Cytotoxic effects of aflatoxin B1 on human brain microvascular endothelial cells of the blood-brain barrier

Medical Mycology

Volumn 53, Issue 4, 2015, Pages 409-416

  Qureshi, Humaira ^a,b   Hamid, Saeed S ^b   Ali, Syed Shayan ^a,b   Anwar, Javeria ^a,b   Siddiqui, Anwar Ali ^a   Khan, Naveed Ahmed ^a  

^a AGA KHAN UNIVERSITY   (Pakistan)

^b AGA KHAN UNIVERSITY HOSPITAL   (Pakistan)

Author keywords

Aflatoxin B1 (AFB1); Aspergillus flavus; blood brain barrier; endothelial cells; Huh7

Indexed keywords

AFLATOXIN B1; DNA; LACTATE DEHYDROGENASE; DNA ADDUCT;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY ENDOTHELIAL CELL; CELL DEATH; CELL IMMORTALIZATION; CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; DRUG CYTOTOXICITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LIVER CELL CARCINOMA; UMBILICAL VEIN ENDOTHELIAL CELL; ANALYSIS; ASPERGILLUS; CELL CULTURE; CELL SURVIVAL; DRUG EFFECTS; ENDOTHELIUM CELL; LIVER CELL;

ASPERGILLUS; ASPERGILLUS FLAVUS;

AFLATOXIN B1; ASPERGILLUS; BLOOD-BRAIN BARRIER; CELL SURVIVAL; CELLS, CULTURED; DNA ADDUCTS; ENDOTHELIAL CELLS; HEPATOCYTES; HUMANS; L-LACTATE DEHYDROGENASE;

EID: 84930854761     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.1093/mmy/myv010     Document Type: Article

References (31)

1. Bbosa GS, Kitya D, Lubega A., et al. Review of the biological and health effects of aflatoxins on body organs and body systems. www.IntechOpen.com.
2. World Health Organization International Agency for Research on Cancer. http://monographs.iarc.fr/ENG/Monographs/vol82/mono82.pdf.
3. World Health Organization Press Release No. 244, 2014. http://www.iarc.fr/en/media-centre/pr/2014/pdfs/pr224-E.pdf.
4. Lang K, Danchenko N, Gondek K., et al. The burden of illness associated with hepatocellular carcinoma in the United States. J Hepatol 2009; 50: 89-99.
5. Yuen MF, Hou JL, Chutaputti A. Hepatocellular carcinoma in the Asia pacific region. J Gastroenterol Hepatol 2009; 24: 346-353.
6. Parkin DM, Bray F, Ferlay J., et al. Global cancer statistics, 2002. CA: A Cancer J Clin 2005; 55: 74-108.
7. Somi MH. Hepatocellular Carcinoma. Hepatitis Monthly 2005; 5: 65-67.
8. Liu Y, Wu F. Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. EnvironHealth Perspectives 2010; 118: 818-824.
9. Williams JH, Phillips TD, Jolly PE., et al. Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions. Am J Clin Nutr 2004; 80: 1106-1122.
10. Wild CP, Hudson GJ, Sabbioni G., et al. Dietary intake of aflatoxins and the level of albumin-bound aflatoxin in peripheral blood in The Gambia, West Africa. Cancer Epidemiol Biomark Preven 1992; 1: 229-234.
11. Gouas D, Shi H, Hainaut P. The aflatoxin-induced TP53 mutation at codon 249 (R249S): biomarker of exposure, early detection and target for therapy. Cancer Lett 2009; 286: 29-37.
12. Bedard LL, Massey TE. Aflatoxin B1-induced DNA damage and its repair. Cancer Lett 2006; 241: 174-183.
13. Yang W, Lian J, Feng Y., et al. Genome-wide miRNA-profiling of aflatoxin B1-induced hepatic injury using deep sequencing. Toxicol Lett 2014; 226: 140-149.
14. Yang XJ, Lu HY, Li ZY., et al. Cytochrome P450 2A13 mediates aflatoxin B1-induced cytotoxicity and apoptosis in human bronchial epithelial cells. Toxicol 2012; 300: 138-148.
15. Oyelami OA, Maxwell SM, Adelusola KA., et al. Aflatoxins in the autopsy brain tissue of children in Nigeria. Mycopathologia 1995; 132: 35-38.
16. Bonsi P, Augusti-Tocco G, Palmery M., et al. Aflatoxin B1 is an inhibitor of cyclic nucleotide phosphodiesterase activity. Gen Pharmacol 1999; 32: 615-619.
17. Waggas AM, Rawi SM. Impact of 90-Day oral dosing with naturally occurrring aflatoxin mixture on male sprague-dawley rats neurochemistry and behavioral pattern Middle-East. J Sci Res 2013; 14: 228-238.
18. Alsam S, Kim KS, StinsMet al. Acanthamoeba interactions with human brain microvascular endothelial cells. Microb Pathogen 2003; 35: 235-241.
19. Stins MF, Gilles F, Kim KS. Selective expression of adhesion molecules on human brain microvascular endothelial cells. J Neuroimmunol 1997; 76: 81-90.
20. Khan NA, Siddiqui R. Acanthamoeba affects the integrity of human brain microvascular endothelial cells and degrades the tight junction proteins. Int J Parasitol 2009; 39: 1611-1616.
21. Gedaly R, Angulo P, Hundley J., et al. PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways. Anticancer Res 2010; 30: 4951-4958.
22. Besaratinia A, Kim SI, Hainaut P., et al. In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure. Gastroenterol 2009; 137: 1127-1137.
23. Sivertsson L, Ek M, Darnell M., et al. CYP3A4 catalytic activity is induced in confluent Huh7 hepatoma cells. Drug Metabol Dispos 2010; 38: 995-1002.
24. Al-Hammadi S, Marzouqi F, Al-Mansouri A., et al. The cytotoxicity of aflatoxin b1 in human lymphocytes. Sult Qab Univ Med Sci J 2014; 14: e65-71.
25. Mersch-Sundermann V, Knasmuller S, Wu XJ., et al. Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents. Toxicol 2004; 198: 329-340.
26. Wilkening S, Stahl F, Bader A. Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties. Drug Metab Dispos 2003; 31: 1035-1042.
27. Iwaki M, Kitagawa T, Akamatsu Y., et al. Cytotoxic effects of aflatoxin B1 and its association with cellular components in chicken embryo primary cultured cells. Biochim Biophys Acta 1990; 1035: 146-153.
28. Newberne PM, Butler WH. Acute and chronic effects of aflatoxin on the liver of domestic and laboratory animals: a review. Cancer Res 1969; 29: 236-250.
29. Jennings GS, Heck R, Oesch F., et al. Metabolism and cytotoxicity of aflatoxin B1 in cultured rat hepatocytes and nonparenchymal cells: implications for tumorigenesis. Toxicol App Pharmacol 1994; 129: 86-94.
30. Gursoy-Yuzugullu O, Yuzugullu H, Yilmaz M., et al. Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation. Liver Int 2011; 31: 561-571.
31. Reddy L, Odhav B, Bhoola K. Aflatoxin B1-induced toxicity in HepG2 cells inhibited by carotenoids: morphology, apoptosis and DNA damage. Biol Chem 2006; 387: 87-93.