Complete pulpodentin complex regeneration by modulating the stiffness of biomimetic matrix

Acta Biomaterialia

Volumn 16, Issue 1, 2015, Pages 60-70

  Qu, Tiejun ^a,b   Jing, Junjun ^a,c   Ren, Yinshi ^a   Ma, Chi ^a   Feng, Jian Q ^a   Yu, Qing ^b   Liu, Xiaohua ^a  

^a BAYLOR COLLEGE OF DENTISTRY   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

Dentin; Gelatin; Pulp; Pulpodentin complex; Stiffness

Indexed keywords

BIOMIMETICS; BIOMINERALIZATION; BLOOD VESSELS; SCAFFOLDS (BIOLOGY); STEM CELLS; STIFFNESS MATRIX; TISSUE; TISSUE REGENERATION;

BIOMIMETIC MATRICES; COMPLETE TOOTH; DENTAL CARIES; DENTAL PULP STEM CELLS; DENTINE; GELATIN; HIGH STIFFNESS; NANO-FIBROUS; PULPODENTINE COMPLEX; STEM CELL DIFFERENTIATION;

STIFFNESS;

ALKALINE PHOSPHATASE; CALCIUM PHOSPHATE; COLLAGEN TYPE 1; DENTIN MATRIX PROTEIN 1; DENTIN SIALOPHOSPHOPROTEIN; GELATIN; MOLECULAR SCAFFOLD; OSTEOCALCIN; PHOSPHOPROTEIN; UNCLASSIFIED DRUG; BIOMIMETIC MATERIAL; NANOFIBER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMIMETICS; BIOMINERALIZATION; CELL ADHESION; CELL DENSITY; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SHAPE; CHEMICAL STRUCTURE; CROSS LINKING; CYTOSKELETON; DENTIN; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHASE SEPARATION; POROSITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULPODENTIN; RIGIDITY; THICKNESS; TISSUE REGENERATION; TOOTH PULP; UPREGULATION; ANIMAL; BIOMECHANICS; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; METABOLISM; NUDE MOUSE; PROSTHESIS IMPLANTATION; REGENERATION; STEM CELL; SUBCUTANEOUS TISSUE; TISSUE SCAFFOLD; ULTRASTRUCTURE;

MUS MUSCULUS;

ANIMALS; BIOMECHANICAL PHENOMENA; BIOMIMETIC MATERIALS; CELL ADHESION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DENTAL PULP; DENTIN; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MICE, NUDE; NANOFIBERS; PROSTHESIS IMPLANTATION; REGENERATION; STEM CELLS; SUBCUTANEOUS TISSUE; TISSUE SCAFFOLDS;

EID: 84930935643     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2015.01.029     Document Type: Article

References (48)

