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Volumn 150, Issue 2, 2009, Pages 73-79

Effects of silymarin supplementation in chronic hepatitis C patients treated with peg-interferon + ribavirin. A placebo-controlled double blind study;Az antioxidáns flavonoid silymarin szupplementációja hatásának placebokontrollos vizsgálata PEG-IFN + ribavirin antivirális kezelésben részesülo krónikus C-hepatitises betegekben

Author keywords

Hepatitis C; Oxidative stress; Silymarin

Indexed keywords

ALANINE AMINOTRANSFERASE; CATALASE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; MYELOPEROXIDASE; PEGINTERFERON; RIBAVIRIN; SILYMARIN; SUPEROXIDE DISMUTASE; VIRUS RNA; ANTIOXIDANT; ANTIVIRUS AGENT; INTERFERON; MACROGOL DERIVATIVE; PEROXIDASE; PROTECTIVE AGENT;

EID: 60749103299     PISSN: 00306002     EISSN: 17886120     Source Type: Journal    
DOI: 10.1556/OH.2009.28517     Document Type: Article
Times cited : (19)

References (24)
  • 2
    • 0026291685 scopus 로고
    • Prevalence of antibody to hepatitis C virus in blood donors, high risk groups and patients with liver diseases in Hungary
    • Pár, A., Kántor, I.: Prevalence of antibody to hepatitis C virus in blood donors, high risk groups and patients with liver diseases in Hungary. Acta Med. Hung., 1991, 48, 167-176.
    • (1991) Acta Med. Hung. , vol.48
    • Pár, A.1    Kántor, I.2
  • 3
    • 0029740935 scopus 로고    scopus 로고
    • Association between reactive oxygen species and disease activity in chronic hepatitis C
    • De Maria, N., Colantoni, A., Fagiuoli, S. és mtsai: Association between reactive oxygen species and disease activity in chronic hepatitis C. Free Rad. Biol. Med., 1996, 21, 291-295.
    • (1996) Free Rad. Biol. Med. , vol.21
    • De Maria, N.1    Colantoni, A.2    Fagiuoli, S.3
  • 5
    • 0033067273 scopus 로고    scopus 로고
    • Serum ferritin and hepatic glutathione concentrations in chronic hepatitis C patients related to the hepatitis C virus genotype
    • Barbaro, G., Di Lorenzo, G., Ribersani, M. és mtsai: Serum ferritin and hepatic glutathione concentrations in chronic hepatitis C patients related to the hepatitis C virus genotype. J. Hepatol., 1999, 30, 774-782.
    • (1999) J. Hepatol. , vol.30
    • Barbaro, G.1    Di Lorenzo, G.2    Ribersani, M.3
  • 6
    • 0344631690 scopus 로고    scopus 로고
    • Antioxidant status and glutathione metabolism in peripheral blood mononuclear cells from patients with chronic hepatitis C
    • Boya, P., de la Pena, A., Beloqui, O. és mtsai: Antioxidant status and glutathione metabolism in peripheral blood mononuclear cells from patients with chronic hepatitis C. J. Hepatol., 1999, 31, 808-814.
    • (1999) J. Hepatol. , vol.31
    • Boya, P.1    De La Pena, A.2    Beloqui, O.3
  • 7
    • 0037218573 scopus 로고    scopus 로고
    • Oxidative stress in viral and alcoholic hepatitis
    • Loguercio, C., Federico, A.: Oxidative stress in viral and alcoholic hepatitis. Free Rad. Biol. Med., 2003, 34, 1-10.
    • (2003) Free Rad. Biol. Med. , vol.34
    • Loguercio, C.1    Federico, A.2
  • 8
    • 0032077192 scopus 로고    scopus 로고
    • Superoxide dismutase in patients with chronic hepatitis C virus infection
    • Larrea, E., Beloqui, O., Munoz-Navas, M-A. és mtsai: Superoxide dismutase in patients with chronic hepatitis C virus infection. Free Rad. Biol. Med., 1998, 24, 1235-1241.
