메뉴 건너뛰기




Volumn 20, Issue 7, 2013, Pages 453-462

Impact of oral silymarin on virus- and non-virus-specific T-cell responses in chronic hepatitis C infection

Author keywords

hepatitis C; interferon gamma; interferon stimulated gene; lymphocyte; silymarin; T cell

Indexed keywords

ALANINE AMINOTRANSFERASE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; LYMPHOTOXIN; PHYTOHEMAGGLUTININ; PLACEBO; SILYMARIN; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; VIRUS RNA;

EID: 84878536109     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/jvh.12050     Document Type: Article
Times cited : (15)

References (38)
  • 2
    • 0037105567 scopus 로고    scopus 로고
    • Impaired effector function of hepatitis C virus-specific CD8 + T cells in chronic hepatitis C virus infection
    • Wedemeyer H, He XS, Nascimbeni M, Davis AR, Greenberg HB, Hoofnagle JH, et al,. Impaired effector function of hepatitis C virus-specific CD8 + T cells in chronic hepatitis C virus infection. J Immunol 2002; 169 (6): 3447-3458.
    • (2002) J Immunol , vol.169 , Issue.6 , pp. 3447-3458
    • Wedemeyer, H.1    He, X.S.2    Nascimbeni, M.3    Davis, A.R.4    Greenberg, H.B.5    Hoofnagle, J.H.6
  • 3
    • 0038374730 scopus 로고    scopus 로고
    • Detection of functionally altered hepatitis C virus-specific CD4 T cells in acute and chronic hepatitis C
    • Ulsenheimer A, Gerlach JT, Gruener NH, Jung MC, Schirren CA, Schraut W, et al,. Detection of functionally altered hepatitis C virus-specific CD4 T cells in acute and chronic hepatitis C. Hepatology 2003; 37 (5): 1189-1198.
    • (2003) Hepatology , vol.37 , Issue.5 , pp. 1189-1198
    • Ulsenheimer, A.1    Gerlach, J.T.2    Gruener, N.H.3    Jung, M.C.4    Schirren, C.A.5    Schraut, W.6
  • 4
    • 33847067210 scopus 로고    scopus 로고
    • Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C
    • Kaplan DE, Sugimoto K, Newton K, Valiga ME, Ikeda F, Aytaman A, et al,. Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology 2007; 132 (2): 654-666.
    • (2007) Gastroenterology , vol.132 , Issue.2 , pp. 654-666
    • Kaplan, D.E.1    Sugimoto, K.2    Newton, K.3    Valiga, M.E.4    Ikeda, F.5    Aytaman, A.6
  • 5
    • 0036727325 scopus 로고    scopus 로고
    • The dynamics of T-lymphocyte responses during combination therapy for chronic hepatitis C virus infection
    • Barnes E, Harcourt G, Brown D, Lucas M, Phillips R, Dusheiko G, et al,. The dynamics of T-lymphocyte responses during combination therapy for chronic hepatitis C virus infection. Hepatology 2002; 36 (3): 743-754.
    • (2002) Hepatology , vol.36 , Issue.3 , pp. 743-754
    • Barnes, E.1    Harcourt, G.2    Brown, D.3    Lucas, M.4    Phillips, R.5    Dusheiko, G.6
  • 6
    • 0033960092 scopus 로고    scopus 로고
    • Hepatitis C virus-specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C
    • Cramp ME, Rossol S, Chokshi S, Carucci P, Williams R, Naoumov NV,. Hepatitis C virus-specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C. Gastroenterology 2000; 118 (2): 346-355.
    • (2000) Gastroenterology , vol.118 , Issue.2 , pp. 346-355
    • Cramp, M.E.1    Rossol, S.2    Chokshi, S.3    Carucci, P.4    Williams, R.5    Naoumov, N.V.6
  • 7
    • 3042780965 scopus 로고    scopus 로고
    • Effects of antiviral therapy on the cellular immune response in acute hepatitis C
    • Rahman F, Heller T, Sobao Y, Mizukoshi E, Nascimbeni M, Alter H, et al,. Effects of antiviral therapy on the cellular immune response in acute hepatitis C. Hepatology 2004; 40 (1): 87-97.