1. Huang GTJ. Pulp and dentin tissue engineering and regeneration: current progress. Regen Med 2009;4:697-707.
2. Goldberg M, Smith AJ. Cells and extracellular matrices of dentin and pulp: a biological basis for repair and tissue engineering. Crit Rev Oral Biol M 2004;15:13-27.
3. Guo WH, He Y, Zhang XJ, Lu W, Wang CM, Yu H, et al. The use of dentin matrix scaffold and dental follicle cells for dentin regeneration. Biomaterials 2009;30:6708-23.
4. Ishimatsu H, Kitamura C, Morotomi T, Tahata Y, Nishihara T, Chen KK, et al. Formation of dentinal bridge on surface of regenerated dental pulp in dentin defects by controlled release of fibroblast growth factor-2 from gelatin hydrogels. J Endodont 2009;35:858-65.
5. Li R, Guo WH, Yang B, Guo LJ, Sheng L, Chen G, et al. Human treated dentin matrix as a natural scaffold for complete human dentin tissue regeneration. Biomaterials 2011;32:4525-38.
6. Prescott RS, Alsanea R, Tayad MI, Johnson BR, Wenckus CS, Hao J, et al. In vivo generation of dental pulp-like tissue by using dental pulp stem cells, dentin matrix protein 1 transplantation in mice. J Endodont 2008;34:421-6.
7. Yu JH, Deng ZH, Shi JN, Zhai HH, Nie X, Zhuang H, et al. Differentiation of dental pulp stem cells into regular-shaped dentin-pulp complex induced by tooth germ cell conditioned medium. Tissue Eng 2006;12:3097-105.
8. Galler KM, Hartgerink JD, Cavender AC, Schmalz G, D'Souza RN. A customized self-assembling peptide hydrogel for dental pulp tissue engineering. Tissue Eng Part A 2012;18:176-84.
9. Murray PE, Garcia-Godoy F. Stem cells and regeneration of the pulpodentin complex. Hanover Park: Quintessence Publishing Co Inc; 2012.
10. Lang H, Korkmaz Y, Schneider K, Raab WHM. Impact of endodontic treatments on the rigidity of the root. J Dent Res 2006;85:364-8.
11. Trope M, Ray HL. Resistance to fracture of endodontically treated roots. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1992;73:99-102.
12. Fernandes AS, Dessai GS. Factors affecting the fracture resistance of post-core reconstructed teeth: a review. Int J Prosthodont 2001;14:355-63.
13. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci USA 2000;97:13625-30.
14. Zhu XF, Zhang CF, Huang GTJ, Cheung GSP, Dissanayaka WL, Zhu WH. Transplantation of dental pulp stem cells and platelet-rich plasma for pulp regeneration. J Endodont 2012;38:1604-9.
15. Wang J, Liu XH, Jin XB, Ma HY, Hu JA, Ni LX, et al. The odontogenic differentiation of human dental pulp stem cells on nanofibrous poly(L-lactic acid) scaffolds in vitro and in vivo. Acta Biomater 2010;6:3856-63.
16. Sloan AJ, Waddington RJ. Dental pulp stem cells: what, where, how? Int J Paediatr Dent 2009;19:61-70.
17. Lee JH, Lee DS, Choung HW, Shon WJ, Seo BM, Lee EH, et al. Odontogenic differentiation of human dental pulp stem cells induced by preameloblastderived factors. Biomaterials 2011;32:9696-706.
18. Simon SR, Berdal A, Cooper PR, Lumley PJ, Tomson PL, Smith AJ. Dentin-pulp complex regeneration: from lab to clinic. Adv Dent Res 2011;23:340-5.
19. Rosa V, Zhang Z, Grande RHM, Nor JE. Dental pulp tissue engineering in fulllength human root canals. J Dent Res 2013;92:970-5.
20. Huang GTJ, Yamaza T, Shea LD, Djouad F, Kuhn NZ, Tuan RS, et al. Stem/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model. Tissue Eng Part A 2010;16:605-15.
21. Huang GTJ, Sonoyama W, Chen J, Park SH. In vitro characterization of human dental pulp cells: various isolation methods and culturing environments. Cell Tissue Res 2006;324:225-36.
22. Discher DE, Janmey P, Wang YL. Tissue cells feel and respond to the stiffness of their substrate. Science 2005;310:1139-43.
23. Her GJ, Wu HC, Chen MH, Chen MY, Chang SC, Wang TW. Control of threedimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages. Acta Biomater 2013;9:5170-80.
24. Miron-Mendoza M, Seemann J, Grinnell F. The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices. Biomaterials 2010;31:6425-35.
