Pulp and dentin tissue engineering and regeneration: Current progress

Regenerative Medicine

Volumn 4, Issue 5, 2009, Pages 697-707

  Huang, George T J ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Dental pulp stem cells; Mesenchymal stem cells; Stem cells from apical papilla; Stem cells from human exfoliated deciduous; Tissue engineering; Tissue regeneration

Indexed keywords

5' NUCLEOTIDASE; BETA1 INTEGRIN; BETA2 INTEGRIN; CD14 ANTIGEN; CD146 ANTIGEN; CD24 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; DENTIN MATRIX PROTEIN 1; ENDOGLIN; HERMES ANTIGEN; HLA DR ANTIGEN; MICROSOMAL AMINOPEPTIDASE; OCTAMER TRANSCRIPTION FACTOR 4; POLYGLACTIN; POLYGLYCOLIC ACID; POLYLACTIC ACID; THY 1 ANTIGEN; TRANSCRIPTION FACTOR NANOG; VASCULAR CELL ADHESION MOLECULE 1;

CELL DIFFERENTIATION; CELL RENEWAL; CHONDROGENESIS; DECIDUOUS TOOTH; DENTIN; ENDODONTICS; HUMAN; MESENCHYMAL STEM CELL; NONHUMAN; ODONTOBLAST; PERIODONTAL DISEASE; PRIORITY JOURNAL; REVIEW; SEVERE COMBINED IMMUNODEFICIENCY; STEM CELL; TISSUE ENGINEERING; TISSUE REGENERATION; TOOTH DEVELOPMENT; TOOTH PULP;

ANIMALS; CELL DIFFERENTIATION; DENTAL PULP; DENTIN; HUMANS; MESENCHYMAL STEM CELLS; MICE; REGENERATION; REGENERATIVE MEDICINE; TISSUE ENGINEERING;

EID: 70350774510     PISSN: 17460751     EISSN: None     Source Type: Journal    
DOI: 10.2217/rme.09.45     Document Type: Review

References (88)

