메뉴 건너뛰기




Volumn 50, Issue 1, 2009, Pages 89-99

The burden of illness associated with hepatocellular carcinoma in the United States

Author keywords

Burden of illness; Cost of illness; Hepatocellular carcinoma (HCC); Outcomes; Prevalence; Treatment pattern

Indexed keywords

ADULT; AGED; ARTICLE; CANCER INCIDENCE; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEALTH CARE COST; HEALTH CARE UTILIZATION; HUMAN; LIVER CELL CARCINOMA; LIVER TRANSPLANTATION; MALE; PREVALENCE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; UNITED STATES;

EID: 56949104495     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2008.07.029     Document Type: Article
Times cited : (115)

References (49)
  • 1
    • 33745698080 scopus 로고    scopus 로고
    • A comparison of trends in the incidence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the United States
    • McGlynn K.A., Tarone R.E., and El-Serag H.B. A comparison of trends in the incidence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the United States. Cancer Epidemiol Biomarkers Prev 15 (2006) 1198-1203
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 1198-1203
    • McGlynn, K.A.1    Tarone, R.E.2    El-Serag, H.B.3
  • 3
    • 27744471890 scopus 로고    scopus 로고
    • Resection of extrahepatic hepatocellular carcinoma metastasis can result in long-term survival
    • Verhoef C., Holman F.A., de Man R.A., de Wilt J.H.W., and Ijzermans J.N.M. Resection of extrahepatic hepatocellular carcinoma metastasis can result in long-term survival. Acta Chir Belg 105 (2005) 533-536
    • (2005) Acta Chir Belg , vol.105 , pp. 533-536
    • Verhoef, C.1    Holman, F.A.2    de Man, R.A.3    de Wilt, J.H.W.4    Ijzermans, J.N.M.5
  • 4
    • 28844480321 scopus 로고    scopus 로고
    • Practice Guidelines Committee, American Association for the Study of Liver Diseases Management of hepatocellular carcinoma
    • Bruix J., and Sherman M. Practice Guidelines Committee, American Association for the Study of Liver Diseases Management of hepatocellular carcinoma. Hepatology 42 (2005) 1208-1236
    • (2005) Hepatology , vol.42 , pp. 1208-1236
    • Bruix, J.1    Sherman, M.2
  • 5
    • 57049090776 scopus 로고    scopus 로고
    • Bayer Corporate Web site. Investor News 2004: Bayer and Onyx Announce Phase II Results of Treatment with BAY 43-9006 in patients with advanced primary liver cancer. Available from: [accessed July 2008].
    • Bayer Corporate Web site. Investor News 2004: Bayer and Onyx Announce Phase II Results of Treatment with BAY 43-9006 in patients with advanced primary liver cancer. Available from: [accessed July 2008].
  • 6
    • 0034113808 scopus 로고    scopus 로고
    • Primary prevention of hepatocellular carcinoma in developing countries
    • Wild C.P., and Hall A.J. Primary prevention of hepatocellular carcinoma in developing countries. Mutat Res 462 (2000) 381-393
    • (2000) Mutat Res , vol.462 , pp. 381-393
    • Wild, C.P.1    Hall, A.J.2
  • 7
    • 0031740458 scopus 로고    scopus 로고
    • Towards global control of liver cancer?
    • Stuver S.O. Towards global control of liver cancer?. Semin Cancer Biol 8 (1998) 299-306
    • (1998) Semin Cancer Biol , vol.8 , pp. 299-306
    • Stuver, S.O.1
  • 8
    • 27544507257 scopus 로고    scopus 로고
    • Prognostic factors and long-term survival after hepatic resection for hepatocellular carcinoma originating from noncirrhotic liver
    • Laurent C., Blanc F., Nobili S., Sa Cunha A., le Bail B., Bioulac-Sage P., et al. Prognostic factors and long-term survival after hepatic resection for hepatocellular carcinoma originating from noncirrhotic liver. J Am Coll Surg 201 (2005) 656-662
    • (2005) J Am Coll Surg , vol.201 , pp. 656-662
    • Laurent, C.1    Blanc, F.2    Nobili, S.3    Sa Cunha, A.4    le Bail, B.5    Bioulac-Sage, P.6