    • (2004) Hepatology , vol.40 , Issue.1 , pp. 87-97
    • Rahman, F.1    Heller, T.2    Sobao, Y.3    Mizukoshi, E.4    Nascimbeni, M.5    Alter, H.6
  • 8
    • 3042782475 scopus 로고    scopus 로고
    • Long-term follow-up after successful interferon therapy of acute hepatitis C
    • Wiegand J, Jackel E, Cornberg M, Hinrichsen H, Dietrich M, Kroeger J, et al,. Long-term follow-up after successful interferon therapy of acute hepatitis C. Hepatology 2004; 40 (1): 98-107.
    • (2004) Hepatology , vol.40 , Issue.1 , pp. 98-107
    • Wiegand, J.1    Jackel, E.2    Cornberg, M.3    Hinrichsen, H.4    Dietrich, M.5    Kroeger, J.6
  • 9
    • 20044395103 scopus 로고    scopus 로고
    • T-cell response relative to genotype and ethnicity during antiviral therapy for chronic hepatitis C
    • Kaplan DE, Sugimoto K, Ikeda F, Stadanlick J, Valiga M, Shetty K, et al,. T-cell response relative to genotype and ethnicity during antiviral therapy for chronic hepatitis C. Hepatology 2005; 41 (6): 1365-1375.
    • (2005) Hepatology , vol.41 , Issue.6 , pp. 1365-1375
    • Kaplan, D.E.1    Sugimoto, K.2    Ikeda, F.3    Stadanlick, J.4    Valiga, M.5    Shetty, K.6
  • 10
    • 77249118149 scopus 로고    scopus 로고
    • Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis
    • Claassen MA, de Knegt RJ, Tilanus HW, Janssen HL, Boonstra A,. Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis. J Hepatol 2010; 52 (3): 315-321.
    • (2010) J Hepatol , vol.52 , Issue.3 , pp. 315-321
    • Claassen, M.A.1    De Knegt, R.J.2    Tilanus, H.W.3    Janssen, H.L.4    Boonstra, A.5
  • 11
    • 43049175169 scopus 로고    scopus 로고
    • Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis
    • Kaplan DE, Ikeda F, Li Y, Nakamoto N, Ganesan S, Valiga ME, et al,. Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis. J Hepatol 2008; 48 (6): 903-913.
    • (2008) J Hepatol , vol.48 , Issue.6 , pp. 903-913
    • Kaplan, D.E.1    Ikeda, F.2    Li, Y.3    Nakamoto, N.4    Ganesan, S.5    Valiga, M.E.6
  • 12
    • 2142702915 scopus 로고    scopus 로고
    • Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection
    • Accapezzato D, Francavilla V, Paroli M, Casciaro M, Chircu LV, Cividini A, et al,. Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection. J Clin Invest 2004; 113 (7): 963-972.
    • (2004) J Clin Invest , vol.113 , Issue.7 , pp. 963-972
    • Accapezzato, D.1    Francavilla, V.2    Paroli, M.3    Casciaro, M.4    Chircu, L.V.5    Cividini, A.6
  • 13
    • 33644652006 scopus 로고    scopus 로고
    • Milk thistle for alcoholic and/or hepatitis B or C liver diseases-A systematic cochrane hepato-biliary group review with meta-analyses of randomized clinical trials
    • Rambaldi A, Jacobs BP, Iaquinto G, Gluud C,. Milk thistle for alcoholic and/or hepatitis B or C liver diseases-a systematic cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Am J Gastroenterol 2005; 100 (11): 2583-2591.
    • (2005) Am J Gastroenterol , vol.100 , Issue.11 , pp. 2583-2591
    • Rambaldi, A.1    Jacobs, B.P.2    Iaquinto, G.3    Gluud, C.4
  • 14
    • 0037280468 scopus 로고    scopus 로고
    • Physiological responses of a natural antioxidant flavonoid mixture, silymarin, in BALB/c mice: III. Silymarin inhibits T-lymphocyte function at low doses but stimulates inflammatory processes at high doses
    • Johnson VJ, He Q, Osuchowski MF, Sharma RP,. Physiological responses of a natural antioxidant flavonoid mixture, silymarin, in BALB/c mice: III. Silymarin inhibits T-lymphocyte function at low doses but stimulates inflammatory processes at high doses. Planta Med 2003; 69 (1): 44-49.