1. Young CS, Terada S, Vacanti JP, Honda M, Bartlett JD, Yelick PC: Tissue engineering of complex tooth structures on biodegradable polymer scaffolds. J. Dent. Res. 81, 695-700 (2002).
2. Young CS, Abukawa H, Asrican R et al.: Tissue-engineered hybrid tooth and bone. Tissue Eng. 11, 1599-1610 (2005).
3. Yen A, Sharpe P: Stem cells and tooth tissue engineering. Cell Tissue Res. 331, 359-372 (2008).
4. Ohazama A, Modino SA, Miletich I, Sharpe PT: Stem-cell-based tissue engineering of murine teeth. J. Dent. Res. 83, 518-522 (2004).
5. Sonoyama W, Liu Y, Fang D et al.: Mesenchymal stem cell-mediated functional tooth regeneration in swine. PLoS ONE 1, e79 (2006).
6. Mooney DJ, Powell C, Piana J, Rutherford B: Engineering dental pulp-like tissue in vitro. Biotechnol. Prog. 12, 865-868 (1996).
7. Bohl KS, Shon J, Rutherford B, Mooney DJ: Role of synthetic extracellular matrix in development of engineered dental pulp. J. Biomater. Sci. Polym. Ed. 9, 749-764 (1998).
8. Buurma B, Gu K, Rutherford RB: Transplantation of human pulpal and gingival fibroblasts attached to synthetic scaffolds. Eur. J. Oral Sci. 107, 282-289 (1999).
9. Tsukamoto Y, Fukutani S, Shin-Ike T et al.: Mineralized nodule formation by cultures of human dental pulp-derived fibroblasts. Arch. Oral Biol. 37, 1045-1055 (1992).
10. About I, Bottero MJ, de Denato P, Camps J, Franquin JC, Mitsiadis TA: Human dentin production in vitro. Exp. Cell Res. 258, 33-41 (2000).
11. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S: Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Prot. Natl Acad. Sci. USA 97, 13625-13630 (2000).
12. Alley BS, Kitchens GG, Alley LW, Eleazer PD: A comparison of survival of teeth following endodontic treatment performed by general dentists or by specialists. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 98, 115-118 (2004).
13. Marending M, Peters OA, Zehnder M: Factors affecting the outcome of orthograde root canal therapy in a general dentistry hospital practice. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 99, 119-124 (2005).
14. Kojima K, Inamoto K, Nagamatsu K et al.: Success rate of endodontic treatment of teeth with vital and nonvital pulps. A meta-analysis. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 97, 95-99 (2004).
15. Dammaschke T, Steven D, Kaup M, Ott KH: Long-term survival of root-canal-treated teeth: a retrospective study over 10 years. J. Endod. 29 638-643 (2003).
16. Ruddle CJ: Broken instrument removal. The endodontic challenge. Dent. Today 21, 70-72, 74, 76 passim. (2002).
17. Ward JR: The use of an ultrasonic technique to remove a fractured rotary nickel-titanium instrument from the apical third of a curved root canal. Aust. Endod. J. 29, 25-30 (2003).
18. Suter B, Lussi A, Sequeira P: Probability of removing fractured instruments from root canals. Int. Endod. J. 38, 112-123 (2005).
19. Bargholz C: Perforation repair with mineral trioxide aggregate: a modified matrix concept. Int. Endod. J. 38, 59-69 (2005).
20. Zenobio EG, Shibli JA: Treatment of endodontic perforations using guided tissue regeneration and demineralized freeze-dried bone allograft: two case reports with 2-4 year post-surgical evaluations. J. Contemp. Dent. Pract. 5, 131-141 (2004).
21. Yoldas O, Oztunc H, Tinaz C, Alparslan N: Perforation risks associated with the use of Masserann endodontic kit drills in mandibular molars. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 97, 513-517 (2004).
22. Andreasen JO, Farik B, Munksgaard EC: Long-term calcium hydroxide as a root canal dressing may increase risk of root fracture. Dent. Traumatol. 18, 134-137 (2002).
23. Feely L, Mackie IC, Macfarlane T: An investigation of root-fractured permanent incisor teeth in children. Dent. Traumatol. 19, 52-54 (2003).
24. Andreasen JO, Andreasen FM, Mejare I, Cvek M: Heating of 400 intra-alveolar root fractures. 1. Effect of pre-injury and injury factors such as sex, age, stage of root development, fracture type, location of fracture and severity of dislocation. Dent. Traumatol. 20, 192-202 (2004).
25. Bastone EB, Freer TJ, McNamara JR: Epidemiology of dental trauma: a review of the literature. Aust. Dent. J. 45, 2-9 (2000).
26. Da Silva AC, Passeri LA, Mazzonetto R, De Moraes M, Moreira RW: Incidence of dental trauma associated with facial trauma in Brazil: a 1-year evaluation. Dent. Traumatol. 20, 6-11 (2004).
27. Sedgley CM, Messer HH: Are endodontically treated teeth more brittle? J. Endod. 18, 332-335 (1992).
28. Huang GT, Schilder H, Nathanson D: Effects of moisture content and endodontic treatment on some mechanical properties of human dentin. J Endodont. 18, 209-215 (1992).
29. Reeh ES, Messer HH, Douglas WH: Reduction in tooth stiffness as a result of endodontic and restorative procedures. J. Endod. 15, 512-516 (1989).
