK, Chawla M. Chitosan: some pharmaceutical and biological aspects - an update. J Pharm Pharmacol 2001;53:1047-67.
    • (2001) J Pharm Pharmacol , vol.53 , pp. 1047-1067
    • Singla, A.K.1    Chawla, M.2
  • 36
    • 75749149383 scopus 로고    scopus 로고
    • Chitosan-tripolyphosphate nanoparticles as a possible skin drug delivery system for aciclovir with enhanced stability
    • Hasanovic A, Zehl M, Reznicek G, Valenta C. Chitosan-tripolyphosphate nanoparticles as a possible skin drug delivery system for aciclovir with enhanced stability. J Pharm Pharmacol 2009;61:1609-16.
    • (2009) J Pharm Pharmacol , vol.61 , pp. 1609-1616
    • Hasanovic, A.1    Zehl, M.2    Reznicek, G.3    Valenta, C.4
  • 38
    • 84929090502 scopus 로고    scopus 로고
    • Development of topical hydrogels of terbinafine hydrochloride and evaluation of their antifungal activity
    • Epub ahead of print
    • Çelebi N, Ermiş S, Özkan S. Development of topical hydrogels of terbinafine hydrochloride and evaluation of their antifungal activity. Drug Dev Ind Pharm 2014. [Epub ahead of print]. doi:10.3109/03639045.2014.891129.
    • (2014) Drug Dev Ind Pharm
    • Çelebi, N.1    Ermiş, S.2    Özkan, S.3
  • 39
    • 85047685252 scopus 로고    scopus 로고
    • Cancer, chitosan nanoparticles and catalytic nucleic acids
    • Tan ML, Choong PFM, Dass CR. Cancer, chitosan nanoparticles and catalytic nucleic acids. J Pharm Pharmacol 2009;61:3-12.
    • (2009) J Pharm Pharmacol , vol.61 , pp. 3-12
    • Tan, M.L.1    Choong, P.F.M.2    Dass, C.R.3
  • 41
    • 0034333696 scopus 로고    scopus 로고
    • Novel injectable neutral solutions of chitosan form biodegradable gels in situ
    • Chenite A, Chaput C, Wang D, et al. Novel injectable neutral solutions of chitosan form biodegradable gels in situ. Biomaterials 2000;21:2155-61.
    • (2000) Biomaterials , vol.21 , pp. 2155-2161
    • Chenite, A.1    Chaput, C.2    Wang, D.3
  • 42
    • 77954316122 scopus 로고    scopus 로고
    • Rheological characterization and in vivo evaluation of thermosensitive poloxamer-based hydrogel for intramuscular injection of piroxicam
    • Xuan J-J, Balakrishnan P, Oh DH, et al. Rheological characterization and in vivo evaluation of thermosensitive poloxamer-based hydrogel for intramuscular injection of piroxicam. Int J Pharm 2010;395:317-23.
    • (2010) Int J Pharm , vol.395 , pp. 317-323
    • Xuan, J.-J.1    Balakrishnan, P.2    Oh, D.H.3
  • 43
    • 84877578578 scopus 로고    scopus 로고
    • Enhanced brain targeting of curcumin by intranasal administration of a thermosensitive poloxamer hydrogel
    • Chen X, Zhi F, Jia X, et al. Enhanced brain targeting of curcumin by intranasal administration of a thermosensitive poloxamer hydrogel. J Pharm Pharmacol 2013;65:807-16.
    • (2013) J Pharm Pharmacol , vol.65 , pp. 807-816
    • Chen, X.1    Zhi, F.2    Jia, X.3
  • 44
    • 0019159174 scopus 로고
    • Novel poloxamer (pluronic) and poloxamine (tetronic) hydrogels: Swelling and drug release
    • Al-Saden A, Florence AT, Whateley TL. Novel poloxamer (pluronic) and poloxamine (tetronic) hydrogels: swelling and drug release. J Pharm Pharmacol 1980;32:5P.
