Substrate-binding domain conformational dynamics mediate Hsp70 allostery

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 22, 2015, Pages E2865-E2873

  Zhuravleva, Anastasia ^a   Gierasch, Lila M ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Conformational selection; Entropically driven allostery; Molecular chaperone; NMR chemical shift perturbations; Protein quality control

Indexed keywords

CHAPERONE; HEAT SHOCK PROTEIN 70; ADENOSINE TRIPHOSPHATE; CARBON; DEUTERIUM; DNAK PROTEIN, E COLI; ESCHERICHIA COLI PROTEIN; NITROGEN; PROTEIN BINDING;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING KINETICS; ESCHERICHIA COLI; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION; STRUCTURE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HOMEOSTASIS; KINETICS; METABOLISM; MOLECULAR DYNAMICS; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ESCHERICHIA COLI;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; CARBON ISOTOPES; DEUTERIUM; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HOMEOSTASIS; HSP70 HEAT-SHOCK PROTEINS; KINETICS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; NITROGEN ISOTOPES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY;

EID: 84930939681     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1506692112     Document Type: Article

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