  • 9
    • 44449085884 scopus 로고    scopus 로고
    • Panel of experts in HCC design clinical trials design and endpoints of clinical trials in hepatocellular carcinoma
    • Llovet J.M., Di Bisceglie A.M., Bruix J., Kramer B.S., Lencioni R., Zhu A.X., et al. Panel of experts in HCC design clinical trials design and endpoints of clinical trials in hepatocellular carcinoma. J Natl Cancer Inst 100 (2008) 698-711
    • (2008) J Natl Cancer Inst , vol.100 , pp. 698-711
    • Llovet, J.M.1    Di Bisceglie, A.M.2    Bruix, J.3    Kramer, B.S.4    Lencioni, R.5    Zhu, A.X.6
  • 10
    • 0036829856 scopus 로고    scopus 로고
    • Hepatocellular carcinoma and hepatitis C in the United States
    • El-Serag H.B. Hepatocellular carcinoma and hepatitis C in the United States. Hepatology 36 (2002) S74-S83
    • (2002) Hepatology , vol.36
    • El-Serag, H.B.1
  • 11
    • 11244303186 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: screening and therapy
    • Rizzetto M. Hepatocellular carcinoma: screening and therapy. Minerva Gastroenterol Dietol 46 (2000) 143-147
    • (2000) Minerva Gastroenterol Dietol , vol.46 , pp. 143-147
    • Rizzetto, M.1
  • 13
    • 0037308133 scopus 로고    scopus 로고
    • Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival
    • Llovet J.M., and Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival. Hepatology 37 (2003) 429-442
    • (2003) Hepatology , vol.37 , pp. 429-442
    • Llovet, J.M.1    Bruix, J.2
  • 15
    • 57049184387 scopus 로고    scopus 로고
    • FDA. Center for Drug Evaluation and Research. Press release: FDA Approves Sorafenib (Nexavar) for the Treatment of Unresectable Hepatocellular Carcinoma. November 20, 2007. Available from: [accessed July 2008].
    • FDA. Center for Drug Evaluation and Research. Press release: FDA Approves Sorafenib (Nexavar) for the Treatment of Unresectable Hepatocellular Carcinoma. November 20, 2007. Available from: [accessed July 2008].
  • 16
    • 11844254502 scopus 로고    scopus 로고
    • Cost-effectiveness of hepatocellular carcinoma surveillance in patients with hepatitis C virus-related cirrhosis
    • Patel D., Terrault N.A., Yao F.Y., Bass N.M., and Ladabaum U. Cost-effectiveness of hepatocellular carcinoma surveillance in patients with hepatitis C virus-related cirrhosis. Clin Gastroenterol Hepatol 3 (2005) 75-84
    • (2005) Clin Gastroenterol Hepatol , vol.3 , pp. 75-84
    • Patel, D.1    Terrault, N.A.2    Yao, F.Y.3    Bass, N.M.4    Ladabaum, U.5
  • 17
    • 13844311268 scopus 로고    scopus 로고
    • In whom, how and how often is surveillance for hepatocellular carcinoma cost-effective?
    • Ruelas-Villavicencio A.L., and Vargas-Vorácková F. In whom, how and how often is surveillance for hepatocellular carcinoma cost-effective?. Ann Hepatol 3 (2004) 152-159
    • (2004) Ann Hepatol , vol.3 , pp. 152-159
    • Ruelas-Villavicencio, A.L.1    Vargas-Vorácková, F.2
  • 18
    • 2942577356 scopus 로고    scopus 로고
    • Cost-effectiveness of screening for hepatocellular carcinoma in patients with cirrhosis due to chronic hepatitis C
    • Lin O.S., Keeffe E.B., Sanders G.D., and Owens D.K. Cost-effectiveness of screening for hepatocellular carcinoma in patients with cirrhosis due to chronic hepatitis C. Aliment Pharmacol Ther 19 (2004) 1159-1172
    • (2004) Aliment Pharmacol Ther , vol.19 , pp. 1159-1172
    • Lin, O.S.1    Keeffe, E.B.2    Sanders, G.D.3    Owens, D.K.4
  • 19
    • 0037343849 scopus 로고    scopus 로고
    • Screening for hepatocellular carcinoma in patients with hepatitis C cirrhosis: a cost-utility analysis
    • Arguedas M.R., Chen V.K., Eloubeidi M.A., and Fallon M.B. Screening for hepatocellular carcinoma in patients with hepatitis C cirrhosis: a cost-utility analysis. Am J Gastroenterol 98 (2003) 679-690