    • (2003) Planta Med , vol.69 , Issue.1 , pp. 44-49
    • Johnson, V.J.1    He, Q.2    Osuchowski, M.F.3    Sharma, R.P.4
  • 15
    • 0036863592 scopus 로고    scopus 로고
    • Physiological responses to a natural antioxidant flavonoid mixture, silymarin, in BALB/c mice: II. alterations in thymic differentiation correlate with changes in c-myc gene expression
    • Johnson VJ, Osuchowski MF, He Q, Sharma RP,. Physiological responses to a natural antioxidant flavonoid mixture, silymarin, in BALB/c mice: II. alterations in thymic differentiation correlate with changes in c-myc gene expression. Planta Med 2002; 68 (11): 961-965.
    • (2002) Planta Med , vol.68 , Issue.11 , pp. 961-965
    • Johnson, V.J.1    Osuchowski, M.F.2    He, Q.3    Sharma, R.P.4
  • 17
    • 55249084176 scopus 로고    scopus 로고
    • Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy
    • 67
    • Ferenci P, Scherzer TM, Kerschner H, Rutter K, Beinhardt S, Hofer H, et al,. Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy. Gastroenterology 2008; 135 (5): 1561-15 67.
    • (2008) Gastroenterology , vol.135 , Issue.5 , pp. 1561-1515
    • Ferenci, P.1    Scherzer, T.M.2    Kerschner, H.3    Rutter, K.4    Beinhardt, S.5    Hofer, H.6
  • 18
    • 67649171662 scopus 로고    scopus 로고
    • Rapid suppression of hepatitis C viremia induced by intravenous silibinin plus ribavirin
    • Biermer M, Berg T,. Rapid suppression of hepatitis C viremia induced by intravenous silibinin plus ribavirin. Gastroenterology 2009; 137 (1): 390-391.
    • (2009) Gastroenterology , vol.137 , Issue.1 , pp. 390-391
    • Biermer, M.1    Berg, T.2
  • 20
    • 75149191891 scopus 로고    scopus 로고
    • Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection
    • Morishima C, Shuhart MC, Wang CC, Paschal DM, Apodaca MC, Liu Y, et al,. Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection. Gastroenterology 2010; 138 (2): 671-681.
    • (2010) Gastroenterology , vol.138 , Issue.2 , pp. 671-681
    • Morishima, C.1    Shuhart, M.C.2    Wang, C.C.3    Paschal, D.M.4    Apodaca, M.C.5    Liu, Y.6
  • 21
    • 34247583381 scopus 로고    scopus 로고
    • Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin
    • Polyak SJ, Morishima C, Shuhart MC, Wang CC, Liu Y, Lee DY,. Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin. Gastroenterology 2007; 132 (5): 1925-1936.
    • (2007) Gastroenterology , vol.132 , Issue.5 , pp. 1925-1936
    • Polyak, S.J.1    Morishima, C.2    Shuhart, M.C.3    Wang, C.C.4    Liu, Y.5    Lee, D.Y.6
  • 22
    • 84863905251 scopus 로고    scopus 로고
    • Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: A randomized controlled trial
    • Fried MW, Navarro VJ, Afdhal N, Belle SH, Wahed AS, Hawke RL, et al,. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. JAMA 2012; 308 (3): 274-282.
    • (2012) JAMA , vol.308 , Issue.3 , pp. 274-282
    • Fried, M.W.1    Navarro, V.J.2    Afdhal, N.3    Belle, S.H.4    Wahed, A.S.5    Hawke, R.L.6
  • 23
    • 0345017746 scopus 로고    scopus 로고
    • Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection
    • Sugimoto K, Ikeda F, Stadanlick J, Nunes FA, Alter HJ, Chang KM,. Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology 2003; 38 (6): 1437-1448.