30. Piwowarczyk A, Lauer HC, Sorensen JA: Microleakage of various cementing agents for full cast crowns. Dent. Mater. 21, 445-453 (2005).
31. Caplan DJ, Cai J, Yin G, White BA: Root canal filled versus non-root canal filled teeth: a retrospective comparison of survival times. J. Public Health Dent. 65, 90-96 (2005).
32. Pappen AF, Bravo M, Gonzalez-Lopez S, Gonzalez-Rodriguez MP: An in vitro study of coronal leakage after intraradicular preparation of cast-dowel space. J. Prosthet. Dent. 94, 214-218 (2005).
33. Demirel F, Saygili G, Sahmali S: Microleakage of endodontically treated teeth restored with prefabricated posts and tooth-colored restorative materials. Int. J. Periadontics Restorative Dent. 25, 73-79 (2005).
34. Bogen G, Kim JS, Bakland LK: Direct pulp capping with mineral trioxide aggregate: an observational study. J. Am. Dent. Assoc. 139, 305-315 (2008).
35. Olsson H, Petersson K, Rohlin M: Formation of a hard tissue barrier after pulp cappings in humans. A systematic review. Int. Endod. J. 39, 429-442 (2006).
36. Seltzer S, Bender IB, Ziontz M: The dynamics of pulp inflammation: correlations between diagnostic data and actual histologic findings in the pulp. Oral Surg. Oral Med. Oral Pathol. 16, 969-977 (1963).
37. Trowbridge H: Histology of pulpal Inflammation. In: Seltzer and Bender's Dental Pulp. Hargreaves KM, Goodis HE (Eds). Quintessence Publishing Co., Inc, Carol Stream, IL, USA 227-245 (2002).
38. Ostby BN: The role of the blood clot in endodontic therapy. An experimental histologic study. Acta Odontol. Scand. 19, 324-353 (1961).
39. Myers WC, Fountain SB: Dental pulp regeneration aided by blood and blood substitutes after experimentally induced periapical infection. Oral Surg. Oral Med. Oral Pathol. 37, 441-450 (1974).
40. Ellis E 3rd, Cox CF, Hitchcock R, Baker J: Vital apicoectomy of the teeth: a 1-4 week histopathological study in Mocaca mulatta. J. Oral Pathol. 14, 718-732 (1985).
41. Hitchcock R, Ellis E 3rd, Cox CF: Intentional vital root transection: a 52-week histopathologic study in Macaca mulatta. Oral Surg. Oral Med. Oral Pathol. 60, 2-14 (1985).
42. Sheridan MH, Shea LD, Peters MC, Mooney DJ: Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery. J. Control. Release 64, 91-102 (2000).
43. Langer R, Vacanti JP: Tissue engineering. Science 260, 920-926 (1993).
44. Nerem RM: Tissue engineering in the USA. Med. Biol. Eng. Comput. 30, CE8-CE12 (1992).
45. Gronthos S, Brahim J, Li W et al.: Stem cell properties of human dental pulp stem cells. J. Dent. Res. 81, 531-535 (2002).
46. Batouli S, Miura M, Brahim J et al.: Comparison of stem-cell-mediated osteogenesis and dentinogenesis. J. Dent. Res. 82, 976-981 (2003).
47. Miura M, Gronthos S, Zhao M et al.: SHED: stem cells from human exfoliated deciduous teeth. Proc. Natl Acad. Sci. USA 100, 5807-5812 (2003).
48. Seo BM, Miura M, Gronthos S et al.: Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364, 149-155 (2004).
49. Sonoyama W, Liu Y, Yamaza T et al.: Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study. J. Endod. 34, 166-171 (2008).
50. Morsczeck C, Gotz W, Schierholz J et al.: Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol. 24 155-165 (2005).
51. Huang GTJ, Gronthos S, Shi S: Mesenchymal stem cells derived from dental tissues vs from other sources: the biology and role in regenerative medicine. J. Dent. Res. (2009) (In Press).
52. Huang GTJ, Sonoyama W, Chen J, Park S: In vitro characterization of human dental pulp cells: various isolation methods and culturing environments. Cell Tissue Res. 324, 225-236 (2006).
53. Murray PE, Garcia-Godoy F, Hargreaves KM: Regenerative endodontics: a review of current status and a call for action. J. Endod. 33, 377-390 (2007).
54. Huang GTJ, Sonoyama W, Liu Y, Liu H, Wang S, Shi S: The hidden treasure in apical papilla, the potential role in pulp/dentin regeneration and bioroot engineering. J. Endod. 34, 645-651 (2008).
55. Mitsiadis TA, Barrandon O, Rochat A, Barrandon Y, De Bari C: Stem cell niches in mammals. Exp. Cell Res. 313, 3377-3385 (2007).
56. Zannettino ACW, Paton S, Arthur A et al.: Multipotential human adipose-derived stromal stem cells exhibit a perivascular phenotype in vitro and in vivo. J Cell. Physiol. 214, 413-421 (2008).
57. Shi S, Gronthos S: Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp. J. Bone Miner. Res. 18, 696-704 (2003).
58. Chen SC, Marino V, Gronthos S, Bartold PM: Location of putative stem cells in human periodontal ligament. J. Periodont. Res. 41, 547-553 (2006).
59. Greco SJ, Liu K, Rameshwar P: Functional similarities among genes regulated by oct4 in human mesenchymal and embryonic stem cells. Stem Cells 25, 3143-3154 (2007).