    • (2003) Am J Gastroenterol , vol.98 , pp. 679-690
    • Arguedas, M.R.1    Chen, V.K.2    Eloubeidi, M.A.3    Fallon, M.B.4
  • 20
    • 0142248269 scopus 로고    scopus 로고
    • Screening for hepatocellular carcinoma: survival benefit and cost-effectiveness
    • Yuen M.-F., and Lai C.-L. Screening for hepatocellular carcinoma: survival benefit and cost-effectiveness. Ann Oncol 14 (2003) 1463-1467
    • (2003) Ann Oncol , vol.14 , pp. 1463-1467
    • Yuen, M.-F.1    Lai, C.-L.2
  • 21
    • 0033402335 scopus 로고    scopus 로고
    • Cost-effectiveness of treatments for chronic hepatitis C
    • Wong J.B. Cost-effectiveness of treatments for chronic hepatitis C. Am J Med 107 (1999) 74S-78S
    • (1999) Am J Med , vol.107
    • Wong, J.B.1
  • 22
    • 0035033087 scopus 로고    scopus 로고
    • Living donor liver transplantation for early hepatocellular carcinoma: a life-expectancy and cost-effectiveness perspective
    • Sarasin F.P., Majno P.E., Llovet J.M., Bruix J., Mentha G., and Hadenque A. Living donor liver transplantation for early hepatocellular carcinoma: a life-expectancy and cost-effectiveness perspective. Hepatology 33 (2001) 1073-1079
    • (2001) Hepatology , vol.33 , pp. 1073-1079
    • Sarasin, F.P.1    Majno, P.E.2    Llovet, J.M.3    Bruix, J.4    Mentha, G.5    Hadenque, A.6
  • 23
    • 33845916155 scopus 로고    scopus 로고
    • Ethanol versus radiofrequency ablation for the treatment of small hepatocellular carcinoma in patients with cirrhosis: a retrospective study of efficacy and cost
    • Seror O., N'Kontchou G., Tin Tin Htar M., Durand-Zaleski I., Trinchet J.C., Sellier N., et al. Ethanol versus radiofrequency ablation for the treatment of small hepatocellular carcinoma in patients with cirrhosis: a retrospective study of efficacy and cost. Gastroenterol Clin Biol 30 (2006) 1265-1273
    • (2006) Gastroenterol Clin Biol , vol.30 , pp. 1265-1273
    • Seror, O.1    N'Kontchou, G.2    Tin Tin Htar, M.3    Durand-Zaleski, I.4    Trinchet, J.C.5    Sellier, N.6
  • 24
    • 29144489161 scopus 로고    scopus 로고
    • Cost-effectiveness of radiofrequency ablation and surgical therapy for small hepatocellular carcinoma of 3 cm or less in diameter
    • Ikeda K., Kobayashi M., Saitoh S., Someya T., Hosaka T., Sezaki H., et al. Cost-effectiveness of radiofrequency ablation and surgical therapy for small hepatocellular carcinoma of 3 cm or less in diameter. Hepatol Res 33 (2005) 241-249
    • (2005) Hepatol Res , vol.33 , pp. 241-249
    • Ikeda, K.1    Kobayashi, M.2    Saitoh, S.3    Someya, T.4    Hosaka, T.5    Sezaki, H.6
  • 25
    • 0032798517 scopus 로고    scopus 로고
    • Pancreatic cancer: total costs and utilization of health services
    • Wilson L.S., and Lightwood J.M. Pancreatic cancer: total costs and utilization of health services. J Surg Oncol 71 (1999) 171-181
    • (1999) J Surg Oncol , vol.71 , pp. 171-181
    • Wilson, L.S.1    Lightwood, J.M.2
  • 26
    • 4444266177 scopus 로고    scopus 로고
    • Estimating the cost of cancer: results on the basis of claims data analyses for cancer patients diagnosed with seven types of cancer during 1999 to 2000
    • Chang S., Long S.R., Kutikova L., Bowman L., Finley D., Crown W.H., et al. Estimating the cost of cancer: results on the basis of claims data analyses for cancer patients diagnosed with seven types of cancer during 1999 to 2000. J Clin Oncol 22 (2004) 3524-3530
    • (2004) J Clin Oncol , vol.22 , pp. 3524-3530
    • Chang, S.1    Long, S.R.2    Kutikova, L.3    Bowman, L.4    Finley, D.5    Crown, W.H.6
  • 27
    • 23244445075 scopus 로고    scopus 로고
    • Mortality and hospital utilization for hepatocellular carcinoma in the United States
    • Kim W.R., Gores G.J., Benson J.T., Therneau R.M., and Melton L.J. Mortality and hospital utilization for hepatocellular carcinoma in the United States. Gastroenterology 129 (2005) 486-493