25. Singh M, Dormer N, Salash JR, Christian JM, Moore DS, Berkland C, et al. Threedimensional macroscopic scaffolds with a gradient in stiffness for functional regeneration of interfacial tissues. J Biomed Mater Res, Part A 2010;94A:870-6.
26. Zouani OF, Kalisky J, Ibarboure E, Durrieu MC. Effect of BMP-2 from matrices of different stiffnesses for the modulation of stem cell fate. Biomaterials 2013;34:2157-66.
27. Sachar A, Strom TA, San Miguel S, Serrano MJ, Svoboda KK, Liu X. Cell-matrix and cell-cell interactions of human gingival fibroblasts on three-dimensional nanofibrous gelatin scaffolds. J Tissue Eng Regen Med 2012.
28. Sachar A, Strom TA, Serrano MJ, Benson MD, Opperman LA, Svoboda KKH, et al. Osteoblasts responses to three-dimensional nanofibrous gelatin scaffolds. J Biomed Mater Res, Part A 2012;100A:3029-41.
29. Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell 2006;126:677-89.
30. Saha K, Keung AJ, Irwin EF, Li Y, Little L, Schaffer DV, et al. Substrate modulus directs neural stem cell behavior. Biophys J 2008;95:4426-38.
31. Sun HL, Zhu F, Hu Q, Krebsbach PH. Controlling stem cell-mediated bone regeneration through tailored mechanical properties of collagen scaffolds. Biomaterials 2014;35:1176-84.
32. Qu T, Jing J, Jiang Y, Taylor RJ, Feng J, Geiger B, et al. Magnesium-containing nano-structured hybrid scaffolds for enhanced dentin regeneration. Tissue Eng Part A 2014 [Epub ahead of print]: PMID: 24593189.
33. Qu TJ, Liu XH. Nano-structured gelatin/bioactive glass hybrid scaffolds for the enhancement of odontogenic differentiation of human dental pulp stem cells. J Mater Chem B 2013;1:4764-72.
34. Liu X, Smith LA, Hu J, Ma PX. Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering. Biomaterials 2009;30:2252-8.
35. Liu XH, Ma PX. Phase separation, pore structure, and properties of nanofibrous gelatin scaffolds. Biomaterials 2009;30:4094-103.
36. Sun Y, Jiang Y, Liu QJ, Gao T, Feng JQ, Dechow P, et al. Biomimetic engineering of nanofibrous gelatin scaffolds with noncollagenous proteins for enhanced bone regeneration. Tissue Eng Part A 2013;19:1754-63.
37. Silva N, Witek L, Coelho PG, Thompson VP, Rekow ED, Smay J. Additive CAD/CAM process for dental prostheses. J Prosthodont 2011;20:93-6.
38. Abarrategi A, Moreno-Vicente C, Martinez-Vazquez FJ, Civantos A, Ramos V, Sanz-Casado JV, et al. Biological properties of solid free form designed ceramic scaffolds with BMP-2: in vitro and in vivo evaluation. Plos One 2012:7.
39. Galler K, Schweikl H, Hiller K-A, Cavender A, Bolay C, D'Souza R, et al. TEGDMA reduces mineralization in dental pulp cells. J Dent Res 2011;90:257-62.
40. Ishizaka R, Iohara K, Murakami M, Fukuta O, Nakashima M. Regeneration of dental pulp following pulpectomy by fractionated stem/progenitor cells from bone marrow and adipose tissue. Biomaterials 2012;33:2109-18.
41. Park JS, Chu JS, Tsou AD, Diop R, Tang ZY, Wang AJ, et al. The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGFbeta. Biomaterials 2011;32:3921-30.
42. Grinnell F, Ho C-H. The effect of growth factor environment on fibroblast morphological response to substrate stiffness. Biomaterials 2013;34:965-74.
43. Huang XB, Hang RQ, Wang XG, Lin NM, Zhang XY, Tang B. Matrix stiffness in three-dimensional systems effects on the behavior of C3A cells. Artif Organs 2013;37:166-74.
44. Fischer RS, Myers KA, Gardel ML, Waterman CM. Stiffness-controlled threedimensional extracellular matrices for high-resolution imaging of cell behavior. Nat Protoc 2012;7:2056-66.
45. Guilak F, Cohen DM, Estes BT, Gimble JM, Liedtke W, Chen CS. Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell 2009;5:17-26.
46. Tang J, Peng R, Ding J. The regulation of stem cell differentiation by cell-cell contact on micropatterned material surfaces. Biomaterials 2010;31:2470-6.
47. Bitar M, Brown RA, Salih V, Kidane AG, Knowles JC, Nazhat SN. Effect of cell density on osteoblastic differentiation and matrix degradation of biomimetic dense collagen scaffolds. Biomacromolecules 2008;9:129-35.
48. Pelham RJ, Wang YL. Cell locomotion and focal adhesions are regulated by substrate flexibility. Proc Natl Acad Sci USA 1997;94:13661-5.