    • (1980) J Pharm Pharmacol , vol.32 , pp. 5P
    • Al-Saden, A.1    Florence, A.T.2    Whateley, T.L.3
  • 45
    • 84869503987 scopus 로고    scopus 로고
    • Synthesis, characterization and in vitro studies of pegylated melphalan conjugates
    • Ajazuddin, Alexander A, Amarji B, Kanaujia P. Synthesis, characterization and in vitro studies of pegylated melphalan conjugates. Drug Dev Ind Pharm 2013;39:1053-62.
    • (2013) Drug Dev Ind Pharm , vol.39 , pp. 1053-1062
    • Ajazuddin1    Alexander, A.2    Amarji, B.3    Kanaujia, P.4
  • 46
    • 84906245679 scopus 로고    scopus 로고
    • Formulation and evaluation of chitosan-based long-acting injectable hydrogel for PEGylated melphalan conjugate
    • Alexander A, Ajazuddin, Khan J, et al. Formulation and evaluation of chitosan-based long-acting injectable hydrogel for PEGylated melphalan conjugate. J Pharm Pharmacol 2014;66:1240-50.
    • (2014) J Pharm Pharmacol , vol.66 , pp. 1240-1250
    • Alexander, A.1    Ajazuddin2    Khan, J.3
  • 47
    • 0015420938 scopus 로고
    • Artificial skin I. Preparation and properties of pluronic F-127 gels for treatment of burns
    • Schmolka IR. Artificial skin I. Preparation and properties of pluronic F-127 gels for treatment of burns. J Biomed Mater Res 1972;6:571-82.
    • (1972) J Biomed Mater Res , vol.6 , pp. 571-582
    • Schmolka, I.R.1
  • 48
    • 1542315271 scopus 로고    scopus 로고
    • Behaviour of the new asbestos amphibole fluoro-edenite in different lung cell systems
    • Cardile V, Renis M, Scifo C, et al. Behaviour of the new asbestos amphibole fluoro-edenite in different lung cell systems. Int J Biochem Cell Biol 2004;36:849-60.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 849-860
    • Cardile, V.1    Renis, M.2    Scifo, C.3
  • 49
    • 67349285178 scopus 로고    scopus 로고
    • A chitosan-dipotassium orthophosphate hydrogel for the delivery of Doxorubicin in the treatment of osteosarcoma
    • Ta HT, Dass CR, Larson I, et al. A chitosan-dipotassium orthophosphate hydrogel for the delivery of Doxorubicin in the treatment of osteosarcoma. Biomaterials 2009;30:3605-13.
    • (2009) Biomaterials , vol.30 , pp. 3605-3613
    • Ta, H.T.1    Dass, C.R.2    Larson, I.3
  • 50
    • 84906867782 scopus 로고    scopus 로고
    • Development and evaluation of pluronic- and methylcellulose-based thermoreversible drug delivery system for insulin
    • Nasir F, Iqbal Z, Khan A, et al. Development and evaluation of pluronic- and methylcellulose-based thermoreversible drug delivery system for insulin. Drug Dev Ind Pharm 2014;40:1503-8.
    • (2014) Drug Dev Ind Pharm , vol.40 , pp. 1503-1508
    • Nasir, F.1    Iqbal, Z.2    Khan, A.3
  • 51
    • 84911493623 scopus 로고    scopus 로고
    • Preparation and characterization of curcumin thermosensitive hydrogels for intratumoral injection treatment
    • Gao M, Xu H, Zhang C, et al. Preparation and characterization of curcumin thermosensitive hydrogels for intratumoral injection treatment. Drug Dev Ind Pharm 2014;40:1557-64.
    • (2014) Drug Dev Ind Pharm , vol.40 , pp. 1557-1564
    • Gao, M.1    Xu, H.2    Zhang, C.3


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