Hypoxia-guided adaptive radiation dose escalation in head and neck carcinoma: A planning study

Acta Oncologica

Volumn 54, Issue 7, 2015, Pages 1008-1016

  Servagi Vernat, Stéphanie ^a,b   Differding, Sarah ^a   Sterpin, Edmond ^a   Hanin, Francois Xavier ^a   Labar, Daniel ^a   Bol, Anne ^a   Lee, John A ^a   Grégoire, Vincent ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b UNIVERSITY HOSPITAL JEAN MINJOZ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; CETUXIMAB; FLUOROAZOMYCIN ARABINOSIDE F 18; FLUOROURACIL; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; FLUOROAZOMYCIN ARABINOSIDE; NITROIMIDAZOLE DERIVATIVE;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER PATIENT; CHEMORADIOTHERAPY; CLINICAL ARTICLE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTINUOUS INFUSION; DOSIMETRY; FEMALE; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HYPOXIA; INTENSITY MODULATED RADIATION THERAPY; LOADING DRUG DOSE; MALE; MULTIPLE CYCLE TREATMENT; PRIORITY JOURNAL; RADIATION DOSE DISTRIBUTION; RADIATION DOSE ESCALATION; RADIATION DOSE FRACTIONATION; TREATMENT PLANNING; CARCINOMA, SQUAMOUS CELL; CLINICAL TRIAL; COMPUTER ASSISTED DIAGNOSIS; COMPUTER ASSISTED TOMOGRAPHY; HEAD AND NECK NEOPLASMS; MIDDLE AGED; MULTIMODAL IMAGING; POSITRON EMISSION TOMOGRAPHY; PROCEDURES; RADIOTHERAPY PLANNING SYSTEM; SCINTISCANNING;

AGED; CARCINOMA, SQUAMOUS CELL; DOSE FRACTIONATION; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALE; MIDDLE AGED; MULTIMODAL IMAGING; NITROIMIDAZOLES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84930903779     PISSN: 0284186X     EISSN: 1651226X     Source Type: Journal    
DOI: 10.3109/0284186X.2014.990109     Document Type: Article

References (45)

