LGR5 activates noncanonical Wnt signaling and inhibits aldosterone production in the human adrenal

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 6, 2015, Pages E836-E844

  Shaikh, Lalarukh Haris ^a   Zhou, Junhua ^a   Teo, Ada E D ^a   Garg, Sumedha ^a   Neogi, Sudeshna Guha ^c   Figg, Nichola ^a   Yeo, Giles S ^b   Yu, Haixiang ^a   Maguire, Janet J ^a   Zhao, Wanfeng ^b   Bennett, Martin R ^a   Azizan, Elena A B ^a,c   Davenport, Anthony P ^a   McKenzie, Grahame ^d   Brown, Morris J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; PROTEIN C JUN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTOME; WNT PROTEIN; G PROTEIN COUPLED RECEPTOR; LGR5 PROTEIN, HUMAN;

ADRENAL CELL; ALDOSTERONE RELEASE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; GENE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LGR5 GENE; PHEOCHROMOCYTOMA; PRIMARY HYPERALDOSTERONISM; PRIORITY JOURNAL; RSPO3 GENE; SIGNAL TRANSDUCTION; UPREGULATION; ZONA FASCICULATA; ZONA GLOMERULOSA; ADRENAL GLAND; BIOSYNTHESIS; CELL COUNT; CYTOLOGY; DOWN REGULATION; GENE EXPRESSION PROFILING; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MICROARRAY ANALYSIS; PHYSIOLOGY; TUMOR CELL CULTURE; WNT SIGNALING PATHWAY;

ADRENAL GLANDS; ALDOSTERONE; CELL COUNT; DOWN-REGULATION; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; MICROARRAY ANALYSIS; RECEPTORS, G-PROTEIN-COUPLED; TUMOR CELLS, CULTURED; UP-REGULATION; WNT SIGNALING PATHWAY; ZONA FASCICULATA; ZONA GLOMERULOSA;

EID: 84930806876     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-1734     Document Type: Article

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