60. Gronthos S, Zannettino ACW: A method to isolate and purify human bone marrow stromal stem cells. In: Mesenchymal Stem Cells Methods and Protocols. Prockop DJ, Bunnell BA, Phinney DG (Eds). Humana Press, USA 45-57 (2008).
61. Dominici M, Le Blanc K, Mueller I et al.: Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8, 315-317 (2006).
62. Gronthos S, Zannettino AC, Hay SJ et al.: Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow. J. Cell Sci. 116, 1827-1835 (2003).
63. Battula VL, Bareiss PM, Treml S et al.: Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation. Differentiation 75, 279-291 (2007).
64. Miura Y, Miura M, Gronthos S et al.: Defective osteogenesis of the stromal stem cells predisposes CD18-null mice to ostcoporosis. Proc. Natl Acad. Sci. USA 102, 14022-14027 (2005).
65. Laino G, d'Aquino R, Graziano A et al.: A new population of human adult dental pulp stem cells: a useful source of living autologous fibrous bone tissue (LAB). J. Bone Miner. Res. 20, 1394-1402 (2005).
66. Laino G, Graziano A, d'Aquino R et al.: An approachable human adult stem cell source for hard-tissue engineering. J. Cell. Physiol. 206, 693-701 (2006).
67. Iohara K, Zheng L, Ito M, Tomokiyo A, Matsushita K, Nakashima M: Side population cells isolated from porcine dental pulp tissue with self-renewal and multipotency for dentinogenesis, chondrogenesis, adipogenesis, and neurogenesis. Stem Cells 24, 2493-2503 (2006).
68. - side population cells from a canine tooth. Regen. Med. 4, 377-385 (2009).
69. Kerkis I, Kerkis A, Dozortsev D et al.: Isolation and characterization of a population of immature dental pulp stem cells expressing OCT-4 and other embryonic stem cell markers. Cells Tissues Organs 184, 105-116 (2006).
70. Arthur A, Rychkov G, Shi S, Koblar SA, Gronthos S: Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues. Stem Cells 26, 1787-1795 (2008).
71. Waddington RJ, Youde SJ, Lee CP, Sloan AJ: Isolation of distinct progenitor stem cell populations from dental pulp. Cells Tissues Organs 189, 268-274 (2009).
72. Hu B, Unda F, Bopp-Kuchler S et al.: Bone marrow cells can give rise to ameloblast-like cells. J. Dent. Res. 85, 416-421 (2006).
73. Yu J, Wang Y, Deng Z et al.: Odontogenic capability: bone marrow stromal stem cells versus dental pulp stem cells. Biol. Cell 99, 465-474 (2007).
74. Huo N, Tang L, Yang Z et al.: Differentiation of dermal multipotent cells into odontogenic lineage induced by embryonic and neonatal tooth germ cell conditioned medium. Stem Cells Dev. (2009) (Epub ahead of print).
75. Cordeiro MM, Dong Z, Kaneko T et al.: Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. J. Endod. 34, 962-969 (2008).
76. Prescott RS, Alsanea R, Fayad MI et al.: In vivo generation of dental pulp-like tissue by using dental pulp stem cells, a collagen scaffold, dentin matrix protein 1 after subcutaneous transplantation in mice. J. Endod. 34, 421-426 (2008).
77. Nakashima M, Akamine A: The application of tissue engineering to regeneration of pulp and dentin in endodontics. J. Endod. 31. 711-718 (2005).
78. Iohara K, Nakashima M, Ito M, Ishikawa M, Nakasima A, Akamine A: Dentin regeneration by dental pulp stem cell therapy with recombinant human bone morphogenetic protein 2. J. Dent. Res. 83, 590-595 (2004).
79. Rutherford RB, Gu K: Treatment of inflamed ferret dental pulps with recombinant bone morphogenetic protein-7. Eur. J. Oral Sci. 108, 202-206 (2000).
80. Peters MC, Polverini PJ, Mooney DJ: Engineering vascular networks in porous polymer matrices. J. Biomed. Mater. Res. 60, 668-678 (2002).
81. Sun Q, Chen RR, Shen Y, Mooney DJ, Rajagopalan S, Grossman PM: Sustained vascular endothelial growth factor delivery enhances angiogenesis and perfusion in ischemic hind limb. Pharm. Res. 22, 1110-1116 (2005).
82. Richardson TP, Peters MC, Ennett AB, Mooney DJ: Polymeric system for dual growth factor delivery. Nat. Biotechnol. 19, 1029-1034 (2001).
83. Stiver SI, Tan X, Brown LF, Hedley-Whyte ET, Dvorak HF: VEGF-A angiogenesis induces a stable neovasculature in adult murine brain. J. Neuropathol. Exp. Neurol. 63, 841-855 (2004).
84. Nosrat IV, Smith CA, Mullally P, Olson L, Nosrat CA: Dental pulp cells provide neurotrophic support for dopaminergic neurons and differentiate into neurons in vitro; implications for tissue engineering and repair in the nervous system. Eur. J. Neurosci. 19 2388-2398 (2004).
85. Takahashi K, Tanabe K, Ohnuki M et al.: Induction of pluripotent stein Cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (2007).
86. Yu J, Vodyanik MA, Smuga-Otto K et al.: Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917-1920 (2007).
87. Seo BM, Sonoyama W, Yamaza T et al.: SHED repair critical-size calvarial defects in mice. Oral Dis. 14, 428-434 (2008).
88. Baksh D, Song L, Tuan RS: Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J. Cell. Mol. Med. 8, 301-316 (2004).