    • (2003) Hepatology , vol.38 , Issue.6 , pp. 1437-1448
    • Sugimoto, K.1    Ikeda, F.2    Stadanlick, J.3    Nunes, F.A.4    Alter, H.J.5    Chang, K.M.6
  • 24
    • 0037369659 scopus 로고    scopus 로고
    • Influence of ethnicity in the outcome of hepatitis C virus infection and cellular immune response
    • Sugimoto K, Stadanlick J, Ikeda F, Brensinger C, Furth EE, Alter HJ, et al,. Influence of ethnicity in the outcome of hepatitis C virus infection and cellular immune response. Hepatology 2003; 37 (3): 590-599.
    • (2003) Hepatology , vol.37 , Issue.3 , pp. 590-599
    • Sugimoto, K.1    Stadanlick, J.2    Ikeda, F.3    Brensinger, C.4    Furth, E.E.5    Alter, H.J.6
  • 25
    • 0029808747 scopus 로고    scopus 로고
    • The role of hepatitis C virus specific CD4 + T lymphocytes in acute and chronic hepatitis C
    • Diepolder HM, Zachoval R, Hoffmann RM, Jung MC, Gerlach T, Pape GR,. The role of hepatitis C virus specific CD4 + T lymphocytes in acute and chronic hepatitis C. J Mol Med 1996; 74 (10): 583-588.
    • (1996) J Mol Med , vol.74 , Issue.10 , pp. 583-588
    • Diepolder, H.M.1    Zachoval, R.2    Hoffmann, R.M.3    Jung, M.C.4    Gerlach, T.5    Pape, G.R.6
  • 26
    • 0031230799 scopus 로고    scopus 로고
    • Effects of interferon treatment on the antiviral T-cell response in hepatitis C virus genotype 1b- and genotype 2c-infected patients
    • Missale G, Cariani E, Lamonaca V, Ravaggi A, Rossini A, Bertoni R, et al,. Effects of interferon treatment on the antiviral T-cell response in hepatitis C virus genotype 1b- and genotype 2c-infected patients. Hepatology 1997; 26 (3): 792-797.
    • (1997) Hepatology , vol.26 , Issue.3 , pp. 792-797
    • Missale, G.1    Cariani, E.2    Lamonaca, V.3    Ravaggi, A.4    Rossini, A.5    Bertoni, R.6
  • 27
    • 0032832514 scopus 로고    scopus 로고
    • Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C
    • Gerlach JT, Diepolder HM, Jung MC, Gruener NH, Schraut WW, Zachoval R, et al,. Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C. Gastroenterology 1999; 117 (4): 933-941.
    • (1999) Gastroenterology , vol.117 , Issue.4 , pp. 933-941
    • Gerlach, J.T.1    Diepolder, H.M.2    Jung, M.C.3    Gruener, N.H.4    Schraut, W.W.5    Zachoval, R.6
  • 28
    • 33749017951 scopus 로고    scopus 로고
    • Interferon (IFN)- gamma -inducible protein-10: Association with histological results, viral kinetics, and outcome during treatment with pegylated IFN- alpha 2a and ribavirin for chronic hepatitis C virus infection
    • Romero AI, Lagging M, Westin J, Dhillon AP, Dustin LB, Pawlotsky JM, et al,. Interferon (IFN)- gamma -inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN- alpha 2a and ribavirin for chronic hepatitis C virus infection. J Infect Dis 2006; 194 (7): 895-903.
    • (2006) J Infect Dis , vol.194 , Issue.7 , pp. 895-903
    • Romero, A.I.1    Lagging, M.2    Westin, J.3    Dhillon, A.P.4    Dustin, L.B.5    Pawlotsky, J.M.6
  • 29
    • 0032008339 scopus 로고    scopus 로고
    • Milk thistle (Silybum marianum) for the therapy of liver disease
    • Flora K, Hahn M, Rosen H, Benner K,. Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol 1998; 93 (2): 139-143.
    • (1998) Am J Gastroenterol , vol.93 , Issue.2 , pp. 139-143
    • Flora, K.1    Hahn, M.2    Rosen, H.3    Benner, K.4
  • 30
    • 34250708509 scopus 로고    scopus 로고
    • Effects of silymarin on the spontaneous proliferation and cell cycle of human peripheral blood leukemia T cells
    • Gharagozloo M, Amirghofran Z,. Effects of silymarin on the spontaneous proliferation and cell cycle of human peripheral blood leukemia T cells. J Cancer Res Clin Oncol 2007; 133 (8): 525-532.
