Comparative study of the different activities of hepatitis B virus whole-X protein and HBx in hepatocarcinogenesis by proteomics and bioinformatics analysis

Archives of Virology

Volumn 160, Issue 7, 2015, Pages 1645-1656

  Zhang, Yu ^a   Liu, Jinfeng ^a   Liu, Hongli ^b   He, Yingli ^a   Yi, Ruitian ^a   Niu, Yinghua ^a   Chen, Tianyan ^a   Yang, Qian ^c   Zhao, Yingren ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B VIRUS;

HEPATITIS B VIRUS X PROTEIN; PROTEIN BINDING; TRANS-ACTIVATORS;

AMINO ACID MOTIFS; CARCINOMA, HEPATOCELLULAR; CHEMISTRY; COMPARATIVE STUDY; COMPUTATIONAL BIOLOGY; GENETICS; HEPATITIS B VIRUS; HUMANS; LIVER NEOPLASMS; METABOLISM; PROTEOMICS; VIROLOGY;

AMINO ACID MOTIFS; CARCINOMA, HEPATOCELLULAR; COMPUTATIONAL BIOLOGY; HEPATITIS B VIRUS; HUMANS; LIVER NEOPLASMS; PROTEIN BINDING; PROTEOMICS; TRANS-ACTIVATORS;

EID: 84930871654     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00705-015-2421-3     Document Type: Article

References (27)