1. Koukourakis M I, Bentzen S M, Giatromanolaki A, Wilson GD, Daley FM, Saunders MI, et al. Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial. J Clin Oncol 2006; 24: 727-35.
2. Nordsmark M, Bentzen SM, Rudat V, Brizel D, Lartigau E, Stadler P, et al. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol 2005; 77: 18-24.
3. Vaupel P, Schlenger K, Knoop C, Hockel M. Oxygenation of human tumors: Evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Res 1991; 51: 3316-22.
4. Janssens G O, Rademakers S E, Terhaard C H, Doornaert P A, Bijl HP, van den Ende P, et al. Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer: Results of a phase III randomized trial. J Clin Oncol 2012; 30: 1777-83. Lee DJ, Pajak TF
5. Lee DJ, Pajak TF, Stetz J, Order SE, Weissberg JB, Fischer JJ. Aphase I/II study of the hypoxic cell sensitizer misonidazole as an adjunct to high fractional dose radiotherapy in patients with unresectable squamous cell carcinoma of the head and neck: A RTOG randomized study (#79-04). Int J Radiat Oncol Biol Phys 1989; 16: 465-70.
6. Mizoe JE, Hasegawa A, Jingu K, Takagi R, Bessyo H, Morikawa T, et al. Results of carbon ion radiotherapy for head and neck cancer. Radiother Oncol 2012; 103: 32-7.
7. Overgaard J. Hypoxic modifi cation of radiotherapy in squamous cell carcinoma of the head and neck - a systematic review and meta-analysis. Radiother Oncol 2011; 100: 22-32.
8. Overgaard J, Horsman M R. Modifi cation of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers. Semin Radiat Oncol 1996; 6: 10-21.
9. Bassler N, Toftegaard J, Luhr A, Sorensen BS, Scifoni E, Kramer M, et al. LET-painting increases tumour control probability in hypoxic tumours. Acta Oncol 2014; 53: 25-32.
10. Thorwarth D, Alber M. Implementation of hypoxia imaging into treatment planning and delivery. Radiother Oncol 2010; 97: 172-5.
11. Bentzen SM, Gregoire V. Molecular imaging-based dose painting: Anovel paradigm for radiation therapy prescription. Semin Radiat Oncol 2011; 21: 101-10.
12. Geets X, Gregoire V, Lee JA. Implementation of hypoxia PET imaging in radiation therapy planning. Q J Nucl Med Mol Imaging 2013; 57: 271-82.
13. Grau C, Olsen D R, Overgaard J, Hoyer M, Lindegaard J C, Muren LP. Biology-guided adaptive radiation therapy - presence or future? Acta Oncol 2010; 49: 884-7.
14. Grau C, Hoyer M, Alber M, Overgaard J, Lindegaard J C, Muren LP. Biology-guided adaptive radiotherapy (BiGART) - more than a vision? Acta Oncol 2013; 52: 1243-7.
15. Horsman MR, Mortensen LS, Petersen JB, Busk M, Overgaard J. Imaging hypoxia to improve radiotherapy outcome. Nat Rev Clin Oncol 2012; 9: 674-87.
16. Carlin S, Zhang H, Reese M, Ramos NN, Chen Q, Ricketts SA. Acomparison of the imaging characteristics and microregional distribution of 4 hypoxia PET tracers. J Nucl Med 2014; 55: 515-21.
17. Carlin S, Humm J L. P ET of hypoxia: Current and future perspectives. J Nucl Med 2012; 53: 1171-4.
18. Busk M, Mortensen LS, Nordsmark M, Overgaard J, Jakobsen S, Hansen KV, et al. PET hypoxia imaging with FAZA: Reproducibility at baseline and during fractionated radiotherapy in tumour-bearing mice. Eur J Nucl Med Mol Imaging 2013; 40: 186-97.
19. Grosu AL, Souvatzoglou M, Roper B, Dobritz M, Wiedenmann N, Jacob V, et al. Hypoxia imaging with FAZAPET and theoretical considerations with regard to dose painting for individualization of radiotherapy in patients with head and neck cancer. Int J Radiat Oncol Biol Phys 2007; 69: 541-51.
20. Mortensen L S, Johansen J, Kallehauge J, Primdahl H, Busk M, Lassen P, et al. FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: Results from the DAHANCA 24 trial. Radiother Oncol 2012; 105: 14-20.
21. Souvatzoglou M, Grosu A L, Roper B, Krause BJ, Beck R, Reischl G, et al. Tumour hypoxia imaging with [18F]FAZA PET in head and neck cancer patients: Apilot study. Eur J Nucl Med Mol Imaging 2007; 34: 1566-75.
22. Trinkaus ME, Blum R, Rischin D, Callahan J, Bressel M, Segard T, et al. Imaging of hypoxia with 18F-FAZA PET in patients with locally advanced non-small cell lung cancer treated with defi nitive chemoradiotherapy. J Med Imaging Radiat Oncol 2013; 57: 475-81.
23. Zips D, Zophel K, Abolmaali N, Perrin R, Abramyuk A, Haase R, et al. Exploratory prospective trial of hypoxiaspecifi c PET imaging during radiochemotherapy in patients with locally advanced head-and-neck cancer. Radiother Oncol 2012; 105: 21-8.