    • (1998) Free Rad. Biol. Med. , vol.24
    • Larrea, E.1    Beloqui, O.2    Munoz-Navas, M.-A.3
  • 9
    • 0036163870 scopus 로고    scopus 로고
    • Hepatitis C virus proteins: Direct link to hepatic oxidative stress, steatosis, carcinogenesis and more
    • [9] Lai, M. M. C.: Hepatitis C virus proteins: direct link to hepatic oxidative stress, steatosis, carcinogenesis and more. Gastroenterology, 2002, 122, 568-571 (Pubitemid 34117007)
    • (2002) Gastroenterology , vol.122 , Issue.2
    • Lai, M.M.C.1
  • 10
    • 0036165333 scopus 로고    scopus 로고
    • Mitochondrial injury, oxidative stress and antioxidant gene expression are induced by hepatitis C virus core protein
    • Okuda, M., Li, K., Beard, M. R. és mtsai: Mitochondrial injury, oxidative stress and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology, 2002, 122, 366-375.
    • (2002) Gastroenterology , vol.122
    • Okuda, M.1    Li, K.2    Beard, M.R.3
  • 11
    • 0032875149 scopus 로고    scopus 로고
    • Herbal products for liver diseases: A therapeutic challenge for the new millennium
    • DOI 10.1002/hep.510300437
    • [11] Schuppan, D., Jia, J. D., Brinkhaus, B. és mtsa: Herbal products for liver diseases: a therapeutic challenge for the new millen nium. Hepatology, 1999, 30, 1099-1104. (Pubitemid 29458302)
    • (1999) Hepatology , vol.30 , Issue.4
    • Schuppan, D.1    Jia, J.I.-D.2    Brinkhaus, B.3    Hahn, E.G.4
  • 12
    • 0035211762 scopus 로고    scopus 로고
    • The use of silymarin in the treatment of liver diseases
    • Saller, R., Meier, R., Brignoli, R.: The use of silymarin in the treatment of liver diseases. Drugs, 2001, 61, 2035-2063.
    • (2001) Drugs , vol.61
    • Saller, R.1    Meier, R.2    Brignoli, R.3
  • 13
    • 27444438669 scopus 로고    scopus 로고
    • Silymarin treatment of viral hepatitis: A systematic review
    • DOI 10.1111/j.1365-2893.2005.00636.x
    • [13] Mayer, K. É., Myers, R. P., Le, S. S.: Silymarin treatment of viral hepatitis: a systematic review. J. Viral. Hepat., 2005, 12, 559-567. (Pubitemid 41532486)
    • (2005) Journal of Viral Hepatitis , vol.12 , Issue.6
    • Mayer, K.E.1    Myers, R.P.2    Lee, S.S.3
  • 14
    • 17044462036 scopus 로고    scopus 로고
    • Oxidativ stress és antioxidáns védelem alkoholos májbetegségben és krónikus C hepatitisben
    • Pár A., R'th E., Rumi Gy. és mtsai: Oxidativ stress és antioxidáns védelem alkoholos májbetegsé gben és krónikus C hepatitisben. Orv. Hetil., 2000, 141, 1655-1659.
    • (2000) Orv. Hetil. , vol.141
    • Pár, A.1    Rth, E.2    Rumi, Gy.3
  • 15
    • 0036783791 scopus 로고    scopus 로고
    • Decrease in CD3- Negative-CD8dim+ and V?2/V?9 TcR+ peripheral blood lymphocyte counts, low perforin expression and the impairment on natural killer cell activity is associated with chronic hepatitis C virus infection
    • Pár, G., Rukavina, D., Podack, E. R. és mtsai: Decrease in CD3- negative-CD8dim+ and V?2/V?9 TcR+ peripheral blood lymphocyte counts, low perforin expression and the impairment on natural killer cell activity is associated with chronic hepatitis C virus infection. J. Hepatol., 2002, 37, 514-522.
    • (2002) J. Hepatol. , vol.37
    • Pár, G.1    Rukavina, D.2    Podack, E.R.3
  • 16
    • 0041822106 scopus 로고    scopus 로고
    • Early virologic response to treatment with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis C