    • (2005) Gastroenterology , vol.129 , pp. 486-493
    • Kim, W.R.1    Gores, G.J.2    Benson, J.T.3    Therneau, R.M.4    Melton, L.J.5
  • 28
    • 33845657790 scopus 로고    scopus 로고
    • Racial disparity in primary hepatocellular carcinoma: tumor stage at presentation, surgical treatment and survival
    • Sloane D., Chen H., and Howell C. Racial disparity in primary hepatocellular carcinoma: tumor stage at presentation, surgical treatment and survival. J Natl Med Assoc 98 (2006) 1934-1939
    • (2006) J Natl Med Assoc , vol.98 , pp. 1934-1939
    • Sloane, D.1    Chen, H.2    Howell, C.3
  • 29
    • 57049161673 scopus 로고    scopus 로고
    • Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence - SEER 13 Regs Public-Use, Nov 2004 Sub (1973-2002 varying), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2005, based on the November 2004 submission.
    • Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence - SEER 13 Regs Public-Use, Nov 2004 Sub (1973-2002 varying), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2005, based on the November 2004 submission.
  • 30
    • 37048999333 scopus 로고    scopus 로고
    • Predictors of survival after hepatic resection among patients with colorectal liver metastasis
    • Wang X., Hershman D.L., Abrams J.A., Feingold D., Grann V.R., Jacobson J.S., et al. Predictors of survival after hepatic resection among patients with colorectal liver metastasis. Br J Cancer 97 (2007) 1606-1612
    • (2007) Br J Cancer , vol.97 , pp. 1606-1612
    • Wang, X.1    Hershman, D.L.2    Abrams, J.A.3    Feingold, D.4    Grann, V.R.5    Jacobson, J.S.6
  • 31
    • 0036676214 scopus 로고    scopus 로고
    • Estimating health care costs related to cancer treatment from SEER-Medicare data
    • Brown M.L., Riley G.F., Schussler N., and Etzioni R. Estimating health care costs related to cancer treatment from SEER-Medicare data. Med Care 40 (2002) IV104-IV117
    • (2002) Med Care , vol.40
    • Brown, M.L.1    Riley, G.F.2    Schussler, N.3    Etzioni, R.4
  • 32
    • 16544380472 scopus 로고    scopus 로고
    • Opioid use and health-care charges at the end of life in patients with metastatic cancer
    • Berger A., Smith M., Lidsky L., Seifeldin R., and Oster G. Opioid use and health-care charges at the end of life in patients with metastatic cancer. Manag Care Interface 17 (2004) 28-34
    • (2004) Manag Care Interface , vol.17 , pp. 28-34
    • Berger, A.1    Smith, M.2    Lidsky, L.3    Seifeldin, R.4    Oster, G.5
  • 33
    • 57049154280 scopus 로고    scopus 로고
    • RxList. Zofran indications and usage, dosage and administration. Available from: [accessed July 2008].
    • RxList. Zofran indications and usage, dosage and administration. Available from: [accessed July 2008].
  • 34
    • 1642558406 scopus 로고    scopus 로고
    • The use of an electronic patient record system to identify advanced cancer patients and antidepressant drug use
    • Fisch M., Callahan C.M., Kesterson J.G., Nichols C., and Tierney W.M. The use of an electronic patient record system to identify advanced cancer patients and antidepressant drug use. J Palliat Med 2 (1999) 403-409
    • (1999) J Palliat Med , vol.2 , pp. 403-409
    • Fisch, M.1    Callahan, C.M.2    Kesterson, J.G.3    Nichols, C.4    Tierney, W.M.5
  • 36
    • 0034767372 scopus 로고    scopus 로고
    • Trends in expenditures for Medicare liver transplant recipients
    • Best J.H., Veenstra D.L., and Geppert J. Trends in expenditures for Medicare liver transplant recipients. Liver Transpl 7 (2001) 858-862
    • (2001) Liver Transpl , vol.7 , pp. 858-862
    • Best, J.H.1    Veenstra, D.L.2    Geppert, J.3
  • 37
    • 10744227495 scopus 로고    scopus 로고