24. Servagi-Vernat S, Differding S, Hanin FX, Labar D, Bol A, Lee JA, et al. Aprospective clinical study of F-FAZA PET-CT hypoxia imaging in head and neck squamous cell carcinoma before and during radiation therapy. Eur J Nucl Med Mol Imaging 2014; 41: 1544-52.
25. Delouya G, Igidbashian L, Houle A, Belair M, Boucher L, Cohade C, et al. (1)(8)F-FDG-PET imaging in radiotherapy tumor volume delineation in treatment of head and neck cancer. Radiother Oncol 2011; 101: 362-8.
26. Hendrickson K, Phillips M, Smith W, Peterson L, Krohn K, Rajendran J. Hypoxia imaging with [F-18] FMISO-PET in head and neck cancer: Potential for guiding intensity modulated radiation therapy in overcoming hypoxia-induced treatment resistance. Radiother Oncol 2011; 101: 369-75.
27. Thorwarth D, Eschmann SM, Paulsen F, Alber M. Hypoxia dose painting by numbers: Aplanning study. Int J Radiat Oncol Biol Phys 2007; 68: 291-300.
28. Bittner M I, Grosu AL. Hypoxia in head and neck tumors: Characteristics and development during therapy. Front Oncol 2013; 3: 223.
29. Bittner MI, Wiedenmann N, Bucher S, Hentschel M, Mix M, Weber WA, et al. Exploratory geographical analysis of hypoxic subvolumes using F-MISO-PET imaging in patients with head and neck cancer in the course of primary chemoradiotherapy. Radiother Oncol 2013; 108: 511-6.
30. Calais G, Alfonsi M, Bardet E, Sire C, Germain T, Bergerot P, et al. Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advancedstage oropharynx carcinoma. J Natl Cancer Inst 1999; 91: 2081-6.
31. Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, et al. Radiotherapy plus cetuximab for squamouscell carcinoma of the head and neck. N Engl J Med 2006; 354: 567-78.
32. Gregoire V, Coche E, Cosnard G, Hamoir M, Reychler H. Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy. Proposal for standardizing terminology and procedure based on the surgical experience. Radiother Oncol 2000; 56: 135-50.
33. Gregoire V, Eisbruch A, Hamoir M, Levendag P. Proposal for the delineation of the nodal CTV in the node-positive and the post-operative neck. Radiother Oncol 2006; 79: 15-20.
34. Sterpin E, Differding S, Janssens G, Geets X, Gregoire V, Lee JA. Generation of prescriptions robust against geometric uncertainties in dose painting by numbers. Acta Oncol Epub 2014 July 3.
35. Deveau MA, Bowen SR, Westerly DC, Jeraj R. Feasibility and sensitivity study of helical tomotherapy for dose painting plans. Acta Oncol 2010; 49: 991-6.
36. Gregoire V MR, editors. I CRU report 83, International Commission on Radiation Units and Measurements. Prescribing, recording, and reporting photon-beam intensitymodulated radiation therapy (IMRT). J ICRU 2010; 10(1).
37. Chao KS, Bosch WR, Mutic S, Lewis JS, Dehdashti F, Mintun MA, et al. Anovel approach to overcome hypoxic tumor resistance: Cu-ATSM-guided intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys 2001; 49: 1171-82.
38. Madani I, Duprez F, Boterberg T, Van de Wiele C, Bonte K, Deron P, et al. Maximum tolerated dose in a phase Itrial on adaptive dose painting by numbers for head and neck cancer. Radiother Oncol 2011; 101: 351-5.
39. Duprez F, De Neve W, De Gersem W, Coghe M, Madani I. Adaptive dose painting by numbers for head-and-neck cancer. Int J Radiat Oncol Biol Phys 2011; 80: 1045-55.
40. Tran L B, Bol A, Labar D, Jordan B, Magat J, Mignion L, et al. Hypoxia imaging with the nitroimidazole 18F-FAZA PET tracer: Acomparison with OxyLite, EPR oximetry and 19F-MRI relaxometry. Radiother Oncol 2012; 105: 29-35.
41. Sovik A, Malinen E, Skogmo HK, Bentzen SM, Bruland OS, Olsen DR. Radiotherapy adapted to spatial and temporal variability in tumor hypoxia. Int J Radiat Oncol Biol Phys 2007; 68: 1496-504.
42. Berwouts D, Olteanu LA, Duprez F, Vercauteren T, De Gersem W, De Neve W, et al. Three-phase adaptive dosepainting- by-numbers for head-and-neck cancer: Initial results of the phase Iclinical trial. Radiother Oncol 2013; 107: 310-6.
43. van Kranen S, Mencarelli A, van Beek S, Rasch C, van Herk M, Sonke JJ. Adaptive radiotherapy with an average anatomy model: Evaluation and quantifi cation of residual deformations in head and neck cancer patients. Radiother Oncol 2013; 109: 463-8.
44. Robbins K T, Medina J E, Wolfe G T, Levine P A, Sessions R B, Pruet CW. Standardizing neck dissection terminology. Offi - cial report of the Academy's Committee for Head and Neck Surgery and Oncology. Arch Otolaryngol Head Neck Surg 1991; 117: 601-5.
45. Sobin L, Gospodarowicz M, Wittekind C, editor. TNM classifi cation of malignant tumours, 7th ed. New York, NY, John Wiley and Sons, 2009.