    • Davis, G. L., Wong, J. B., McHutchison, J. G. és mtsai: Early virologic response to treatment with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis C. Hepatology, 2003, 38, 645-652.
    • (2003) Hepatology , vol.38
    • Davis, G.L.1    Wong, J.B.2    McHutchison, J.G.3
  • 17
    • 0024973097 scopus 로고
    • A silymarin (Legalon) therapia májvéd' hatása alkoholos májbetegségekben
    • Fehér J., Deák Gy., Müzes Gy. és mtsai: A silymarin (Legalon) therapia májvéd' hatása alkoholos májbetegségekben. Orv. Hetil., 1989, 130, 2723-2727.
    • (1989) Orv. Hetil. , vol.130
    • Fehér, J.1    Gy, D.2    Gy, M.3
  • 18
    • 0022408907 scopus 로고
    • Effects of cianidanol on the blood lipid peroxide status in patients with chronic hepatitis
    • Pár, A., Mézes, M., Németh, P. és mtsa: Effects of cianidanol on the blood lipid peroxide status in patients with chronic hepatitis. Int. J. Clin. Pharm. Res., 1985, 6, 389-392.
    • (1985) Int. J. Clin. Pharm. Res. , vol.6
    • Pár, A.1    Mézes, M.2    Németh, P.3
  • 19
    • 0022311985 scopus 로고
    • Immunomodulatory effects of cyanidanol in chronic active hepatitis
    • Pár, A., Király, T., Magyarlaki, T. és mtsai: Immunomodulatory effects of cyanidanol in chronic active hepatitis. Int. J. Immunother., 1985, 1, 27-33.
    • (1985) Int. J. Immunother. , vol.1
    • Pár, A.1    Király, T.2    Magyarlaki, T.3
  • 20
    • 0023183220 scopus 로고
    • Effect of cianidanol on natural killer cell activity in patients with chronic B viral hepatitis
    • Pár, A., Szekeres-Bartho, J., Pácsa, S. és mtsa: Effect of cianidanol on natural killer cell activity in patients with chronic B viral hepatitis. Int. J. Clin. Pharm. Res., 1987, 7, 301-306.
    • (1987) Int. J. Clin. Pharm. Res. , vol.7
    • Pár, A.1    Szekeres-Bartho, J.2    Pácsa, S.3
  • 22
    • 33645307385 scopus 로고    scopus 로고
    • Effects of Silybum marianum on serum hepatitis C virus RNS, alanine aminotransferase levels and well-being in patients with chronic hepatitis C
    • Gordon, A., Hobbs, D. A., Bowden, D. S. és mtsai: Effects of Silybum marianum on serum hepatitis C virus RNS, alanine aminotransferase levels and well-being in patients with chronic hepatitis C. J. Gastroenterol. Hepatol., 2006, 21, 275-280.
    • (2006) J. Gastroenterol. Hepatol. , vol.21
    • Gordon, A.1    Hobbs, D.A.2    Bowden, D.S.3
  • 23
    • 34247583381 scopus 로고    scopus 로고
    • Inhibition of T-cell infl ammatory cytokines, hepatocyte NF-B signaling, and HCV infection by standardized silymarin
    • Polyak, S. J., Morishima, C., Shuart, M. C. és mtsai: Inhibition of T-cell infl ammatory cytokines, hepatocyte NF-B signaling, and HCV infection by standardized silymarin. Gastroenterology, 2007, 132, 1925-1936.
    • (2007) Gastroenterology , vol.132
    • Polyak, S.J.1    Morishima, C.2    Shuart, M.C.3
  • 24
    • 53049098488 scopus 로고    scopus 로고
    • Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to antiviral combination therapy
    • Ferenci, P., Scherzer, T. M., Hofer, A. és mtsai: Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to antiviral combination therapy. J. Hepatology, 2008, 48 (Suppl. 1, S28.
    • (2008) J. Hepatology , vol.48 , Issue.SUPPL. 1
    • Ferenci, P.1    Scherzer, T.M.2    Hofer, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.