Intravenous silibinin monotherapy shows significant antiviral activity in HCV-infected patients in the peri-transplantation period

Journal of Hepatology

Volumn 58, Issue 3, 2013, Pages 415-420

  Mariño, Zoe ^a   Crespo, Gonzalo ^a   D'Amato, Massimo ^b   Brambilla, Nadia ^b   Giacovelli, Giampaolo ^b   Rovati, Lucio ^b   Costa, Josep ^c   Navasa, Miquel ^a   Forns, Xavier ^a  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b Rotta Research Laboratorium   (Italy)

^c HOSPITAL CLÍNIC   (Spain)

Author keywords

Antiviral therapy; Hepatitis C recurrence; Liver transplantation; Silibini; Viral kinetics

Indexed keywords

BILIRUBIN; LEGALON SIL; PLACEBO; SILYMARIN; UNCLASSIFIED DRUG; VIRUS RNA;

ABDOMINAL DISCOMFORT; ABDOMINAL PAIN; ADULT; AGED; ANTIVIRAL ACTIVITY; ARTICLE; ASTHENIA; BACKACHE; BILIRUBIN BLOOD LEVEL; BODY TEMPERATURE; CHILL; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIARRHEA; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FEVER; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HEPATIC ENCEPHALOPATHY; HEPATITIS C; HOSPITAL ADMISSION; HUMAN; HYPERGLYCEMIA; HYPERTENSION; INSOMNIA; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIVER TRANSPLANTATION; MALE; MONOTHERAPY; MYALGIA; NAUSEA AND VOMITING; PERIPHERAL EDEMA; PHLEBITIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT DURATION; TREATMENT OUTCOME; VIRUS LOAD;

ADULT; AGED; ANTIVIRAL AGENTS; DOUBLE-BLIND METHOD; FEMALE; HEPATITIS C; HUMANS; INJECTIONS, INTRAVENOUS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RNA, VIRAL; SILYMARIN; VIRAL LOAD;

EID: 84874112756     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.09.034     Document Type: Article

References (11)

1. M. Garcia-Retortillo, X. Forns, A. Feliu, E. Moitinho, J. Costa, and M. Navasa Hepatitis C virus kinetics during and immediately after liver transplantation Hepatology 35 2002 680 687
2. M. Prieto, M. Berenguer, J.M. Rayon, J. Córdoba, L. Argüello, and D. Carrasco High incidence of allograft cirrhosis in hepatitis C virus genotype 1b infection following transplantation: relationship with rejection episodes Hepatology 29 1999 250 256
3. X. Forns, M. Garcia-Retortillo, T. Serrano, A. Feliu, F. Suarez, and M. de la Mata Antiviral therapy of patients with decompensated cirrhosis to prevent recurrence of hepatitis C after liver transplantation J Hepatol 39 2003 389 396
4. J.A. Carrion, E. Martinez-Bauer, G. Crespo, S. Ramírez, S. Pérez-del-Pulgar, and J.C. García-Valdecasas Antiviral therapy increases the risk of bacterial infections in HCV-infected cirrhotic patients awaiting liver transplantation: a retrospective study J Hepatol 50 2009 719 728
5. G. Everson, N. Terrault, A. Lok, L. Rodrigo, R.S. Brown Jr., and S. Saab A randomized controlled trial of pretransplant antiviral therapy to prevent recurrence of hepatitis C after liver transplantation Hepatology 2012 10.1002/hep.25976
6. P. Ferenci, T.M. Scherzer, H. Kerschner, K. Rutter, S. Beinhardt, and H. Hofer Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to Pegylated interferon/ribavirin therapy Gastroenterology 135 2008 1561 1567
7. U.P. Neumann, M. Biermer, D. Eurich, P. Neuhaus, and T. Berg Successful prevention of hepatitis C virus (HCV) liver graft reinfection by silibinin mono-therapy J Hepatol 52 2010 951 954
8. S. Beinhardt, S. Rasoul-Rockenschau, T.M. Scherzer, and P. Fervency Silibinin monotherapy prevents graft infection after orthotopic liver transplantation in a patient with chronic hepatitis C J Hepatol 54 2011 588 595
9. A. Ahmed-Belkacem, A. Ahnou, L. Barbotte, C. Wychowski, C. Pallier, and R. Brillet Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymerase Gastroenterology 138 2010 1112 1122
10. J. Wagoner, A. Negash, O. Kane, L.E. Martinez, Y. Nahmias, and N. Bourne Multiple effects of silymarin on the hepatitis C virus life cycle Hepatology 51 2010 1912 1921
11. J. Guedj, H. Dahari, R. Pohl, P. Ferenci, and A. Perelson Understanding silibinin's modes of action against HCV using viral kinetic modelling J Hepatol 56 2012 1019 1024