1. Bosch FX, Ribes J, Díaz M, Cléries R (2004) Primary liver cancer: worldwide incidence and trends. Gastroenterology 127(5 Suppl 1):S5–S16. doi:10.1053/j.gastro.2004.09.011
2. Kew MC (2010) Epidemiology of chronic hepatitis B virus infection, hepatocellular carcinoma, and hepatitis B virus-induced hepatocellular carcinoma. Pathol Biol (Paris) 58(4):273–277. doi:10.1016/j.patbio.2010.01.005
3. Michielsen P, Ho E (2011) Viral hepatitis B and hepatocellular carcinoma. Acta Gastroenterol Belg 74(1):4–8
4. Fares N, Peron JM (2013) Epidemiology, natural history, and risk factors of hepatocellular carcinoma. Rev Prat 63 (2):216–217, 220–212
5. Ng SA, Lee C (2011) Hepatitis B virus X gene and hepatocarcinogenesis. J Gastroenterol 46(8):974–990. doi:10.1007/s00535-011-0415-9
6. Kew MC (2011) Hepatitis B virus x protein in the pathogenesis of hepatitis B virus-induced hepatocellular carcinoma. J Gastroenterol Hepatol 26(Suppl 1):144–152. doi:10.1111/j.1440-1746.2010.06546.x
7. Doria M, Klein N, Lucito R, Schneider RJ (1995) The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors. EMBO J 14(19):4747–4757
8. Murakami S (2001) Hepatitis B virus X protein: a multifunctional viral regulator. J Gastroenterol 36(10):651–660
9. Loncarevic IF, Zentgraf H, Schroder CH (1990) Sequence of a replication competent hepatitis B virus genome with a preX open reading frame. Nucleic Acids Res 18(16):4940
10. Loncarevic IF, Schranz P, Zentgraf H, Liang XH, Herrmann G, Tang ZY, Schroder CH (1990) Replication of hepatitis B virus in a hepatocellular carcinoma. Virology 174(1):158–168
11. Takahashi SK (1995) A unique set of mutations in the ‘preX’ region of hepatitis B virus DNA frequently found in patients but not in asymptomatic carriers: implication for a novel variant. Int Hepatol Commun 3(3):131–138
12. Takahashi K, Akahane Y, Hino K, Ohta Y, Mishiro S (1998) Hepatitis B virus genomic sequence in the circulation of hepatocellular carcinoma patients: comparative analysis of 40 full-length isolates. Arch Virol 143(12):2313–2326
13. Yang Q, Dong J, Cheng J, Liu Y, Hong Y (2003) Definition of pre-X promoter sequence from hepatitis B virus genome and characterization of its transcription activity. JiefangJun YiXue Zazhi 28:763–765
14. Dong JCJ (2003) Study on definition of pre-X region in hepatitis B virus genome. World Chin J Digestol 11(8):1097–1101
15. Faure E (2006) Alternative peptide-fusion proteins generated by out-of-frame mutations, just upstream ORFs or elongations in mutants of human hepatitis B viruses. Virus Res 117(2):185–201. doi:10.1016/j.virusres.2005.10.023
16. Yang Q, Cheng J, Dong J, Zhang J, Zhang SL (2005) Molecular epidemiological study on pre-X region of hepatitis B virus and identification of hepatocyte proteins interacting with whole-X protein by yeast two-hybrid. World J Gastroenterol 11(22):3473–3478
17. Wisniewski JR, Zougman A, Mann M (2009) Combination of FASP and StageTip-based fractionation allows in-depth analysis of the hippocampal membrane proteome. J Proteome Res 8(12):5674–5678. doi:10.1021/pr900748n
18. Sun D, Zhang H, Guo D, Sun A, Wang H (2013) Shotgun proteomic analysis of plasma from dairy cattle suffering from footrot: characterization of potential disease-associated factors. PLoS One 8(2):e55973. doi:10.1371/journal.pone.0055973
19. Dai J, Shieh CH, Sheng QH, Zhou H, Zeng R (2005) Proteomic analysis with integrated multiple dimensional liquid chromatography/mass spectrometry based on elution of ion exchange column using pH steps. Anal Chem 77(18):5793–5799. doi:10.1021/ac050251w
20. Zhang T, Xie N, He W, Liu R, Lei Y, Chen Y, Tang H, Liu B, Huang C, Wei Y (2013) An integrated proteomics and bioinformatics analyses of hepatitis B virus X interacting proteins and identification of a novel interactor apoA-I. J Proteomics 84:92–105. doi:10.1016/j.jprot.2013.03.028
21. Lara-Pezzi E, Roche S, Andrisani OM, Sanchez-Madrid F, Lopez-Cabrera M (2001) The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner. Oncogene 20(26):3323–3331. doi:10.1038/sj.onc.1204451
22. Lee JO, Kwun HJ, Jung JK, Choi KH, Min DS, Jang KL (2005) Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1. Oncogene 24(44):6617–6625. doi:10.1038/sj.onc.1208827
23. Liu J, Lian Z, Han S, Waye MMY, Wang H, Wu MC, Wu K, Ding J, Arbuthnot P, Kew M, Fan D, Feitelson MA (2006) Downregulation of E-cadherin by hepatitis B virus X antigen in hepatocellullar carcinoma. Oncogene 25(7):1008–1017. doi:10.1038/sj.onc.1209138
24. Liu HO, Xu L, He HY, Zhu Y, Liu J, Wang SS, Chen L, Wu Q, Xu JJ, Gu JX (2012) Hepatitis B virus X protein promotes hepatoma cell invasion and metastasis by stabilizing Snail protein. Cancer Sci 103(12):2072–2081. doi:10.1111/cas.12017
25. Chen L, Hu L, Li L, Liu Y, Tu Q-Q, Chang Y-X, Yan H-X, Wu M-C, Wang H-Y (2010) Dysregulation of beta-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas. Front Med China 4(4):399–411. doi:10.1007/s11684-010-0170-y
26. Williams GH, Stoeber K (2012) The cell cycle and cancer. J Pathol 226(2):352–364. doi:10.1002/path.3022
27. Krisher RL, Prather RS (2012) A role for the Warburg effect in preimplantation embryo development: metabolic modification to support rapid cell proliferation. Mol Reprod Dev 79(5):311–320. doi:10.1002/mrd.22037