    • Can we expand the indications for liver transplantation among hepatocellular carcinoma patients with increased tumor size?
    • Fernandez J.A., Robles R., Marin C., Sánchez-Bueno F., Ramirez P., Pons J.A., et al. Can we expand the indications for liver transplantation among hepatocellular carcinoma patients with increased tumor size?. Transplant Proc 35 (2003) 1818-1820
    • (2003) Transplant Proc , vol.35 , pp. 1818-1820
    • Fernandez, J.A.1    Robles, R.2    Marin, C.3    Sánchez-Bueno, F.4    Ramirez, P.5    Pons, J.A.6
  • 38
    • 0034991518 scopus 로고    scopus 로고
    • Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival
    • Yao F.Y., Ferrell L., Bass N.M., Watson J.J., Bacchetti P., Venook A., et al. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. Hepatology 33 (2001) 1394-1403
    • (2001) Hepatology , vol.33 , pp. 1394-1403
    • Yao, F.Y.1    Ferrell, L.2    Bass, N.M.3    Watson, J.J.4    Bacchetti, P.5    Venook, A.6
  • 39
    • 57049084849 scopus 로고    scopus 로고
    • Easton Associates Interviews and Analysis. Unpublished data collected by Easton Associates, LLC, 2004.
    • Easton Associates Interviews and Analysis. Unpublished data collected by Easton Associates, LLC, 2004.
  • 41
    • 57049121982 scopus 로고    scopus 로고
    • Drug Topics. Red book. Montvale (NJ): Medical Economics; 2004.
    • Drug Topics. Red book. Montvale (NJ): Medical Economics; 2004.
  • 42
    • 4444335882 scopus 로고    scopus 로고
    • Burden of illness in cancer survivors: findings from a population-based national sample
    • Yabroff K.R., Lawrence W.F., Clauser S., Davis W.W., and Brown M.L. Burden of illness in cancer survivors: findings from a population-based national sample. J Natl Cancer Inst 96 (2004) 1322-1330
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1322-1330
    • Yabroff, K.R.1    Lawrence, W.F.2    Clauser, S.3    Davis, W.W.4    Brown, M.L.5
  • 43
    • 57049176761 scopus 로고    scopus 로고
    • US Bureau of Labor Statistics. Median usual weekly earnings of full-time wage and salary workers. Available from: [accessed July 2008].
    • US Bureau of Labor Statistics. Median usual weekly earnings of full-time wage and salary workers. Available from: [accessed July 2008].
  • 44
    • 57049188555 scopus 로고    scopus 로고
    • Rice DP. Estimating the cost of illness. Health Economics Series, No. 6, DHEW Pub No. (PHS) 947-6. Rockville (MD): U.S. Department of Health Education and Welfare; 1966.
    • Rice DP. Estimating the cost of illness. Health Economics Series, No. 6, DHEW Pub No. (PHS) 947-6. Rockville (MD): U.S. Department of Health Education and Welfare; 1966.
  • 47
    • 41849131802 scopus 로고    scopus 로고
    • Natural history of hepatitis-related hepatocellular carcinoma
    • But D.Y., Lai C.L., and Yuen M.F. Natural history of hepatitis-related hepatocellular carcinoma. World J Gastroenterol 14 (2008) 1652-1656
    • (2008) World J Gastroenterol , vol.14 , pp. 1652-1656
    • But, D.Y.1    Lai, C.L.2    Yuen, M.F.3
  • 48
    • 0032976638 scopus 로고    scopus 로고
    • Information on radiation treatment in patients with breast cancer: the advantages of the linked Medicare and SEER data
    • Du X., Freeman J.L., and Goodwin J.S. Information on radiation treatment in patients with breast cancer: the advantages of the linked Medicare and SEER data. J Clin Epidemiol 52 (1999) 463-470
    • (1999) J Clin Epidemiol , vol.52 , pp. 463-470
    • Du, X.1    Freeman, J.L.2    Goodwin, J.S.3
  • 49
    • 57049124548 scopus 로고    scopus 로고
    • National Cancer Institute. SEER-Medicare Publications, 2005. Available from: [accessed October 2007].
    • National Cancer Institute. SEER-Medicare Publications, 2005. Available from: [accessed October 2007].


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.