    • (2007) J Cancer Res Clin Oncol , vol.133 , Issue.8 , pp. 525-532
    • Gharagozloo, M.1    Amirghofran, Z.2
  • 31
    • 47149093695 scopus 로고    scopus 로고
    • Antiviral effects of silymarin against hepatitis C: The jury is still out
    • Polyak SJ, Morishima C, Hawke R,. Antiviral effects of silymarin against hepatitis C: the jury is still out. Hepatology 2008; 48 (1): 345-346.
    • (2008) Hepatology , vol.48 , Issue.1 , pp. 345-346
    • Polyak, S.J.1    Morishima, C.2    Hawke, R.3
  • 32
    • 78650028517 scopus 로고    scopus 로고
    • Silymarin use and liver disease progression in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis trial
    • Freedman ND, Curto TM, Morishima C, Seeff LB, Goodman ZD, Wright EC, et al,. Silymarin use and liver disease progression in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis trial. Aliment Pharmacol Ther 2011; 33 (1): 127-137.
    • (2011) Aliment Pharmacol Ther , vol.33 , Issue.1 , pp. 127-137
    • Freedman, N.D.1    Curto, T.M.2    Morishima, C.3    Seeff, L.B.4    Goodman, Z.D.5    Wright, E.C.6
  • 33
    • 77957265017 scopus 로고    scopus 로고
    • Silymarin ascending multiple oral dosing phase i study in noncirrhotic patients with chronic hepatitis C
    • Hawke RL, Schrieber SJ, Soule TA, Wen Z, Smith PC, Reddy KR, et al,. Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C. J Clin Pharmacol 2010; 50 (4): 434-449.
    • (2010) J Clin Pharmacol , vol.50 , Issue.4 , pp. 434-449
    • Hawke, R.L.1    Schrieber, S.J.2    Soule, T.A.3    Wen, Z.4    Smith, P.C.5    Reddy, K.R.6
  • 36
    • 77249169773 scopus 로고    scopus 로고
    • Cell-type specific gene expression signature in liver underlies response to interferon therapy in chronic hepatitis C infection
    • Chen L, Borozan I, Sun J, Guindi M, Fischer S, Feld J, et al,. Cell-type specific gene expression signature in liver underlies response to interferon therapy in chronic hepatitis C infection. Gastroenterology 2010; 138 (3): 1123-1133.
    • (2010) Gastroenterology , vol.138 , Issue.3 , pp. 1123-1133
    • Chen, L.1    Borozan, I.2    Sun, J.3    Guindi, M.4    Fischer, S.5    Feld, J.6
  • 37
    • 36348960622 scopus 로고    scopus 로고
    • Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response
    • Feld JJ, Nanda S, Huang Y, Chen W, Cam M, Pusek SN, et al,. Hepatic gene expression during treatment with peginterferon and ribavirin: identifying molecular pathways for treatment response. Hepatology 2007; 46 (5): 1548-1563.
    • (2007) Hepatology , vol.46 , Issue.5 , pp. 1548-1563
    • Feld, J.J.1    Nanda, S.2    Huang, Y.3    Chen, W.4    Cam, M.5    Pusek, S.N.6
  • 38
    • 83455179381 scopus 로고    scopus 로고
    • Intravenous silibinin as 'rescue treatment' for on-treatment non-responders to pegylated interferon/ribavirin combination therapy
    • Rutter K, Scherzer TM, Beinhardt S, Kerschner H, Stattermayer AF, Hofer H, et al,. Intravenous silibinin as 'rescue treatment' for on-treatment non-responders to pegylated interferon/ribavirin combination therapy. Antivir Ther 2011; 16 (8): 1327-1333.
    • (2011) Antivir Ther , vol.16 , Issue.8 , pp. 1327-1333
    • Rutter, K.1    Scherzer, T.M.2    Beinhardt, S.3    Kerschner, H.4    Stattermayer, A.F.5    Hofer, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.