SCOPUS 정보 검색 플랫폼

Volumn 21, Issue 13, 2013, Pages 3919-3926

Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle

(9) Althagafy, Hanan S a Graf, Tyler N a Sy Cordero, Arlene A a Gufford, Brandon T b Paine, Mary F b Wagoner, Jessica c Polyak, Stephen J c Croatt, Mitchell P a Oberlies, Nicholas H a

a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (United States)

b UNC Hamner Institute for Drug Safety Sciences (United States)

c UNIVERSITY OF WASHINGTON (United States)

Author keywords

Cytochrome P450; Flavonolignans; Hepatitis C virus; Methylation; Milk thistle; Silybum marianum; Silymarin; UDP glucuronosyl transferase

Indexed keywords

7 O METHYLISOSILYBIN A; 7 O METHYLISOSILYBIN B; 7 O METHYLISOSILYCHRISTIN; 7 O METHYLSILYBIN A; 7 O METHYLSILYBIN B; 7 O METHYLSILYCHRISTIN; 7 O METHYLSILYDIANIN; ANTIVIRUS AGENT; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOTOXIC AGENT; FLAVONOLIGNAN; GLUCURONOSYLTRANSFERASE; ISOSILYBIN A; ISOSILYBIN B; ISOSILYCHRISTIN; RESVERATROL; SILICRISTIN; SILIDIANIN; SILYBIN A; SILYBIN B; UNCLASSIFIED DRUG; CYP2C9 PROTEIN, HUMAN; CYTOCHROME P-450 CYP3A45; CYTOCHROME P450; SILYMARIN; UNSPECIFIC MONOOXYGENASE;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IC 50; INTESTINE CELL; LIVER MICROSOME; METHYLATION; MOLECULAR INTERACTION; NONHUMAN; SILYBUM MARIANUM; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG INTERACTION; ENZYMOLOGY; HEPACIVIRUS; HEPATITIS C; ISOLATION AND PURIFICATION; METABOLISM; MICROSOME; TOXICITY;

HEPATITIS C VIRUS; SILYBUM MARIANUM;

ANTIVIRAL AGENTS; ARYL HYDROCARBON HYDROXYLASES; CELL LINE; CELL SURVIVAL; CYTOCHROME P-450 CYP2C9; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; GLUCURONOSYLTRANSFERASE; HEPACIVIRUS; HEPATITIS C; HUMANS; METHYLATION; MICROSOMES; MILK THISTLE; SILYMARIN;

EID: 84878563030 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.04.017 Document Type: Article

Times cited : (24)

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